62,440 results match your criteria vessel wall

Segmentation of common and internal carotid arteries from 3D ultrasound images based on adaptive triple loss.

Med Phys 2021 Jul 26. Epub 2021 Jul 26.

Department of Electrical Engineering, City University of Hong Kong, Hong Kong.

Purpose: Vessel-wall-volume (VWV) and localized vessel-wall-thickness (VWT) measured from 3D ultrasound (US) carotid images are sensitive to anti-atherosclerotic effects of medical/dietary treatments. VWV and VWT measurements require the lumen-intima (LIB) and media-adventitia boundaries (MAB) at the common and internal carotid arteries (CCA and ICA). However, most existing segmentation techniques were capable of segmenting the CCA only. Read More

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Tissue Ki67 proliferative index expression and pathological changes in hemodialysis arteriovenous fistulae: Preliminary single-center results.

J Vasc Access 2021 Jul 24:11297298211015495. Epub 2021 Jul 24.

Department of Specialty, Diagnostic and Experimental Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Background: Arteriovenous fistula (AVF) for hemodialysis integrates outward remodeling with vessel wall thickening in response to drastic hemodynamic changes. Aim of this study is to determine the role of Ki67, a well-established proliferative marker, related to AVF, and its relationship with time-dependent histological morphologic changes.

Materials And Methods: All patients were enrolled in 1 year and stratified in two groups: (A) pre-dialysis patients submitted to first AVF and (B) patients submitted to revision of AVF. Read More

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Gelfoam embolization for distal, medium vessel injury during mechanical thrombectomy in acute stroke: A case report.

World J Clin Cases 2021 Jul;9(20):5668-5674

Department of Radiology, Chungbuk National University Hospital, Cheongju 28644, South Korea.

Background: Arterial perforation has inevitably increased as endovascular treatments have become more common for intracranial large vessel occlusions, and even distal, medium vessel occlusions. A distal, medium vessel has a tortuous course and thinner wall compared to large arteries, making it more susceptible to damage. Here, we review the treatment strategies for arterial perforation during mechanical thrombectomy, and we report the case of a patient treated with gelfoam embolization. Read More

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Nanoparticle-Assisted Diagnosis and Treatment for Abdominal Aortic Aneurysm.

Front Med (Lausanne) 2021 7;8:665846. Epub 2021 Jul 7.

Department of Vascular Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

An abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta related to the regional weakening of the wall structure, resulting in substantial morbidity and mortality with the aortic ruptures as complications. Ruptured AAA is a dramatic catastrophe, and aortic emergencies constitute one of the leading causes of acute death in older adults. AAA management has been centered on surgical repair of larger aneurysms to mitigate the risks of rupture, and curative early diagnosis and effective pharmacological treatments for this condition are still lacking. Read More

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Autopsy findings in a patient with primary systemic AL (kappa light chain) amyloidosis.

Autops Case Rep 2021 6;11:e2021273. Epub 2021 May 6.

Universidade de São Paulo (USP), Hospital das Clínicas, Divisão de Anatomia Patológica, São Paulo, SP, Brasil.

First described by Rokitansky in 1842, and further characterized by Virchow in 1854, amyloidosis is a disorder caused by amyloid deposition, a fibrillary insoluble protein. The clinical spectrum of amyloidosis is broad, as the amyloid deposition may virtually occur in all tissues. Herein, we report the case of a 66-year-old man with a long-lasting emaciating disease, diagnosed, at autopsy, with primary systemic amyloidosis. Read More

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The Effect of Diltiazem on Microcirculation of Transplanted Tissue Flaps: Experimental Study on Rabbits.

World J Plast Surg 2021 May;10(2):61-66

Department of Plastic, Reconstructive and Aesthetic Surgery, Tehran University of Medical Sciences, Tehran, Iran.

Background: The aim of the presented study was to investigate the inhibitory effect of diltiazem on the microcirculation of the tissue flaps created in the delay phenomenon applied rabbits.

Methods: The experiment was performed in Central Research Laboratory of Azerbaijan Medical University, Baku, Azerbaijan in 2018. Ischemia model on the flaps were formed in 30 rabbits for experiment. Read More

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Infrarenal Vena Cava Leiomyosarcoma Treated With Surgical Resection and Vascular Reconstruction.

