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The bacterial phylum Planctomycetes as novel source for bioactive small molecules.

Biotechnol Adv 2021 Sep 16:107818. Epub 2021 Sep 16.

Department of Microbial Interactions, Institute of Microbiology, Friedrich Schiller University, Jena, Germany. Electronic address:

Extensive knowledge and methodological expertise on the bacterial cell biology has been accumulated over the last decades and bacterial cells have now become an integral part of several (bio-)technical processes. While it appears reasonable to focus on a relatively small number of fast-growing and genetically easily manipulable model bacteria as biotechnological workhorses, the for the most part untapped diversity of bacteria needs to be explored when it comes to bioprospecting for natural product discovery. Members of the underexplored and evolutionarily deep-branching phylum Planctomycetes have only recently gained increased attention with respect to the production of small molecules with biomedical activities, e. Read More

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September 2021

Catalase Nanocrystals Loaded with Methylene Blue as Oxygen Self-Supplied, Imaging-Guided Platform for Photodynamic Therapy of Hypoxic Tumors.

Small 2021 Sep 17:e2103569. Epub 2021 Sep 17.

College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, Shenzhen, 518060, P. R. China.

Photodynamic therapy (PDT) is a well-known method for cancer therapy in the clinic. However, the inherent hypoxia microenvironment of solid tumors enormously restricts the PDT efficiency. Herein, catalase nanocrystals (CatCry) are introduced as in situ oxygen (O )-generating system to relieve tumor hypoxia and enhance PDT efficiency for solid tumors. Read More

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September 2021

Utilizing a Community Dance to Hold STD Testing for Chlamydia and Gonorrhea in High-Risk Adolescents.

PRiMER 2021 9;5:30. Epub 2021 Feb 9.

Department of Family Medicine, University of Nebraska Medical Center, Omaha, NE.

Introduction: Sexually transmitted diseases (STDs) in adolescents are a major public health concern, particularly in underserved communities. While STD screening is recommended by the United States Preventive Services Task Force, limited access remains one of a number of barriers. Community-based approaches may provide greater access and enhance screening rates. Read More

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February 2021

Integrating magnetic capabilities to intracellular chips for cell trapping.

Sci Rep 2021 Sep 16;11(1):18495. Epub 2021 Sep 16.

Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), Esfera UAB, Campus UAB, 08193, Cerdanyola, Barcelona, Spain.

Current microtechnologies have shown plenty of room inside a living cell for silicon chips. Microchips as barcodes, biochemical sensors, mechanical sensors and even electrical devices have been internalized into living cells without interfering their cell viability. However, these technologies lack from the ability to trap and preconcentrate cells in a specific region, which are prerequisites for cell separation, purification and posterior studies with enhanced sensitivity. Read More

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September 2021

Risk Factors Associated With SARS-CoV-2 Infection Among Farmworkers in Monterey County, California.

JAMA Netw Open 2021 Sep 1;4(9):e2124116. Epub 2021 Sep 1.

Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley.

Importance: Essential workers in agriculture and food production have been severely affected by the ongoing COVID-19 pandemic.

Objective: To identify risk factors associated with SARS-CoV-2 infection among farmworkers in California.

Design, Setting, And Participants: This cross-sectional study invited farmworkers in California's Salinas Valley (Monterey County) receiving transcription-mediated amplification (TMA) tests for SARS-CoV-2 infection at federally qualified community clinics and community sites to participate. Read More

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September 2021

Novel quaternary structures of the human prion protein globular domain.

Biochimie 2021 Sep 10;191:118-125. Epub 2021 Sep 10.

Laboratory of Protein Crystallography, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Prion disease is caused by the misfolding of the cellular prion protein, PrP, into a self-templating conformer, PrP. Nuclear magnetic resonance (NMR) and X-ray crystallography revealed the 3D structure of the globular domain of PrP and the possibility of its dimerization via an interchain disulfide bridge that forms due to domain swap or by non-covalent association of two monomers. On the contrary, PrP is composed by a complex and heterogeneous ensemble of poorly defined conformations and quaternary arrangements that are related to different patterns of neurotoxicity. Read More

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September 2021

Viability of Bacteriophages in the Complex Hydrogel Wound Dressings .

