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Curr Opin Nephrol Hypertens 2021 Apr 16. Epub 2021 Apr 16.

Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow AGE Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Purpose Of Review: Vascular calcification is a common and important cardiovascular risk factor in patients with chronic kidney disease (CKD). Recent advances in the understanding of the biology of vascular calcification implicate vitamin K-dependent proteins as important regulators in this process. This review highlights recent key advances in vascular biology, epidemiology, and clinical trials in this rapidly evolving field. Read More

Front Med (Lausanne) 2021 1;8:625647. Epub 2021 Apr 1.

Laboratorio de Investigacao Medica 12 (LIM12), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Chronic kidney disease (CKD) remains a global public health problem. The initial damage after ischemia/reperfusion (I/R) injury plays an important role in the pathogenesis of acute kidney injury (AKI) and predisposition to CKD. Several studies have been showing that risk factors such as AKI and hypovitaminosis D could also be involved in CKD progression. Read More

Eur J Case Rep Intern Med 2021 5;8(3):002357. Epub 2021 Mar 5.

Internal Medicine Department, Centro Hospitalar e Universitário São João, Porto, Portugal.

Before the development of transfusion medicine, severe anaemia was an important cause of morbidity and mortality. The discovery of haematopoietic mechanisms and essential nutrients made it possible to easily treat and prevent this condition. Nevertheless, it is often fatal in patients presenting with extreme anaemia (haemoglobin levels <2 g/dl). Read More

Gastroenterol Hepatol Bed Bench 2021 ;14(1):44-52

Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt.

Aim: The aim of this study was to determine the efficacy of a 6-month intramuscular vitamin D supplementation in improving the liver parameters in adult patients with non-alcoholic fatty liver disease (NAFLD).

Background: The association between vitamin D level and NAFLD has not been determined.

Methods: A single-blinded non-randomized controlled trial was conducted in 80 NAFLD patients assigned to receive a monthly single intramuscular dose of 200,000 IU cholecalciferol/vitamin D3 (n= 40), or placebo (n= 40) for six months. Read More

Int J Endocrinol 2021 1;2021:5598319. Epub 2021 Apr 1.

Upstate University Hospital, 3229 East Genesee Street, Syracuse 13214, NY, USA.

Background: Post-thyroidectomy hypocalcemia is the most common complication after total thyroidectomy. Studies to examine the role of low vitamin D in increasing post-thyroidectomy hypocalcemia incidence have produced varying results. This study aimed to assess whether vitamin D deficiency increases the risk of post-thyroidectomy hypocalcemia. Read More

Front Genet 2021 1;12:658446. Epub 2021 Apr 1.

Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.

Thiamine (vitamin B1) is often deficient in oncopatients, particularly those undergoing chemotherapy. However, interaction between the thiamine deficiency and anticancer action of drugs has not been characterized. A major natural thiamine derivative, thiamine diphosphate (ThDP), is a coenzyme of central metabolism, also known to affect transcriptional activity of the master metabolic regulator and genome guardian p53. Read More

Indian J Clin Biochem 2021 Apr 1;36(2):167-174. Epub 2020 Feb 1.

Department of Clinical and Operational Research, ICMR-National Institute for Research in Reproductive Health, Parel, India.

Despite ample sunshine, 50-90% Indian children have Vitamin D deficiency (VDD). This enigma of widespread VDD needs exploration especially among under-fives as physiological variations in Vitamin D Binding Protein (VDBP) levels could be potential confounders in the interpretation of total 25-hydroxyvitamin D [25(OH)D]. However, there is scarce information about relevance of VDBP levels in under-five age group. Read More

Clin Pediatr Endocrinol 2021 3;30(2):105-110. Epub 2021 Apr 3.

Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.

Vitamin D deficiency is a major cause of hypocalcemic seizures in infants. Chronic enteropathy can cause both malnutrition and vitamin deficiency disorders, such as celiac disease, in Western Caucasians. However, gluten-related disorders are considered uncommon in most Asian countries, and there have been no reports of any infant being diagnosed with a gluten-related disorder in Japan. Read More

Nutr Hosp 2021 Apr 19. Epub 2021 Apr 19.

