13,882 results match your criteria ventricular diameter

Percutaneous Balloon Pulmonary Valvuloplasty of Critical Pulmonary Stenosis and severe pulmonary stenosis in Neonates and Early Infancy: A Challenge in the Cyanotic.

J Cardiovasc Thorac Res 2021 20;13(2):156-161. Epub 2021 May 20.

Rajaie Cardiovascular Medical and Research Center, Iran University of medical sciences, Tehran, Iran.

Pulmonary stenosis with an intact ventricular septum (PS-IVS) is one of the common causes of cyanotic heart disease in neonates with diverse morphologies as well as management and treatment protocols. The aim of this study was to evaluate short and midterm results of balloon pulmonary valvuloplasty (BPV) for this disorder. Between 2012 and 2016, Totally 45 neonates and infants under 6 months old were evaluated. Read More

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Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension.

Sci Rep 2021 Jul 29;11(1):15502. Epub 2021 Jul 29.

Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic biomarker of PH. Read More

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Myocardial Glucose Metabolism Is Increased in Newly Diagnosed Lung Adenocarcinoma.

Cardiology 2021 Jul 29:1-9. Epub 2021 Jul 29.

Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Cardiac metabolism alterations may be involved in abnormalities of cancer patients' cardiovascular system. This study aimed to explore whether left ventricular myocardial glucose metabolism is altered and its related factors in newly diagnosed patients with lung adenocarcinoma (LAD) who underwent fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT).

Methods: From our 18F-FDG PET/CT imaging database, 171 patients with newly diagnosed LAD and 43 nononcologic subjects with matched age and sex were retrospectively analyzed. Read More

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The Expression of miR-365 in Serum of Hypertension Patients with Left Ventricular Hypertrophy Was Up-Regulated, Which Was Positively Correlated with Left Ventricular Mass Index.

Pharmgenomics Pers Med 2021 21;14:905-913. Epub 2021 Jul 21.

Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.

Objective: The present study aims to investigate micro ribonucleic acid-365 (miR-365) serum expression and its correlation with left ventricular hypertrophy (LVH) in patients with hypertension (HT).

Methods: Eighty-four patients were selected as study subjects and divided into three groups: the experimental group (n = 28), the observation group (n = 29), and the control group (n = 27). The experimental group included patients with LVH-accompanied HT who were treated in the People's Hospital of Hebei Province between November 2019 and November 2020, the observation group included patients with HT unaccompanied by LVH, and the control group included healthy age and gender-matched subjects who underwent health examinations in our physical examination center. Read More

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HE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy.

J Am Heart Assoc 2021 Jul 29:e021069. Epub 2021 Jul 29.

Department of Cardiovascular Medicine Faculty of Life Sciences Kumamoto University Kumamoto Japan.

Background Cardiac fibrosis plays a crucial role in the pathogenesis of dilated cardiomyopathy (DCM). HE4 (human epididymis protein 4) is a secretory protein expressed in activated fibroblasts that exacerbates tissue fibrosis. In the present study, we investigated the clinical utility of HE4 measurement in patients with DCM and its pathophysiological role in preclinical experiments in vivo and in vitro. Read More

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Relatively Benign yet a Reversible Cause of Dilated Cardiomyopathy.

JACC Case Rep 2021 Jul 2;3(8):1081-1085. Epub 2021 Jun 2.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Arrhythmia-induced cardiomyopathy secondary to frequent ventricular premature contractions is a well-studied phenomenon; however, there is a paucity of data showing a similar association with frequent atrial premature contractions (APCs). Early recognition and successful APC ablation can reverse left ventricular dysfunction in these patients. (). Read More

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TGA With Interarterial Course and Athletes Heart: A Diagnostic Dilemma Answered by Stress CMR.

JACC Case Rep 2020 May 20;2(5):740-744. Epub 2020 May 20.

National Heart Centre Singapore, Singapore.

