345,782 results match your criteria versus diagnostic


Prediction of breast cancer molecular subtypes using DCE-MRI based on CNNs combined with ensemble learning.

Phys Med Biol 2021 Jul 30. Epub 2021 Jul 30.

Institute of Medical Imaging Engineering, Shanghai University of Science and Technology, Shanghai 200093, Shanghai, CHINA.

To design an ensemble learning based prediction model using different breast DCE-MR post-contrast sequence images to distinguish two kinds of breast cancer subtypes (luminal and non-luminal). We retrospectively studied preoperative DCE-MRIs and molecular information of 266 breast cancer cases with either luminal subtype (luminal A and luminal B) or non-luminal subtype (human epidermal growth factor receptor 2 and triple negative). Then, multiple bounding boxes covering tumor lesions were acquired from three series of post-contrast DCE-MR sequence images which were determined by radiologists. Read More

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Multi-model and multi-slice ensemble learning architecture based on 2D convolutional neural networks for Alzheimer's disease diagnosis.

Comput Biol Med 2021 Jul 22;136:104678. Epub 2021 Jul 22.

Intelligent Physiological Measurement and Clinical Translation, Beijing International Platform for Scientific and Technological Cooperation, Department of Biomedical Engineering, Faculty of Environment and Life Sciences, Beijing University of Technology, Beijing, 100124, China.

Alzheimer's Disease (AD) is a chronic neurodegenerative disease without effective medications or supplemental treatments. Thus, predicting AD progression is crucial for clinical practice and medical research. Due to limited neuroimaging data, two-dimensional convolutional neural networks (2D CNNs) have been commonly adopted to differentiate among cognitively normal subjects (CN), people with mild cognitive impairment (MCI), and AD patients. Read More

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Outcome of carpal tunnel release surgery in patients with and without Linburg-Comstock anomaly.

Hand Surg Rehabil 2021 Jul 27. Epub 2021 Jul 27.

Hand Surgery Unit, Department of Orthopedic Surgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Borges Lagoa 786, São Paulo 04038-032, Brazil.

Anatomical variations may entail increased volume within the carpal tunnel and consequently the development of carpal tunnel syndrome (CTS) symptoms. The clinical importance of anomalous connection between the flexor pollicis longus (FPL) and flexor digitorum profundus (FDP) tendons was described by Linburg and Comstock. The objective of the present study was to compare postoperative outcomes of carpal tunnel release surgery in patients with and without Linburg-Comstock anomaly (LCA). Read More

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The Impact of Extended Delayed Surgery for Indolent Lung Cancer or Part-solid Ground Glass Nodules.

Ann Thorac Surg 2021 Jul 27. Epub 2021 Jul 27.

Massachusetts General Hospital. Electronic address:

Background: During the COVID-19 pandemic, patients with lung cancer may experience treatment delays. The objective of this study was to evaluate the impact of extended treatment delays on survival among patients with stage I typical bronchopulmonary carcinoid (BC), lepidic predominant adenocarcinoma (LPA) or invasive adenocarcinoma with a lepidic component (ADL).

Methods: Using National Cancer Data Base data (2004-2015), multivariable Cox regression analysis with penalized smoothing splines was performed to examine the association between treatment delay and all-cause mortality for stage I BC, LPA and ADL. Read More

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Treatment and Prognosis of Resectable Cervical Esophageal Cancer: A Population-based Study.

Ann Thorac Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Background: The optimal treatment strategy for resectable cervical esophageal cancer (CEC) remains controversial. This study aimed to explore prognostic factors and optimal treatment strategies in the context of staging.

Methods: In this population-based study, 1371 patients with resectable CEC were identified in the SEER database. Read More

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The validity urine color scoring at different light conditions to assess low versus high urine concentration.

J Athl Train 2021 Jul 30. Epub 2021 Jul 30.

College of Health Solutions Arizona State University,

Context: Urine color (Uc) is used to asses urine concentration when lab techniques are not feasible.

Objective: To compare the accuracy of Uc scoring using four different light conditions and two different scoring techniques with a 7-color Uc chart. Additionally to assess the results' generalizability, a subsample was compared to scores obtained from fresh samples. Read More

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Plasma hsa-mir-19b is a potential LevoDopa therapy marker.

