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Illness-Related Parenting Stress and Maladjustment in Congenital Heart Disease: Mindfulness as a Moderator.

J Pediatr Psychol 2020 11;45(10):1208-1215

Department of Psychology, Georgia State University.

Objective: Congenital heart disease (CHD) is characterized by structural defects to the heart or the coronary blood vessels and often requires surgical repair. Raising an infant or toddler with CHD can be challenging and lead to high parenting stress and maladjustment. The parenting literature suggests that mindfulness may buffer parenting stress. Read More

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November 2020

Primary Angiitis of the Central Nervous System Mimicking Glioblastoma: A Case Report and Literature Review.

Front Neurol 2019 13;10:1208. Epub 2019 Nov 13.

Department of Neurology, Stroke Center, The First Hospital of Jilin University, Changchun, China.

Primary angiitis of the central nervous system (PACNS) is a rare disorder resulting in idiopathic inflammation affecting the parenchymal and leptomeningeal vessels confined to the central nervous system (CNS), of which a tumor-like mass lesion is an even rare subtype. We described a case of PACNS initially misdiagnosed as glioblastoma. The patient was a 35 year-old female with right-sided weakness and expressive dysphasia. Read More

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November 2019

Unilateral Access Is Safe and Facilitates Peripheral Bailout During Transfemoral-Approach Transcatheter Aortic Valve Replacement.

JACC Cardiovasc Interv 2019 11;12(21):2210-2220

Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objectives: The aim of this study was to compare the rate and trend of vascular complications when placing a second arterial sheath in the contralateral femoral artery during transcatheter aortic valve replacement (TAVR) unilaterally versus bilaterally.

Background: Vascular complications occur in approximately 5% to 8% of TAVR procedures. Many operators place a second arterial sheath in the contralateral femoral artery to perform aortic root angiography. Read More

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November 2019

Sex-specific distributions and determinants of thoracic aortic diameters in the elderly.

Heart 2020 01 24;106(2):133-139. Epub 2019 Sep 24.

Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

Objective: To provide population-based distributions of thoracic aortic diameters in men and women aged 55 years or older and to identify determinants of thoracic aortic diameters.

Methods: From 2003 to 2006, 2505 participants (1208 men, mean age 69.1±6. Read More

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January 2020

Comparison of End-Tidal, Arterial, Venous, and Transcutaneous P.

Respir Care 2019 Oct 23;64(10):1208-1214. Epub 2019 Jul 23.

Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.

Background: We investigated the measurement of end-tidal partial pressure of carbon dioxide (P ) with a capnometer in patients with respiratory failure, and we determined whether this technique could provide an alternative to measurement of P using arterial blood gas analysis in the clinical setting.

Methods: We measured P in subjects with hypoxemic and hypercarbic respiratory failure using a capnometer. We simultaneously measured P , venous partial pressure of carbon dioxide (P ), and transcutaneously measured partial pressure P (P ). Read More

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October 2019

A rare case of anomalous origin of the left anterior descending artery from the pulmonary artery.

Echocardiography 2019 06 22;36(6):1208-1210. Epub 2019 Apr 22.

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital heart disease, with an incidence of <1 in 300 000 live births. We describe a rare case of a 23-month-old infant admitted for cough and fever. Echocardiography showed a branch of the left coronary artery originating from the pulmonary artery. Read More

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1-Year Impact on Medical Practice and Clinical Outcomes of FFR: The ADVANCE Registry.

JACC Cardiovasc Imaging 2020 01 17;13(1 Pt 1):97-105. Epub 2019 Mar 17.

Department of Radiology, Providence Health Care, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.

Objectives: The 1-year data from the international ADVANCE (Assessing Diagnostic Value of Non-invasive FFR in Coronary Care) Registry of patients undergoing coronary computed tomography angiography (CTA) was used to evaluate the relationship of fractional flow reserve derived from coronary CTA (FFR) with downstream care and clinical outcomes.

Background: Guidelines for management of chest pain using noninvasive imaging pathways are based on short- to intermediate-term outcomes.

Methods: Patients (N = 5,083) evaluated for clinically suspected coronary artery disease and in whom atherosclerosis was identified by coronary CTA were prospectively enrolled at 38 international sites from July 15, 2015, to October 20, 2017. Read More

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January 2020

The lateral patellar retinaculum defect: anatomical study using ultrasound.

Skeletal Radiol 2019 Nov 26;48(11):1753-1758. Epub 2019 Mar 26.

Hôpital Sainte Marguerite, 13009, Marseille, France.

Objective: The purpose of this study was to evaluate whether ultrasound allows precise assessment of a focal defect at the lateral patellar retinaculum (LPR) and to determine its anatomical significance.