We report a case of coronary artery compression and athlete's heart in a patient with a history of transposition of the great arteries. We present the diagnostic dilemmas and demonstrate the use of cardiac magnetic resonance imaging and cycle-ergometer stress cardiac magnetic resonance in the management of our patient. (). Read More

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Dynamic Right Ventricular Outflow Tract Obstruction in Straight Back Syndrome.

JACC Case Rep 2019 Oct 2;1(3):436-437. Epub 2019 Oct 2.

Department of Cardiology, Government Medical College and Hospital, Chandigarh, India.

Straight back syndrome is a congenital skeletal abnormality of the upper dorsal spine. This clinical case describes a 29-year-old woman with atypical chest pain and a changing murmur that was attributed to dynamic right ventricular outflow tract obstruction on echocardiography. (). Read More

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October 2019

Right ventricular anatomical and functional parameters in healthy Mexican term newborns.

Arch Cardiol Mex 2021 ;91(3):315-320

Department of Neonatology, Cambridge University Hospitals NHS Foundation Trust and University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

Objective: Right ventricle (RV) function plays an important role during fetal and neonatal transitional circulation. Despite the published echocardiography guidelines in children including neonates, there is scare evidence on RV assessment using echocardiography in Mexican neonates. This study was aimed at assessing RV function and anatomical measures in healthy term newborns and defines normal values in this cohort of patients. Read More

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January 2021

Adipose-derived mesenchymal stem cells preserve cardiac function via ANT-1 in dilated cardiomyopathy hamster model.

Regen Ther 2021 Dec 9;18:182-190. Epub 2021 Jul 9.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Introduction: Idiopathic dilated cardiomyopathy (DCM) is associated with abnormalities in cytoskeletal proteins, mitochondrial ATP transporter, microvasculature, and fibrosis. Mesenchymal stem cells (MSCs) can ameliorate distressed mitochondrial and structural proteins, as well as fibrosis, via the paracrine effect of cytokines. This study aimed to investigate whether the transplantation of adipose tissue-derived MSCs (ADSCs) reverses histological and functional abnormalities in the distressed myocardium of DCM-like hamsters by modulating the expression of adenine nucleotide translocase 1 (ANT-1). Read More

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December 2021

Risk Factors of Pulmonary Arterial Hypertension and Its Relationship With Atrial Fibrillation in Patients With Obstructive Hypertrophic Cardiomyopathy.

Front Cardiovasc Med 2021 7;8:666431. Epub 2021 Jul 7.

Department of Cardiovascular Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital, Beijing, China.

Pulmonary arterial hypertension (PH) is a common complication in patients with obstructive hypertrophic cardiomyopathy (OHCM). The risk factor of PH in patients with OHCM has not been fully elucidated, and even atrial fibrillation (AF) was considered a risk factor of PH. Thus, our study aimed to investigate risk factors of PH and the relationship between PH and AF in patients with OHCM. Read More

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Anatomic Variability of the Morphometric Parameters of the Third Ventricle of the Brain and Its Relations to the Shape of the Skull.

J Neurol Surg B Skull Base 2021 Jul 7;82(Suppl 3):e315-e320. Epub 2020 Feb 7.

Department of Anatomy and Embryology, American University of the Caribbean, Cupecoy, St. Maarten.

 The defining of the normal parameters of spacious relations and symmetry of the ventricular system of the brain depending on the gender and age is currently one of the topical research problems of clinical anatomy. The present research aims to identify the correlation between the morphometric parameters of the third ventricle of the brain and the shape of the skull in the middle aged people.  This is a prospective cohort study. Read More

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Clinical significance of sFRP5, RBP-4 and NT-proBNP in patients with chronic heart failure.

Am J Transl Res 2021 15;13(6):6305-6311. Epub 2021 Jun 15.

Chengde Health Commission Chengde, Hebei Province, China.

Objective: This study was designed to investigate the levels and clinical significance of secretory frizzled-related protein 5 (sFRP5), retinol binding protein 4 (RBP-4) and N-terminal (NT)-pro hormone BNP (NT-proBNP) in patients with chronic heart failure (CHF).