Sovrem Tekhnologii Med 2021 30;13(2):32-38. Epub 2021 Apr 30.

Professor, Head of the Department of Epidemiology, Microbiology and Evidence-Based Medicine, Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.

Using bacteriophages to overcome the increasing resistance of microorganisms to antibiotics is a novel research venue of clinical importance. Among other challenges, this technique is expected to create and maintain an adequate local concentration of bacteriophages at the site of application. In addition, the possibility of combining the phage preparation with antioxidants and anesthetics may provide new options for stimulating the reparative process. Read More

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Model-based assessment of the risks of viral transmission in non-confined crowds.

Saf Sci 2021 Dec 5;144:105453. Epub 2021 Sep 5.

Institut Lumière Matière, CNRS & Université Claude Bernard Lyon 1, Villeurbanne, F-69622, France.

This work assesses the risks of Covid-19 spread in diverse daily-life situations involving crowds of maskless pedestrians, mostly outdoors. More concretely, we develop a method to infer the global number of new infections from patchy observations, by coupling ad hoc spatial models for disease transmission via respiratory droplets to detailed field-data about pedestrian trajectories and head orientations. This allows us to rank the investigated situations by the infection risks that they present; importantly, the obtained hierarchy of risks is very largely conserved across transmission models: Street cafés present the largest average rate of new infections caused by an attendant, followed by busy outdoor markets, and then metro and train stations, whereas the risks incurred while walking on fairly busy streets are comparatively quite low. Read More

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December 2021

Enhancing Linkage to Hepatitis C Virus Treatment Following Pregnancy in Women Identified During Perinatal Care.

Hepatol Commun 2021 Sep 1;5(9):1543-1554. Epub 2021 Jul 1.

Department of Pediatrics, Section of Infectious Diseases, Boston University School of Medicine, Boston, MA, USA.

Amid the current US opioid crisis, hepatitis C virus (HCV) infection rates continue to rise in young adults, including among pregnant women, yet few studies describe linkage to care and treatment in pregnant or postpartum women with HCV infection. We used electronic health record data to estimate HCV treatment rates for postpartum women before (January 2014-September 2016) and during (October 2016-March 2018) implementation of a maternal-infant HCV linkage program in combination with a multidisciplinary clinic to colocate mother and infant care. Using Poisson regression models, we compared HCV treatment initiation rates, adjusting for demographics, substance use, and treatment. Read More

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September 2021

Eye contact marks the rise and fall of shared attention in conversation.

Proc Natl Acad Sci U S A 2021 Sep;118(37)

Psychological and Brain Sciences Department, Dartmouth College, Hanover, NH 03755.

Conversation is the platform where minds meet: the venue where information is shared, ideas cocreated, cultural norms shaped, and social bonds forged. Its frequency and ease belie its complexity. Every conversation weaves a unique shared narrative from the contributions of independent minds, requiring partners to flexibly move into and out of alignment as needed for conversation to both cohere and evolve. Read More

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September 2021

Examining the Role of Service Quality, Perceived Values, and Trust in Macau Food Festival.

Int J Environ Res Public Health 2021 Sep 1;18(17). Epub 2021 Sep 1.

Department of Tourism Management, College of Social Sciences, Gangneung-Wonju National University, Jukheon-gil 7, Gangneung 25457, Korea.

An emerging paradigm for festival and event management reveals that hosting theme-based festivals can foster economic growth at the local and national levels. As a case of this research, the annual Macau Food Festival was selected to explore relationships among visitors' perceptions of festival quality, festival value, trust in the festival, visitors' satisfaction, and behavior intention. Out of 453 questionnaires distributed, 433 questionnaires were valid for data analysis using partial least squares-structural equation modeling. Read More

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September 2021

Anatomical Societies Find New Ways to Come Together in a Post-Covid World.

Anat Sci Educ 2021 Sep 9. Epub 2021 Sep 9.

Institute of Human Anatomy, Department of Neurosciences, University of Padova, Padova, Italy.

