202 results match your criteria vincristine-induced peripheral

Punicalagin and ellagic acid containing fruit rind extract prevents vincristine-induced neuropathic pain in rats: an and evidence of GABAergic action and cytokine inhibition.

Nutr Neurosci 2021 Aug 9:1-18. Epub 2021 Aug 9.

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.

We aimed to investigate the protective potential of Punica granatum L. fruit rind extract (PFE) containing punicalagin (10.3% W/W), ellagic acid (EA) (2. Read More

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CaMKII and Ca3.2 T-type calcium channel mediate Connexin-43-dependent inflammation by activating astrocytes in vincristine-induced neuropathic pain.

Cell Biol Toxicol 2021 Jul 20. Epub 2021 Jul 20.

School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, China.

Vincristine (VCR), an alkaloid isolated from vinca, is a commonly used chemotherapeutic drug. However, VCR therapy can lead to dose-dependent peripheral neurotoxicity, mainly manifesting as neuropathic pain, which is one of the dominant reasons for limiting its utility. Experimentally, we discovered that VCR-induced neuropathic pain (VINP) was accompanied by astrocyte activation; the upregulation of phospho-CaMKII (p-CaMKII), Ca3. Read More

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Characteristics and patterns of pediatric chemotherapy-induced peripheral neuropathy: A systematic review.

Cancer Treat Res Commun 2021 8;28:100420. Epub 2021 Jun 8.

Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza (MB), Italy; NeuroMI (Milan Center for Neuroscience), Milan, Italy. Electronic address:

This systematic review provides a high-quality synthesis of the empirical evidence regarding chemotherapy-induced peripheral neuropathy (CIPN) characteristics and patterns described in studies of children who received neurotoxic chemotherapy to treat cancer. PubMed, CINAHL, PsycINFO, and Embase were searched for articles published 2009 - 2019, yielding 861. Forty-two papers met the eligibility criteria, including 31 that described characteristics and patterns of vincristine-induced CIPN. Read More

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Suppression of TRPV1/TRPM8/P2Y Nociceptors by Withametelin via Downregulating MAPK Signaling in Mouse Model of Vincristine-Induced Neuropathic Pain.

Int J Mol Sci 2021 Jun 4;22(11). Epub 2021 Jun 4.

Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential (TRP) channels, purinergic receptor (P2Y), and mitogen-activated protein kinase (MAPK) signaling play a crucial role in the pathogenesis of neuropathic pain. Read More

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Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors.

Cancer Chemother Pharmacol 2021 Sep 2;88(3):451-464. Epub 2021 Jun 2.

Quantitative Clinical Pharmacology, AstraZeneca , South San Francisco, CA, USA.

Purpose: Limited information is available regarding the drug-drug interaction (DDI) potential of molecular targeted agents and rituximab plus cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin), and prednisone (R-CHOP) therapy. The addition of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib to R-CHOP therapy results in increased toxicity versus R-CHOP alone, including higher incidence of peripheral neuropathy. Vincristine is a substrate of P-glycoprotein (P-gp, ABCB1); drugs that inhibit P-gp could potentially cause increased toxicity when co-administered with vincristine through DDI. Read More

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September 2021

Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment.

Int J Mol Sci 2021 Apr 16;22(8). Epub 2021 Apr 16.

Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, Italy.

Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of vincristine chemotherapy among pediatric patients with cancer. Neuropathy may be sensory, motor and/or autonomic, with consequent reduction, delay or discontinuation of vincristine-chemotherapy, but also pain, disability, reduced quality of life of patients and an increase in medical costs. Vincristine acts out its antineoplastic function by altering the normal assembly and disassembly of microtubules, with their consequent mitosis block and death. Read More

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Immune-mediated vincristine-induced neuropathy: Unlocking therapies.

J Exp Med 2021 May;218(5)

NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor, MI.

Vincristine-induced peripheral neuropathy (VIPN) is a prevalent and painful complication in cancer patients that lacks effective treatments. In this issue of JEM, Starobova et al. (2021. Read More

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Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.

Clin Transl Sci 2021 Jul 31;14(4):1490-1504. Epub 2021 May 31.

Hematological Malignancies Program and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Vincristine (VCR) is one of the most widely prescribed medications for treating solid tumors and acute lymphoblastic leukemia (ALL) in children and adults. However, its major dose-limiting toxicity is peripheral neuropathy that can disrupt curative therapy. Peripheral neuropathy can also persist into adulthood, compromising quality of life of childhood cancer survivors. Read More

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Rapid quantification of vincristine in mouse plasma using ESI-LC-MS/MS: Application to pharmacokinetic studies.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Apr 21;1168:122591. Epub 2021 Feb 21.

Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA. Electronic address:

A simple, rapid, and sensitive LC-MS/MS method for determining concentrations of the anticancer alkaloid vincristine in micro volumes of mouse plasma was developed and validated in positive ion mode. Separation of vincristine and the internal standard [H]-vincristine was achieved on an Accucore aQ column with a gradient mobile phase delivered at a flow rate of 0.4 mL/min and a run time of 2. Read More

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Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release.

J Exp Med 2021 May;218(5)

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.

Vincristine is an important component of many regimens used for pediatric and adult malignancies, but it causes a dose-limiting sensorimotor neuropathy for which there is no effective treatment. This study aimed to delineate the neuro-inflammatory mechanisms contributing to the development of mechanical allodynia and gait disturbances in a murine model of vincristine-induced neuropathy, as well as to identify novel treatment approaches. Here, we show that vincristine-induced peripheral neuropathy is driven by activation of the NLRP3 inflammasome and subsequent release of interleukin-1β from macrophages, with mechanical allodynia and gait disturbances significantly reduced in knockout mice lacking NLRP3 signaling pathway components, or after treatment with the NLRP3 inhibitor MCC950. Read More

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Vinorelbine as substitute for vincristine in patients with diffuse large B cell lymphoma and vincristine-induced neuropathy.

Support Care Cancer 2021 Sep 24;29(9):5197-5207. Epub 2021 Feb 24.

Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Background: A combination of rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the standard first-line therapy for diffuse large B cell lymphoma (DLBCL), the most common aggressive lymphoma in adults. One of the major adverse effects of this regimen is vincristine-induced polyneuropathy which leads to discontinuation of vincristine in up to 30% of DLBCL-patients. Dose reduction of vincristine might worsen treatment outcomes of DLBCL but identification of treatment alternatives for patients exhibiting peripheral neuropathy during R-CHOP is an unmet need in hematology. Read More

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September 2021

Effect of pyridoxine plus pyridostigmine treatment on vincristine-induced peripheral neuropathy in pediatric patients with acute lymphoblastic leukemia: a single-center experience.

Neurol Sci 2021 Sep 13;42(9):3681-3686. Epub 2021 Jan 13.

Department of Pediatric Hematology and Oncology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey.

Background: Vincristine (VCR), which is a key component of chemotherapy, is important for survival. VCR is associated with a well-known side effect, including neurotoxicity.

Aims: The aim of this study was to evaluate the features of vincristine-induced peripheral neuropathy (VIPN) and the effectiveness of pyridoxine plus pyridostigmine therapy in children with acute lymphoblastic leukemia. Read More

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September 2021

The neuroprotective effect of oxytocin on vincristine-induced neurotoxicity in mice.

Toxicol Lett 2021 Apr 8;340:67-76. Epub 2021 Jan 8.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, PR China. Electronic address:

Vincristine (VCR) is commonly used to treat a variety of hematological malignancies and solid tumors in pediatric and adult patients. However, peripheral neuropathy is a dose-limiting side effect that leaves some patients with functional disability and long-term pain. Oxytocin (OT) has demonstrated analgesic and anti-inflammatory properties, but there is no evidence regarding its effects on VCR-induced neurotoxicity. Read More

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Comparative Analysis of Chemotherapy-Induced Peripheral Neuropathy in Bioengineered Sensory Nerve Tissue Distinguishes Mechanistic Differences in Early-Stage Vincristine-, Cisplatin-, and Paclitaxel-Induced Nerve Damage.

Toxicol Sci 2021 02;180(1):76-88

Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA.

Chemotherapy-induced peripheral neuropathy (CIPN) is a well-known, potentially permanent side effect of widely used antineoplastic agents. The mechanisms of neuropathic progression are poorly understood, and the need to test efficacy of novel interventions to treat CIPN continues to grow. Bioengineered microphysiological nerve tissue ("nerve on a chip") has been suggested as an in vitro platform for modeling the structure and physiology of in situ peripheral nerve tissue. Read More

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February 2021

Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology: A Randomized Controlled Trial Comparing Push Injections with One-Hour Infusions (The VINCA Trial).

Cancers (Basel) 2020 Dec 12;12(12). Epub 2020 Dec 12.

Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric oncology, 1081 HV Amsterdam, The Netherlands.

