1,287,306 results match your criteria virus

Dengue virus is involved in insulin resistance via the downregulation of IRS-1 by inducing TNF-α secretion.

Biochim Biophys Acta Mol Basis Dis 2022 Jun 22:166472. Epub 2022 Jun 22.

BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China. Electronic address:

During the epidemic, the individuals with underlying diseases usually have a higher rate of mortality. Diabetes is highly prevalent worldwide, making it a frequent comorbidity in dengue fever patients. Therefore, understanding the relationship between dengue virus (DENV) infection and diabetes is important. Read More

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High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis.

Microb Pathog 2022 Jun 22:105644. Epub 2022 Jun 22.

Laboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, Affiliated to Istituto Pasteur Italia, 00185, Rome, Italy. Electronic address:

Merkel cell polyomavirus (MCPyV) has been detected in respiratory specimens including those from Cystic Fibrosis (CF) patients, raising questions about its immunological and clinical relevance in the respiratory tract. MCPyV might promote an inappropriate antiviral response contributing to a chronic inflammatory response and resulting in detrimental effects in CF. Respiratory samples (n = 1138) were randomly collected from respiratory tract of CF patients (n = 539) during July 2018-October 2019. Read More

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Identification and functional characterization of mRNAs that exhibit stop codon readthrough in Arabidopsis thaliana.

J Biol Chem 2022 Jun 22:102173. Epub 2022 Jun 22.

Department of Biochemistry, Indian Institute of Science, Bengaluru, India. Electronic address:

Stop codon readthrough (SCR) is the process of continuation of translation beyond the stop codon, generating protein isoforms with C-terminal extensions. SCR has been observed in viruses, fungi, and multicellular organisms, including mammals. However, SCR is largely unexplored in plants. Read More

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High-density lipoproteins negatively regulate innate immunity and facilitate red-spotted grouper nervous necrosis virus entry via scavenger receptor B type 1.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266000, China. Electronic address:

Lipid metabolism plays an important role in viral infections, and it can directly or indirectly affect various stages of viral infection in cells. As an important component of lipid metabolism, high-density lipoprotein (HDL) plays crucial roles in inflammation, immunity, and viral infections. Scavenger receptor B type 1 (SR-B1), a receptor of HDL, cannot be ignored in the regulation of lipid metabolism. Read More

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SARS-CoV-2 infection at the Huanan seafood market.

Environ Res 2022 Jun 22:113702. Epub 2022 Jun 22.

Universidad Pontificia Comillas, Madrid, Spain.

The Huanan market harbored many of the early COVID-19 cases in 2019 and is a key element to understanding the origin of the pandemic. Whether the initial animal-to-human transmission did occur at this market is still debated. Here we do not examine how SARS-CoV-2 virus was introduced at the market, but focus on how early cases may have been infected at the market. Read More

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A new class of half-sandwich ruthenium complexes containing Biginelli hybrids: anticancer and anti-SARS-CoV-2 activities.

Chem Biol Interact 2022 Jun 22:110025. Epub 2022 Jun 22.

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 72341, Saudi Arabia.

In order to discover new dual-active agents, a series of novel Biginelli hybrids (tetrahydropyrimidines) and their ruthenium(II) complexes were synthesized. Newly synthesized compounds were characterized by IR, NMR, and X-ray techniques and investigated for their cytotoxic effect on human cancer cell lines HeLa, LS174, A549, A375, K562 and normal fibroblasts (MRC-5). For further examination of the cytotoxic mechanisms of novel complexes, two of them were chosen for analyzing their effects on the distribution of HeLa cells in the cell cycle phases. Read More

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Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections.

J Control Release 2022 Jun 22. Epub 2022 Jun 22.

Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, United States of America; Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, United States of America; Deptartment of Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States of America; Center for Nanomedicine, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, United States of America. Electronic address:

Peptides and peptide-based materials have an increasing role in the treatment of viral infections through their use as active pharmaceutical ingredients, targeting moieties, excipients, carriers, or structural components in drug delivery systems. The discovery of peptide-based therapeutic compounds, coupled with the development of new stabilization and formulation strategies, has led to a resurgence of antiviral peptide therapeutics over the past two decades. The ability of peptides to bind cell receptors and to facilitate membrane penetration and subsequent intracellular trafficking enables their use in various antiviral systems for improved targeting efficiency and treatment efficacy. Read More

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A recent chikungunya outbreak associated with the occurrence of Aedes vectors (Diptera: Culicidae) in Kassala state, eastern Sudan in 2018.

Parasitol Int 2022 Jun 22:102613. Epub 2022 Jun 22.

Entomology Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt.