The world has been turned upside down by a global health emergency caused by the Covid-19. Given the high contagiousness of the virus and the need to contain its spread, social distancing rules, self-isolation policies, and geographical lockdowns have been enforced globally. Over the pandemic emergency the majority of the planned in-person meetings and congresses of national and international anatomical societies have been postponed or canceled. Read More

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September 2021

Socializing the evidence for diabetes control to develop "mindlines": a qualitative pilot study.

BMC Fam Pract 2021 Sep 7;22(1):177. Epub 2021 Sep 7.

Department of Family & Community Medicine, Virginia Tech Carilion School of Medicine and The Carilion Clinic, 1 Riverside Circle, Suite 102, Roanoke, VA, 24016, USA.

Background: Evidence on specific interventions to improve diabetes control in primary care is available, but this evidence is not always well-implemented. The concept of "mindlines" has been proposed to explain how clinicians integrate evidence using specifics of their practices and patients to produce knowledge-in-practice-in-context. The goal of this pilot study was to operationalize this concept by creating a venue for clinician-staff interaction concerning evidence. Read More

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September 2021

TP-CNN: A Detection Method for atrial fibrillation based on transposed projection signals with compressed sensed ECG.

Comput Methods Programs Biomed 2021 Aug 26;210:106358. Epub 2021 Aug 26.

Cooperative Innovation Center of Internet Healthcare, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address:

Background And Objective: Atrial fibrillation (AF) is the most prevalent arrhythmia, which increases the mortality of several complications. The use of wearable devices to detect atrial fibrillation is currently attracting a great deal of attention. Patients use wearable devices to continuously collect individual ECG signals and transmit them to the cloud for diagnosis. Read More

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Monitoring compliance with Kenya's shisha ban in select public hospitality venues in Nairobi.

Tob Control 2021 Sep 2. Epub 2021 Sep 2.

International Research, Campaign for Tobacco-Free Kids, Washington, DC, USA

Introduction: Seven countries in the WHO African Region have banned the sale and/or use of shisha. In 2017, Kenya implemented a comprehensive ban on shisha, including the use, import, manufacture, sale, offer of sale, advertising, promotion, distribution and encouraging or facilitating its use. The objective of this study was to assess compliance with the ban of shisha use in select public hospitality venues in Nairobi, Kenya. Read More

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September 2021

High Acceptance and Completion of HIV Self-testing Among Diverse Populations of Young People in Kenya Using a Community-Based Distribution Strategy.

AIDS Behav 2021 Sep 1. Epub 2021 Sep 1.

Department of Global Health, Harborview Medical Center, University of Washington, 325 9th Avenue, Box 359931, Seattle, WA, 98104, USA.

Oral HIV self-testing (HIVST) may expand access to testing among hard-to-reach reach adolescents and young adults (AYA). We evaluated community-based HIVST services for AYA in an urban settlement in Kenya. Peer-mobilizers recruited AYA ages 15-24 through homes, bars/clubs, and pharmacies. Read More

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September 2021

Promoting Adolescent Healthy Relationships (The About Us Program): Protocol for a Randomized Clinical Trial.

JMIR Res Protoc 2021 Sep 1;10(9):e30499. Epub 2021 Sep 1.

Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, United States.

Background: Romantic relationships play a critical role in adolescent development, and by middle adolescence, most young people have been involved in at least one romantic relationship, a context in which most sexual interactions occur. Research suggests adolescents lack positive models and skills related to building healthy relationships.

Objective: This project aims to test the impact of an innovative healthy relationships intervention, called About Us, implemented in school-based health centers (SBHCs) in California in a randomized controlled trial. Read More

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September 2021

Mental health on the move: An observational study to characterize post-migration depression symptoms among migrants from Sub-Saharan Africa in China.

J Psychosom Res 2021 Oct 24;149:110602. Epub 2021 Aug 24.

