45,542 results match your criteria visual loss

The majority of conversion total hip arthroplasties can be considered primary replacements - a matched cohort study.

Acta Orthop Belg 2021 Mar;87(1):17-23

The success of conversion Total Hip Arthroplasty (THA) among primary THA and revision THA re- mains unclear. We hypothesized that most conversion THAss can be performed using primary implants and will have an uncomplicated post-operative course. Thirty-six patients (23 females, mean age 68,0y) who underwent conversion THA for failed interventions for proximal femur fractures in the period 2006-2018 were matched sequentially against patients of the same sex and age who underwent primary THA or revision THA. Read More

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Complications and visual outcomes of cataract surgery in patients with pseudoexfoliation.

Int Ophthalmol 2021 Jun 15. Epub 2021 Jun 15.

Cataract & Refractive Surgery Services, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To compare outcomes of cataract surgery performed by ophthalmic trainees and consultants in patients associated with pseudoexfoliation (PXF) METHODS: Retrospective review of medical records of all patients with PXF who had undergone cataract surgery from January 2016 to December 2018 at L V Prasad Eye Institute, Hyderabad, India, were analysed RESULTS: A total of 914 eyes were included in the study; surgeries on 501 (54.8%) eyes with PXF were performed by trainees, while 413 (45.2%) were performed by consultants. Read More

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Enhanced Sensitivity to Optimistic Cues is Manifested in Brain Structure: A Voxel-Based Morphometry Study.

Soc Cogn Affect Neurosci 2021 Jun 15. Epub 2021 Jun 15.

Institute of Psychology, University of Bern, Bern, Switzerland.

Recent research shows that congruent outcomes are more rapidly (and incongruent less rapidly) detected when individuals receive optimistic rather than pessimistic cues, an effect that was termed optimism robustness. In the current voxel-based morphometry study, we examined whether optimism robustness has a counterpart in brain structure. The participants' task was to detect two different letters (symbolizing monetary gain or loss) in a visual search matrix. Read More

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Neuro-ophthalmic manifestations of tuberculosis.

Eye (Lond) 2021 Jun 14. Epub 2021 Jun 14.

Neuro-Ophthalmology Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Neuro-ophthalmic features are a known association in tuberculosis, especially common in central nervous system tuberculosis (CNS-TB). They are mostly the result of the visual pathway and/or ocular motor and other cranial nerve involvement. Furthermore, toxic optic neuropathy and paradoxical response to anti-tubercular drugs (ATT) are also not uncommon. Read More

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Othello Syndrome: Delusional Disorder - Jealous Type ≠ Violence.

CNS Spectr 2021 Apr;26(2):160-161

University of Florida College of Medicine, Department of Psychiatry, Gainesville, FL, USA.

Background: Othello syndrome, also known as morbid jealousy, pathological jealousy, and conjugal paranoia, is a rare delusional disorder related to partner's infidelity. There are no large scale or comprehensive studies on delusional jealousy, and only few case reports and cases series leave delusional disorder jealous type (DDJT) largely unknown. Herein, we report a case of DDJT, its possible etiology and describe its characteristics, comorbidities, and interventions. Read More

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Treatment outcomes in the neovascular glaucoma tube versus trabeculectomy study.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Purpose: To compare surgical outcomes between patients who underwent Baerveldt glaucoma implantation versus trabeculectomy (TLE) for the treatment of neovascular glaucoma.

Methods: We performed a prospective, randomized, controlled clinical trial at Hiroshima University and Tsukazaki Hospital, Japan. Patients were randomized to Baerveldt glaucoma implantation (23 patients) or TLE (27 patients). Read More

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Paracentral Acute Middle Maculopathy Revealing a Giant Aortic Aneurysm.

Ocul Immunol Inflamm 2021 Jun 14:1-5. Epub 2021 Jun 14.

