Biophys J 2021 Sep 13. Epub 2021 Sep 13.
Department of Molecular Biology and Microbiology, Tufts University School of Medicine and School of Graduate Biomedical Sciences, Boston, MA, 02111, USA; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, 01605, USA; Department of Biochemistry and Molecules Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01605, USA. Electronic address:
During HIV-1 assembly the viral Gag polyprotein specifically selects the dimeric RNA genome for packaging into new virions. The 5' untranslated region (5'UTR) of the dimeric genome may adopt a conformation that is optimal for recognition by Gag. Further conformational rearrangement of the 5'UTR, promoted by the NC domain of Gag, is predicted during virus maturation. Read More