Dermatology Hospital of Southern Medical University, Guangzhou, China; Southern Medical University Institute for Global Health and Sexually Transmitted Diseases, Guangzhou, China; Guangdong Provincial Center for Skin Disease and STI Control, Guangzhou, Guangdong, China. Electronic address:

Objective: Migrants from Sub-Saharan Africa to China faced challenges in accessing healthcare. Less is known about their depression prevalence. We aim to address this gap by providing an initial estimation on symptoms indicative of depression. Read More

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October 2021

Intracranial pressure analysis software: A mapping study and proposal.

Comput Methods Programs Biomed 2021 Sep 10;209:106334. Epub 2021 Aug 10.

Department of Informatics and Systems, Faculty of Computer Science, University of Murcia, Murcia, Spain. Electronic address:

Introduction Intracranial pressure (ICP) monitoring and analysis are techniques that are, each year, applied to millions of patients with pathologies with million of patients annually. The detection of the so called A and B-waves, and the analysis of subtle changes in C-waves, which are present in ICP waveform, may indicate decreased intracranial compliance, and may improve the clinical outcome. Despite the advances in the field of computerized data analysis, the visual screening of ICP continues to be the means principally employed to detect these waves. Read More

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September 2021

Associations between breast cancer screening participation and residential area sociodemographic features, geographic accessibility, and features of screening venue location in Greater Sydney, Australia.

Prev Med 2021 Aug 24;153:106774. Epub 2021 Aug 24.

Australian Geospatial Health Laboratory, Health Research Institute, University of Canberra, Canberra, Australian Capital Territory, Australia; Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, Victoria, Australia.

Breast cancer screening (BCS) participation rates are often suboptimal and vary geographically. Environmental features may influence BCS participation, but few studies have assessed this relationship. This study assessed the associations between BCS participation, residential area sociodemographic characteristics, distance to BCS venue, and venue location attributes. Read More

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Does Self-Perception Equal the Truth When Judging Own Body Weight and Height?

Int J Environ Res Public Health 2021 08 11;18(16). Epub 2021 Aug 11.

Department of Sports Medicine, Norwegian School of Sports Sciences, 0806 Oslo, Norway.

Background: Data from the research project "Fitness clubs-a venue for public health?" provided an opportunity to evaluate the accuracy of self-reported body weight and height, and subsequent Body Mass Index (BMI), as well as the "trueness" of novice exercisers perception of weight status category, which has not been examined in this population. The aims were to examine self-reported body weight, height, and calculated BMI data from an online survey compared with measured data at fitness club start-up, investigate how accurately novice exercisers place themselves within self-classified weight group (underweight, normal weight, overweight, and obese), and compare this with fitness club attendance at three months follow-up.

Methods: Prior to anthropometric measurements, 62 men and 63 women responded to an online questionnaire, including body weight (kilogram, kg) and height (centimeters, cm), and self-classified weight group (""). Read More

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The playful unliving: Creativity and contingency in scientific practice.

Endeavour 2021 Sep 18;45(3):100782. Epub 2021 Aug 18.

Universidad Autónoma Metropolitana, Unidad Cuajimalpa, Mexico City, Mexico. Electronic address:

Standing apart from Martin Heidegger's 1929-1930 metaphysical lessons is his description of a photograph taken by Josef Maria Eder, for Sigmund Exner, using the lens of a glow worm's eye. Since the technical details of the production of such a photography are not readily available, I will reconstruct the experimental setting. Paying attention to the technical details opens up a venue for historical and philosophical reflection based on the creative potential of scientific practices. Read More

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September 2021

The Exchange of Informational Support in Online Health Communities at the Onset of the COVID-19 Pandemic: Content Analysis.

JMIRx Med 2021 Jul-Sep;2(3):e27485. Epub 2021 Jul 22.

College of Computing and Informatics Drexel University Philadelphia, PA United States.

Background: Online health communities (OHCs) provide social support for ongoing health-related problems. COVID-19, the disease caused by SARS-CoV-2, has been an acute and substantial stressor worldwide. The disease and its impact, especially in the beginning phases, left many people with questions about the nature, treatment, and prevention of COVID-19. Read More

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Transvenous Lead Extraction without Procedure-Related Deaths in 1000 Consecutive Patients: A Single-Center Experience.

