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50-gene risk profiles in peripheral blood predict COVID-19 outcomes: A retrospective, multicenter cohort study.

EBioMedicine 2021 Jun 19;69:103439. Epub 2021 Jun 19.

Divison of Pulmonary, Critical Care & Sleep Medicine. University of South Florida, Morsani College of Medicine, Tampa, FL 33602, USA. Electronic address:

Background: COVID-19 has been associated with Interstitial Lung Disease features. The immune transcriptomic overlap between Idiopathic Pulmonary Fibrosis (IPF) and COVID-19 has not been investigated.

Methods: we analyzed blood transcript levels of 50 genes known to predict IPF mortality in three COVID-19 and two IPF cohorts. Read More

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Tracheostomy and Long-Term Mechanical Ventilation in Children after Veno-Venous Extracorporeal Membrane Oxygenation.

Pediatr Pulmonol 2021 Jun 22. Epub 2021 Jun 22.

Division of Pediatric Critical Care, Riley Hospital for Children, Indiana University, Indianapolis, IN.

Objective: Our objective is to characterize the incidence of tracheostomy placement and of new requirement for long-term mechanical ventilation after extracorporeal membrane oxygenation (ECMO) among children with acute respiratory failure. We examine whether an association exists between demographics, pre-ECMO and ECMO clinical factors, and the placement of a tracheostomy or need for long-term mechanical ventilation.

Methods: A retrospective multicenter cohort study was conducted at 10 quaternary care pediatric academic centers, including children supported with veno-venous (V-V) ECMO from 2011 to 2016. Read More

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COVID-19 morbidity and mortality associated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers use among 14,129 patients with hypertension from a US integrated healthcare system.

Int J Cardiol Hypertens 2021 Jun 15;9:100088. Epub 2021 Jun 15.

Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.

Objective: Although recent evidence suggests no increased risk of severe COVID-19 outcomes associated with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) use, the relationship is less clear among patients with hypertension and diverse racial/ethnic groups. This study evaluates the risk of hospitalization and mortality among patients with hypertension and COVID-19 in a large US integrated healthcare system.

Methods: Patients with hypertension and COVID-19 (between March 1- September 1, 2020) on ACEIs or ARBs were compared with patients on other frequently used antihypertensive medications. Read More

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Experimental evaluation of particle exposure at different seats in a single-aisle aircraft cabin.

Build Environ 2021 Sep 16;202:108049. Epub 2021 Jun 16.

Tianjin Key Laboratory of Indoor Air Environmental Quality Control, School of Environmental Science and Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China.

During the COVID-19 pandemic, exposure to particles exhaled by infected passengers in commercial aircraft cabins has been a great concern. Currently, aircraft cabins adopt mixing ventilation. However, complete mixing may not be achieved, and thus the particle concentration in the respiratory zone may vary from seat to seat in a cabin. Read More

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September 2021

Outcomes for head and neck cancer patients admitted to intensive care in Australia and New Zealand between 2000 and 2016.

J Laryngol Otol 2021 Jun 22:1-8. Epub 2021 Jun 22.

Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.

Objective: To report intensive care unit admission outcomes for head and neck cancer patients.

Methods: A retrospective, observational cohort analysis of all Australian and New Zealander head and neck cancer patient intensive care unit admissions from January 2000 to June 2016, including data from 192 intensive care units.

Results: There were 10 721 head and neck cancer patients, with a median age of 64 years (71. Read More

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Covid-19 severe hypoxemic pneumonia: A clinical experience using high-flow nasal oxygen therapy as first-line management.

Respir Med Res 2021 Jun 4;80:100834. Epub 2021 Jun 4.

UNIROUEN, Inserm U1096, medical intensive care unit, Rouen university hospital, Normandie university, 76000 Rouen, France.

Purpose: To report a French experience in patients admitted to Intensive Care Unit (ICU) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requiring high fractional concentration of inspired oxygen supported by high flow nasal cannula (HFNC) as first-line therapy.

