1,200 results match your criteria vinyl ether

Protection Conferred by Drinking Water Administration of a Nanoparticle-Based Vaccine against Enteritidis in Hens.

Vaccines (Basel) 2021 Mar 3;9(3). Epub 2021 Mar 3.

Department of Microbiology and Parasitology, Universidad de Navarra, 31008 Pamplona, Spain.

Salmonellosis remains a major medical and an unmet socioeconomic challenge. Worldwide, more than three million deaths per year are associated with serovar Enteritidis infections. Although commercially available vaccines for use in poultry exist, their efficacy is limited. Read More

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Coronavirus-Induced Host Cubic Membranes and Lipid-Related Antiviral Therapies: A Focus on Bioactive Plasmalogens.

Front Cell Dev Biol 2021 12;9:630242. Epub 2021 Mar 12.

Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay UMR 8612, Châtenay-Malabry, France.

Coronaviruses have lipid envelopes required for their activity. The fact that coronavirus infection provokes the formation of cubic membranes (CM) (denoted also as convoluted membranes) in host cells has not been rationalized in the development of antiviral therapies yet. In this context, the role of bioactive plasmalogens (vinyl ether glycerophospholipids) is not completely understood. Read More

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Vinyl ethers and epoxides photoinduced copolymerization with perfluoropolyalkylether monomers.

Colloid Polym Sci 2021 9;299(3):509-521. Epub 2020 Sep 9.

Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.

New perfluoropolyalkylether (PFPAE) monomers, chain extended with different alkyl groups and functionalized with vinyl ether or epoxide end-groups, were employed, together with trimethylolpropane trivinyl ether or trimethylolpropane triglycidyl ether, to produce fluorinated copolymers. The photoinduced cationic polymerization was investigated, and the PFPAE-based copolymer properties were thoroughly characterized. Interesting surface properties and two different values of refractive index were observed: thus, these fluorinated copolymers can be suitable materials for the manufacture of self-cleaning coatings and optical waveguides. Read More

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September 2020

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis.

Cell Death Differ 2021 Mar 17. Epub 2021 Mar 17.

Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

It is well established that ferroptosis is primarily induced by peroxidation of long-chain poly-unsaturated fatty acid (PUFA) through nonenzymatic oxidation by free radicals or enzymatic stimulation of lipoxygenase. Although there is emerging evidence that long-chain saturated fatty acid (SFA) might be implicated in ferroptosis, it remains unclear whether and how SFA participates in the process of ferroptosis. Using endogenous metabolites and genome-wide CRISPR screening, we have identified FAR1 as a critical factor for SFA-mediated ferroptosis. Read More

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Synthesis of a plasmenylethanolamine.

Biosci Biotechnol Biochem 2021 Mar 11. Epub 2021 Mar 11.

Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aza-Aoba, Aoba-ku, Sendai 980-8572, Japan.

A concise synthesis of a plasmenylethanolamine (PlsEtn-[16:0/18:1 n-9]), known as antioxidative phospholipids commonly found in cell membranes, has been achieved from an optically active known diol through eight steps. The key transformations for the synthesis of PlsEtn-[16:0/18:1 n-9] are, (1) regio- and Z-selective vinyl ether formation via alkylation of a lithioalkoxy allyl intermediate with an alkyl iodide, and (2) a one-pot phosphite esterification-oxidation sequence to construct the ethanolamine phosphonate moiety in the presence of the vinyl ether functionality. The piperidine salt of synthetic PlsEtn-[16:0/18:1 n-9] was desalinated through reversed-phase HPLC purification. Read More

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Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells by Attenuating Induced Inflammatory Stress.

ACS Omega 2021 Feb 22;6(4):3140-3148. Epub 2021 Jan 22.

Department of Life and Food Sciences, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.

Ethanolamine plasmalogen (PlsEtn) is a subtype of ethanolamine glycerophospholipids (EtnGpl). Recently, PlsEtn has attracted increasing research interest due to its beneficial effects in health and disease; however, its functional role in colonic health has not been well established. This study was conducted to determine the mechanism underlying the antiapoptotic effect of PlsEtn in human intestinal tract cells under induced inflammatory stress. Read More

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February 2021

Expansion of Ovarian Cancer Stem-like Cells in Poly(ethylene glycol)-Cross-Linked Poly(methyl vinyl ether--maleic acid) and Alginate Double-Network Hydrogels.

ACS Biomater Sci Eng 2020 06 21;6(6):3310-3326. Epub 2020 Apr 21.