Department of Neurology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

: This report describes a case with paracentral acute middle maculopathy revealing a giant aortic aneurysm.: A 41-year-old man presented with unilaterally unexplained sudden vision loss in the left eye. Fundoscopy revealed a slightly pale r -26etinal reflex in the superior retinal hemifield. Read More

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Exercise vs Conventional Treatment for Treatment of Primary Osteoporosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Orthop Surg 2021 Jun 14. Epub 2021 Jun 14.

Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Objective: Physical exercise has obvious effects on bone loss, pain relief, and improvement of bone metabolism indexes in patients with osteoporosis, but currently lacks sufficient evidence. The aim of this systematic review and meta-analysis was to synthesize and present the best available evidence on the effectiveness and safety of exercises in the treatment of primary osteoporosis.

Methods: Publications pertaining to the effectiveness of exercise on bone mineral density (BMD), visual analog scores (VAS), and biochemical markers of bone metabolism in primary osteoporosis (POP) from PubMed, Cochrane Library, Embase, VIP, CNKI, and Wanfang Database were retrieved from their inception to April 2020. Read More

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Damage to the Superior Retinae After 30 Gy Whole-Brain Radiation.

Adv Radiat Oncol 2021 Jul-Aug;6(4):100706. Epub 2021 Apr 18.

Departments of Ophthalmology, University of California, San Francisco.

Purpose: The most common treatment protocol for whole-brain radiation therapy (WBRT) is 30 Gy in 10 fractions. This regimen entails a low risk of radiation retinopathy, with fewer than a dozen reported cases. We describe a case of radiation retinopathy that was confined to the superior retinae. Read More

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-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation Mesenchymal Stem Cells.

Front Cell Dev Biol 2021 27;9:650599. Epub 2021 May 27.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Myeloid cells have been identified as hematopoietic stem cell (HSC)-regulating cells. However, the mechanisms by which myeloid cells regulate the function of HSCs are not fully defined. Our previous study indicated that the HSCs are over-expanded in mice. Read More

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Leber Hereditary Optic Neuropathy: Review of Treatment and Management.

Front Neurol 2021 26;12:651639. Epub 2021 May 26.

Neuro-ophthalmology Department, Hôpital Fondation Rothschild, Paris, France.

Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease that specifically targets the retinal ganglion cells by reducing their ability to produce enough energy to sustain. The mutations of the mitochondrial DNA that cause LHON are silent until an unknown trigger causes bilateral central visual scotoma. After the onset of loss of vision, most patients experience progressive worsening within the following months. Read More

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The Interaction Between Microglia and Macroglia in Glaucoma.

Front Neurosci 2021 28;15:610788. Epub 2021 May 28.

Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.

Glaucoma, a neurodegenerative disease that leads to irreversible vision loss, is characterized by progressive loss of retinal ganglion cells (RGCs) and optic axons. To date, elevated intraocular pressure (IOP) has been recognized as the main phenotypic factor associated with glaucoma. However, some patients with normal IOP also have glaucomatous visual impairment and RGC loss. Read More

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Frequency and risk factors for hydroxychloroquine retinopathy among patients with systemic lupus erythematosus.

Egypt J Intern Med 2021 8;33(1):18. Epub 2021 Jun 8.

Department of Medicine Division of Rheumatology, Ain Shams University, Cairo, Egypt.

Background: Hydroxychloroquine (HCQ) is an antimalarial drug, recently used in COVID-19 treatment. Also it is considered over many years the cornerstone in treating systemic lupus erythematosus (SLE) in adults and children. The incidence of retinal affection and retinal toxicity from hydroxychloroquine is rare, but even after the HCQ is stopped, loss of vision may not be reversible and may continue to progress. Read More

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Determinants of hearing loss in children with cerebral palsy in Kano, Nigeria.

Niger J Clin Pract 2021 Jun;24(6):802-807

Department of Otorhinolaryngology, Aminu Kano Teaching Hospital and Bayero University, Kano, Nigeria.