Cureus 2021 Jun 21;13(6):e15808. Epub 2021 Jun 21.

Surgical Oncology, Mohammed VI University Hospital, Regional Oncology Center, Oujda, MAR.

Leiomyosarcoma of the inferior vena cava is a rare malignant tumor with a poor prognosis. We report a case of a 39-year-old woman admitted for a surgical resection of a retroperitoneal mass revealed by pain localised in the right lumbar fossa. Computed tomography of the abdomen revealed a heterogeneous retroperitoneal mass compressing the inferior vena cava. Read More

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A method for revision of a foreshortened transjugular intrahepatic portosystemic shunt (TIPS) stent using transhepatic trans-stent access.

Radiol Case Rep 2021 Sep 1;16(9):2376-2381. Epub 2021 Jul 1.

Vanderbilt University Medical Center, 1211 Medical Center Dr. Nashville, Tennessee 37232.

The high technical success rate of transjugular intrahepatic portosystemic shunt (TIPS) placement makes the procedure a popular treatment option for symptomatic portal hypertension. Among the major drawbacks of the procedure - hepatic encephalopathy, acute hepatic failure, hemorrhage, biliary injury - TIPS dysfunction is one of the most prevalent, often requiring endovascular reintervention. Conventional techniques for shunt revision rely on transjugular access to the stent; but in technically difficult cases of abnormal angulation or severe stenosis, transhepatic access may also be required. Read More

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September 2021

Treatment of Intracranial Aneurysms Using the New Silk Vista Flow Diverter: Safety Outcomes at Short-Term Follow-Up.

Front Neurol 2021 9;12:713389. Epub 2021 Jul 9.

Neuroradiology Department, Hospital Universitario de Cruces, Barakaldo, Spain.

Flow diverters are widely used as the first endovascular treatment option for complex brain aneurysms due to their high percentage of occlusion and low morbi-mortality. The Silk Vista device is a new generation of flow diverters designed to facilitate full visibility, improve apposition to the vessel wall, and enhance navigability. Indeed, its greatest advantage is that it enables the easier navigation of stents between 3. Read More

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Hydrodynamic model of blood flow in major arteries pulsing in various modes.

Med Biol Eng Comput 2021 Jul 24. Epub 2021 Jul 24.

Research Institute of Experimental Cardiology, 121552, Moscow, Russian Federation.

Traditionally, the arteries in mammals are viewed as the tubes with elastic wall, whose elasticity could be slowly (during a minute) tuned to change its diameter thereby regulating regional blood supply. Recent findings showed that an artery is a much more sophisticated organ, which can change elasticity of vascular wall within a fraction of a second during a cardiac cycle due to activation of its smooth muscles manifested by generation of arterial action potentials. The rapid variations in elasticity of vascular wall resulted in three basic modes of arterial pulsing: passive, active, and intermediate. Read More

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Anti-Inflammatory Effect of Very High Dose Local Vessel Wall Statin Administration: Poly(L,L-Lactide) Biodegradable Microspheres with Simvastatin for Drug Delivery System (DDS).

Int J Mol Sci 2021 Jul 13;22(14). Epub 2021 Jul 13.

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, H. Sienkiewicza 112, 90-363 Lodz, Poland.

Atherosclerosis involves an ongoing inflammatory response of the vascular endothelium and vessel wall of the aorta and vein. The pleiotropic effects of statins have been well described in many in vitro and in vivo studies, but these effects are difficult to achieve in clinical practice due to the low bioavailability of statins and their first-pass metabolism in the liver. The aim of this study was to test a vessel wall local drug delivery system (DDS) using PLA microstructures loaded with simvastatin. Read More

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Cellular Crosstalk between Endothelial and Smooth Muscle Cells in Vascular Wall Remodeling.

Int J Mol Sci 2021 Jul 6;22(14). Epub 2021 Jul 6.

Vascular Research Laboratory, IIS-Fundación Jiménez Díaz University Hospital, Av. Reyes Católicos 2, 28040 Madrid, Spain.

Pathological vascular wall remodeling refers to the structural and functional changes of the vessel wall that occur in response to injury that eventually leads to cardiovascular disease (CVD). Vessel wall are composed of two major primary cells types, endothelial cells (EC) and vascular smooth muscle cells (VSMCs). The physiological communications between these two cell types (EC-VSMCs) are crucial in the development of the vasculature and in the homeostasis of mature vessels. Read More

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Splenic and Portal Vein Thrombosis With Concurrent Splenic Infarction: A Rare Manifestation of Essential Thrombocythemia.