State Key Lab of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

A better understanding of cancer stem cells (CSCs) is essential for research on cancer therapy and drug resistance. Currently, increasingly more investigations are focused on obtaining CSCs to study the mechanism of their enhanced malignancy. In this work, three kinds of double-network hydrogels (PEMM/alginate), consisting of poly(ethylene glycol) (PEG) covalently cross-linked poly(methyl vinyl ether--maleic acid) (P(MVE--MA)) (network 1, denoted as PEMM) and Sr (or Ca, Fe) ionically cross-linked alginates (network 2, denoted as SrAlg, CaAlg, or FeAlg), were prepared. Read More

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Sequence-Controlled Polyurethane Block Copolymer Displays Differentiated Immunoglobulin-G Adsorption That Influences Human Monocyte Adhesion and Activity.

ACS Biomater Sci Eng 2020 08 8;6(8):4433-4445. Epub 2020 Jul 8.

Ted Rogers Centre for Heart Research, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1M1, Canada.

The ability to specify an adsorbed protein layer through the polymer chemistry design of immunomodulatory biomaterials is important when considering a desired immune response, such as reducing pro-inflammatory activity. Limited work has been undertaken to elucidate the role of monomer sequence in this process, when copolymeric systems are involved. In this study, we demonstrate the advantage of an alternating radical copolymerization strategy as opposed to a random statistical copolymerization to order monomers in the synthesis of degradable polar-hydrophobic-ionic polyurethanes (D-PHI), biomaterials originally designed to reduce inflammatory monocyte activation. Read More

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Antibacterial Properties of Plasma-Activated Perfluorinated Substrates with Silver Nanoclusters Deposition.

Nanomaterials (Basel) 2021 Jan 13;11(1). Epub 2021 Jan 13.

Department of Solid State Engineering, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.

This article is focused on the evaluation of surface properties of polytetrafluoroethylene (PTFE) nanotextile and a tetrafluoroethylene-perfluoro(alkoxy vinyl ether) (PFA) film and their surface activation with argon plasma treatment followed with silver nanoclusters deposition. Samples were subjected to plasma modification for a different time exposure, silver deposition for different time periods, or their combination. As an alternative approach, the foils were coated with poly-L-lactic acid (PLLA) and silver. Read More

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January 2021

Facile Route to Targeted, Biodegradable Polymeric Prodrugs for the Delivery of Combination Therapy for Malaria.

ACS Biomater Sci Eng 2020 11 7;6(11):6217-6227. Epub 2020 Oct 7.

Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.

A facile synthetic methodology has been developed to prepare multifaceted polymeric prodrugs that are targeted, biodegradable, and nontoxic, and used for the delivery of combination therapy. This is the first instance of the delivery of the WHO recommended antimalarial combination of lumefantrine (LUM, drug 1) and artemether (AM, drug 2) a polymeric prodrug. To achieve this, reversible addition-fragmentation chain transfer (RAFT)-mediated polymerization of -vinylpyrrolidone (NVP) was conducted using a hydroxy-functional RAFT agent, and the resulting polymer was used as the macroinitiator in the ring-opening polymerization (ROP) of α-allylvalerolactone (AVL) to synthesize the biodegradable block copolymer of poly(-vinylpyrrolidone) and poly(α-allylvalerolactone) (PVP--PAVL). Read More

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November 2020

Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in .

ACS Chem Biol 2021 01 22;16(1):6-13. Epub 2020 Dec 22.

Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston Massachusetts 02115, United States.

Plasmalogens are vinyl ether-containing lipids produced by mammals and bacteria. The aerobic biosynthetic pathway in eukaryotes and bacteria is known, but the anaerobic pathway has remained a mystery. Here, we describe a two-gene operon (plasmalogen synthase, ) responsible for plasmalogen production in the anaerobic bacterium . Read More

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January 2021

Theoretical Simulations of Heavy-Atom Kinetic Isotope Effects in Aliphatic Claisen Rearrangement.

J Phys Chem A 2020 Dec 10;124(51):10678-10686. Epub 2020 Dec 10.

School of Physics and Optoelectronic Engineering, Ludong University, Yantai 264025, People's Republic of China.

The aliphatic Claisen rearrangement of allyl vinyl ether has attracted great interest for its broad applications in chemical synthesis and biosynthesis. Although it is well agreed that this reaction proceeds a concerted, "chair-like" transition state, certain inconsistencies of kinetic isotope effect (KIE) data between experimental measurements and theoretical simulations or between independent experiments indicate that the nature and mechanism of this important reaction need to be investigated in more detail. In order to verify two independent sets of experimental data, we present theoretical calculations on heavy-atom KIE values of alipahtic Claisen rearrangement, using our recently developed path-integral method with the second-order Kleinert's variational perturbation theory, which goes beyond the traditional method for computing KIE values by employing the Bigeleisen equation. Read More

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December 2020

Effect of RGD content in poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-alt-maleic acid) hydrogels on the expansion of ovarian cancer stem-like cells.