Background: Cerebral palsy (CP) is a commonly occurring disorder of movement and posture that starts in early childhood. It is accompanied by other disturbances including hearing loss which has been shown to worsen the quality of life of the patients due to problems associated with speech and language acquisition. Several factors are responsible for developing hearing loss in CP. Read More

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Observational outcomes in proliferative diabetic retinopathy patients following treatment with ranibizumab, panretinal laser photocoagulation or combination therapy - The non-interventional second year follow-up to the PRIDE study.

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

Cologne Image Reading Center, Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.

Purpose: Ranibizumab monotherapy showed stronger effects on area of retinal neovascularization (NV) reduction while offering better visual acuity (VA) results than panretinal laser photocoagulation (PRP) monotherapy during the first 12 months of the PRIDE study. The second year of PRIDE was an observational, non-interventional follow-up, performed to evaluate long-term anatomical and functional outcomes in proliferative diabetic retinopathy (PDR) patients under real-life conditions, prior to the approval of ranibizumab for PDR.

Methods: Seventy-three PDR patients (28 from the ranibizumab group; 20 from the PRP group; 25 from the combination group) were included in the observational follow-up phase and treated at the investigators discretion. Read More

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Long-term Clinical Outcomes of Microendoscopic Laminotomy for Cervical Spondylotic Myelopathy: A 5-Year Follow-up Study Compared With Conventional Laminoplasty.

Clin Spine Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama Department of Orthopaedic Surgery, Dokkyo Medical University, Tochigi, Japan Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Study Design: This was a retrospective cohort study.

Objective: The objective of this study was to characterize the long-term clinical and radiographic results of articular segmental decompression surgery using endoscopy [cervical microendoscopic laminotomy (CMEL)] for cervical spondylotic myelopathy (CSM) and to compare outcomes to conventional expansive laminoplasty (ELAP).

Summary Of Background Data: The spinal cord compression in CSM consists of a pincer mechanism due to bulging disk and a hypertrophied ligamentum flavum. Read More

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The red eye.

Stefano Bonini

Eur J Ophthalmol 2021 Jun 12:11206721211024827. Epub 2021 Jun 12.

Department of Ophthalmology, University of Rome Campus BioMedico, Rome, Italy.

The red eye is one of the most common cause encountered in ophthalmic practice but a red eye is not always related to eye diseases, instead, it may be a clinical sign of several systemic diseases which may the alarmin signal of sight-threatening or life-threatening condition. Frequently, GPs, pediatricians, immunologists, and rheumatologists are the first landing of patients with a "red eye." This paper is addressed to non-ophthalmic specialists who may be faced with patients having a red eye. Read More

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Application of lateral supraclavicular incision in unilateral thyroid papillary carcinoma surgery.

Braz J Otorhinolaryngol 2021 Apr 20. Epub 2021 Apr 20.

Kunming Medical University, Third Affiliated Hospital, Kunming, Yunnan Province, China. Electronic address:

Introduction: The standard approach to thyroidectomy is a collar incision via the anterior neck, and the neck scar has always been a source of worry for patients. Acceptable wound cosmetology has become a focus for thyroid surgeons.

Objective: To verify the effectiveness and cosmetic results of thyroidectomy through a lateral supraclavicular incision. Read More

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Does Loss of Spondylolisthesis Reduction Impact Clinical and Radiographic Outcomes after Minimally Invasive Transforaminal Lumbar Interbody Fusion.

Spine J 2021 Jun 9. Epub 2021 Jun 9.

Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA; Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA. Electronic address:

Background Context: Minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) is a common operative approach to address degenerative lumbar stenosis and spondylolisthesis which has failed nonoperative care. Compared to open TLIF, MI-TLIF relies to a greater extent on indirect decompression resulting in a heightened awareness of spondylolisthesis reduction among MI surgeons. To what extent intraoperative reduction is achieved as well as the rate and clinical impact of loss or reduction and slip recurrence remain unknown. Read More

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Ultrastructural Alterations of Grafted Corneal Buttons: The Anatomic Basis for Stromal Peeling along a Natural Plane of Separation.