Materials And Methods: This work was initially undertaken in four cadaveric specimens and followed by high-resolution ultrasound study in 48 healthy adult volunteers (96 knees) by two musculoskeletal radiologists. Dimension and location of the LPR defect and its relations to adjacent anatomical structures were analyzed. Read More

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November 2019

Anti-vascular endothelial growth factor for neovascular age-related macular degeneration.

Cochrane Database Syst Rev 2019 03 4;3:CD005139. Epub 2019 Mar 4.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Maumenee 740, Baltimore, Maryland, USA, 21287.

Background: Age-related macular degeneration (AMD) is the most common cause of uncorrectable severe vision loss in people aged 55 years and older in the developed world. Choroidal neovascularization (CNV) secondary to AMD accounts for most cases of AMD-related severe vision loss. Intravitreous injection of anti-vascular endothelial growth factor (anti-VEGF) agents aims to block the growth of abnormal blood vessels in the eye to prevent vision loss and, in some instances, to improve vision. Read More

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High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass.

Hypertension 2018 11;72(5):1208-1216

From the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).

High salt, Ang II (angiotensin II), and reactive oxygen species enhance progression of chronic kidney disease. We tested the hypothesis that a high salt intake generates specific reactive oxygen species to enhance Ang II contractions of afferent arterioles from mice with reduced renal mass (RRM). C57BL/6 mice were subjected to surgical RRM or sham operations and received 6% or 0. Read More

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November 2018

Use Side Branch of the Aortic Graft to Facilitate Coronary Reconstruction During Complex Aortic Surgery.

Semin Thorac Cardiovasc Surg 2019 4;31(2):201-206. Epub 2018 Oct 4.

Division of Cardiac, Thoracic and Vascular Surgery, Department of Surgery, Columbia University Medical Center, New York, New York. Electronic address:

The interposition graft could be used for difficult coronary reconstruction during aortic root replacement. We introduced a new technique that utilizes side branch of an aortic graft to facilitate coronary reconstruction. The present study describes this technique and its outcomes. Read More

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December 2019

Multiple small branch retinal arteriolar occlusions following coil embolization of an internal carotid artery aneurysm.

Indian J Ophthalmol 2018 08;66(8):1208-1210

Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 134-701, South Korea.

A 41-year-old male was referred from the neurosurgery department with visual disturbance immediately following coil embolization of a distal internal carotid artery aneurysm. On initial fundus examination, diffuse retinal opacification sparing the papillomacular bundle area was observed in his right eye. Optical coherence tomography showed inner retinal edema, and fluorescein angiography showed delayed arterial filling and multiple small arteriolar obstructions in that eye. Read More

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Diagnostic Performance of a Novel Coronary CT Angiography Algorithm: Prospective Multicenter Validation of an Intracycle CT Motion Correction Algorithm for Diagnostic Accuracy.

AJR Am J Roentgenol 2018 Jun 18;210(6):1208-1215. Epub 2018 Apr 18.

2 Dalio Institute of Cardiovascular Imaging, Weill Cornell Medicine and New York-Presbyterian Hospital, 413 E 69th St, Ste 108, New York, NY 10021.

Objective: Motion artifact can reduce the diagnostic accuracy of coronary CT angiography (CCTA) for coronary artery disease (CAD). The purpose of this study was to compare the diagnostic performance of an algorithm dedicated to correcting coronary motion artifact with the performance of standard reconstruction methods in a prospective international multicenter study.

Subjects And Methods: Patients referred for clinically indicated invasive coronary angiography (ICA) for suspected CAD prospectively underwent an investigational CCTA examination free from heart rate-lowering medications before they underwent ICA. Read More

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Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography.

Br J Ophthalmol 2018 09 2;102(9):1208-1212. Epub 2017 Dec 2.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto City, Japan.

Background/aims: This study aimed to evaluate blood flow in the choriocapillaris in patients with Bietti crystalline dystrophy (BCD) with mutations using optical coherence tomography angiography (OCTA), and to explore the parameters associated with visual function.

Methods: This prospective case-series study included 13 eyes of 13 consecutive patients with BCD with mutations and 20 healthy eyes. Using OCTA, we obtained en face images of blood flow in the choriocapillaris. Read More

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September 2018

Surfactant protein-D deficiency suppresses systemic inflammation and reduces atherosclerosis in ApoE knockout mice.

Cardiovasc Res 2017 Aug;113(10):1208-1218

Department of Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Vancouver, BC V5Z 1M9, Canada.

Aims: Although surfactant protein-D (SP-D) is a pneumoprotein that is predominantly synthesized by type II epithelial cells in the lung, individuals with increased circulating levels of SP-D are at an elevated risk of mortality from ischemic heart disease. Whether SP-D contributes directly to atherosclerosis is unknown. We determined the effects of SP-D gene deletion in a mouse model of atherosclerosis. Read More

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Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions.

