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Int Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, Beyoglu Eye Training and Research Hospital, University of Health Sciences Turkey, Istanbul, Turkey.

Purpose: To investigate refractive and visual outcomes as well as rotational stability following implantation of Eyecryl phakic toric intraocular lens (pIOL) for moderate-to-high myopic astigmatism.

Methods: The efficacy, safety, predictability, stability, and adverse events of Eyecryl toric pIOL were evaluated in patients with spherical refraction from - 4.50 to - 18. Read More

Ocul Immunol Inflamm 2021 Apr 7:1-6. Epub 2021 Apr 7.

Eye Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.

: To summarize ophthalmic manifestations of coronavirus disease (COVID-19) reported in the literature thus far.: The PubMed database was systematically searched through October 24, 2020, to identify relevant articles using the following search terms: ("COVID-19" OR "SARS-CoV-2") AND ("eye" OR "ophthalmology" OR "retina" OR "retinal findings" OR "cornea" OR "conjunctiva"). Only articles published in English were included in this review. Read More

Rom J Ophthalmol 2021 Jan-Mar;65(1):10-14

Cluj County Emergency Hospital, Cluj-Napoca, Romania.

ANCA+ associated vasculitis (AAV) is a group of rare diseases with potentially vision-threatening complications. Ocular and orbital complications of these diseases are caused by vasculitis of the small vessels of the eye or by granulomatous mass formation. ANCA (anti-neutrophil cytoplasmic antibodies) represent a key component of pathophysiological pathways as well as a diagnostic marker. Read More

JAMA Ophthalmol 2021 Mar 30. Epub 2021 Mar 30.

Joslin Diabetes Center, Beetham Eye Institute, Harvard Department of Ophthalmology, Boston, Massachusetts.

Importance: The role of anti-vascular endothelial growth factor injections for the management of nonproliferative diabetic retinopathy (NPDR) without center-involved diabetic macular edema (CI-DME) has not been clearly established.

Objective: To determine the efficacy of intravitreous aflibercept injections compared with sham treatment in preventing potentially vision-threatening complications in eyes with moderate to severe NPDR.

Design, Setting, And Participants: Data for this study were collected between January 15, 2016, and May 28, 2020, from the ongoing DRCR Retina Network Protocol W randomized clinical trial, conducted at 64 US and Canadian sites among 328 adults (399 eyes) with moderate to severe NPDR (Early Treatment Diabetic Retinopathy Study severity level, 43-53), without CI-DME. Read More

Arch Soc Esp Oftalmol 2021 Mar 1. Epub 2021 Mar 1.

Departamento de Oftalmologíat, Ain Shams University Hospitals, Ain Shams University, El Cairo, Egipto.

Objective: To evaluate the efficacy and safety of MicroPulse® transscleral laser therapy (TLT) in the management of glaucoma patients.

Methods: A prospective, interventional, non-comparative case series was conducted in the department of ophthalmology, Ain Shams University Hospital on 61 eyes of 46 patients with various glaucoma types and of severity, ranging from mild to severe. In addition to best-corrected visual acuity (BCVA), intraocular pressure (IOP) and the number of glaucoma medications were recorded before and after treatment, along with the postoperative need for systemic carbonic anhydrase inhibitors (CAI), success rates, number of treatment sessions and postoperative complications. Read More

J Neurosci 2021 Apr 23;41(14):3275-3299. Epub 2021 Feb 23.

Research Service, Veterans Administration Northeast Ohio Healthcare System, Cleveland, Ohio 44106

Hyperglycemia is a key determinant for development of diabetic retinopathy (DR). Inadequate glycemic control exacerbates retinopathy, while normalization of glucose levels delays its progression. In hyperglycemia, hexokinase is saturated and excess glucose is metabolized to sorbitol by aldose reductase via the polyol pathway. Read More

Dis Mon 2021 Feb 15:101116. Epub 2021 Feb 15.

