4,150 results match your criteria ventilator induced

Step-by-step inpatient rehabilitation for critical illness after coronavirus disease 2019: A CARE-compliant case report.

Medicine (Baltimore) 2021 Jun;100(23):e26317

Department of Rehabilitation Medicine, Kyungpook National University Hospital.

Introduction: Since the coronavirus disease (COVID-19) outbreak in Wuhan, China, in December 2019, COVID-19 has become a worldwide pandemic. Muscle weakness and deconditioning caused by COVID-19-induced critical illness requires rehabilitation.

Patient Concerns: A 74-year-old male patient complained of general weakness after COVID-19, requiring ventilator treatment. Read More

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Diaphragm neurostimulation during mechanical ventilation reduces atelectasis and transpulmonary plateau pressure, preserving lung homogeneity and PaO2/FiO2.

J Appl Physiol (1985) 2021 Jun 10. Epub 2021 Jun 10.

grid.61971.38Simon Fraser University, British Columbia, Canada.

Tidal volume delivered by mechanical ventilation to a sedated patient is distributed in a non-physiological pattern, causing atelectasis (underinflation) and overdistension (overinflation). Activation of the diaphragm during mechanical ventilation provides a way to reduce atelectasis and alveolar inhomogeneity, protecting the lungs from ventilator-induced lung injury while also protecting the diaphragm by preventing ventilator-induced diaphragm dysfunction. We studied the hypothesis that diaphragm contractions elicited by transvenous phrenic nerve stimulation, delivered in synchrony with volume-control ventilation, would reduce atelectasis and lung inhomogeneity in a healthy, normal-lung pig model. Read More

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Effects of The Prone Position on Regional Neutrophilic Lung Inflammation According To 18F-FDG PET In An Experimental Ventilator-Induced Lung Injury Model.

Shock 2021 Jun 8. Epub 2021 Jun 8.

Department of Emergency and Critical Care Center, Mie University Hospital, Tsu, Japan Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan Department of Molecular Imaging, Institute for Medical Photonics Research, Hamamatsu University School of Medicine, Hamamatsu, Japan Department of Surgery, National Defense Medical College, Tokorozawa, Japan Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan Division of Anesthesia and Perioperative Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan Department of Acute and Critical Care Medicine, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.

Abstract: Ventilator-induced lung injury (VILI) can be life-threatening and it is important to prevent the development of VILI. It remains unclear whether the prone position affects neutrophilic inflammation in the lung regions in vivo, which plays a crucial role in the pathogenesis of VILI. This study aimed to assess the relationship between the use of the prone position and the development of VILI-associated regional neutrophilic lung inflammation. Read More

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Selective Lobe Ventilation and a Novel Platform for Pulmonary Drug Delivery.

J Cardiothorac Vasc Anesth 2021 May 4. Epub 2021 May 4.

Department of Cardiothoracic Surgery, Wake Forest Baptist Medical Center, Wake Forest University, Winston-Salem, NC.

The current methods of mechanical ventilation and pulmonary drug delivery do not account for the heterogeneity of acute respiratory distress syndrome or its dependence on gravity. The severe lung disease caused by severe acute respiratory distress syndrome coronavirus 2, coronavirus disease 2019, is one of the many causes of acute respiratory distress syndrome. Severe acute respiratory distress syndrome coronavirus 2 has caused more than three million deaths worldwide and has challenged all therapeutic options for mechanical ventilation. Read More

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Does Severity of Brain Injury on Magnetic Resonance Imaging Predict Short-Term Outcome in Neonates Who Received Therapeutic Hypothermia?

Am J Perinatol 2021 Jun 8. Epub 2021 Jun 8.

Neonatal-Perinatal Medicine, Children's Hospital of Michigan, Detroit, Michigan.