J Cell Mol Med 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

Parkinson's disease (PD) is the second most common neurodegenerative disorder among the elderly, the diagnostic and prognostic of which is based mostly on clinical signs. LevoDopa replacement is the gold standard therapy for PD, as it ameliorates the motor symptoms. However, it does not affect the progression of the disease and its long-term use triggers severe complications. Read More

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Snakebite-associated thrombotic microangiopathy: an Australian prospective cohort study [ASP30].

Clin Toxicol (Phila) 2021 Jul 30:1-9. Epub 2021 Jul 30.

Clinical Toxicology Research Group, University of Newcastle, Newcastle, Australia.

Background: Snakebite-associated thrombotic microangiopathy (TMA) occurs in a subset of patients with venom-induced consumption coagulopathy (VICC) following snakebite. Acute kidney injury (AKI) is the commonest end-organ manifestation of TMA. The epidemiology, diagnostic features, outcomes, and effectiveness of interventions including therapeutic plasma-exchange (TPE), in snakebite-associated TMA are poorly understood. Read More

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Effect of prenatal screening on trends in perinatal mortality associated with congenital anomalies before and after the introduction of prenatal screening: A population-based study in the Northern Netherlands.

Paediatr Perinat Epidemiol 2021 Jul 30. Epub 2021 Jul 30.

Department of Genetics, EUROCAT Registration Northern Netherlands, University Medical Centre Groningen, Groningen, The Netherlands.

Background: Perinatal mortality in foetuses/children with congenital anomalies remains high. Prenatal diagnosis, essential for risk assessment and organisation of perinatal/postnatal care, offers parents the opportunity to consider the termination of pregnancy. In times of quick changes in prenatal screening programmes, it is relevant to evaluate the effect of prenatal screening on perinatal mortality rates. Read More

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Presentation, patterns of care, and outcomes of patients with prostate cancer in sub-Saharan Africa: A population-based registry study.

Cancer 2021 Jul 30. Epub 2021 Jul 30.

Institute of Medical Epidemiology, Biometrics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Although prostate cancer (PCa) is the most commonly diagnosed cancer in men of sub-Saharan Africa (SSA), little is known about its management and survival. The objective of the current study was to describe the presentation, patterns of diagnosis, treatment, and survival of patients with PCa in 10 countries of SSA.

Methods: In this observational registry study with data collection from 2010 to 2018, the authors drew a random sample of 738 patients with PCa who were registered in 11 population-based cancer registries. Read More

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[Neurological complications in haematopoietic stem cell transplant patients].

Rev Neurol 2021 Sep;73(5):174-183

Hospital de la Santa Creu i Sant Pau , Barcelona, España.

Introduction: Neurological complications are some of the most important complications that can occur in a patient undergoing haematopoietic stem cell transplantation (HSCT), not only because of the high mortality rate, but also because of the sequelae that appear in survivors. The causes of such complications are manifold and very often coexist in the same patient: toxicity of the conditioning regimen, graft-versus-host disease and its treatment, infections and their treatment, platelets and coagulation disorders, liver failure or arterial hypertension with low platelet count.

Aims: The aim of the present study is to provide a clinical description and to describe the risk factors for complications involving the central nervous system that may occur during the course of HSCT, in order to assist in the early detection of these disorders that may have a negative influence on the morbidity and mortality of these patients. Read More

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September 2021

Diagnostic performance of two different maternal near-miss approaches in a High Obstetric Risk Unit.

Women Health 2021 Jul 30:1-14. Epub 2021 Jul 30.

Intensive Care in Obstetric Research Group (GRICIO), Department of Obstetrics and Gynecology, University of Cartagena, Cartagena, Colombia.

Maternal near-miss (MNM) is a maternal quality care indicator. The World Health Organization (WHO) defines it as a state in which a woman nearly dies but survives due to a complication during pregnancy, birth, or puerperium. The Latin American Federation of Obstetrics and Gynecology (FLASOG) and the Colombian National Health Institute (INS) established recommendations for the event's epidemiological surveillance; nonetheless, the operational definitions of the cases are different. Read More

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Inflammatory breast cancer appearance at presentation is associated with overall survival.

Cancer Med 2021 Jul 30. Epub 2021 Jul 30.

Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Inflammatory breast cancer (IBC) is a clinical diagnosis. Here, we examined the association of a "classic" triad of clinical signs, swollen involved breast, nipple change, and diffuse skin change, with overall survival (OS).

Method: Breast medical photographs from patients enrolled on a prospective IBC registry were scored by two independent reviewers as classic (triad above), not classic, and difficult to assign. Read More

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How sleepy patients differ from non-sleepy patients in mild obstructive sleep apnea?

J Sleep Res 2021 Jul 29:e13431. Epub 2021 Jul 29.

Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.

To aim is investigate whether demographic, polysomnographic or sleep behaviour data differ between non-sleepy, sleepy and very sleepy patients with mild obstructive sleep apnea. The study population consisted of 439 consecutive adult patients diagnosed with mild obstructive sleep apnea (5 ≤ apnea-hypopnea index < 15) after a complete polysomnographic evaluation. The patients were divided into three groups based on subjective sleepiness: very sleepy (Epworth Sleepiness Scale ≥ 16, n = 59); sleepy (10 < Epworth Sleepiness Scale < 16, n = 102); and non-sleepy (Epworth Sleepiness Scale ≤ 10, n = 278). Read More

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Acute ischemic stroke in childhood: a comprehensive review.

Eur J Pediatr 2021 Jul 29. Epub 2021 Jul 29.

Child Neurology and Infantile Psychiatry Unit, Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

This review provides an updated analysis of the main aspects involving the diagnosis and the management of children with acute ischemic stroke. Acute ischemic stroke is an emergency of rare occurrence in children (rate of incidence of 1/3500 live birth in newborns and 1-2/100,000 per year during childhood with peaks of incidence during the perinatal period, under the age of 5 and in adolescence). The management of ischemic stroke in the paediatric age is often challenging because of pleomorphic age-dependent risk factors and aetiologies, high frequency of subtle or atypical clinical presentation, and lacking evidence-based data about acute recanalization therapies. Read More

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Dose-dense ABVD as first-line therapy in early-stage unfavorable Hodgkin lymphoma: results of a prospective, multicenter double-step phase II study by Fondazione Italiana Linfomi.

Ann Hematol 2021 Jul 30. Epub 2021 Jul 30.

Hematology Department, Azienda Unità Sanitaria Locale IRCCS Di Reggio Emilia, Reggio Emilia, Italy.

We investigated the feasibility and activity of an intensified dose-dense ABVD (dd-ABVD) regimen in patients with early-stage unfavorable Hodgkin lymphoma (HL). This prospective, multicenter, phase II study enrolled 96 patients with newly diagnosed, unfavorable stage I or II classical HL. The patients received four cycles of dd-ABVD followed by radiotherapy. Read More

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Congenital Aorto-Cardiac Connections (CACC) Revisited: Introduction of a Novel Anatomic-therapeutic Classification.

Pediatr Cardiol 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatric Cardiology, Children's Medical Center (Pediatric Center of Excellence), Tehran University of Medical Sciences, Tehran, Iran.

Abnormal congenital aorto-cardiac communications (CACC) are a heterogeneous constellation of anomalies that provide an abnormal connection between the aorta and other cardiac chambers or structures, including the atria, ventricles, the main pulmonary artery, and the coronary sinus. The current terminology of CACC has significant errors and shortcomings including inconsistent and interchangeable use of terms of fistula and tunnel and lack of an inclusive classification with practical information on therapeutic management. The aims of this study were threefold: firstly, to perform a concise narrative review of congenital pathologic connections between the aortic root and cardiac chambers which include rupture of congenital sinus of Valsalva aneurysm, aorto-left ventricular and less commonly right ventricular tunnels, coronary cameral fistulas, and aorto-atrial communications; secondly, to investigate the differentiating features of the so-called aorta right atrial tunnel (ARAT), with and without coronary artery take-off from the tunnel, and coronary cameral fistula (CCF) by applying a differential diagnostic assistance toolbox to two groups of patients with ARAT and CCF; and lastly, to propose a practical and inclusive anatomic-therapeutic classification for CACCs. Read More

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Development of a Machine Learning Classifier Based on Radiomic Features Extracted From Post-Contrast 3D T1-Weighted MR Images to Distinguish Glioblastoma From Solitary Brain Metastasis.

