1,346 results match your criteria vitamin covid-19

An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank.

Sci Rep 2021 09 14;11(1):18262. Epub 2021 Sep 14.

Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.

A growing body of evidence suggests that vitamin D deficiency has been associated with an increased susceptibility to viral and bacterial respiratory infections. In this study, we aimed to examine the association between vitamin D and COVID-19 risk and outcomes. We used logistic regression to identify associations between vitamin D variables and COVID-19 (risk of infection, hospitalisation and death) in 417,342 participants from UK Biobank. Read More

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September 2021

Vitamin D deficiency and inactivated SARS-CoV-2 vaccines.

Eur J Intern Med 2021 Sep 9. Epub 2021 Sep 9.

Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan. Electronic address:

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September 2021

Nutritional and lifestyle changes required for minimizing the recovery period in home quarantined COVID-19 patients of Punjab, Pakistan.

Food Sci Nutr 2021 Jul 9. Epub 2021 Jul 9.

National Institute of Food Science and Technology University of Agriculture Faisalabad Pakistan.

The COVID-19 pandemic has introduced a new battle in human history for a safe and fearless life. Therefore, this cross-sectional survey was conducted (Punjab, Pakistan) on healthy recovered, home quarantined COVID-19 patients to draw conclusive health support guidelines in the fight against this pandemic. COVID-19 recovered patients ( = 80) of age ≥14 years were randomly selected during the period November 2020 to February 2021. Read More

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Prevalence and predictors of self-medication drugs to prevent or treat COVID-19: experience from a Middle Eastern country.

Int J Clin Pract 2021 Sep 13:e14860. Epub 2021 Sep 13.

Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan.

Background: Lack of definitive cure for COVID-19 and the late introduction of a vaccine were responsible to push the general public to look for a remedy to treat or prevent COVID-19. The objective of this study was to evaluate patterns and factors that affect self-medication practices in Jordan during the pandemic.

Methods: This was a cross-sectional study using an online questionnaire that was developed, piloted and distributed to the general public via various social media platforms. Read More

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September 2021

Ethnicity as a risk factor for vitamin D deficiency and undesirable COVID-19 outcomes.

Rev Med Virol 2021 Sep 13:e2291. Epub 2021 Sep 13.

Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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September 2021

Metformin - a new approach.

Pediatr Endocrinol Diabetes Metab 2021 ;27(2):134-140

Chair and Department of Basic Medical Sciences, Wroclaw Medical University, Wroclaw, Poland.

Metformin is a widely used biguanide drug recommended as a first-line antidiabetic for type 2 diabetes. Currently, metformin is used not only in the treatment of diabetes but also in other diseases. Some studies have shown that metformin causes weight loss in insulin-sensitive and insulin-resistant overweight and obese patients. Read More

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January 2021

A Debate on Vitamin C: Supplementation on the Hotline for Critically Ill Patients with COVID-19.

Adv Pharm Bull 2021 May 17;11(3):395-396. Epub 2020 Aug 17.

Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

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A Randomized Pilot Study Using Calcitriol in Hospitalized Patients.

Bone 2021 Sep 8:116175. Epub 2021 Sep 8.

Division of Endocrinology Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Beth Israel, Mount Sinai Morningside, Mount Sinai West.

The systemic illness associated with SARS-CoV-2 infection results in hospitalization rate of 380.3 hospitalizations per 100,000 population, overwhelming health care systems. Vitamin D regulates expression of approximately 11,000 genes spanning many physiologic functions that include regulation of both innate and adaptive immune function. Read More

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September 2021

Potential role of flavonoids against SARS-CoV-2 induced diarrhea.

Trop Biomed 2021 Sep;38(3):360-365

School of Pharmacy, University of Nottingham Malaysia Campus, Semenyih 43500, Selangor Darul Ehsan, Malaysia.

COVID-19, caused by the SARS-CoV-2 virus, can lead to massive inflammation in the gastrointestinal tract causing severe clinical symptoms. SARS-CoV-2 infects lungs after binding its spike proteins with alveolar angiotensin-converting enzyme 2 (ACE2), and it also triggers inflammation in the gastrointestinal tract. SARS-CoV-2 invades the gastrointestinal tract by interacting with Toll-like receptor-4 (TLR4) that induces the expression of ACE2. Read More

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September 2021

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells.