Objective:  The National Institute of Child Health and Human Development (NICHD) magnetic resonance imaging (MRI) pattern of brain injury is a known biomarker of childhood outcome following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE). However, usefulness of this classification has not been evaluated to predict short-term outcomes. The study aimed to test the hypothesis that infants with NICHD MRI pattern of severe hypoxic-ischemic brain injury will be sicker with more severe asphyxia-induced multiorgan dysfunction resulting in prolonged length of stay (LOS) following therapeutic hypothermia. Read More

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Robust arterial spin labeling MRI measurement of pharmacologically induced perfusion change in rat kidneys.

NMR Biomed 2021 Jun 6:e4566. Epub 2021 Jun 6.

Merck & Co. Inc., Kenilworth, New Jersey, USA.

Kidney diseases such as acute kidney injury, diabetic nephropathy and chronic kidney disease (CKD) are related to dysfunctions of the microvasculature in the kidney causing a decrease in renal blood perfusion (RBP). Pharmacological intervention to improve the function of the microvasculature is a viable strategy for the potential treatment of these diseases. The measurement of RBP is a reliable biomarker to evaluate the efficacy of pharmacological agents' actions on the microvasculature, and measurement of RBP responses to different pharmacological agents can also help elucidate the mechanism of hemodynamic regulation in the kidney. Read More

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Use of pressure-regulated volume control in the first 48 hours of hospitalization of mechanically ventilated patients with sepsis or septic shock, with or without ARDS.

J Intensive Care Soc 2020 Nov 21;21(4):305-311. Epub 2019 Oct 21.

Department of Medicine, Pulmonary & Critical Care, Santa Barbara Cottage Hospital, Santa Barbara, CA, USA.

Purpose: To evaluate the impact of pressure-regulated volume control (PRVC/VC+) use on delivered tidal volumes in patients with acute respiratory distress syndrome (ARDS) or at risk for ARDS.

Materials And Methods: Retrospective study of mechanically ventilated adult patients with severe sepsis or septic shock.

Results: A total of 272 patients were divided into patients with recognized ARDS, patients without ARDS, and patients with unrecognized ARDS. Read More

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November 2020

Oxygen Toxicity in Critically Ill Adults.

Am J Respir Crit Care Med 2021 Jun 4. Epub 2021 Jun 4.

Johns Hopkins University School of Medicine, 1500, Pulmonary and Critical Care, Baltimore, Maryland, United States.

Oxygen supplementation is one of the most common interventions in critically ill patients. Despite over a century of data suggesting both beneficial and detrimental effects of supplemental oxygen, optimal arterial oxygenation targets in adult patients remain unclear. Experimental animal studies have consistently showed that exposure to a high fraction of inspired oxygen causes respiratory failure and early death. Read More

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Nanoparticle-mediated surfactant therapy in patients with severe COVID-19: a perspective.

J Mater Chem B 2021 Jun 4. Epub 2021 Jun 4.

Department of Chemical and Biological Engineering, The University of Alabama, P. O. Box 870203, Tuscaloosa, AL 35401, USA.

Coronavirus disease 2019 (COVID-19) is an RNA virus-based disease that can be deadly. For critically ill patients, mechanical ventilation is an important life-saving treatment. However, mechanical ventilation shows a trade-off between supporting respiratory function and ventilator-induced lung injury (VILI). Read More

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Reply to: The 4DPRR Index and Mechanical Power: A Step Ahead or 4 Steps Backwards?

Am J Respir Crit Care Med 2021 Jun 3. Epub 2021 Jun 3.

Universidade de São Paulo, 28133, Sao Paulo, Brazil.

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Hydrogen sulfide donor protects against mechanical ventilation-induced atrophy and contractile dysfunction in the rat diaphragm.

Clin Transl Sci 2021 Jun 3. Epub 2021 Jun 3.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.