Tarragona-Reus Research Support Unit. Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol).

Background And Objectives: despite long hours of sunlight in Spain, vitamin D deficiency has been rising of late. We aimed to describe vitamin D deficiency and insufficiency in at-risk patients in La Rioja, a region in northern Spain.

Methods: a retrospective, cross-sectional study involving 21,490 patients (74. Read More

J Coll Physicians Surg Pak 2021 Apr;30(4):393-398

Department of Medical Biology, Faculty of Medicine, Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey.

Objective: To evaluate the vitamin D receptor (VDR) gene polymorphisms and vitamin D levels in inactive hepatitis B virus (HBV) carriers.

Study Design: A cross-sectional analytical study.

Place And Duration Of Study: From March to September 2017 at the Izmir Katip Celebi University (İKCU) Ataturk Training and Research Hospital, Izmir, Turkey. Read More

BMC Musculoskelet Disord 2021 Apr 17;22(1):364. Epub 2021 Apr 17.

Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea.

Background: Vitamin B (Vit B) deficiency results in elevated homocysteine levels and interference with collagen cross-linking, which may affect tendon integrity. The purpose of this study was to investigate whether serum Vit B levels were correlated with degenerative rotator cuff (RC) tear.

Methods: Eighty-seven consecutive patients with or without degenerative RC tear were enrolled as study participants. Read More

Asian Pac J Allergy Immunol 2021 Apr 18. Epub 2021 Apr 18.

Department of Children Healthcare, Chongqing Health Center for Women and Children, 120 Longshan Road, Yubei District, Chongqing, China.

Background: Vitamin D is closely related to childhood allergic diseases, such as food allergies, atopic dermatitis, and asthma. However, it is unclear whether vitamin D status in the cord blood from mothers is related to food allergies in infants.

Objective: We performed a prospective cohort study on the relationship between the cord blood vitamin D [i. Read More

J Pediatr Endocrinol Metab 2021 Apr 16. Epub 2021 Apr 16.

Department of Paediatric Endocrinology, Evelina London Children's Hospital, London, UK.

Objectives: Nutritional rickets may be a preventable cause of craniosynostosis. This potential association is under-recognised. A late diagnosis of craniosynostosis may result in reduced brain growth, raised intracranial pressure and long-term psychosocial problems. Read More

Clin Endocrinol (Oxf) 2021 Apr 18. Epub 2021 Apr 18.

Department of Medicine, University of Auckland, Private Bag 92 019, Auckland, 1142, New Zealand.

Objective: Prolonged severe vitamin D deficiency can cause osteomalacia, but the 25-hydroxyvitamin D (25OHD) concentration below which this occurs is unknown. We investigated the prevalence of biochemical osteomalacia in adults with a measurement of 25OHD.

Design, Measurement, And Patients: 25OHD results between 1/1/2009 and 15/6/2020 were obtained from the regional laboratory database, together with measurements of serum calcium, parathyroid hormone (PTH) and alkaline phosphatase (ALP) within 6 months of the index 25OHD. Read More

Photochem Photobiol 2021 Apr 18. Epub 2021 Apr 18.

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Cátedra de Inmunología. Buenos Aires, Biotecnología, Argentina.

There are limited and controversial studies that address the role of vitamin D (vitD), a vitamin with immunomodulatory effects, in myasthenia gravis (MG), a neuromuscular autoimmune disease. We aimed to assess 25-hydroxy vitamin D (25(OH)D) levels and to evaluate possible associations with the clinical severity and other biomarkers of the disease. Serum levels of 25(OH)D, anti-acetylcholine receptor antibodies, and complement factor C5a were measured in MG patients (n=66) and healthy volunteers (HV) (n=25). Read More

Indian Pediatr 2021 Apr 17. Epub 2021 Apr 17.

Department of Orthopedics, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

Objectives: To compare serum 25-hydroxy vitamin D (25-OHD) status, bone mineral density and Insulin growth factor (IGF-1) level among children with cerebral palsy (CP) aged 1 to 8 years with age and gender matched controls.