Vincristine (VCR) is a frequently used chemotherapeutic agent. However, it can lead to VCR-induced peripheral neuropathy (VIPN). In this study we investigated if one-hour infusions of VCR instead of push-injections reduces VIPN in pediatric oncology patients. Read More

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December 2020

Pain Management in Childhood Leukemia: Diagnosis and Available Analgesic Treatments.

Cancers (Basel) 2020 Dec 7;12(12). Epub 2020 Dec 7.

Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

Pain is one of the most common symptoms in children suffering from leukemia, who are often misdiagnosed with other childhood painful diseases such as juvenile idiopathic arthritis. Corticosteroid-induced osteonecrosis (ON) and vincristine-induced peripheral neuropathy (VIPN) are the most common painful manifestations. Additionally, ongoing pain may continue to impact quality of life in survivorship. Read More

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December 2020

The Involvement of Central Noradrenergic Pathway in the Analgesic Effect of Bee Venom Acupuncture on Vincristine-Induced Peripheral Neuropathy in Rats.

Toxins (Basel) 2020 12 6;12(12). Epub 2020 Dec 6.

Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.

Vincristine is a vinca alkaloid anti-mitotic drug with a broad spectrum of effects on solid and hematologic cancers. The major dose-limiting factor of this anti-cancer regimen is painful peripheral neuropathy. However, no gold-standard analgesic option has been used clinically. Read More

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December 2020

Genetic factors influencing the development of vincristine-induced neurotoxicity.

Expert Opin Drug Metab Toxicol 2021 Feb 6;17(2):215-226. Epub 2020 Dec 6.

Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca , Monza, Italy.

: One of the most common side effects during vincristine (VCR) use is the establishment of VCR-induced peripheral neuropathy (VIPN). Among several risk factors that can influence the development of VIPN, such as cumulative dose and patient's age, sex, ethnicity, and genetic variants, this review is focused on the genetic variability. : A literature research was performed firstly using the following PubMed search string but also other relevant papers cited by the selected articles were included. Read More

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February 2021

Correction: Association of CEP72 rs924607 TT Genotype with Vincristine-induced Peripheral Neuropathy Measured by Motor Nerve Conduction Studies.

Klin Padiatr 2020 Nov 26;232(6):e12. Epub 2020 Nov 26.

Unit for Special Laboratory Diagnostics, University Medical Centre Ljubljana, Division of Paediatrics, Ljubljana, Slovenia.

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November 2020

Vincristine-induced peripheral neuropathy: A mini-review.

Neurotoxicology 2020 12 11;81:161-171. Epub 2020 Oct 11.

Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Vincristine (VCR), an alkaloid extracted from vinca, is often used in combination with other chemotherapeutic drugs to treat a variety of cancers, such as acute lymphoblastic leukaemia (ALL), malignant lymphoma, and neuroblastoma. However, VCR possesses dose-dependent neurotoxicity, which is the main factor restricting its application. Vincristine-induced peripheral neuropathy (VIPN) not only limits the dose of VCR and leads to the discontinuation of treatment but also triggers serious damage to the physical and mental health of patients. Read More

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December 2020

Association of CEP72 rs924607 TT Genotype with Vincristine-induced Peripheral Neuropathy Measured by Motor Nerve Conduction Studies.

Klin Padiatr 2020 Nov 2;232(6):331-333. Epub 2020 Sep 2.

Unit for Special Laboratory Diagnostics, University Medical Centre Ljubljana, Division of Paediatrics, Ljubljana, Slovenia.

Vincristine is at the core of many treatment protocols for childhood malignancies. The major dose-limiting side effect is vincristine-induced peripheral neuropathy (VIPN) which may cause morbidity and disrupt curative treatment. Several studies have tried to identify pharmacogenetic biomarkers for susceptibility to vincristine-induced toxicity (Egbelakin A et al. Read More

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November 2020

Suppressing BRD4 exhibits protective effects against vincristine-induced peripheral neuropathy by alleviating inflammation and oxidative stress.

Ke Zhang Yanbing Xu

Biochem Biophys Res Commun 2020 11 29;532(2):271-279. Epub 2020 Aug 29.

Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, China. Electronic address:

Vincristine (VCR) is a well-known anticancer drug, and frequently causes painful neuropathy and impairs the quality of life of patients. However, the molecular mechanisms revealing VCR-induced neuropathy are still unclear, and effectively therapeutic strategy is still necessary. Bromodomain-containing protein 4 (BRD4) has long been implicated in many different pathological processes, in particular, the development of oxidative stress and inflammation. Read More

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November 2020

Sodium channel Nav1.6 in sensory neurons contributes to vincristine-induced allodynia.