Vasc Health Risk Manag 2021 5;17:445-459. Epub 2021 Aug 5.

Department of Cardiology, Medical University, Lublin, Poland.

Background: Transvenous lead extraction (TLE) is now a first-line technique for the treatment of complications related to cardiac implantable electronic devices. The aim of the study was to demonstrate that it is possible to safely perform difficult TLE procedures with a maximum reduction of peri-procedural major complications.

Methods: A total of 1000 consecutive patients undergoing TLE in a single high-volume center from 2016 to 2019 were studied. Read More

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Biomonitoring of toxic metals, organochlorine pesticides, and polybrominated biphenyl 153 in Michigan urban anglers.

Environ Res 2021 Aug 9;203:111851. Epub 2021 Aug 9.

Office of Associate Director, Agency for Toxic Substances and Disease Registry, 4770 Buford Highway, Atlanta, GA, 30341, United States.

The 32-mile Detroit River and surrounding tributaries have been designated as a Great Lakes Area of Concern due to pollution from decades of municipal and industrial discharges, sewer overflows and urban development. The Agency for Toxic Substances and Disease Registry and the Michigan Department of Health and Human Services conducted a biomonitoring study to assess exposures to persistent toxic substances in Detroit urban shoreline anglers who may be at high exposure risk due to consumption of locally caught fish. Using a modified venue-based sampling approach, 287 adult shoreline anglers along the Detroit River were recruited and participated in the program. Read More

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Stigma, Social Support, and Sexual Behavior Among Female Sex Workers at Risk for HIV in Malawi.

AIDS Educ Prev 2021 08;33(4):290-302

The Ohio State University, Columbus, Ohio.

Lack of social support and sex work stigma may hinder STI/HIV prevention for female sex workers (FSW). We explored the associations between sex work stigma and social support with sexual behaviors in Malawi. In 2017, 150 HIV-negative, venue-based FSW completed a behavioral survey containing sex work stigma items and social support. Read More

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Alcohol policy, multi-level governance and corporate political strategy: The campaign for Scotland's minimum unit pricing in Edinburgh, London and Brussels.

Br J Polit Int Relat 2021 Aug 3;23(3):391-409. Epub 2020 Nov 3.

Department of Health Sciences, University of York, York, UK.

The Scottish government's plans for a minimum unit price for alcohol were vehemently opposed by the alcohol industry leading to a 6-year delay in implementation after legislation was passed. This article seeks to explain the consequences of devolution and European Union membership for the development of minimum unit price in Scotland through the concepts of multi-level governance, veto points and venue shifting. Systems of multi-level governance create policy interdependencies between settings, an increased number of veto points at which policies can be blocked, and the potential for policy actors to shift decision-making to forums where favourable outcomes are more likely to be attained. Read More

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An Analysis of Differences in the Role of Friendships and the School Class in Children's Perceptions of in England and in Japan: A Translation and Expansion of Kanetsuna (2009).

Int J Environ Res Public Health 2021 08 3;18(15). Epub 2021 Aug 3.

Unit for School and Family Studies, Department of Psychology, Goldsmiths, University of London, London SE14 6NW, UK.

This is an English translation with some expansion of the article originally published in Japanese as a university bulletin in 2009. Previous research has found both differences and similarities between in Japan and in England. is often by pupils in different classes or higher year groups whom the victim does not know very well; is often by victims' classmates whom the victim knows very well. Read More

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Engineering Concanavalin B to Release Bioactive Peptides against Metabolic Syndrome.

Foods 2021 Jul 5;10(7). Epub 2021 Jul 5.

Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera Estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Mexico.

Metabolic syndrome is a severe public health issue characterized by multiple metabolic disturbances. Current treatments prescribe a particular drug for each of them, producing multiple side effects. As a first step towards a more integral approach, we applied our recently described methodology to design single proteins, based in the Concanavalin B scaffold (1CNV), that contain several bioactive peptides (BPs), including antioxidant and lipid-lowering activities as well as inhibitors of dipeptidyl peptidase IV (DPPIV) and the angiotensin converting enzyme. Read More

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