Department of Ophthalmology, C/O Rona Redmond, 1950 W. Polk St., Chicago, IL, United States. Electronic address:

Diabetes is one of the leading causes of morbidity and mortality in the United States. Patients with diabetes are at risk for multiple ophthalmologic complications including, but not limited to, cataracts, glaucoma, and retinopathy. Eye-exams are an important screening tool for patients with diabetes in order to prevent the more severe and vision-threatening sequela of disease. Read More

Indian J Ophthalmol 2021 03;69(3):488-509

President, All India Ophthalmological Society and Chairman, Centre for Sight, New Delhi, India.

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had health implications of unprecedented magnitude. The infection can range from asymptomatic, mild to life threatening respiratory distress. It can affect almost every organ of the body. Read More

Saudi Med J 2021 Feb;42(2):131-145

From the Department of Surgery (AlQahtani), Division of Ophthalmology, National Guard Hospital, and from King Saud bin Abdulaziz University for Health Sciences; from the Department of Ophthalmology (Waheeb), King Fisal Specialist Hospital and Research Center; from the Department of Ophthalmology (Elgendy), Retina Unit, Magrabi Eye and Ear Hospital, Jeddah; from the Department of Surgery (Hazzazi), Division of Ophthalmology, Riyadh National Guard Hospital, and from King Saud bin Abdulaziz University for Health Sciences; from the Department of Vitreoretinal (Semidey, Al-Dhibi), King Khalid Eye Specialist Hospital; from the Department of Ophthalmology (Abouammoh), College of Medicine, King Saud University, Riyadh; and from the Department of Retina and Uveitis (Alkhars), Dhahran Eye Specialist Hospital, Dhahran, Kingdom of Saudi Arabia.

Diabetes mellitus (DM) and its complications are major public health burdens in Saudi Arabia. The prevalence of diabetic retinopathy (DR) is 19.7% and the prevalence of diabetic macular edema (DME) is 5. Read More

Saudi J Ophthalmol 2020 Jan-Mar;34(1):59-61. Epub 2020 Nov 22.

Department of Ophthalmology, BARC Hospital, Mumbai, India.

We present a rare case of Lamellar Ichthyosis with bilateral ectropion with left sided corneal ulcer with descemetocele in a four-month-old female child, the youngest ever reported. Ichthyosis is a group of skin disorders characterized by the presence of fish-like scales all over the body (Mushriff, 2016; Turgut ., 2009). Read More

Cleft Palate Craniofac J 2021 Feb 2:1055665621989129. Epub 2021 Feb 2.

Department of Ophthalmology, University of California, Davis, Sacramento, CA, USA.

Bilateral Tessier type 4 craniofacial clefts are extremely rare and disfiguring malformations with vision-threatening ramifications. To date, there is no consensus in the literature with respect to the ideal surgical technique and management of these patients. Emergent eyelid reconstruction and additional procedures may be required to protect the cornea and avoid further ophthalmic and surgical complications. Read More

J Ophthalmol 2021 12;2021:8820926. Epub 2021 Jan 12.

Department of Ophthalmology, Faculty of Medicine, Menofia University, Shebin El Kom, Menofia, Egypt.

Objectives: To evaluate the safety and efficacy of augmenting conjunctival autografting with intraoperative mitomycin C (MMC) application Ologen implantation in the management of recurrent pterygium.

Materials And Methods: This prospective randomised study included 63 eyes of 63 patients, with recurrent nasal pterygium, who presented to the outpatient clinic of Menoufia University Hospital in Shebin El Kom and Manshiet Soltan from January 2016 to December 2019. Patients were randomly enrolled into two groups. Read More

Am J Ophthalmol 2021 Jan 22;226:56-67. Epub 2021 Jan 22.

Department of Ophthalmology, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada. Electronic address:

Purpose: To evaluate glaucoma risk factors and associated outcomes of the Boston keratoprosthesis type I (KPro).