Mechanical ventilation (MV) is a clinical tool providing adequate alveolar ventilation in patients that require respiratory support. Although a life-saving intervention for critically ill patients, prolonged MV results in the rapid development of inspiratory muscle weakness due to both diaphragmatic atrophy and contractile dysfunction; collectively known as "ventilator-induced diaphragm dysfunction" (VIDD). VIDD is a severe clinical problem because diaphragmatic weakness is a risk factor for difficulties in weaning patients from MV. Read More

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Individualization of PEEP and tidal volume in ARDS patients with electrical impedance tomography: a pilot feasibility study.

Ann Intensive Care 2021 Jun 2;11(1):89. Epub 2021 Jun 2.

Department of Anesthesiology and Intensive Care Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Background: In mechanically ventilated patients with acute respiratory distress syndrome (ARDS), electrical impedance tomography (EIT) provides information on alveolar cycling and overdistension as well as assessment of recruitability at the bedside. We developed a protocol for individualization of positive end-expiratory pressure (PEEP) and tidal volume (V) utilizing EIT-derived information on recruitability, overdistension and alveolar cycling. The aim of this study was to assess whether the EIT-based protocol allows individualization of ventilator settings without causing lung overdistension, and to evaluate its effects on respiratory system compliance, oxygenation and alveolar cycling. Read More

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Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes.

Crit Care Explor 2021 May 12;3(5):e0415. Epub 2021 May 12.

Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

Objectives: Determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course.

Design: Retrospective cohort study.

Setting: Northwestern Memorial Hospital ICUs. Read More

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Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients.

SLAS Discov 2021 Jun 2:24725552211019405. Epub 2021 Jun 2.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Lung imaging and autopsy reports among COVID-19 patients show elevated lung scarring (fibrosis). Early data from COVID-19 patients as well as previous studies from severe acute respiratory syndrome, Middle East respiratory syndrome, and other respiratory disorders show that the extent of lung fibrosis is associated with a higher mortality, prolonged ventilator dependence, and poorer long-term health prognosis. Current treatments to halt or reverse lung fibrosis are limited; thus, the rapid development of effective antifibrotic therapies is a major global medical need that will continue far beyond the current COVID-19 pandemic. Read More

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Quantification of Volatile Aldehydes Deriving from In Vitro Lipid Peroxidation in the Breath of Ventilated Patients.

Molecules 2021 May 21;26(11). Epub 2021 May 21.

CBR-Center of Breath Research, Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center, Homburg, 66421 Saarland, Germany.

Exhaled aliphatic aldehydes were proposed as non-invasive biomarkers to detect increased lipid peroxidation in various diseases. As a prelude to clinical application of the multicapillary column-ion mobility spectrometry for the evaluation of aldehyde exhalation, we, therefore: (1) identified the most abundant volatile aliphatic aldehydes originating from in vitro oxidation of various polyunsaturated fatty acids; (2) evaluated emittance of aldehydes from plastic parts of the breathing circuit; (3) conducted a pilot study for in vivo quantification of exhaled aldehydes in mechanically ventilated patients. Pentanal, hexanal, heptanal, and nonanal were quantifiable in the headspace of oxidizing polyunsaturated fatty acids, with pentanal and hexanal predominating. Read More

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Development of a multi-patient ventilator circuit with validation in an ARDS porcine model.

J Anesth 2021 Jun 1. Epub 2021 Jun 1.

Department of Mechanical and Materials Engineering, University of NE-Lincoln, Lincoln, NE, 68588, USA.

Purpose: The COVID-19 pandemic threatens our current ICU capabilities nationwide. As the number of COVID-19 positive patients across the nation continues to increase, the need for options to address ventilator shortages is inevitable. Multi-patient ventilation (MPV), in which more than one patient can use a single ventilator base unit, has been proposed as a potential solution to this problem. Read More

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Histopathological features in fatal COVID-19 acute respiratory distress syndrome.

Med Intensiva (Engl Ed) 2021 Jun-Jul;45(5):261-270. Epub 2021 Feb 27.