Cureus 2021 Jun 20;13(6):e15768. Epub 2021 Jun 20.

Internal Medicine, Government Medical College and Hospital, Chandigarh, IND.

Mesenteric venous thrombosis (MVT) presents with a wide range of clinical presentations depending on the vessel involved, degree of thrombosis, and the extent of bowel wall ischemia. MVT usually has an insidious presentation and is often a forerunner of an underlying disorder. Essential thrombocythemia (ET) presenting itself as MVT along with splenic infarction is a rare presentation. Read More

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Geometric Features of the Pial Arteriolar Networks in Spontaneous Hypertensive Rats: A Crucial Aspect Underlying the Blood Flow Regulation.

Front Physiol 2021 5;12:664683. Epub 2021 Jul 5.

Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.

Background: Several studies indicate that hypertension causes major changes in the structure of the vessel wall by affecting the regulation of blood supply to the tissues. Recently, it has been observed that capillary blood flow is also considerably influenced by the structural arrangement of the microvascular networks that undergo rarefaction (reduction of the perfused vessel number). Therefore, this study aimed to assess the geometric arrangements of the pial arteriolar networks and the arteriolar rhythmic diameter changes in spontaneously hypertensive rats (SHRs). Read More

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Monitoring Intramural Hematoma on Vessel Wall Imaging to Evaluate the Healing of Intracranial Vertebral Artery Dissection.

J Stroke Cerebrovasc Dis 2021 Jul 19;30(9):105992. Epub 2021 Jul 19.

Department of Neurosurgery Graduate School of Biomedical and Health Sciences Hiroshima University, Hiroshima, Japan.

Objective: Unruptured intracranial vertebral artery dissection (VAD) generally heals spontaneously. A chronological evaluation of intramural hematoma (IMH) using T1-weighted vessel wall imaging (VWI) may provide a more detailed understanding of the pathophysiology of VAD. We herein investigated the relationship between chronological signal changes in IMH on VWI and the spontaneous healing of VAD. Read More

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Can the arterial clamp method be used safely where a tourniquet cannot be used?

Cardiovasc J Afr 2021 Jul 7;32:1-7. Epub 2021 Jul 7.

Department of Pathology, Faculty of Medicine, Bezmialem University, Istanbul, Turkey.

Background: Clamp application is safe and widely used in the visceral organs. This raises the question: why not use clamping in orthopaedic, oncological, fracture and revision surgeries of areas where tourniquets are not suitable. This experimental animal study aimed to compare tourniquet and arterial clamp applications with regard to their histological effects and inflammatory responses on a molecular level, on the artery, vein, nerve and muscle tissue. Read More

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Ex Vivo Evaluation of IVUS-VH Imaging and the Role of Plaque Structure on Peripheral Artery Disease.

Med Nov Technol Devices 2020 Dec 24;8. Epub 2020 Aug 24.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

Peripheral artery disease (PAD) results from the buildup of atherosclerotic plaque in the arterial wall, can progress to severe ischemia and lead to tissue necrosis and limb amputation. We evaluated a means of assessing PAD mechanics using ten human peripheral arteries with PAD. Pressure-inflation testing was performed at six physiological pressure intervals ranging from 10-200 mmHg. Read More

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December 2020

Ultrasonography to detect cardiovascular damage in children with essential hypertension.

Cardiovasc Ultrasound 2021 Jul 21;19(1):26. Epub 2021 Jul 21.

Cardiology Department, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, 215025, China.

Background: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at early stage using ultrasonography. Read More

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Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting With Serum Response Factor.

Arterioscler Thromb Vasc Biol 2021 Jul 22:ATVBAHA120315911. Epub 2021 Jul 22.

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA (H.N., S.H., Y.D., J.C., V.S., D.Y., G. Sukhova, E.S., A.K.M.K.W., H.S.C., D.P.-C., C.A., G. Sausen, Z.R., M.W.F.).

