EBioMedicine 2021 Sep 23;72:103591. Epub 2021 Sep 23.
Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, PR China; Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, PR China; Graduate School of Anhui Medical University, Hefei 230601, PR China; Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases, Beijing 100191, PR China. Electronic address:
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality, however with no effective therapy available.
Methods: The effect of favipiravir (FPV) in treating SFTS was evaluated by an integrated analysis on data collected from a single-arm study (n=428), a surveillance study (n=2350) and published data from a randomized controlled trial study (n=145). A 1:1 propensity score matching was performed to include 780 patients: 390 received FPV and 390 received supportive therapy only. Read More