Mater Sci Eng C Mater Biol Appl 2021 Jan 3;118:111477. Epub 2020 Sep 3.

State Key Lab of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. Electronic address:

The extracellular matrix (ECM) affects cell behaviors, such as survival, proliferation, motility, invasion, and differentiation. The arginine-glycine-aspartic acid (RGD) sequence is present in several ECM proteins, such as fibronectin, collagen type I, fibrinogen, laminin, vitronectin, and osteopontin. It is very critical to develop ECM-like substrates with well-controlled features for the investigation of influence of RGD on the behavior of tumor cells. Read More

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January 2021

tert-Butyl Esters as Potential Reversible Chain Transfer Agents for Concurrent Cationic Vinyl-Addition and Ring-Opening Copolymerization of Vinyl Ethers and Oxiranes.

Macromol Rapid Commun 2020 Nov 16:e2000479. Epub 2020 Nov 16.

Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043, Japan.

tert-Butyl esters are demonstrated to function as chain transfer agents (CTAs) in the cationic copolymerization of vinyl ether (VE) and oxirane via concurrent vinyl-addition and ring-opening mechanisms. In the copolymerization of isopropyl VE and isobutylene oxide (IBO), the IBO-derived propagating species reacts with tert-butyl acetate to generate a copolymer chain with an acetoxy group at the ω-end. This reaction liberates a tert-butyl cation; hence, a polymer chain with a tert-butyl group at the α-end is subsequently generated. Read More

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November 2020

Surface Antifouling Modification on Polyethylene Filtration Membranes by Plasma Polymerization.

Materials (Basel) 2020 Nov 6;13(21). Epub 2020 Nov 6.

Department of Chemical Engineering, National Taiwan University of Science and Technology, 43, Keelung Rd., Sec. 4, Taipei 106, Taiwan.

Surface modification on microporous polyethylene (PE) membranes was facilitated by plasma polymerizing with two hydrophilic precursors: ethylene oxide vinyl ether (EO1V) and diethylene oxide vinyl ether (EO2V) to effectively improve the fouling against mammalian cells (Chinese hamster ovary, CHO cells) and proteins (bovine serum albumin, BSA). The plasma polymerization procedure incorporated uniform and pin-hole free ethylene oxide-containing moieties on the filtration membrane in a dry single-step process. The successful deposition of the plasma polymers was verified by Fourier-transform infrared (FTIR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) analyses. Read More

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November 2020

Ion Exchange Nanoparticles for Ophthalmic Drug Delivery.

Bioconjug Chem 2020 12 2;31(12):2726-2736. Epub 2020 Nov 2.

School of Pharmacy, Institute of Drug Research-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.

We report here on ion-exchange polymeric nanoparticles from a linear copolymer of maleic anhydride methyl vinyl ether esterified with 30% octadecanol. The side chains for the polymer structure were optimized through metadynamics simulations, which revealed the use of octadecanol esters generates ideal free energy surfaces for drug encapsulation and release. Nanoparticles were synthesized using a solvent evaporation-precipitation method by mixing the polymer solution in acetone into water; upon acetone evaporation, a nanodispersion with an average particle size of ∼150 nm was obtained. Read More

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December 2020

Mechanistic Studies for Palladium Catalyzed Copolymerization of Ethylene with Vinyl Ethers.

Polymers (Basel) 2020 Oct 19;12(10). Epub 2020 Oct 19.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.

The mechanism of ethylene with vinyl ether (VE, CH=CHOEt) copolymerization catalyzed by phosphine-sulfonate palladium complex () was investigated by density functional theory (DFT) calculation. On achieving an agreement between theory and experiment, it is found that the favorable 1,2-selective insertion of VE into the complex originates from stronger hydrogen interaction between the oxygen atom of VE and the ancillary ligand of catalyst . Additionally, VE insertion is easier into the ethylene pre-inserted intermediate than that into the catalyst to form the resultant copolymers with the major units of OEt in chain and minor units of OEt at the chain end. Read More

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October 2020

Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum.

Front Cell Dev Biol 2020 11;8:855. Epub 2020 Sep 11.

Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Plasmalogens are a subclass of ether glycerophospholipids characterized by a vinyl-ether bond at the -1 position of the glycerol backbone. Plasmalogen biosynthesis is initiated in peroxisomes. At the third step of plasmalogen synthesis, alkyl-dihydroxyacetonephosphate (DHAP) is enzymatically reduced to 1-alkyl--glycero-3-phospate by acyl/alkyl DHAP reductase (ADHAPR), whose activity is found in both peroxisomes and microsomes. Read More

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September 2020

Synthesis of Well-Defined Alternating Copolymer Composed of Ethylmaleimide and Hydroxy-Functionalized Vinyl Ether by RAFT Polymerization and Their Thermoresponsive Properties.

Polymers (Basel) 2020 Oct 1;12(10). Epub 2020 Oct 1.

Faculty of Molecular Chemistry and Engineering, Graduate School of Science and Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.

Here we report the controlled synthesis of alternating copolymers by reversible addition-fragmentation chain transfer (RAFT) polymerization of hydroxy-functionalized vinyl ether (DEGV) and ethylmaleimide (EtMI) using dithiocarbonate derivative (CPDB) as the RAFT reagent. The resulting alternating copolymer poly[ethylmaleimide--(diethylene glycol mono vinyl ether)] (poly(MalMI--DEGV)) had a relatively narrow molecular weight distribution (/ < 1.4). Read More

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October 2020

Directionally-Grown Carboxymethyl Cellulose/Reduced Graphene Oxide Aerogel with Excellent Structure Stability and Adsorption Capacity.

Polymers (Basel) 2020 Sep 27;12(10). Epub 2020 Sep 27.

Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing 210042, China.

A novel three-dimensional carboxymethyl cellulose (CMC)/reduced graphene oxide (rGO) composite aerogel crosslinked by poly (methyl vinyl ether--maleic acid)/poly (ethylene glycol) system via a directional freezing technique exhibits high structure stability while simultaneously maintaining its excellent adsorption capacity to remove organic dyes from liquid. A series of crosslinked aerogels with different amounts of GO were investigated for their adsorption capacity of methylene blue (MB), which were found to be superb adsorbents, and the maximum adsorption capacity reached 520.67 mg/g with the incorporation of rGO. Read More

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September 2020

Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH-Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage.

Lipids 2021 03 29;56(2):167-180. Epub 2020 Sep 29.

Department of Life and Food Sciences, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, 080-8555, Japan.

Ethanolamine plasmalogen (PlsEtn), a sub-class of ethanolamine glycerophospholipids (EtnGpl), is a universal phospholipid in mammalian membranes. Several researchers are interested in the relationship between colon carcinogenesis and colon PlsEtn levels. Here, we evaluated the functional role of dietary purified EtnGpl from the ascidian muscle (87. Read More

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Mechanistic Insight into the Stereoselective Cationic Polymerization of Vinyl Ethers.

J Am Chem Soc 2020 10 28;142(40):17175-17186. Epub 2020 Sep 28.

Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

The control of the tacticity of synthetic polymers enables the realization of emergent physical properties from readily available starting materials. While stereodefined polymers derived from nonpolar vinyl monomers can be efficiently prepared using early transition metal catalysts, general methods for the stereoselective polymerization of polar vinyl monomers remain underdeveloped. We recently demonstrated asymmetric ion pairing catalysis as an effective approach to achieve stereoselective cationic polymerization of vinyl ethers. Read More

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October 2020

Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine.

Front Cell Dev Biol 2020 31;8:765. Epub 2020 Aug 31.

MOE Key Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, China.

Plasmalogens are a special class of polar glycerolipids containing a vinyl-ether bond and an ester bond at sn-1 and sn-2 positions of the glycerol backbone, respectively. In animals, impaired biosynthesis and regulation of plasmalogens may lead to certain neurological and metabolic diseases. Plasmalogens deficiency was proposed to be strongly associated with neurodegenerative and metabolic diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), and appropriate supplement of plasmalogens could help to prevent and possibly provide therapy of these diseases. Read More

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NIR-Sensitized Cationic and Hybrid Radical/Cationic Polymerization and Crosslinking.

Angew Chem Int Ed Engl 2021 Jan 16;60(3):1465-1473. Epub 2020 Nov 16.

Department of Chemistry, Institute for Coatings and Surface Chemistry, Niederrhein University of Applied Sciences, Adlerstr. 1, 47798, Krefeld, Germany.

NIR-sensitized cationic polymerization proceeded with good efficiency, as was demonstrated with epoxides, vinyl ether, and oxetane. A heptacyanine functioned as sensitizer while iodonium salt served as coinitiator. The anion adopts a special function in a series selected from fluorinated phosphates (a: [PF ] , b: [PF (C F ) ] , c: [PF (n-C F ) ] ), aluminates (d: [Al(O-t-C F ) ] , e: [Al(O(C F )CH ) ] ), and methide [C(O-SO CF ) ] (f). Read More

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January 2021

Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications.