Front Oncol 2021 13;11:638262. Epub 2021 Jul 13.

Radiothérapie Moléculaire et Innovation Thérapeutique, INSERM UMR1030, Gustave Roussy Cancer Campus, Université Paris Saclay, Villejuif, France.

Objectives: To differentiate Glioblastomas (GBM) and Brain Metastases (BM) using a radiomic features-based Machine Learning (ML) classifier trained from post-contrast three-dimensional T1-weighted (post-contrast 3DT1) MR imaging, and compare its performance in medical diagnosis human experts, on a testing cohort.

Methods: We enrolled 143 patients (71 GBM and 72 BM) in a retrospective bicentric study from January 2010 to May 2019 to train the classifier. Post-contrast 3DT1 MR images were performed on a 3-Tesla MR unit and 100 radiomic features were extracted. Read More

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The Clinicopathological Features of Mediastinal Tuberculous Lymphadenitis in Cancer Patients and the Diagnostic Role of Endobronchial Ultrasound.

Cureus 2021 Jun 22;13(6):e15837. Epub 2021 Jun 22.

Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Introduction Mediastinal lymphadenopathy in cancer patients can be of both malignant and non-malignant (including infectious) etiology. Tuberculosis (TB) is an important differential in this regard, particularly in regions with high TB endemicity. Objectives To determine the incidence and clinical characteristics of mediastinal tuberculous lymphadenitis (MTBLA) in cancer patients of a TB-endemic region, and the diagnostic role of endobronchial ultrasound (EBUS) guided transbronchial needle aspiration (TBNA) in such patients, utilizing both cytopathological and microbiological parameters for diagnosing TB. Read More

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The relation of 12 lead ECG to the cardiac anatomy: The normal CineECG.

J Electrocardiol 2021 Jul 22. Epub 2021 Jul 22.

Department of Cardiology, University Medical Center Utrecht, the Netherlands.

Background: The interpretation of the 12‑lead ECG is notoriously difficult and requires experts to distinguish normal from abnormal ECG waveforms. ECG waveforms depend on body build and electrode positions, both often different in males and females. To relate the ECG waveforms to cardiac anatomical structures is even more difficult. Read More

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Use of the Montreal Cognitive Assessment Thai Version to Discriminate Amnestic Mild Cognitive Impairment from Alzheimer's Disease and Healthy Controls: Machine Learning Results.

Dement Geriatr Cogn Disord 2021 Jul 29:1-12. Epub 2021 Jul 29.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: The Montreal Cognitive Assessment (MoCA) is an effective and applicable screening instrument to confirm the diagnosis of amnestic mild cognitive impairment (aMCI) from patients with Alzheimer's disease (AD) and healthy controls (HCs).

Objectives: This study aimed to determine the reliability and validity of the following: (a) Thai translation of the MoCA (MoCA-Thai) and (b) delineate the key features of aMCI based on the MoCA subdomains.

Methods: This study included 60 HCs, 61 aMCI patients, and 60 AD patients. Read More

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Reduction in healthcare services during the COVID-19 pandemic: Patient screening based on symptoms is an effective strategy for avoiding delayed laryngeal cancer diagnosis.

Am J Otolaryngol 2021 Jul 24;42(6):103162. Epub 2021 Jul 24.

Otolaryngology Unit, Azienda USL-IRCCS di Reggio Emilia, Italy.

Objective: Restriction in healthcare services during the COVID-19 pandemic caused delays in the diagnosis and treatment of several diseases. To overcome the risk of missed diagnosis of head and neck cancers, before deleting the scheduled appointments, we have introduced a selection of the patients by examining the clinical presenting issue and previous medical history. The aim of this study is to show the effects of the abovementioned strategy on the diagnosis and management of laryngeal cancer. Read More

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Clinical and laboratory features of Strongyloides stercoralis infection at diagnosis and after treatment: a systematic review and meta-analysis.

Clin Microbiol Infect 2021 Jul 26. Epub 2021 Jul 26.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: The clinical and laboratory characterization of Strongyloides stercoralis infection at diagnosis and after treatment is still poorly defined.

Objectives: Primary objective was to describe pattern and frequency of clinical and laboratory characteristics associated to S. stercoralis infection. Read More

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Association between cirrhosis and herpes zoster in a cohort study in Taiwan.