Methods: Retrospective cohort study conducted in two ICUs of a French university hospital. All consecutive patients admitted during 28-days after the first admission for SARS-CoV-2 pneumonia were screened. Read More

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Hypoglossal nerve stimulation for obstructive sleep apnea: updated position paper of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery.

Eur Arch Otorhinolaryngol 2021 Jun 21. Epub 2021 Jun 21.

Work Group Apnea of the German Society for Sleep Research and Medicine (DGSM) (DGSM), Schwalmstadt-Treysa, Germany.

Since the first statement of the German Society of Oto-Rhino-Laryngology, hypoglossal nerve stimulation (HNS) is meanwhile an established treatment option for obstructive sleep apnea (OSA). There are three HNS systems available in Germany which differ in their technical details of the underlying comparable basic principle. For the unilateral HNS with respiratory sensing, several comparative studies, high-volume register analysis and long-term reports exist. Read More

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Cardiopulmonary Pathophysiological Aspects in the Context of COVID-19 and Obesity.

SN Compr Clin Med 2021 Jun 14:1-10. Epub 2021 Jun 14.

Service de maladies infectieuses, Hôpital Raymond Poincaré, APHP, AP-HP, Université Paris Saclay/UFR Simone Veil-Santé-Université de Versailles Saint Quentin en Yvelines, Garches, France.

Obesity is a significant public health concern associated with high morbidity. Obese patients are at risk of severe COVID-19 infection, and obesity is a high-risk factor for admission to the intensive care unit. We aimed to write a narrative review of cardiac and pulmonary pathophysiological aspects of obese patients in the context of COVID-19 infection. Read More

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causing early onset neonatal sepsis complicated by solitary liver abscess in a preterm infant.

Access Microbiol 2021 Mar 3;3(3):000200. Epub 2021 Feb 3.

Department of Neonatology, KK Women's and Children's Hospital, Singapore.

) is an uncommon but increasingly recognized cause of neonatal sepsis and meningitis. Liver abscess in neonates is extremely rare. But liver abscess due to SG has never been reported in the literature. Read More

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HVAC system attack detection dataset.

Data Brief 2021 Aug 28;37:107166. Epub 2021 May 28.

Department of Computer Science and Engineering, Washington University in St. Louis, USA.

The importance of the security of building management systems (BMSs) has increased given the advances in the technologies used. Since the Heating, Ventilation, and Air Conditioning (HVAC) system in buildings accounts for about 40% of the total energy consumption, threats targeting the HVAC system can be quite severe and costly. Given the limitations on accessing a real HVAC system for research purposes and the unavailability of public labeled datasets to investigate the cybersecurity of HVAC systems, this paper presents a dataset of a 12-zone HVAC system that was collected from a simulation model using the Transient System Simulation Tool (TRNSYS). Read More

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Airborne Spread of Methicillin Resistant From a Swine Farm.

Front Vet Sci 2021 4;8:644729. Epub 2021 Jun 4.

Department of Environmental Science, Aarhus University, Roskilde, Denmark.

Spread of livestock-associated methicillin resistant (LA-MRSA) to farmworkers has been recognized as a risk when working in LA-MRSA positive stables, due to LA-MRSA being present on airborne dust particles. Based on this, airborne spread of LA-MRSA through stable vents is a concern that is addressed in this study. The aim of the investigation was to quantify the airborne spread of LA-MRSA from a MRSA positive swine farm. Read More

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Environmental Tobacco Smoke in Occupational Settings: Effect and Susceptibility Biomarkers in Workers From Lisbon Restaurants and Bars.

Front Public Health 2021 4;9:674142. Epub 2021 Jun 4.

Department of Human Genetics, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.