Hum Reprod 2017 06;32(6):1208-1217

Department of Obstetrics and Gynecology, Reproductive Biology Unit, Medical University of Vienna, Währinger Gürtel 18-20, 5Q, 1090 Vienna, Austria.

Study Question: Do extravillous trophoblasts (EVTs) invade non-arterial decidual vessels in healthy and pathological pregnancies?

Summary Answer: Our results reveal that trophoblast invasion of venous and lymphatic vessels is a frequent event during the first trimester of pregnancy and is compromised in  recurrent spontaneous abortion (RSA). In addition, the present data suggest that EVTs populate regional lymph nodes during pregnancy.

What Is Already Known: Human trophoblasts remodel and invade decidual spiral arteries. Read More

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Biological effects of ticagrelor over clopidogrel in patients with stable coronary artery disease and chronic obstructive pulmonary disease.

Thromb Haemost 2017 03 23;117(6):1208-1216. Epub 2017 Mar 23.

Gianluca Campo, MD, Cardiovascular Institute, Azienda Ospedaliero-Universitaria S.Anna, Via A. Moro 8, Cona (FE), Italy, Tel.: +39 0532237079, Fax: +39 0532241885, E-mail:

Patients with SCAD and concomitant COPD are at high risk of cardiovascular adverse events, due to chronic inflammation, responsible of endothelial dysfunction, oxidative stress and heightened platelet reactivity (PR). The objective of this randomised clinical trial was to test if ticagrelor is superior to clopidogrel in improving endothelial function in patients with stable coronary artery disease (SCAD) and concomitant chronic obstructive pulmonary disease (COPD). Forty-six patients with SCAD and COPD undergoing percutaneous coronary intervention (PCI) were randomly assigned to receive clopidogrel (n=23) or ticagrelor (n=23) on top of standard therapy with aspirin. Read More

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Takayasu's arteritis with total occlusion of the distal thoraco-abdominal aorta involving multiple visceral arteries.

Eur J Cardiothorac Surg 2017 Jun;51(6):1208

Division of Cardiovascular Surgery, Kagoshima Medical Center, National Hospital Organization, Kagoshima, Japan.

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Impact of multiple arterial grafts in off-pump and on-pump coronary artery bypass surgery.

J Thorac Cardiovasc Surg 2017 02 16;153(2):300-309.e6. Epub 2016 Nov 16.

Bristol Heart Institute, University of Bristol, School of Clinical Sciences, Bristol, United Kingdom.

Objectives: There is growing concern that off-pump coronary artery bypass (OPCAB) is associated with reduced long-term survival compared with traditional on-pump coronary artery bypass (ONCAB); however, most of available comparisons between OPCAB and ONCAB focus on single-artery (SA) revascularization. We sought to investigate the impact of using multiple arterial (MA) conduits in the comparison between OPCAB versus ONCAB by performing a single-center, long-term propensity score base analysis.

Methods: The study population included 5195 SA-ONCAB, 1208 MA-ONCAB, 4412 SA-OPCAB, and 1818 MA-OPCAB procedures. Read More

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February 2017

Defining Inflammatory Levels of Carotid Artery and Aortic FDG Uptake: Implications for Clinical Trial Design and Individual Patient Management.

JACC Cardiovasc Imaging 2016 10 14;9(10):1208-1210. Epub 2016 Sep 14.

Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

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October 2016

Coagulation parameters in patients with cirrhosis and portal vein thrombosis treated sequentially with low molecular weight heparin and vitamin K antagonists.

Dig Liver Dis 2016 Oct 1;48(10):1208-13. Epub 2016 Jul 1.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy; IRCCS Maggiore Hospital Foundation, Milano, Italy.

Background/aims: Information on coagulation for cirrhotics on anticoagulants is scanty. We investigated plasma from 23 cirrhotics treated with low-molecular-weight-heparin (LMWH) followed by vitamin K antagonists (VKA).

Methods: On days 1-4 patients received full-dose LMWH. Read More

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October 2016

Double-Switch Repair of Corrected Transposition in Association With Criss-Cross Atrial Morphology.

Ann Thorac Surg 2016 Mar;101(3):1208-10

Division of Pediatric Cardiac Surgery, Lucile Packard Children's Hospital/Stanford University, Stanford, California.

Corrected transposition is a relatively uncommon congenital heart defect characterized by discordance at both the atrioventricular and ventriculoarterial levels. A rare subset of patients with corrected transposition also have criss-cross atrial morphology. We report the surgical treatment of 2 patients with corrected transposition in association with criss-cross atrial morphology, emphasizing the novel atrial baffle required for this operation. Read More

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Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction.

Proc Natl Acad Sci U S A 2016 Feb 19;113(5):1208-13. Epub 2016 Jan 19.