Methods: Eighty-nine patients with CHF treated in our hospital were included as the observation group. Seventy-five healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. Read More

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Clinical findings associated with incomplete hemodynamic left ventricular unloading in patients with a left ventricular assist device.

Rev Esp Cardiol (Engl Ed) 2021 Jul 21. Epub 2021 Jul 21.

Division of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW Bad Oeynhausen, Ruhr-University Bochum, Germany.

Introduction And Objectives: The effect of a centrifugal continuous-flow left ventricular assist device (cfLVAD) on hemodynamic left ventricular unloading (HLVU) and the clinical conditions that interfere with hemodynamic optimization are not well defined.

Methods: We retrospectively evaluated the likelihood of incomplete HLVU, defined as high pulmonary capillary wedge pressure (hPCWP)> 15mmHg in 104 ambulatory cfLVAD patients when the current standard recommendations for cfLVAD rotor speed setting were applied. We also evaluated the ability of clinical, hemodynamic and echocardiographic variables to predict hPCWP in ambulatory cfLVAD patients. Read More

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Long-term relief of obstruction in a dog with double-chambered right ventricle using combined cutting balloon and high-pressure balloon dilation.

J Vet Cardiol 2021 Jun 25;36:180-185. Epub 2021 Jun 25.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, OH, 43220, USA.

A 4-month-old intact female Golden Retriever dog was diagnosed with double-chambered right ventricle (DCRV) without infundibular stenosis, tricuspid valve dysplasia, and subsequent severe right atrial enlargement and was referred for combined cutting balloon and high-pressure balloon dilation. On presentation, these diagnoses were confirmed, and the peak systolic pressure gradient across the DCRV obstructive lesion assessed by continuous wave Doppler interrogation was 80 mm Hg. The obstructive lesion within the mid-right ventricle had a diameter of 6 mm through which blood flowed from the proximal right ventricular (RV) chamber to the distal RV chamber. Read More

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Diabetes induces remodeling of the left atrial appendage independently of atrial fibrillation in a rodent model of type-2 diabetes.

Cardiovasc Diabetol 2021 Jul 23;20(1):149. Epub 2021 Jul 23.

Department of Cardiology, Barzilai University Medical Center, 2 Hahistadrut Street, 78278, Ashkelon, Israel.

Background: Diabetic patients have an increased predisposition to thromboembolic events, in most cases originating from thrombi in the left atrial appendage (LAA). Remodeling of the LAA, which predisposes to thrombi formation, has been previously described in diabetic patients with atrial fibrillation, but whether remodeling of the LAA occurs in diabetics also in the absence of atrial fibrillation is unknown. To investigate the contribution of diabetes, as opposed to atrial fibrillation, to remodeling of the LAA, we went from humans to the animal model. Read More

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Differential Factors for Predicting Outcomes in Left Main versus Non-Left Main Coronary Bifurcation Stenting.

J Clin Med 2021 Jul 7;10(14). Epub 2021 Jul 7.

Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul 03080, Korea.

Background: No large-scale study has compared the clinical and angiographic predictors of cardiovascular events in patients with left main bifurcation (LMB) and non-LMB stenting after second-generation DES implantation. Herein, we investigated differential clinical and angiographic factors for predicting outcomes in LMB versus non-LMB stenting.

Methods: A total of 2648 patients with bifurcation lesions treated with second-generation DESs from the retrospective patient cohort were divided into an LMB group ( = 935) and a non-LMB group ( = 1713). Read More

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Comparison of transorbital ultrasound measurements to predict intracranial pressure in brain-injured patients requiring external ventricular drainage.

J Neurosurg 2021 Jul 23:1-7. Epub 2021 Jul 23.

3Department of Neurosurgery, Dong-A University College of Medicine, Busan, Korea.

Objective: The optic nerve sheath diameter (ONSD) excluding the dura mater (ONSDE; i.e., the subarachnoid diameter) and the ONSD including the dura mater (ONSDI) have been used differently in studies, but the predictive ability of these two different measurements of the ONSD as measured by invasive intracranial pressure (ICP) monitoring has never been compared. Read More

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Fetal Superior Vena Cava Blood Flow and Its Fraction of Cardiac Output: A Longitudinal Ultrasound Study in the Second Half of Pregnancy.