PLoS Pathog 2021 09 9;17(9):e1009840. Epub 2021 Sep 9.

Wellcome Centre for Cell-Matrix Research, University of Manchester, Oxford Road, Manchester, United Kingdom.

COVID-19 vaccines based on the Spike protein of SARS-CoV-2 have been developed that appear to be largely successful in stopping infection. However, therapeutics that can help manage the disease are still required until immunity has been achieved globally. The identification of repurposed drugs that stop SARS-CoV-2 replication could have enormous utility in stemming the disease. Read More

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September 2021

High-dose vitamin C ameliorates cardiac injury in COVID-19 pandemic: a retrospective cohort study.

Aging (Albany NY) 2021 Sep 9;13(undefined). Epub 2021 Sep 9.

Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.

Background: Cardiac injury is common and associated with poor clinical outcomes in COVID-19. Data are lacking whether high-dose intravenous vitamin C (HIVC) could help to ameliorate myocardial injury in the pandemic.

Methods: The retrospective cohort study included consecutive severe and critically ill COVID-19 patients with cardiac injury receiving symptomatic supportive treatments alone or together with HIVC. Read More

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September 2021

General methodological aspects in the Brazilian National Survey on Child Nutrition (ENANI-2019): a population-based household survey.

Cad Saude Publica 2021 30;37(8):e00300020. Epub 2021 Aug 30.

Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

This article aims to present general methodological aspects of the Brazilian National Survey on Child Nutrition (ENANI-2019), from the conception of the study design to details of the data collection. This is a household-based population survey with a sample calculated at 15,000 households to identify children under five years of age, conducted in 123 municipalities in Brazil's 26 states and the Federal District. ENANI-2019 includes data on breastfeeding and dietary intake; anthropometric nutritional status of all children and their biological mothers; and nutritional status concerning the following micronutrients: iron (hemoglobin and ferritin), zinc, selenium, and vitamins A, B1, B6, B12, D, E, and folic acid of children from 6 to 59 months of age. Read More

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September 2021

Clinical characteristics, treatment modalities and outcome of coronavirus disease 2019 patients treated at thisday dome isolation and treatment centre, federal capital territory Abuja, Nigeria.

Niger Postgrad Med J 2021 Apr-Jun;28(2):81-87

Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital; Department of Psychiatry, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.

Introduction: Coronavirus disease 2019 (COVID-19), a highly transmissible viral infection has spread worldwide causing exponential increase in morbidity and mortality. But so far, there is limited information available to describe the presenting characteristics, outcomes and treatment modalities of COVID-19 patients in Nigeria. This study aimed to describe the demographic and clinical characteristics, underlying comorbidities, treatment modalities and outcomes of patients isolated and treated in a repurposed COVID-19 isolation and treatment centre in Abuja, Nigeria. Read More

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September 2021

The Role of Micronutrients to Support Immunity for COVID-19 Prevention.

Rev Bras Farmacogn 2021 Sep 2:1-14. Epub 2021 Sep 2.

Faculty of Agricultural and Food Sciences, Széchenyi István University, 9200 Mosonmagyaróvár, Hungary.

The World Health Organization declared the novel coronavirus, named as SARS-CoV-2, as a global pandemic in early 2020 after the disease spread to more than 180 countries leading to tens of thousands of cases and many deaths within a couple of months. Consequently, this paper aims to summarize the evidence for the relationships between nutrition and the boosting of the immune system in the fight against the disease caused by SARS-CoV-2. This review, in particular, assesses the impact of vitamin and mineral supplements on the body's defence mechanisms against SARS-CoV-2. Read More

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September 2021

A critical update on the role of mild and serious vitamin D deficiency prevalence and the COVID-19 epidemic in Europe.

Nutrition 2021 Jul 30;93:111441. Epub 2021 Jul 30.

Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, Thessaloniki, Greece. Electronic address:

Objectives: Coronavirus disease 2019 (COVID-19) has emerged as a pandemic, affecting nearly 180 million people worldwide as of June 22, 2021. Previous studies have examined the association between the mean vitamin D (Vit D) concentration of each country and COVID-19 infection and mortality rate in European countries. The aim of the present study was to critically evaluate the relationship between prevalence of mild and severe Vit D deficiency in each country and COVID-19 infection, recovery, and mortality using updated data and a different methodological approach. Read More

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Vitamin D levels and mortality with SARS-COV-2 infection: a retrospective two-centre cohort study.