Design: Clinical case-control study.

Methods: This is a single-center study of 140 eyes of 118 patients who underwent KPro surgery between October 2008 and March 2017 by a single surgeon. Read More

Int Ophthalmol 2021 Apr 3;41(4):1233-1240. Epub 2021 Jan 3.

Department of Nephrology and Hypertension, Edith Wolfson Medical Center, Holon, Israel.

Purpose: The aim of this study was to employ newly developed advanced image analysis software to evaluate changes in retinal layer thickness following hemodialysis.

Methods: A non-randomized prospective study of patients with end-stage renal disease assessed on the same day before and after hemodialysis. Intraocular pressure and central corneal thickness were analyzed, and spectral domain optical coherence tomography results were automatically segmented using the Orion software and then compared. Read More

Am J Ophthalmol 2020 Dec 29;225:11-17. Epub 2020 Dec 29.

Center for Ocular Regeneration, LV Prasad Eye Institute, Hyderabad, Telangana, India; Brien Holden Eye Research Center, LV Prasad Eye Institute, Hyderabad, Telangana, India; The Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India. Electronic address:

Purpose: To assess the risk factors for severe visual impairment (SVI) and corneal complications in primary and secondary Sjögren syndrome (SS).

Design: Retrospective case series.

Methods: Ocular data of all consecutive SS patients presenting to an eye-care network and receiving a diagnosis according to 2012 American College of Rheumatology criteria over the past 8 years were reviewed. Read More

Ann Agric Environ Med 2020 Dec 3;27(4):644-649. Epub 2020 Sep 3.

SPKSO Ophthalmic Hospital, Warsaw, Poland.

Introduction: The non-infectious uveitis, a serious vision-threatening disease is the fourth most common cause of blindness in working population of the developed world. Various antimetabolites are applied in corticosteroid-sparing therapy also in Poland but their efficacy was not compared in our country. The aim of our study was to compare mycophenolate mofetil and azathioprine in terms of therapeutic effect of the antimetabolites in Polish patients with this disease. Read More

J Drugs Dermatol 2020 Dec;19(12):1192-1198

Certain dermatologic conditions and drugs used for their treatment are associated with uveitis, a vision-threatening group of inflammatory eye diseases. Dermatologists may therefore be the first healthcare providers to recognize the presence of uveitis in certain patients and can help ensure morbidity is minimized. Posterior uveitis in particular, which may manifest as insidious, painless vision loss, may first be identified by a careful review of systems by a dermatologist. Read More

Sci Rep 2020 12 10;10(1):21686. Epub 2020 Dec 10.

Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.

This study was aimed to review the etiology and the outcomes of current posterior chamber phakic intraocular lens (Visian ICL, STAAR Surgical) extraction. This review comprised 770 eyes of 403 consecutive patients undergoing ICL extraction. We evaluated prevalence, etiology, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), predictability, and patient satisfaction. Read More

West Afr J Med 2020 Dec;37(7):721-725

Department of Ophthalmology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.

Background And Objective: Retinal vein occlusion (RVO) is the second most common retinal vascular disease. This study aims to determine its clinical presentations, complications and treatment outcome in a Nigerian tertiary hospital.

Methods: The medical records of consecutive patients with RVO who presented to the vitreoretinal clinic of Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife over a 5-year period were retrieved. Read More

Asia Pac J Ophthalmol (Phila) 2020 Dec 7;10(2):212-223. Epub 2020 Dec 7.

Department of Uveitis and Ocular Pathology, Sankara Nethralaya, Chennai, India.

Abstract: Scleritis is a rare, vision-threatening inflammation of the sclera that is often associated with life-threatening systemic illnesses. Rheumatoid arthritis remains the most common associated systemic rheumatic disease and the commonest systemic association of scleritis. Granulomatosis with polyangiitis is the most common cause of vasculitis-associated scleritis. Read More

Cornea 2020 Nov 19. Epub 2020 Nov 19.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA.