Am J Ophthalmol 2021 Jun 9. Epub 2021 Jun 9.

University of Ferrara, Department of Translational Medicine, Ferrara, Italy; Ospedali Privati Forlì "Villa Igea", Department of Ophthalmology, Forlì, Italy; Istituto Internazionale per la Ricerca e Formazione in Oftalmologia (IRFO), Forlì, Italy.

Purpose: To examine the ultrastructure of the natural plane of separation in grafted corneas and evaluate the outcomes of stromal peeling.

Design: Interventional case series METHODS: In this multicenter study, stromal peeling was attempted in 96 consecutive eyes with unsatisfactory vision following penetrating keratoplasty (PK) for keratoconus(n=79), herpetic keratitis(n=11) and granular dystrophy(n=6). Stromal exchange was performed by: 1) 9mm partial-thickness trephination; 2) creation of a corneal flap across the PK wound; 3) opening of the stromal component of the PK wound until a smooth, translucent natural plane was identified; 4) severing the attachment of the PK scar; 5) stromal peeling along the identified plane; 6) suturing of donor lamella. Read More

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Noninfectious Intermediate, Posterior, or Panuveitis: Results from the Retrospective, Observational, International EyeCOPE Study.

Ophthalmol Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Ophthalmology, Faculty of Medicine, Gazi University, 13th Floor, Besevler, Cankaya, 06500, Ankara, Turkey.

Introduction: The EyeCOPE study characterized noninfectious intermediate posterior, or panuveitis (NIIPPU) before biologic agents were widely available.

Methods: This retrospective, observational study included adults with NIIPPU attending a routine ophthalmological visit. Data were collected from the study visit and medical records. Read More

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Five year results of a prospective, randomised, contralateral eye trial of corneal crosslinking for keratoconus.

Clin Exp Ophthalmol 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, University of Auckland, Auckland, New Zealand.

Background: Few studies have evaluated corneal crosslinking in a prospective, randomised fashion. This study aimed to determine the efficacy and safety of corneal crosslinking to reduce the progression of keratoconus.

Methods: Prospective, unmasked, randomised, contralateral eye controlled trial at a tertiary eye centre. Read More

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Calcaneal fractures: 3D-printing model to assist spatial weaving of percutaneous screws versus conventional open fixation-a retrospective cohort study.

Int Orthop 2021 Jun 11. Epub 2021 Jun 11.

Department of Foot and Ankle Surgery, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.

Purpose: This study compared the clinical effectiveness and wound complications of a three-dimensional model-assisted spatial weaving screw fixation (3D-SWSF) versus open reduction and internal fixation (ORIF) via an L-shaped extensile lateral approach for calcaneal fractures.

Methods: This single-centre retrospective cohort study was conducted with two cohort groups in which patients with Sanders II and III calcaneal fractures underwent 3D-SWSF or conventional ORIF. The clinical outcome measures included operation duration, time to operation, wound complications, blood loss volume, hospital stays, American Orthopedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot score, and visual analog scale (VAS) score. Read More

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Non-infectious uveitis affecting the posterior segment treated with fluocinolone acetonide intravitreal implant: 3-year fellow eye analysis.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, St. Franziskus Hospital Muenster, Muenster, Germany.

Background: Prevention of non-infectious uveitis of the posterior segment (NIU-PS) recurrence using 0.2 μg/day fluocinolone acetonide implant (FAi) was assessed over 3 years (NCT01694186). Outcomes for FAi-treated and fellow eyes with NIU-PS were compared, to evaluate FAi versus conventional treatment strategies. Read More

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Comparison of DMEK and DSAEK in Eyes With Endothelial Decompensation After Previous Penetrating Keratoplasty.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Purpose: Posterior lamellar keratoplasty is increasingly applied in patients with endothelial decompensation after penetrating keratoplasty (PK). The aim of this study was to compare the results of Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK) after PK.