Int J Clin Pract 2021 Jul 29:e14677. Epub 2021 Jul 29.

Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan.

Objectives: The aim of the study was to assess if an association exists between cirrhosis and herpes zoster in Taiwan.

Methods: A retrospective cohort study was designed to analyze the 2000-2013 claims dataset of 1 million insured residents who were randomly sampled from the Taiwan National Health Insurance Program. Totally, 16190 subjects ages 20-84 years old with newly diagnosed cirrhosis since 2000 to 2012 were identified as the cirrhosis group and 16190 sex- and age-matched subjects without cirrhosis were selected as the non-cirrhosis group. Read More

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Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease.

PLoS Genet 2021 Jul 29;17(7):e1009679. Epub 2021 Jul 29.

Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.

Numerous genetic studies have established a role for rare genomic variants in Congenital Heart Disease (CHD) at the copy number variation (CNV) and de novo variant (DNV) level. To identify novel haploinsufficient CHD disease genes, we performed an integrative analysis of CNVs and DNVs identified in probands with CHD including cases with sporadic thoracic aortic aneurysm. We assembled CNV data from 7,958 cases and 14,082 controls and performed a gene-wise analysis of the burden of rare genomic deletions in cases versus controls. Read More

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The challenge of prostate biopsy guidance in the era of mpMRI detected lesion: ultrasound-guided versus in-bore biopsy.

Br J Radiol 2021 Jul 29:20210363. Epub 2021 Jul 29.

Department of Urology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

The current recommendation in patients with a clinical suspicion for prostate cancer is to perform systematic biopsies extended with targeted biopsies, depending on mpMRI results. Following a positive mpMRI [i.e. Read More

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Differences in survival and mortality in minority ethnic groups with dementia: A systematic review and meta-analysis.

Int J Geriatr Psychiatry 2021 Jun 18. Epub 2021 Jun 18.

Department of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Objectives: Although there are disparities in both risk of developing dementia and accessibility of dementia services for certain minority ethnic groups in the United States and United Kingdom, disparities in survival after a dementia diagnosis are less well-studied. Our objective was to systematically review the literature to investigate racial/ethnic differences in survival and mortality in dementia.

Methods: We searched Embase, Ovid MEDLINE, Global Health and PsycINFO from inception to November 2018 for studies comparing survival or mortality over time in at least two race/ethnicity groups. Read More

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Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging.

Biogerontology 2021 Jul 29. Epub 2021 Jul 29.

CIAFEL, Faculty of Sport, University of Porto, Dr. Plácido da Costa 91, 4200-450, Porto, Portugal.

Muscle wasting is one of the major health problems in older adults and is traditionally associated to sarcopenia. Nonetheless, muscle loss may also occur in older adults in the presence of cancer, and in this case, it is associated to cancer cachexia. The clinical management of these conditions is a challenge due to, at least in part, the difficulties in their differential diagnosis. Read More

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Visual impairment and depression in uveal melanoma: Optimism and pessimism as moderators.

Health Psychol 2021 Jun;40(6):408-417

Department of Psychology, University of California, Los Angeles.

Objective: Uveal melanoma, a rare eye cancer, presents potential vision loss and life threat. This prospective, longitudinal study interrogated the predictive utility of visual impairment, as moderated by optimism/pessimism, on depressive symptoms in 299 adults undergoing diagnostic evaluation.

Method: Depressive symptoms (Center for Epidemiologic Studies Depression Scale), subjective (Measure of Outcome in Ocular Disease vision subscale) and objective (logarithm of the minimum angle of resolution) visual impairment, and optimism/pessimism (Life Orientation Test-Revised) were assessed before diagnostic evaluation and 1 week, 3 months, and 12 months after diagnosis. Read More

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Pediatric Lichen Sclerosus et Atrophicus: A Retrospective Analysis of 38 Pediatric Patients.

Int J Clin Pract 2021 Jul 29:e14661. Epub 2021 Jul 29.

Hacettepe University, Faculty of Medicine, Department of Dermatology and Venereology.

Background: Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory cutaneous disease.

Aim: To evaluate the characteristics of pediatric LSA patients in Turkey.

Material And Methods: Data for patients aged <18 years that were diagnosed with LSA by a pediatric dermatologist were retrospectively reviewed. Read More

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