Chemistry 2021 Jan 10;27(4):1316-1322. Epub 2020 Dec 10.

International Tomography Center SB RAS, 3A Institutskaya St., 630090, Novosibirsk, Russia.

Magnetic resonance imaging (MRI) with the use of hyperpolarized gases as contrast agents provides valuable information on lungs structure and function. While the technology of Xe hyperpolarization for clinical MRI research is well developed, it requires the expensive equipment for production and detection of hyperpolarized Xe. Herein we present the H hyperpolarization of diethyl ether vapor that can be imaged on any clinical MRI scanner. Read More

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January 2021

Synthesis of an UV-Curable Divinyl-Fumarate Poly-ε-Caprolactone for Stereolithography Applications.

Methods Mol Biol 2021 ;2147:55-62

Institute of Polymers, Composites and Biomaterials - National Research Council (IPCB-CNR), Naples, Italy.

The limited number of commercially available photocrosslinkable resins for stereolithography has often been considered the main limitation of this technique. In this manuscript, a photocrosslinkable poly-ε-caprolactone (PCL) has been synthesized by a two-step method starting from ring opening polymerization (ROP) of ε-caprolactone. Hydroxyethyl vinyl ether (HEVE) has been used both as the initiator of ROP and as photo-curable functional group to obtain a vinyl poly-ε-caprolactone (VPCL). Read More

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The Cyclic Nitronate Route to Pharmaceutical Molecules: Synthesis of GSK's Potent PDE4 Inhibitor as a Case Study.

Molecules 2020 Aug 8;25(16). Epub 2020 Aug 8.

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia.

An efficient asymmetric synthesis of GlaxoSmithKline's potent PDE4 inhibitor was accomplished in eight steps from a catechol-derived nitroalkene. The key intermediate (3-acyloxymethyl-substituted 1,2-oxazine) was prepared in a straightforward manner by tandem acylation/(3,3)-sigmatropic rearrangement of the corresponding 1,2-oxazine--oxide. The latter was assembled by a (4 + 2)-cycloaddition between the suitably substituted nitroalkene and vinyl ether. Read More

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Chemically Cross-Linked Cellulose Nanocrystal Aerogels for Effective Removal of Cation Dye.

Front Chem 2020 7;8:570. Epub 2020 Jul 7.

Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, Knoxville, TN, United States.

In this study, porous aerogels were prepared by directional freeze-drying via cross-linking cellulose nanocrystals (CNCs) with poly(methyl vinyl ether-co-maleic acid) (PMVEMA) and poly(ethylene glycol) (PEG). The thermal properties and physical adsorption performance toward cation methylene blue dye of the obtained CNC aerogels were investigated. The maximum degradation temperature was increased from 324°C of CNCs to 355°C of cross-linked CNC aerogels. Read More

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Unequivocal Mapping of Molecular Ether Lipid Species by LC-MS/MS in Plasmalogen-Deficient Mice.

Anal Chem 2020 08 7;92(16):11268-11276. Epub 2020 Aug 7.

Institute of Human Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Deficient ether lipid biosynthesis in rhizomelic chondrodysplasia punctata and other disorders is associated with a wide range of severe symptoms including small stature with proximal shortening of the limbs, contractures, facial dysmorphism, congenital cataracts, ichthyosis, spasticity, microcephaly, and mental disability. Mouse models are available but show less severe symptoms. In both humans and mice, it has remained elusive which of the symptoms can be attributed to lack of plasmanyl or plasmenyl ether lipids. Read More

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Alternating Cascade Metathesis Polymerization of Enynes and Cyclic Enol Ethers with Active Ruthenium Fischer Carbenes.

J Am Chem Soc 2020 07 20;142(30):12942-12947. Epub 2020 Jul 20.

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, Georgia 30332, United States.

Ruthenium alkoxymethylidene complexes have rarely been demonstrated as active species in metathesis reactions and are frequently regarded as inert. Herein, we highlight the ability of these Fischer-type carbenes to participate in cascade alternating ring-opening metathesis polymerization through their efficient alkyne addition reactions. When enyne monomers are combined with low-strain cyclic vinyl ethers, a controlled chain-growth copolymerization occurs that exhibits high degrees of alternation (>90% alternating diads) and produces degradable poly(vinyl ether) materials with low dispersities and targetable molecular weights. Read More

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