Methods: A cross-sectional study enrolled thirty children in each group: CP with epilepsy, CP without epilepsy, and healthy controls and bone mineral density (BMD), serum 25-OHD levels, and serum insulin like growth factor (IGF)-1 levels were measured.

Results: Z scores of BMD [-1. Read More

Br J Oral Maxillofac Surg 2020 Aug 28. Epub 2020 Aug 28.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziosmanpasa University, Tokat, Turkey. Electronic address:

Vitamin D (VD) levels and several variants in the vitamin D receptor (VDR) gene are associated with the occurrence of diseases of the bones and cartilage. The aim of this research was to study and compare the association of the BsmI variant in the VDR gene as well as VD levels in disc displacement with reduction (DDR) between patients and healthy controls. This was a case-control study, in which 104 patients of DDR and 102 healthy individuals were studied. Read More

BMC Cardiovasc Disord 2021 Apr 16;21(1):188. Epub 2021 Apr 16.

Faculty of Health Studies, University of Rijeka, Viktora Cara Emina 5, 51000, Rijeka, Croatia.

Background: Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Therefore, the objective of this study was to analyze three well-studied VDR gene polymorphisms-Fok1 (rs2228570), BsmI (rs1544410) and Taq1 (rs731236)-in a cohort of CAD patients after acute myocardial infarction. Read More

J Endocrinol 2021 May;249(2):113-124

Mitochondrial Metabolism and Ageing Laboratory, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

Vitamin D deficiency is associated with symptoms of skeletal muscle myopathy including muscle weakness and fatigue. Recently, vitamin D-related metabolites have been linked to the maintenance of mitochondrial function within skeletal muscle. However, current evidence is limited to in vitro models and the effects of diet-induced vitamin D deficiency upon skeletal muscle mitochondrial function in vivo have received little attention. Read More

J Inherit Metab Dis 2021 Apr 16. Epub 2021 Apr 16.

Dermatology Department, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

Acute intermittent porphyria (AIP) is a rare metabolic disease caused by mutations within the hydroxymethylbilane synthase gene. Previous studies have reported increased levels of plasma total homocysteine (tHcy) in symptomatic AIP patients. In this study, we present long-term data for tHcy and related parameters for an AIP patient cohort (n = 37) in different clinical disease-states. Read More

J Cosmet Dermatol 2021 Apr 15. Epub 2021 Apr 15.

Department of Dermatology, National Research Centre, Egypt.

Background: Cutaneous warts are frequent conditions that possess much challenge to treat.

Objective: To verify the potential role of vitamin D in the pathogenesis of viral warts by measuring the serum levels of vitamin D in patients diagnosed with viral warts compared to healthy controls and to verify whether oral vitamin D supplementation of those vitamin D- deficient patients would result in wart clearance.

Methods: To evaluate the serum vitamin D levels, the study recruited 80 subjects, including 40 patients diagnosed with viral warts and 40 age and sex matched healthy controls. Read More

Hamostaseologie 2021 Apr 15;41(2):104-110. Epub 2021 Apr 15.

Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

Despite advances in anticoagulant therapy, thrombosis remains the leading cause of morbidity and mortality worldwide. Heparin and vitamin K antagonists (VKAs), the first anticoagulants to be used successfully for the prevention and treatment of thrombosis, are associated with a risk of bleeding. These agents target multiple coagulation factors. Read More

Cureus 2021 Mar 13;13(3):e13866. Epub 2021 Mar 13.

Internal Medicine, St. Luke's University Health Network, Easton, USA.

Protein S is a potent anticoagulant that downregulates thrombin formation and is a vitamin K-dependent glycoprotein which is primarily synthesized in the liver. A deficiency in this protein or decreased activity, as seen in hereditary protein S deficiency, can lead to life-threatening thrombosis. Hereditary protein S deficiency is a rare disease as listed by the National Organization for Rare Disorders (NORD). Read More

Case Rep Med 2021 30;2021:5519937. Epub 2021 Mar 30.

