Ann Thorac Surg 2021 Jul 17. Epub 2021 Jul 17.
Cardiac Registry, Departments of Cardiology, Pathology, and Cardiac Surgery, Boston Children's Hospital, Boston, MA; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA.
Background: Patients with congenitally corrected transposition of the great arteries (ccTGA) with intact ventricular septum (IVS) or d-looped transposition of the great arteries (DTGA) with IVS post atrial switch operation often develop left ventricular dysfunction after anatomical repair despite prior retraining of the morphologically left ventricle (mLV) using pulmonary artery banding (PAB). We examined histopathological changes in such mLV.
Methods: Capillary density, myocyte diameter, and interstitial fibrous area in the mLV were retrospectively evaluated in postmortem or explanted heart specimens obtained from patients with ccTGA/IVS or DTGA/IVS post atrial switch operation after PAB for retraining and compared with those of patients with normal cardiac anatomy, ccTGA/IVS or DTGA/IVS without PAB, and ccTGA or DTGA with high mLV pressure using generalized estimating equations models. Read More