Vet Microbiol 2021 Mar 19;256:109041. Epub 2021 Mar 19.
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430000, China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430000, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430000, China. Electronic address:
Owing to viral recombination, interspecies transmission, and evolution, variant pseudorabies virus (PRV) strains exhibit different biological characteristics and pathogenicity. To improve the understanding of common and specific metabolic changes that occur upon infection by different PRV strains, we herein describe the comprehensive analysis of metabolites of PRV vaccine strain (Bartha K61), classical strain (EA) and variant strain (HNX) infection in immortalized porcine alveolar macrophage cells. Compared with uninfected cells, cells infected with Bartha K61, EA and HNX had 246, 225, and 272 differing metabolites, respectively. Read More