Department of Physics and Center for Nanoscience, Ludwig Maximilian University of Munich, 80799 Munich, Germany;

The large plasma glycoprotein von Willebrand factor (VWF) senses hydrodynamic forces in the bloodstream and responds to elevated forces with abrupt elongation, thereby increasing its adhesiveness to platelets and collagen. Remarkably, forces on VWF are elevated at sites of vascular injury, where VWF's hemostatic potential is important to mediate platelet aggregation and to recruit platelets to the subendothelial layer. Adversely, elevated forces in stenosed vessels lead to an increased risk of VWF-mediated thrombosis. Read More

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February 2016

Asymptomatic spinal arteriovenous fistula presenting only as continuous murmur.

Pediatr Int 2015 Dec;57(6):1208-10

Department of Pediatric Cardiology and Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Spinal arteriovenous fistula is extremely rare in children. Weakness and sensory disturbance in the lower extremities are the specific clinical presentations. Children, however, commonly have no subjective symptoms; in rare cases, a continuous murmur is the only physical finding. Read More

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December 2015

The Effects of the Selective Serotonin Reuptake Inhibitor Fluvoxamine on Voltage-Dependent K(+) Channels in Rabbit Coronary Arterial Smooth Muscle Cells.

Biol Pharm Bull 2015 ;38(8):1208-13

Department of Physiology, Kangwon National University School of Medicine.

We demonstrated the inhibitory effect of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K(+) (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Fluvoxamine reduced the amplitude of Kv currents in a concentration-dependent manner with an IC50 value of 3.71±1. Read More

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Effect of pistachio nut consumption on endothelial function and arterial stiffness.

Nutrition 2015 May 7;31(5):678-85. Epub 2014 Nov 7.

Department of Cardiothoracic Surgery, Medanta-The Medicity, Gurgaon, India.

Objectives: Previous studies have demonstrated beneficial effects of regular consumption of pistachio nuts on glycemic, lipid, and oxidative stress parameters. The aim of this study was to determine its effect on vascular health, which has not been adequately studied so far.

Methods: In this open label, randomized parallel-group study, 60 adults with mild dyslipidemia were randomized to lifestyle modification (LSM) alone or LSM with consumption of 80 g (in-shell) pistachios (equivalent to 40 g or 1. Read More

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Torcular dural arteriovenous fistula treated via stent placement and angioplasty in the affected straight and transverse sinuses: case report.

J Neurosurg 2015 May 13;122(5):1208-13. Epub 2015 Feb 13.

Department of Neurosurgery, Hikone Municipal Hospital, Hikone, Japan.

The successful obliteration of torcular dural arteriovenous fistula (DAVF) with a diffuse shunt in the affected sinus may require complex treatment strategies. Therapeutic goals include the preservation of normal venous drainage and complete obliteration of shunt flow. The authors report the case of a torcular DAVF. Read More

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Nitric oxide availability as a marker of oxidative stress.

Methods Mol Biol 2015 ;1208:63-71

Department of Integrative Biology and Pharmacology, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Nitric oxide (NO) is widely considered one of the most important molecules produced in the human body, acting as a necessary regulator in a vast array of vital physiological functions, namely, blood pressure, immune response, and neural communication. Healthy endothelium is defined by the ability to produce adequate levels of NO. Reactive oxygen species (ROS) play a major role in NO-based cell signaling. Read More

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Interleukin-1 receptor antagonist originating from bone marrowderived cells and non-bone marrow-derived cells helps to suppress arterial inflammation and reduce neointimal formation after injury.

J Atheroscler Thromb 2014 16;21(11):1208-18. Epub 2014 Sep 16.

Division of Cardiology, Juntendo University.

Aim: Interleukin-1 receptor antagonist (IL-1Ra) negatively regulates IL-1 signaling by blocking the functional receptor. We previously demonstrated that IL-1Ra-deficient (IL-1Ra-/-) mice exhibit marked neointimal formation after injury. IL-1Ra is expressed on bone marrow (BM)-derived cells as well as non-BM intrinsic arterial cells. Read More

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ECG and navigator-free four-dimensional whole-heart coronary MRA for simultaneous visualization of cardiac anatomy and function.

Magn Reson Med 2014 Nov 12;72(5):1208-17. Epub 2014 Sep 12.

Department of Radiology and Biomedical Engineering, Northwestern University, Chicago, Illinois, USA; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Purpose: To develop a cardiac and respiratory self-gated four-dimensional (4D) coronary MRA technique for simultaneous cardiac anatomy and function visualization.

Methods: A contrast-enhanced, ungated spoiled gradient echo sequence with self-gating (SG) and 3DPR trajectory was used for image acquisition. Data were retrospectively binned into different cardiac and respiratory phases based on information extracted from SG projections using principal component analysis. Read More

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November 2014