Département de Pathologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Background: COVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established.

Objective: To describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS. Read More

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Review of the Mechanisms of Ventilator Induced Lung Injury and the Principles of Intraoperative Lung Protective Ventilation.

AANA J 2021 Jun;89(3):227-233

is employed by Duke University School of Nursing, Durham, North Carolina.

Intraoperative ventilator induced lung injury is associated with development of postoperative pulmonary complications. Despite advances in modes and methods of mechanical ventilation, postoperative pulmonary complications remain as one of the leading causes of adverse outcomes following surgery and anesthesia. In an attempt to reduce the incidence of postoperative pulmonary complications, the use of an intraoperative ventilatory technique to minimize lung injury has been introduced. Read More

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The CypA-netics of Ventilator-Induced Lung Injury.

Am J Respir Crit Care Med 2021 May 25. Epub 2021 May 25.

Institute of Physiology. Charité Universitätsmedizin, Berlin, Germany.

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Effect and Mechanism Study of Sodium Houttuyfonate on Ventilator-Induced Lung Injury by Inhibiting ROS and Inflammation.

Yonsei Med J 2021 Jun;62(6):545-554

Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Purpose: Ventilator-induced lung injury (VILI) is a serious complication of mechanical ventilation (MV) that increases morbidity and mortality of patients receiving ventilator treatment. This study aimed to reveal the molecular mechanism of sodium houttuyfonate (SH) on VILI.

Materials And Methods: The male mice VILI model was established by high tidal volume ventilation. Read More

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Close Association Between Platelet Biogenesis and Alveolarization of the Developing Lung.

Front Pediatr 2021 7;9:625031. Epub 2021 May 7.

Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Bronchopulmonary dysplasia (BPD) is a neonatal chronic lung disease characterized by an arrest in alveolar and vascular development. BPD is secondary to lung immaturity, ventilator-induced lung injury, and exposure to hyperoxia in extremely premature infants, leading to a lifelong impairment of lung function. Recent studies indicate that the lung plays an important role in platelet biogenesis. Read More

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Mechanical ventilation enhances Acinetobacter baumannii-induced lung injury through JNK pathways.

Respir Res 2021 May 22;22(1):159. Epub 2021 May 22.

Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.

Background: Patients in intensive care units (ICUs) often received broad-spectrum antibiotic treatment and Acinetobacter baumannii (A.b.) and Pseudomonas aeruginosa (P. Read More

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Interleukin-6 Inhibition Reduces Neuronal Injury In A Murine Model of Ventilator-Induced Lung Injury.

Am J Respir Cell Mol Biol 2021 May 20. Epub 2021 May 20.

Cedars-Sinai Health System, 5149, Neurology and Neurosurgery, Los Angeles, California, United States;

Mechanical ventilation is a known risk factor for delirium, a cognitive impairment characterized by frontal cortex and hippocampal dysfunction. Although interleukin-6 (IL-6) is upregulated in mechanical ventilation-induced lung injury (VILI) and may contribute to delirium, it is not known whether inhibition of systemic IL-6 mitigates delirium-relevant neuropathology. To histologically define neuropathological effects of IL-6 inhibition in an experimental VILI model. Read More

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Extracorporeal membrane oxygenation in critically ill neonatal and pediatric patients with acute respiratory failure: a guide for the clinician.

Expert Rev Respir Med 2021 Jun 8:1-11. Epub 2021 Jun 8.

Division of Pediatric Critical Care Medicine, Duke University Health System, Durham, NC, USA.

: Extracorporeal membrane oxygenation for neonatal and pediatric respiratory failure continues to demonstrate improving outcomes, largely due to advances in technology along with refined management strategies despite mounting patient acuity and complexity. Successful use of ECMO requires thoughtful initiation and candidacy strategies, along with reducing the risk of ventilator induced lung injury and the progression to multiorgan failure.: This review describes current ECMO management strategies for neonatal and pediatric patients with acute refractory respiratory failure and summarizes relevant published literature. Read More

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Laryngectomy with a Tritube and flow-controlled ventilation.