Purpose: To describe a case of new-onset benign paroxysmal positional vertigo (BPPV) after uncomplicated Descemet stripping automated endothelial keratoplasty.

Methods: Case report and review of literature.

Results: A 61-year-old woman with a history of steroid-induced glaucoma and penetrating keratoplasty for Fuchs endothelial dystrophy, and no history of BPPV or other vertigo, underwent Descemet stripping automated endothelial keratoplasty for penetrating keratoplasty graft failure. Read More

Retin Cases Brief Rep 2020 Nov 17. Epub 2020 Nov 17.

Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois, USA.

Purpose: To describe a patient with a choroidal osteoma treated with PDT to prevent tumor growth in whom choroidal neovascularization (CNV) developed after being treated with PDT.

Methods: Case report.

Results: A 5-year-old Hispanic female presented with an asymptomatic choroidal osteoma, temporal to the macula of her right eye. Read More

J AAPOS 2020 12 20;24(6):347.e1-347.e6. Epub 2020 Nov 20.

Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: To report the results of surgical treatment of glaucoma in patients with facial port wine mark at a single institution over a 10-year period.

Methods: The study was conducted on 21 eyes (10 right eyes) of 17 children (8 males) with glaucoma associated with facial port wine mark presenting to the pediatric ophthalmology practice at a single institution between January 2008 and December 2017. All study eyes underwent combined angle and filtering surgery with antimetabolite (mitomycin C) and were followed for 2 years. Read More

Diabetes Res Clin Pract 2021 Jan 16;171:108540. Epub 2020 Nov 16.

Department of Ophthalmology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada - Sardjito Eye Center, Dr. Sardjito General Hospital, Yogyakarta, Indonesia.

Among 100 Indonesian adults with type 2 diabetes having vision-threatening diabetic retinopathy, less than 25% of individuals had appropriate treatment within 12 months from their initial screening due to lack of information about the treatment cost (88%), no permission from family member (77.3%) and having no eye complaint (77%). Read More

Eur J Ophthalmol 2020 Nov 8:1120672120963447. Epub 2020 Nov 8.

Serviço de Oftalmologia, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Purpose: To analyse the long-term efficacy and safety of bleb needling in glaucoma patients previously submitted to XEN implantation.

Methods: Retrospective, observational study. Charts from patients who underwent XEN gel implant surgery between October 2015 and December 2017 were reviewed. Read More

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:5101-5105

Retinal vein occlusion (RVO) is a vision threatening condition occurring in the central or the branch retinal veins. Risk factors include but are not limited to hypercoagulability, thrombus or other cause of low blood flow. Current clinically proven treatment options limit complications of vein occlusion without treating the causative occlusion. Read More

Expert Opin Biol Ther 2020 12 12;20(12):1385-1393. Epub 2020 Oct 12.

The Chinese University of Hong Kong , Kowloon, Hong Kong.

Introduction: Myopic choroidal neovascularization (CNV) is one of the most vision-threatening complications in patients with pathologic myopia. Over the last decade, anti-angiogenesis therapy with anti-vascular endothelial growth factor (anti-VEGF) agents has become the standard-of-care treatment for myopic CNV and ranibizumab has been approved for treating myopic CNV.

Areas Covered: Review of preclinical studies and clinical trials data supporting the use of ranibizumab for myopic CNV. Read More

Adv Ther 2020 11 24;37(11):4675-4684. Epub 2020 Sep 24.

Università Cattolica del Sacro Cuore, Rome, Italy.

Introduction: Cataract surgery can be associated with vision-threatening complications in patients with diabetes. This study aimed to assess the functional and anatomic outcomes of the intravitreal dexamethasone (DEX) implant, administered at the time as cataract surgery, in patients with diabetic retinopathy and diabetic macular edema (DME).

Methods: This was a retrospective, observational, and single-center study. Read More