Geisinger Medical Center, 100 N Academy Ave, Danville, PA 17822, USA.

Introduction: Pulmonary hypertension secondary to scurvy is a rare manifestation that historically has not been well studied and is only described in a handful of case reports.

Case: Our case is about a 35-year-old female with a history significant for drug and tobacco abuse, obesity, poor diet, anxiety, and major depressive disorder who was found to have severe pulmonary hypertension in the setting of vitamin C deficiency (<0.01 mg/L). Read More

Endocr Metab Immune Disord Drug Targets 2021 Apr 14. Epub 2021 Apr 14.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran. Iran.

Background: In Congenital Disorder of Glycosylation (CDG) type Ia, homozygous mutations of the PMM2 gene cause phosphomannomutase 2 dysfunction.

Case Presentation: Herein, a 10-month-old girl is presented with severe hypotonia along with inappropriately normal mental status and normal facies. High 2-ketoglutaric acid was detected in her urine; therefore the diagnosis of 2-Ketoglutarate dehydrogenase complex (KDHC) deficiency was made for this patient. Read More

Expert Rev Respir Med 2021 Apr 15. Epub 2021 Apr 15.

Halal Research Center of IRI, FDA, Tehran, Iran.

: Viral respiratory tract infections (RTIs) have been recognized as a global public health burden. Despite current theories about their effectiveness, the true benefits of dietary supplements on the prevention and treatment of viral RTIs remain elusive, due to contradictory reports. Hence, we aimed to evaluate the effectiveness of dietary supplements on the prevention and treatment of viral RTIs. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Apr;55(4):485-491

School of Public Health, Fudan University, Shanghai 200032, China.

To explore the relationship between the level of blood homocysteine (Hcy) and the total score of Chinese Healthy Eating Index (CHEI) and its item score. The subjects were recruited from the East China Natural Population Cohort Study, led by the School of Public Health in Fudan University, which was conducted in Zhongshan Community, Songjiang District of Shanghai from April to September 2017. By using the cluster random sampling method, 8 neighborhood committees were randomly selected from 18 neighborhood committees in Zhongshan community (Beimen, Baiyun, Dongwai, Huaqiao, Lantian village 1, Lantian village 2, Lantian village 4, and Lantian village 5). Read More

J Bone Miner Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada, K7L3N6.

Genetic causes of vitamin D-related hypercalcemia are known to involve mutation of 25-hydroxyvitamin D-24-hydroxylase CYP24A1 or the sodium phosphate co-transporter SLC34A1; which result in excessive 1,25-(OH) D hormonal action. However, at least 20% of idiopathic hypercalcemia (IH) cases remain unresolved. In this case-control study, we used precision vitamin D metabolite profiling based on LC-MS/MS of an expanded range of vitamin D metabolites - to screen German and French cohorts of hypercalcemia patients, to identify patients with altered vitamin D metabolism where involvement of CYP24A1 or SLC34A1 mutation had been ruled out, and possessed normal 25-OH-D :24,25-(OH) D ratios. Read More

Photochem Photobiol Sci 2020 Jun 27;19(6):800-809. Epub 2020 Oct 27.

Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.

There is widespread acknowledgement of the presence of vitamin D deficiency in the community and the pressing need to address this. From a public health perspective, emphasis has been placed on addressing vitamin D deficiency through dietary means. However, naturally rich food sources of vitamin D are few and infrequently consumed, and nutrition survey data from various countries have indicated that habitual vitamin D intakes in the community are much lower than the current vitamin D dietary guidelines. Read More

Oncol Nurs Forum 2021 05;48(3):352-360

Loyola University Chicago.

Objectives: To assess the potential effect of cholecalciferol supplementation to reduce symptom burden for women with metastatic breast cancer (MBC).

Sample & Setting: 11 clinically stable women with estrogen receptor-positive MBC were recruited from a single cancer center for this phase 1, nonrandomized study (NCT02186015).

Methods & Variables: Women with insufficient serum 25-hydroxyvitamin D (25[OH]D) levels qualified to receive high-dose repletion therapy. Read More