Anaesth Rep 2021 Jan-Jun;9(1):86-89. Epub 2021 May 7.

Department of Head and Neck Surgery Poole Hospital NHS Trust Poole UK.

We describe the novel use of the TriTube and Evone ventilator (Ventinova, Eindhoven, Netherlands) to facilitate curative resection of a transglottic squamous cell carcinoma. A 43-year-old man presented with acute laryngeal and subglottic airway obstruction secondary to a stage 4 transglottic squamous cell carcinoma. The patient underwent magnetic resonance imaging followed by a diagnostic panendoscopy. Read More

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Ventilatory management of patients on ECMO.

Indian J Thorac Cardiovasc Surg 2021 Apr 12;37(Suppl 2):248-253. Epub 2020 Aug 12.

Department of Cardio-Thoracic and Vascular Surgery, Cardio-Thoracic Sciences Center, All India Institute of Medical Sciences, New Delhi, 110029 India.

Extracorporeal membrane oxygenation (ECMO) is the final treatment offered to patients of acute respiratory distress syndrome (ARDS). The survival (to discharge) of patients on veno-venous ECMO is approximately 59% with an average duration of 8 days. The ventilatory management of lungs during the ECMO may have an impact on mortality. Read More

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[Patient self-inflicted lung injury (P-SILI) : From pathophysiology to clinical evaluation with differentiated management].

Med Klin Intensivmed Notfmed 2021 May 7. Epub 2021 May 7.

Thoraxklinik am Universitätsklinikum Heidelberg, Pneumologie und Beatmungsmedizin, Translational Lung Research Center Heidelberg (TLRC), Röntgenstraße 1, 69126, Heidelberg, Deutschland.

The establishment of assisted spontaneous breathing is a phase of ventilation therapy that is generally considered to be beneficial and not dangerous. However, recent findings regarding potential damage from vigorous spontaneous breathing effort should be noticed in patients with acute injured lungs. This syndrome is called patient self-inflicted lung injury. Read More

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Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study.

Skelet Muscle 2021 05 3;11(1):11. Epub 2021 May 3.

Department of Physiology and Pharmacology, Karolinska Institutet, Bioclinicum, J8:30, SE-171 77, Stockholm, Sweden.

Background: Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation (CMV) and suggested to be due to the hyperinflammatory response associated with the viral infection. However, our understanding of age-related differences in the response to CMV in the absence of a viral infection remains insufficient.

Methods: Young (7-8 months) and old (28-32 months) F344 BN hybrid rats were exposed to the ICU condition for 5 days, i. Read More

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Mathematical modeling of ventilator-induced lung inflammation.

J Theor Biol 2021 Apr 27;526:110738. Epub 2021 Apr 27.

Department of Mathematics & Applied Mathematics, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

Despite the benefits of mechanical ventilators, prolonged or misuse of ventilators may lead to ventilation-associated/ventilation-induced lung injury (VILI). Lung insults, such as respiratory infections and lung injuries, can damage the pulmonary epithelium, with the most severe cases needing mechanical ventilation for effective breathing and survival. Damaged epithelial cells within the alveoli trigger a local immune response. Read More

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Volutrauma Increases Exhaled Pentanal in Rats: A Potential Breath Biomarker for Ventilator-Induced Lung Injury.

Anesth Analg 2021 07;133(1):263-273

From the CBR - Center of Breath Research, Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg, Germany.

Background: Mechanical ventilation injures lungs, but there are currently no reliable methods for detecting early injury. We therefore evaluated whether exhaled pentanal, a lipid peroxidation product, might be a useful breath biomarker for stretch-induced lung injury in rats.

Methods: A total of 150 male Sprague-Dawley rats were investigated in 2 substudies. Read More

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