Postgrad Med J 2021 Sep 6. Epub 2021 Sep 6.

Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.

Background: The role of vitamin D in increased mortality with SARS-COV-2 virus, namely, COVID-19, remains uncertain. We analysed all the patients who were treated as COVID-19-positive with or without a positive swab and were tested for vitamin D levels.

Methods: This was a retrospective, study involving 1226 patients swabbed for SARS-CoV-2 between the 10 February 2020 and 1 May 2020 at two hospitals of East Sussex Healthcare NHS Trust. Read More

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September 2021

The effect of plant metabolites on coronaviruses: A comprehensive review focusing on their IC50 values and molecular docking scores.

Mini Rev Med Chem 2021 Aug 31. Epub 2021 Aug 31.

Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Coronaviruses have caused worldwide outbreaks in different periods. SARS (severe acute respiratory syndrome), was the first emerged virus from this family, followed by MERS (Middle East respiratory syndrome) and SARS-CoV-2 (2019-nCoV or COVID 19), which is newly emerged. Many studies have been conducted on the application of chemical and natural drugs for treating these coronaviruses and they are mostly focused on inhibiting the proteases of viruses or blocking their protein receptors through binding to amino acid residues. Read More

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Vitamin K deficient bleeding and COVID-19: How are they related?

J J Volpe

J Neonatal Perinatal Med 2021 Aug 28. Epub 2021 Aug 28.

Department of Neurology, Harvard Medical School, Boston, MA, USA.

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NEPA (netupitant/palonosetron) for the antiemetic prophylaxis of nausea and vomiting induced by chemotherapy (CINV) with Folfirinox and Folfoxiri even during the COVID-19 pandemic: a real-life study.

Eur Rev Med Pharmacol Sci 2021 08;25(16):5310-5317

Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy.

Objective: The outbreak of coronavirus disease 2019 (COVID-19) has affected the treatment of cancer patients, with particular regard to the management of both chemotherapy and side effects. Chemotherapy-induced nausea and vomiting (CINV) are amongst the most troublesome side effects that impair patients' adherence to treatments and their quality of life (QoL). NEPA (Akynzeo®), is an oral fixed-dose combination of netupitant [a neurokinin-1 receptor antagonist (NK1RA), 300 mg] and palonosetron [(5-hydroxytryptamine (serotonin or 5HT) type3 receptor antagonist (5HT3RA), 0. Read More

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Increase in urolithiasis prevalence due to vitamins C and D supplementation during the COVID-19 pandemic.

J Public Health (Oxf) 2021 Sep 6. Epub 2021 Sep 6.

Hotel-Dieu de France, Saint Joseph University, Beirut 1004, Lebanon.

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September 2021

Effects of Potential Micro- and Macro-nutrients in Combatting COVID-19.

Curr Surg Rep 2021 30;9(10):24. Epub 2021 Aug 30.

Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL USA.

Purpose Of Review: Gain insight on the effect of some recently studied nutrients and nutritional markers on the COVID-19 disease course.

Recent Findings: In vitro studies indicate that SCFAs do not interfere with SARS-CoV-2 infectivity. Observational studies indicate that eating processed or red meat three or more times per week had overall higher risk of pneumonia. Read More

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Molecular docking and dynamics studies of Nicotinamide Riboside as a potential multi-target nutraceutical against SARS-CoV-2 entry, replication, and transcription: A new insight.

J Mol Struct 2022 Jan 30;1247:131394. Epub 2021 Aug 30.

Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari, Iran.

The highly contagious Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which is a newborn infectious member of the dangerous beta-coronaviruses (β-CoVs) following SARS and MERS-CoVs, can be regarded as the most significant issue afflicting the whole world shortly after December 2019. Considering CoVs as RNA viruses with a single-stranded RNA genome (+ssRNA), the critical viral enzyme RNA dependent RNA polymerase (RdRp) is a promising therapeutic target for the potentially fatal infection COVID-19. Nicotinamide riboside (NR), which is a naturally occurring analogue of Niacin (vitamin B3), is expected to have therapeutic effects on COVID-19 due to its super close structural similarity to the proven RdRp inhibitors. Read More

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January 2022

Self-assembled polymeric micelle as a novel mRNA delivery carrier.

J Control Release 2021 Sep 2;338:537-547. Epub 2021 Sep 2.