Objective: Vascular smooth muscle cell (VSMC) plasticity plays a critical role in the development of atherosclerosis. Long noncoding RNAs (lncRNAs) are emerging as important regulators in the vessel wall and impact cellular function through diverse interactors. However, the role of lncRNAs in regulating VSMCs plasticity and atherosclerosis remains unclear. Read More

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Characterizing Intracranial Hemodynamics in Sickle Cell Anemia: Impact of Patient-Specific Viscosity.

Cardiovasc Eng Technol 2021 Jul 20. Epub 2021 Jul 20.

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.

Purpose: Pediatric and adult patients with sickle cell anemia (SCA) are at increased risk of stroke and cerebrovascular accident. In the general adult population, there is a relationship between arterial hemodynamics and pathology; however, this relationship in SCA patients remains to be elucidated. The aim of this work was to characterize circle of Willis hemodynamics in patients with SCA and quantify the impact of viscosity choice on pathophysiologically-relevant hemodynamics measures. Read More

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Acta Clin Croat 2020 Dec;59(4):754-760

1Department of Radiology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3University of Applied Health Sciences, Zagreb, Croatia; 4Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; 5Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health, Osijek, Croatia; 6Department of Neurosurgery, Dubrava University Hospital, Zagreb, Croatia.

Infected intracranial aneurysms are a rare type of inflammatory vascular lesions that occur due to infection of intracranial arterial wall. Brain aneurysms of distal arterial branches are equally rare and frequently multiple, including those situated at the peripheral middle cerebral artery segments. Although both types represent a small percentage of all intracranial aneurysms, they may bring about high mortality in case of rupture. Read More

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December 2020

Albumin Infusion in Critically Ill COVID-19 Patients: Hemodilution and Anticoagulation.

Int J Mol Sci 2021 Jul 1;22(13). Epub 2021 Jul 1.

Internal Medicine University Clinic, University of Göttingen, Göttingen, Germany Robert-Koch-Strasse 40, 37075 Göttingen, Germany.

Hypercoagulation is one of the major risk factors for ICU treatment, mechanical ventilation, and death in critically ill patients infected with SARS-CoV-2. At the same time, hypoalbuminemia is one risk factor in such patients, independent of age and comorbidities. Especially in patients with severe SARS-CoV-2-infection, albumin infusion may be essential to improve hemodynamics and to reduce the plasma level of the main marker of thromboembolism, namely, the D-dimer plasma level, as suggested by a recent report. Read More

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High-Throughput Characterization of Cell Adhesion Strength Using Long-Channel Constriction-Based Microfluidics.

ACS Sens 2021 Jul 19. Epub 2021 Jul 19.

School of Electrical and Information Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.

The adhesion strength of a cancer cell is a valuable biophysical marker of its metastatic potential, tightly associated with various metastatic processes; for example, cancer cells escape from a primary tumor, and circulating tumor cells (CTCs) are anchored to the vessel wall. Although constriction-based microfluidics can realize the high-throughput characterization of single-cell deformability, due to the influence of cell size heterogeneity, accurately evaluating the adhesion strength of a cancer cell at high throughputs in constriction remains difficult. In this paper, we first proposed an approach for the assessment of adhesion strength of BGC-823 and SGC-7901 cell lines at high throughputs based on a friction coefficient using the constant velocity stage of cell transit in a long-channel constriction. Read More

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Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction.

Eur Heart J 2021 Jul 19. Epub 2021 Jul 19.

Department of Biology, Stanford University, Stanford, CA 94305, USA.

Aims: Non-compaction cardiomyopathy is a devastating genetic disease caused by insufficient consolidation of ventricular wall muscle that can result in inadequate cardiac performance. Despite being the third most common cardiomyopathy, the mechanisms underlying the disease, including the cell types involved, are poorly understood. We have previously shown that endothelial cell-specific deletion of the chromatin remodeller gene Ino80 results in defective coronary vessel development that leads to ventricular non-compaction in embryonic mouse hearts. Read More

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Preclinical Evaluation of the Temporary Drug-Coated Spur Stent System in Porcine Peripheral Arteries.

J Endovasc Ther 2021 Jul 19:15266028211028219. Epub 2021 Jul 19.

Clinical and Experimental Interventional Cardiology, University of Saarland, HomburgSaar, Germany.

Background: Drug penetration into the deeper arterial wall of heavily calcified lesions is one of the limitations of drug-coated balloons and drug-eluting stents in vascular interventions. The Temporary Spur Stent (TSS) system is characterized by a self-expanding nitinol stent that is uniformly covered in radialspikes, which, when coated, should allow a deeper penetration and longer retention of the drug into the diseased artery walls by penetrating through the calcified plaques.