Environmental tobacco smoke (ETS) has been recognized as a major health hazard by environmental and public health authorities worldwide. In Portugal, smoke-free laws are in force for some years, banning smoking in most indoor public spaces. However, in hospitality venues such as restaurants and bars, owners can still choose between a total smoke-free policy or a partial smoking restriction with designated smoking areas, if adequate reinforced ventilation systems are implemented. Read More

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Changes in Physicians' Perceptions and Practices on Neonatal Pain Management Over the Past 20 Years. A Survey Conducted at Two Time-Points.

Front Pediatr 2021 4;9:667806. Epub 2021 Jun 4.

1st Department of Neonatology and Neonatal Intensive Care, School of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, Thessaloniki, Greece.

Intense research for more than three decades expelled the view that neonates do not experience pain. The aim of this survey was to investigate whether the Greek physicians involved in neonatal intensive care have changed their perceptions regarding neonatal pain, adapting their management practices to the knowledge that have emerged in the past 20-years. This study is a survey conducted at two time-points, 20 years apart. Read More

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Prolonged Hypophosphatemia and Intensive Care After Curative Surgery of Tumor Induced Osteomalacia: A Case Report.

Front Endocrinol (Lausanne) 2021 3;12:686135. Epub 2021 Jun 3.

Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Introduction: Rare FGF23-producing mesenchymal tumors lead to paraneoplastic tumor-induced osteomalacia (TIO) presenting with phosphate wasting, hypophosphatemia, chronic hypomineralization of the bone, fragility fractures and muscle weakness. Diagnosis of TIO requires exclusion of other etiologies and careful search for a mesenchymal tumor that often is very small and can appear anywhere in the body. Surgical removal of the tumor is the only definitive treatment of TIO. Read More

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The use of electrical impedance tomography (EIT) to evaluate pulse rate in anaesthetised horses.

Vet J 2021 Jul 14;273:105694. Epub 2021 May 14.

Department of Anesthesiology and Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany.

Electrical impedance tomography (EIT) provides clinically useful lung images; however, it would be an advantage to extract additional cardiovascular information from the data. The aim of this study was to evaluate if cardiac-related changes measured by EIT can be used to measure pulse rate (PR) under physiological as well as high and low blood pressure states in anaesthetised horses. Electrical impedance tomography data and PR from seven horses anaesthetised in dorsal recumbency were recorded over 1 min during mechanical ventilation and 1 min of apnoea. Read More

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Assessing flammable storage cabinets as sources of VOC exposure in laboratories using real-time direct reading wireless detectors.

J Chem Health Saf 2018 Sep;25(5):2-9

NIOSH (National Institute for Occupational Safety and Health), 1090 Tusculum Ave., Cincinnati, OH 45226, United States.

Herein we present the results of measurements using wireless direct-reading photoionization detector-based gas sensors to quantify concentrations of vapors of volatile organic compounds (VOCs) in and around flammable storage cabinets containing common organic solvents, including acetone, dichloromethane, trichloroethylene, and benzene. Such cabinets are commonly employed in laboratories to contain flammable liquids. A sensor array was deployed in a series of flammable storage cabinets in working laboratories. Read More

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September 2018

Early tracheostomy for managing ICU capacity during the COVID-19 outbreak: a propensity-matched cohort study.

Chest 2021 Jun 17. Epub 2021 Jun 17.

Intensive Care Unit, University Hospital Virgen de la Salud. Toledo, Spain.

Background: During the first wave of the COVID-19 pandemic, shortages of ventilators and intensive care unit (ICU) beds overwhelmed healthcare systems. Whether early tracheostomy reduces the duration of mechanical ventilation and ICU stay is controversial.

Research Question: Can "failure-free days" outcomes focused on ICU resources could help decide the optimal timing of tracheostomy in overburdened healthcare systems during viral epidemics?

Study Design And Methods: This retrospective cohort study included consecutive patients with COVID-19 pneumonia tracheostomized in 15 Spanish ICUs during the surge, when ICU occupancy modified clinicians criteria to perform tracheostomy in COVID-19 patients. Read More

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Duration of Carbapenemase-producing Enterobacteriales Carriage among ICU Patients in Miami, FL: a Retrospective Cohort Study.