Beijing Institute of Radiation Medicine, Beijing 100850, PR China. Electronic address:

mRNA-based therapy has been evaluated in preclinical and clinical studies for the treatment of a wide variety of disease such as cancer immunotherapies and infectious disease vaccines. However, it remains challenging to development safe and efficient delivery system. Here, we have designed a novel self-assembled polymeric micelle based on vitamin E succinate modified polyethyleneimine copolymer (PVES) to delivery mRNA. Read More

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September 2021

Efficacy and safety of direct-acting oral anticoagulants compared to vitamin K antagonists in COVID-19 outpatients with cardiometabolic diseases.

Cardiovasc Diabetol 2021 09 4;20(1):176. Epub 2021 Sep 4.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK.

Background: It remains uncertain if prior use of oral anticoagulants (OACs) in COVID-19 outpatients with multimorbidity impacts prognosis, especially if cardiometabolic diseases are present. Clinical outcomes 30-days after COVID-19 diagnosis were compared between outpatients with cardiometabolic disease receiving vitamin K antagonist (VKA) or direct-acting OAC (DOAC) therapy at time of COVID-19 diagnosis.

Methods: A study was conducted using TriNetX, a global federated health research network. Read More

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September 2021

Ascorbic acid as an adjunctive therapy in critically ill patients with COVID-19: a propensity score matched study.

Sci Rep 2021 09 3;11(1):17648. Epub 2021 Sep 3.

College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

Ascorbic acid represents an appealing option for clinicians to utilize in the context of the global COVID-19 pandemic due to its proposed clinical efficacy, relative safety, and low cost. The aim of this study was to evaluate the efficacy and safety of using ascorbic acid in supplemental doses as adjunctive therapy for patients critically ill with COVID-19. This was a two-center, non-interventional, retrospective cohort study. Read More

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September 2021

The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality.

Sci Rep 2021 09 2;11(1):17594. Epub 2021 Sep 2.

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Supplemental vitamin D can reduce the risk and mortality of viral pneumonia. The relationship between 25 hydroxyvitamin D [25(OH)D] levels and the severity and mortality of Coronavirus disease 2019 (COVID-19) was evaluated. In this cross-sectional study, the admitted patients with COVID-19 were categorized as mild, moderate, severe, and critical based on clinical and radiologic characteristics. Read More

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September 2021

Decentralized vitamin C & D dual biosensor chip: Toward personalized immune system support.

Biosens Bioelectron 2021 Aug 26;194:113590. Epub 2021 Aug 26.

Dept. Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA. Electronic address:

Combating the ongoing COVID-19 pandemic has put the spotlight on nutritional support of the immune system through consumption of vitamins C and D. Accordingly, there are urgent demands for an effective on-the-spot multi-vitamin self-testing platform that monitors the levels of these immune-supporting micronutrients for guiding precision nutrition recommendations. Herein, we present a compact bioelectronic dual sensor chip aimed at frequent on-the-spot simultaneous monitoring of the salivary vitamin C and D dynamics. Read More

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Examination of the Moderating Effect of Race on the Relationship between Vitamin D Status and COVID-19 Test Positivity Using Propensity Score Methods.

J Am Coll Nutr 2021 Sep 2:1-12. Epub 2021 Sep 2.

Center for Biostatistics and Health Data Sciences, Virginia Polytechnic Institute and State University, Roanoke, Virginia, USA.

Introduction: With a well-established role in inflammation and immune function, vitamin D status has emerged as a potential factor for coronavirus disease-2019 (COVID-19).

Objective: The purpose of this study was to evaluate the moderating effect of race on the relationship between vitamin D status and the risk of COVID-19 test positivity, and to compare propensity score (PS) model results to those obtained from classical bivariate and multivariable models, which have primarily comprised the literature to date.

Methods: Electronic health record (EHR) data from TriNetX (unmatched n = 21,629; matched n = 16,602) were used to investigate the effect of vitamin D status, as measured by 25-hydroxyvitamin D [25(OH)D], on the odds of experiencing a positive COVID-19 test using multivariable logistic regression models with and without PS methodology. Read More

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September 2021

Role of Folate, Cobalamin, and Probiotics in COVID-19 Disease Management [Letter].

Drug Des Devel Ther 2021 25;15:3709-3710. Epub 2021 Aug 25.

Dow Medical College, Karachi, Sindh, Pakistan.

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September 2021