Methods: In this retrospective study, clinical data of 30 patients who received DMEK (n = 19) or DSAEK (n = 11) for endothelial decompensation after PK were evaluated. Read More

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Keratoconus: Diagnosis and Staging.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ; and University Information Technology Services, University of Arizona, Tucson, AZ.

Abstract: The advent of refractive surgery and corneal cross-linking for ectatic disease has further highlighted the need to recognize early or subclinical ectatic disease. Historical systems depend on anterior corneal changes that occur late in the disease course and are commonly associated with visual loss. Tomographic imaging allows for the acquisition of posterior corneal surface data and corneal thickness distribution. Read More

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Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium.

Invest Ophthalmol Vis Sci 2021 Jun;62(7):15

Department of Ophthalmology, Harkness Eye Institute, Columbia University, New York, New York, United States.

When using spectral domain optical coherence tomography (SD-OCT) to inform the status of outer retina, we have noted discrete hyperreflective lesions extending through photoreceptor-attributable bands that have a similar presentation in multiple retinal diseases. These lesions present as either corrugated thickenings of interdigitation zone and ellipsoid zone bands or in later stages as rectangular or pyramidal shaped foci that extend radially through photoreceptor cell-attributable bands. In ABCA4-related and peripherin-2/RDS-disease (PRPH2/RDS), monogenic forms of retinopathy caused by mutations in proteins expressed in photoreceptor cells, these punctate lesions colocalize with fundus flecks in en face images. Read More

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The Interdisciplinary Management of Newly Diagnosed Pituitary Tumors.

Dtsch Arztebl Int 2021 Apr;118(14):237-243

Department of Internal Medicine/Endocrinology, DKD Helios Klinik Wiesbaden Medicover Oldenburg MVZ; Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of; Würzburg, Würzburg, Germany; Department of Neurosurgery, Johannes Wesling Klinikum Minden; Institute of Neuropathology, UKE Hamburg; Department of Neurosurgery, UKE Hamburg.

Background: The increasing use of cranial tomographic imaging has led to the more frequent discovery of pituitary tumors. In this review, we discuss the clinical symptoms that point toward a pituitary tumor, the required diagnostic studies, the potential need for follow-up studies, and the indications for neurosurgical treatment.

Methods: This review is based on pertinent publications from the years 2005-2020 that were retrieved by a selective search in PubMed, as well as on the current German S2k guideline, which was created with the present authors playing a coordinating role, and on further guidelines from abroad. Read More

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Efficacy and Safety of Bioabsorbable Bone Hemostatic Agent in Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211023589

Department of Orthopedic Surgery, 37990Seoul National University College of Medicine, Jongno-gu, Seoul, South Korea.

Although a bioabsorbable bone hemostatic agent (BBHA) was developed approximately 20 years ago to overcome the shortcomings of conventional bone wax, its bleeding control capacity has not yet been studied. This study was aimed at investigating the efficacy and safety of BBHA in total knee arthroplasty (TKA). Sixty-two patients who underwent unilateral primary TKA for knee osteoarthritis were included and randomized to the control or BBHA group. Read More

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Long term observation of hydrogel buckle intrusion without vision loss.

Am J Ophthalmol Case Rep 2021 Sep 26;23:101127. Epub 2021 May 26.

University of Hawaii John A. Burns School of Medicine, 651 Ilalo St., Honolulu, HI, 96813, USA.

Hydrogel buckle intrusion due to progressive swelling is a known complication, which usually requires surgical intervention due to vitreous hemorrhage, retinal detachment, or progressive encroachment into the optic nerve or macula. Hydrogel buckle surgery with successful retinal detachment repair was performed in this one-eyed physician in 1990, and there was slow progressive intrusion towards the macula and optic nerve without surgical intervention for 30 years and with visual acuity maintained at 20/40. Read More

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September 2021