Front Pediatr 2021 6;9:658502. Epub 2021 Jul 6.

Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention & Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

In the fetus, a large proportion of the superior vena cava blood flow (Q) comes from the brain. To provide the possibility of using this blood flow as a representation of fetal brain circulation, we aimed to determine the fetal Q and its fraction of cardiac output during the second half of physiological pregnancies. This was a prospective longitudinal study specifically designed for studying fetal hemodynamic development. Read More

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Dengue and the heart.

Cardiovasc J Afr 2021 Jul 20;32:1-6. Epub 2021 Jul 20.

Department of Anaesthesiology, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Email:

Background: Peri-operative morbidity and mortality are increased in patients with rheumatic heart disease. Pre-operative risk stratification is imperative for optimisation and a better outcome.

Methods: This was a descriptive, retrospective, contextual study. Read More

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Elabela gene therapy promotes angiogenesis after myocardial infarction.

J Cell Mol Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

This study was aimed at investigating whether Elabela (ELA) gene therapy can promote angiogenesis in the treatment of myocardial infarction (MI). The fusion expression plasmid pAAV-3 × Flag/ELA-32 was successfully constructed using molecular cloning technique. The model of acute MI was established by ligating the left anterior descending coronary artery in mice. Read More

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Ultrasonography to detect cardiovascular damage in children with essential hypertension.

Cardiovasc Ultrasound 2021 Jul 21;19(1):26. Epub 2021 Jul 21.

Cardiology Department, Children's Hospital of Soochow University, Suzhou City, Jiangsu Province, 215025, China.

Background: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at early stage using ultrasonography. Read More

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The effects of lower body compression on left ventricular rotational mechanics in lymphoedema (from the MAGYAR-Path Study).

ESC Heart Fail 2021 Jul 20. Epub 2021 Jul 20.

Department of Dermatology and Allergology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.

Aims: Lower body half compression of bilateral secondary leg lymphoedema (LE) without relevant cardiac insufficiency gives rise to whether external leg compression may influence left ventricular (LV) function. Patients with LE were subjected to baseline two-dimensional transthoracic echocardiography (2DTTE) for general assessment then three-dimensional speckle-tracking echocardiography (3DSTE) before and 1 h after lower body half external compression for LV torsion analysis.

Methods And Results: Baseline 2DTTE was performed in the cohort of 25 LE patients, and the results were compared with those of age- and gender-matched 52 healthy controls (mean age: 47. Read More

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Palliative Endovascular Intervention in Infants with Tetralogy of Fallot: A Case Series.

Arq Bras Cardiol 2021 Jul 16. Epub 2021 Jul 16.

Universidade federal do Paraná (UFPR), Curitiba, PR - Brasil.

Background: Endovascular stent placement in the right ventricular outflow tract (RVOT) has been an alternative to Blalock-Taussig (BT) surgery in the treatment of Tetralogy of Fallot (TOF) in symptomatic infants with low birth weight and complex anatomy.

Objective: To evaluate endovascular stent placement in the RVOT as a primary treatment for infants with TOF who are not candidates for BT surgery, and evaluate medium-term outcomes until the stent is removed during corrective surgery.

Methods: Six infants with TOF were treated with RVOT stenting from October 2015 to April 2018. Read More

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Right ventricular dysfunction and right ventricular-arterial uncoupling at admission increase the in-hospital mortality in patients with COVID-19 disease.

Echocardiography 2021 Jul 19. Epub 2021 Jul 19.

Surgical and Medical Specialties Direction, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Background: Coronavirus disease 2019 (COVID-19) frequently involves cardiovascular manifestations such as right ventricular (RV) dysfunction and alterations in pulmonary hemodynamics. We evaluated the application of the critical care ultrasonography ORACLE protocol to identify the most frequent alterations and their influence on adverse outcomes, especially those involving the RV (dilatation and dysfunction).