Aedes aegypti and Ae. albopictus (Diptera: Culicidae) are primary vectors of human arboviral diseases such as dengue, chikungunya, yellow fever, and Zika viruses. Aedes aegypti is well distributed in Sudan, except in Northern and Khartoum states, while Ae. Read More

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Association of single nucleotide polymorphisms in immune-related genes with spontaneous HBsAg seroconversion: A systematic review and meta-analysis.

Int Immunopharmacol 2022 Jun 22;110:108982. Epub 2022 Jun 22.

Middle East Liver Diseases (MELD) Center, Tehran, Iran. Electronic address:

Background: Studies have reported that the immune system modulation genes are involved in the seroconversion during hepatitis B virus (HBV) infection. Here, a systematic review with meta-analysis is implemented on the association of polymorphisms in immune-related genes with the spontaneous hepatitis B surface antigen (HBsAg) seroconversion.

Methods: A systematic literature search was conducted in the main electronic databases of Scopus, PubMed, and Web of Science before May 2022. Read More

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Transcriptome analysis and screening of putative sex-determining genes in the invasive pest, Frankliniella occidentalis (Thysanoptera: Thripidae).

Comp Biochem Physiol Part D Genomics Proteomics 2022 Jun 11;43:101008. Epub 2022 Jun 11.

College of Horticulture and Plant Protection, Institute of Applied Entomology, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education, Yangzhou University, Yangzhou, China. Electronic address:

The invasive insect pest, Frankliniella occidentalis, is a well-known vector that transmits a variety of ornamental and vegetable viruses. The mechanistic basis of sex determination in F. occidentalis is not well understood, and this hinders our ability to deploy sterile insect technology as an integrated pest management strategy. Read More

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Targeting miR-30d reverses pathological cardiac hypertrophy.

EBioMedicine 2022 Jun 22;81:104108. Epub 2022 Jun 22.

Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai 200444, China. Electronic address:

Background: Pathological cardiac hypertrophy occurs in response to numerous stimuli and precedes heart failure (HF). Therapies that ameliorate pathological cardiac hypertrophy are highly needed.

Methods: The expression level of miR-30d was analyzed in hypertrophy models and serum of patients with chronic heart failure by qRT-PCR. Read More

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Induction and modulation of the unfolded protein response during porcine deltacoronavirus infection.

Vet Microbiol 2022 Jun 14;271:109494. Epub 2022 Jun 14.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China. Electronic address:

Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that has the potential for cross-species infection. Many viruses have been reported to induce endoplasmic reticulum stress (ERS) and activate the unfolded protein response (UPR). To date, little is known about whether and, if so, how the UPR is activated by PDCoV infection. Read More

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Mechanism of drug resistance of BVDV induced by F224S mutation in RdRp: A case study of VP32947.

Comput Biol Chem 2022 Jun 20;99:107715. Epub 2022 Jun 20.

Gansu Province Livestock Embryo Engineering Research Center, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, PR China. Electronic address:

Bovine viral diarrhea virus (BVDV) is an enveloped virus with an RNA genome, causing serious economic losses to the areas dominated by livestock industry. Currently, although several compounds with biological activities of inhibiting virus replication have been reported, amino acid mutations (especially F224S mutation) frequently occurring in the RNA-dependent RNA polymerase (RdRp) have greatly reduce their value of further research. In this study, we introduced an effective and rapid in silico strategy to explore the differences in the binding modes of VP32947 between the wild/mutant-type RdRp at the molecular level, and further explained the main reasons for the variations in the inhibitory activities of VP32947 against the two types of enzymes. Read More

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Exposure of white-tailed deer in North America to influenza D virus.

Virology 2022 Jun 17;573:111-117. Epub 2022 Jun 17.

Center for Influenza and Emerging Infectious Diseases, Columbia, MO, USA; School of Medicine, University of Missouri, Columbia, MO, USA; Bond Life Sciences Center, University of Missouri, Columbia, MO, USA; College of Engineering, University of Missouri, Columbia, MO, USA. Electronic address:

Influenza D virus (IDV) infections have been identified worldwide in cattle, swine, camelid, and small ruminants, mostly in domestic livestock. Here we report that the wild white-tailed deer in North America were exposed to IDVs, suggesting IDVs infect a wide range of hosts including wild animal populations. Read More

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MicroRNAs in the development of potential therapeutic targets against COVID-19: A narrative review.

J Infect Public Health 2022 Jun 21;15(7):788-799. Epub 2022 Jun 21.

Public Health Laboratory Management-Erbil, Kurdistan Region, Iraq.