Materials And Methods And Results: Uncoated TSS and paclitaxel (PTX)-coated TSS systems have been deployed in porcine peripheral arteries. Read More

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Physical forces regulating hemostasis and thrombosis: Vessels, cells, and molecules in illustrated review.

Res Pract Thromb Haemost 2021 Jul 14;5(5):e12548. Epub 2021 Jul 14.

Department of Bioengineering University of Colorado Denver Anschutz Medical Campus Aurora CO USA.

This illustrated review focuses on the physical forces that regulate hemostasis and thrombosis. These phenomena span from the vessel to the cellular to the molecular scales. Blood is a complex fluid with a viscosity that varies with how fast it flows and the size of the vessel through which it flows. Read More

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Aortic Dissection With Complete Occlusion of Left Main Coronary Artery Presenting as Acute ST-Segment Elevation Myocardial Infarction.

Cureus 2021 Jun 11;13(6):e15595. Epub 2021 Jun 11.

Cardiology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, IND.

Acute Aortic Dissection (AAD) is a life-threatening condition, which presents with a wide variety of symptoms ranging from being asymptomatic to sudden cardiac death. A retrograde extension of AAD can lead to partial or complete occlusion of coronary vessels, leading to an exceedingly rare presentation in the form of acute Myocardial Infarction (MI). A prognosis of AAD depends on prompt diagnosis and urgent surgical intervention to re-establish coronary blood flow. Read More

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The evaluation of functional small intestinal submucosa for abdominal wall defect repair in a rat model: Potent effect of sequential release of VEGF and TGF-β1 on host integration.

Biomaterials 2021 Jul 8;276:120999. Epub 2021 Jul 8.

Department of Hernia and Abdominal Wall Surgery, Shanghai East Hospital, TongJi University, 150 Ji Mo Road, Shanghai, 200120, PR China. Electronic address:

Ineffective vessel penetration and extracellular matrix (ECM) remodeling are responsible for the failure of porcine small intestinal submucosa (SIS)-repaired abdominal wall defects. Combined growth factors could be used as directing signals in a nature-mimicking strategy to improve this repair through mesh functionalization. In this work, vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGF-β1) were incorporated into a silk fibroin membrane via coaxial aqueous electrospinning to exploit their benefits of biological interactions. Read More

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Simulation of turbulence induced sound generation inside stenosed femoral artery models with different severities and eccentricities.

Comput Methods Programs Biomed 2021 Jun 30;208:106253. Epub 2021 Jun 30.

Department of Mechanical Engineering, Middle East Technical University, Ankara 06800, Turkey. Electronic address:

Background And Objectives: Recent developments of low-cost, compact acoustic sensors, advanced signal processing tools and powerful computational resources allow researchers design new scoring systems for acoustic detection of arterial stenoses. In this study, numerical simulations of blood flow inside stenosed arteries are performed to understand the effect of stenosis severity and eccentricity on the turbulence induced wall pressure fluctuations and the generated sound.

Methods: Axisymmetric and eccentric elliptic stenoses of five different severities are generated inside a 6. Read More

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Finite element computation of magneto-hemodynamic flow and heat transfer in a bifurcated artery with saccular aneurysm using the Carreau-Yasuda biorheological model.

Microvasc Res 2021 Jul 13;138:104221. Epub 2021 Jul 13.

Department of Aeronautics and Astronautics, Air force Institute of Technology, Wright Patterson Air Force Base, Dayton, OH, USA.

"Existing computational fluid dynamics studies of blood flows have demonstrated that the lower wall stress and higher oscillatory shear index might be the cause of acceleration in atherogenesis of vascular walls in hemodynamics. To prevent the chances of aneurysm wall rupture in the saccular aneurysm at distal aortic bifurcation, clinical biomagnetic studies have shown that extra-corporeal magnetic fields can be deployed to regulate the blood flow. Motivated by these developments, in the current study a finite element computational fluid dynamics simulation has been conducted of unsteady two-dimensional non-Newtonian magneto-hemodynamic heat transfer in electrically conducting blood flow in a bifurcated artery featuring a saccular aneurysm. Read More

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