Methods: This cross-sectional study included 204 adult patients with confirmed COVID-19 admitted at three centers. Read More

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Comparison between myocardial function assessed by echocardiography during hospitalization for COVID-19 and at 4 months follow-up.

Int J Cardiovasc Imaging 2021 Jul 20. Epub 2021 Jul 20.

Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.

In patients hospitalized for corona virus infectious disease 19 (COVID-19) it is currently unknown whether myocardial function changes after recovery and whether this is related to elevated cardiac biomarkers. In this single center, prospective cohort study we consecutively enrolled hospitalized COVID-19 patients between 1 April and 12 May 2020. All patients underwent transthoracic echocardiography (TTE) evaluation during hospitalization and at a median of 131 days (IQR; 116-136) follow-up. Read More

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Early clinical and haemodynamic matched comparison of balloon-expandable valves.

Heart 2021 Jul 20. Epub 2021 Jul 20.

Cardiology, Universitary Clinical Hospital, Valladolid, Spain

Objectives: The balloon-expandable Sapien-3 valve demonstrated superior results in terms of residual aortic regurgitation when compared with self-expandable devices. We aimed to compare for the first-time early outcomes of Sapien-3 transcatheter heart valve (THV) with the balloon-expandable Myval device.

Methods: Consecutive real-world patients from nine European institutions with symptomatic severe aortic stenosis treated either with Sapien-3 or Myval THV devices after June 2018 were compared. Read More

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Histological changes after pulmonary artery banding for retraining of subpulmonary left ventricle.

Ann Thorac Surg 2021 Jul 17. Epub 2021 Jul 17.

Cardiac Registry, Departments of Cardiology, Pathology, and Cardiac Surgery, Boston Children's Hospital, Boston, MA; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA.

Background: Patients with congenitally corrected transposition of the great arteries (ccTGA) with intact ventricular septum (IVS) or d-looped transposition of the great arteries (DTGA) with IVS post atrial switch operation often develop left ventricular dysfunction after anatomical repair despite prior retraining of the morphologically left ventricle (mLV) using pulmonary artery banding (PAB). We examined histopathological changes in such mLV.

Methods: Capillary density, myocyte diameter, and interstitial fibrous area in the mLV were retrospectively evaluated in postmortem or explanted heart specimens obtained from patients with ccTGA/IVS or DTGA/IVS post atrial switch operation after PAB for retraining and compared with those of patients with normal cardiac anatomy, ccTGA/IVS or DTGA/IVS without PAB, and ccTGA or DTGA with high mLV pressure using generalized estimating equations models. Read More

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Association between computed tomography-derived tricuspid annular dimensions and prognosis: insights from whole-beat computed tomography assessment.

Eur Heart J Cardiovasc Imaging 2021 Jul 19. Epub 2021 Jul 19.

Department of Cardiology, Heart Lung Centre, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.

Aims: Tricuspid regurgitation (TR) has been associated with outcome in patients treated with transcatheter aortic valve implantation (TAVI). Tricuspid annulus (TA) dimensions are associated with TR. However, the TA is highly dynamic during the cardiac cycle, and the interaction between the TA dimensions, TR, and patient prognosis has never been evaluated. Read More

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Use of Angiotensin Receptor Neprilysin Inhibitor in Patients on Maintenance Hemodialysis with Reduced Cardiac Ejection Fraction, Real-World Experience From a Single Center.

Iran J Kidney Dis 2021 Jul;15(4):288-299

Department of Kidney Disease and Blood Purification Centre, 2nd Hospital of Tianjin Medical University, Tianjin, PR China.

Introduction: Angiotensin receptor neprilysin inhibitor (ARNI) has been recommended by major guidelines as the leading therapy for heart failure with reduced ejection fraction (HFrEF). But little is known about its safety and effectiveness among maintenance hemodialysis patients with HFrEF in real-word practice.

Methods: An observational study was conducted among maintenance hemodialysis patients who received ARNI at our dialysis center. Read More

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