Background: As the therapeutic regimens against the COVID-19 remain scarce, the microRNAs (miRNAs) can be exploited to generate efficient therapeutic targets. The miRNAs have been found to play pivotal roles in the several regulatory functions influencing the prognosis of viral infection. The miRNAs have a prospective role in the up and down regulation of the ACE2 receptors. Read More

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Cardiovascular Damage in COVID-19: What We Know Two Years Later.

Curr Cardiol Rep 2022 Jun 25. Epub 2022 Jun 25.

Cardiothoracovascular Department, Azienda Sanitaria Universitaria Integrata Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.

Purpose Of The Review: The Coronavirus disease 2019 (COVID-19) pandemic has profoundly influenced cardiological clinical and basic research in the past two years. In the present review, we summarize the current knowledge on myocardial involvement in COVID-19, providing an overview on the incidence, the pathogenetic mechanisms, and the clinical implications of cardiac injury in this setting.

Recent Findings: The possibility of heart involvement in patients with COVID-19 has received great attention since the beginning of the pandemic. Read More

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Foreign gene expression attenuates a virulent Newcastle disease virus in chickens.

Virus Genes 2022 Jun 25. Epub 2022 Jun 25.

Key Laboratory of Animal Infectious Diseases, School of Veterinary Medicine, Yangzhou University, Yangzhou, China.

Newcastle disease virus (NDV) is an important pathogen for poultry and is used as a vector for developing novel poultry vaccines. Previous studies showed that foreign gene insertion in NDV vector decreases virulence determined by in vitro assays; however, the impact of foreign gene expression on the pathogenicity of NDV in susceptible chickens is not fully investigated. In this study, a recombinant NDV based on a velogenic strain carrying the orange fluorescent protein (OFP) gene between the phosphoprotein (P) and matrix (M) genes was generated using reverse genetics. Read More

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Incidence, Mortality Features and Lifetime Risk Estimation of Digestive Tract Cancers in an Urban District of Shanghai, China.

J Epidemiol Glob Health 2022 Jun 25. Epub 2022 Jun 25.

School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.

Digestive tract cancers are the common cause of cancer deaths in both China and worldwide. This study aimed to describe the burden, recent trends and lifetime risks in the incidence and mortality of digestive tract cancers in an urban district of Shanghai, China. Our study extracted data on stomach, colon, rectum and liver cancers diagnosed in Changning District between 2010 and 2019 from the Shanghai Cancer Registry. Read More

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Complete genome analysis of a novel iflavirus from the spotted lanternfly Lycorma delicatula.

Arch Virol 2022 Jun 25. Epub 2022 Jun 25.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‑products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.

The spotted lanternfly (Lycorma delicatula) is an invasive pest that causes serious economic losses in fruit and wood production. Here, we identified a novel iflavirus named "Lycorma delicatula iflavirus 1" (LDIV1), in a spotted lanternfly. The full genome sequence of LDIV1 is 10,222 nt in length and encodes a polyprotein containing a picornavirus capsid-protein-domain-like domain, a cricket paralysis virus capsid superfamily domain, an RNA helicase domain, a peptidase C3 superfamily domain, and an RNA-dependent RNA polymerase (RdRp) domain. Read More

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Characteristics and Results of Hospital Admission Caused by Influenza Virus Infections in Children under 5 Years Old.

J Trop Pediatr 2022 Jun;68(4)

Department of Pediatric Diseases, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey.

Aims: The influenza virus is an infectious disease with acute respiratory tract infections, caused secondary bacterial infections and death. In this study, we aimed to determine which predictors were associated with the need for high-flow nasal cannula oxygen therapy (HFNC) and transition to intensive care for influenza virus and also to compare single viral pathogens with multiple ones.

Methods: Inpatients under the age of 5 with influenza virus-related respiratory tract infections between November 2015 and March 2019 were included in the study. Read More

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Impact of pharmacogenetics on variability in exposure to oral vinorelbine among pediatric patients: a model-based population pharmacokinetic analysis.

Cancer Chemother Pharmacol 2022 Jun 25. Epub 2022 Jun 25.

SMARTc Unit, Cancer Research Center of Marseille, Inserm U1068-CNRS UMR 7258, Aix-Marseille University U105, 27 Boulevard Jean Moulin, 13385, Marseille, France.

Purpose: Better understanding of pharmacokinetics of oral vinorelbine (VNR) in children would help predicting drug exposure and, beyond, clinical outcome. Here, we have characterized the population pharmacokinetics of oral VNR and studied the factors likely to explain the variability observed in VNR exposure among young patients.

Design/methods: We collected blood samples from 36 patients (mean age 11. Read More

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The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19.

Inflamm Res 2022 Jun 25. Epub 2022 Jun 25.