Brain 2020 08;143(8):2421-2436

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.

Vincristine, a widely used chemotherapeutic agent, produces painful peripheral neuropathy. The underlying mechanisms are not well understood. In this study, we investigated whether voltage-gated sodium channels are involved in the development of vincristine-induced neuropathy. Read More

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Aripiprazole prevents from development of vincristine-induced neuropathic nociception by limiting neural NOS overexpression and NF-kB hyperactivation.

Cancer Chemother Pharmacol 2020 09 14;86(3):393-404. Epub 2020 Aug 14.

Experimental Medicine Research Center, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran.

Purpose: Increased nitric oxide (NO) synthesis and NF-kB activation have been shown as critical players in the pathophysiology of vincristine-induced peripheral neuropathy. Consistently, neural nitric oxide synthase (nNOS) inhibitors alleviated the neuropathic pain. Previous studies demonstrated that aripiprazole is capable of modulating NO synthesis and also has been reported its modulatory effect on NF-kB activity. Read More

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September 2020

rs924607 and vincristine-induced neuropathy in pediatric acute lymphocytic leukemia: meta-analysis.

Future Sci OA 2020 May 27;6(7):FSO582. Epub 2020 May 27.

Department for Pediatric Hematology & Oncology, University Children's Hospital of Ljubljana, University Medical Centre Ljubljana, Bohoričeva street 20, Ljubljana, Slovenia.

Aim: We examined the utility of the rs924607 TT genotype of the () as a potential biomarker for predilection toward vincristine-induced peripheral neuropathy in children treated for acute lymphoblastic leukemia.

Materials & Methods: We conducted a random-effects meta-analysis of data from four studies comprising 817 patients. We tested for an association using a recessive model where a one-sided p-value < 0. Read More

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A Rare Case of Vincristine-Induced Neuropathy Presenting as Foot Drop in the Postoperative Period.

AANA J 2020 Aug;88(4):299-302

is in the Department of Onco-Anaesthesiology and Palliative Medicine, Dr Bhim Rao Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences.

Patients with cancer receiving chemotherapy are at risk of neuropathy development. Many of them may have subclinical neuropathies, which may be missed before planning anesthesia, especially in emergency scenarios. This case report highlights the importance of a thorough neurologic examination in patients with subclinical neuropathy to avoid any complications and medicolegal issues. Read More

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Fluoroquinolone prophylaxis does not increase risk of neuropathy in children with acute lymphoblastic leukemia.

Cancer Med 2020 09 25;9(18):6550-6555. Epub 2020 Jul 25.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.

Background: Fluoroquinolone antibiotics are frequently utilized in pediatric oncology patients as prophylaxis or step-down therapy following broad spectrum beta-lactam therapy for febrile neutropenia. Concerns regarding neurotoxicity limit the use of these agents. No studies have evaluated the association between fluoroquinolone use and neurotoxicity in pediatric oncology patients receiving other neurotoxic agents such as vincristine. Read More

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September 2020

The protective effect of modafinil on vincristine-induced peripheral neuropathy in rats: A possible role for TRPA1 receptors.

Basic Clin Pharmacol Toxicol 2020 Nov 3;127(5):405-418. Epub 2020 Jul 3.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Vincristine (VCR) induces peripheral neuropathy. We aimed to assess the efficacy of modafinil on VCR-induced neuropathy in rats. Neuropathy was induced by intraperitoneal (i. Read More

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November 2020

A Metabolomics Approach for Early Prediction of Vincristine-Induced Peripheral Neuropathy.

Sci Rep 2020 06 15;10(1):9659. Epub 2020 Jun 15.

Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.

Vincristine is a core chemotherapeutic drug administered to pediatric acute lymphoblastic leukemia patients. Despite its efficacy in treating leukemia, it can lead to severe peripheral neuropathy in a subgroup of the patients. Peripheral neuropathy is a debilitating and painful side-effect that can severely impact an individual's quality of life. Read More

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Hydroethanolic Stem Bark Extract of Attenuates Vincristine-Induced Peripheral Neuropathy in Rats.

Adv Pharmacol Pharm Sci 2020 12;2020:7232579. Epub 2020 Feb 12.

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

. The stem bark of the savanna tree (Hook) (family: Leguminosae) is used in the Ghanaian traditional medicine for the management of various pain-related diseases.

Objective: This study seeks to investigate the possible antiallodynic and antihyperalgesic effects of the hydroethanolic stem bark extract of in a vincristine-induced peripheral neuropathy model in rats. Read More

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February 2020