Department of Health Information Management, School of Medicine and Allied Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran.

A global pandemic has erupted as a result of the new brand coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated with widespread mortality worldwide. The antiviral immune response is an imperative factor in confronting the recent coronavirus disease 2019 (COVID-19) infections. Read More

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Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza.

APMIS 2022 Jun 25. Epub 2022 Jun 25.

Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.

Background: Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared to CAP caused by bacteria or influenza virus in hospitalized patients. Read More

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Vaccine-Strain Varicella Virus Transmitted to a Term Infant Following Maternal Postpartum Vaccination.

J Pediatric Infect Dis Soc 2022 Jun 25. Epub 2022 Jun 25.

Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA.

Varicella is a highly contagious disease caused by Varicella-zoster virus (VZV). The American College of Obstetricians and Gynecologists (ACOG) adopted the routine administration of varicella vaccine to varicella non-immune mothers postpartum before leaving the facility per the Advisory Committee in Immunization Practices (ACIP) recommendation of Varicella prevention. While the vaccine is well-tolerated, a live attenuated vaccine has the potential to cause clinical symptoms and complications, including rash. Read More

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Detection frequencies and viral load distribution of parvovirus B19 DNA in blood and plasma donations in England.

Transfus Med 2022 Jun 25. Epub 2022 Jun 25.

Microbiology Services, NHS Blood and Transplant, UK.

Background And Objectives: Infections with human parvovirus B19 (B19V) are transmissible by blood components and plasma-derived medicines. The European Pharmacopoeia regulates maximum levels of virus allowed in manufacturers' plasma pools. To evaluate contamination risk prior to re-introduction of UK-sourced plasma for manufacturing, we investigated viraemia frequencies of B19V in plasma samples collected from blood donors before and during COVID-enforced lockdown. Read More

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The potential of developing a protective peptide-based vaccines against SARS-CoV-2.

Drug Dev Res 2022 Jun 25. Epub 2022 Jun 25.

School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia.

COVID-19 pandemic has been the deadliest infectious disease outbreak since Spanish flu. The emerging variant lineages, decay of neutralizing antibodies, and occur of reinfections require the development of highly protective and safe vaccines. As currently approved COVID-19 vaccines that utilize virus-related genetic material are less than ideal, other vaccine types have been also widely investigated. Read More

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Comparison of the Immunogenicity of five COVID-19 vaccines in Sri Lanka.

Immunology 2022 Jun 25. Epub 2022 Jun 25.

Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular, Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Background: To determine the antibody responses elicited by different vaccines against SARS-CoV-2, we compared antibody responses in individuals 3 months post-vaccination in those who had received different vaccines in Sri Lanka.

Methods: Abs to the RBD of the ancestral (wild type) virus (WT) as well as to variants of concern (VoCs), and ACE2 blocking Abs, were assessed in individuals vaccinated with Moderna (n=225), Sputnik V (n=128) or Sputnik light (n=184) and the results were compared with previously reported data on Sinopharm and AZD1222 vaccinees.

Results: 99. Read More

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Diagnostic challenge of Strongyloides stercoralis hyperinfection syndrome: a case report.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):79-81

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Strongyloides stercoralis causes chronic, mostly asymptomatic infections but hyperinfection syndrome may occur in immunosuppressed patients, especially in those receiving corticosteroids. We report a case of S. stercoralis hyperinfection syndrome in a solid organ transplant recipient that occurred approximately 2. Read More

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The kinetics of IgG subclasses and contributions to neutralizing activity against SARS-CoV-2 wild-type strain and variants in healthy adults immunized with inactivated vaccine.

Immunology 2022 Jun 25. Epub 2022 Jun 25.

Beijing Center for Disease Prevention and Control, Beijing, China.

Neutralizing antibody is an important indicator of vaccine efficacy, of which IgG is the main component. IgG can be divided into 4 subclasses. Up to now, studies analyzing the humoral response to SARS-CoV-2 vaccination have mostly focused on measuring total IgG, and the contribution of specific IgG subclasses remains elusive. Read More

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Monkeypox Virus Emerges from The Shadow of Its More Infamous Cousin: Family Biology Matters.

Emerg Microbes Infect 2022 Jun 24:1-14. Epub 2022 Jun 24.

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

Monkeypox virus (MPXV) is closely related to the infamous variola (smallpox) virus, causing a febrile rash illness in humans similar to but milder than smallpox. In the 20 century, human monkeypox had been mostly a rare zoonotic disease confined to forested areas in West and Central Africa. However, the case number and geographic range have increased significantly in this century, coincided with the waning of the smallpox vaccine-induced immunity in the global population. Read More

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