Am J Infect Control 2021 Jun 16. Epub 2021 Jun 16.

Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, Florida.

Background: Current recommendations by the Centers for Disease Control and Prevention (CDC) suggest placing patients with carbapenem-producing Enterobacteriales (CPE) in contact precautions (CP), but there is no consensus on the appropriate duration of precautions.

Aim: We aimed to evaluate predictors for prolonged CPE carriage and median clearance time.

Methods: Patients with first isolated CPE identified from 2012 to 2016 were followed for clearance of CPE using at least two rectal or tracheal aspirate surveillance cultures and clinical cultures during intensive-care-unit (ICU) admission. Read More

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COVID-19 and post-traumatic stress disorder among nurses: a descriptive cross-sectional study in a COVID hospital.

Med Lav 2021 Jun 15;112(3):241-249. Epub 2021 Jun 15.

Department of Clinical Psychology, Crema Hospital, Italy.

Background: In March 2020, the World Health Organisation (WHO) declared the novel coronavirus (COVID-19) outbreak a global pandemic. Healthcare professionals directly involved in diagnosing, treating and caring for patients with COVID-19 are at risk of developing post-traumatic stress disorder (PTSD).

Objective: This study investigated the prevalence of PTSD among nurses working in a COVID hospital and evaluated associated factors. Read More

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The effect of coincidental SARS-CoV-2 infection on pre-operative cardiopulmonary exercise testing.

Anaesth Rep 2021 Jan-Jun;9(1):122-126. Epub 2021 Jun 9.

Department of Anaesthesia University Hospital of Wales Cardiff UK.

This case report demonstrates the significant impact active infection with SARS-CoV-2 can have on functional capacity evaluated by cardiopulmonary exercise testing, even in minimally symptomatic individuals. A 75-year-old man underwent cardiopulmonary exercise testing before a right hemicolectomy; SARS-CoV-2 was incidentally diagnosed following his test. The patient underwent a period of isolation and recovery before a second pre-operative cardiopulmonary exercise test 6 weeks later. Read More

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Intensivists' response to hyperoxemia in mechanical ventilation patients: The status quo and related factors.

World J Emerg Med 2021 ;12(3):202-206

Department of Emergency Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Background: Due to the still sparse literature in China, the investigation of hyperoxemia management is required. Thus, we aim to conduct a retrospective study to provide more information about hyperoxemia management in intensive care unit (ICU) patients.

Methods: We retrospectively screened the medical records of adult patients (age ≥18 years) who required mechanical ventilation (MV) ≥24 hours from January 1, 2018, to December 31, 2018. Read More

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January 2021

Management of Asthma Exacerbations in Southeast Asian Tertiary Care.

J Asthma Allergy 2021 10;14:629-640. Epub 2021 Jun 10.

The Lung Centre, Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Background: There have been limited reports looking into the care of patients with asthma exacerbations admitted to tertiary hospitals in Southeast Asia. This study aims to determine the extent in which the 2019 Global Initiative for Asthma (GINA) guidelines were being met.

Methods: A retrospective study of patients with asthma exacerbations admitted to the University of Malaya Medical Centre (UMMC) and Pantai Hospital Kuala Lumpur (PHKL), Malaysia from 1 July 2019 to 31 December 2019. Read More

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Optimal Nutritional Factors Influencing the Duration of Mechanical Ventilation Among Adult Patients with Critical Illnesses in an Intensive Care Unit.

J Multidiscip Healthc 2021 10;14:1385-1393. Epub 2021 Jun 10.

College of Allied Health Sciences, Suan Sunandha Rajabhat University, Samut Songkram, Thailand.

Objective: This study aims to identify the impact of nutritional factors on mechanical ventilation duration for critical patients.

Patients And Methods: The current study was a single-center, prospective observational design which enrolled one-hundred critically ill patients who were admitted to an intensive care unit (ICU). It demonstrates purposive sampling and also performs the descriptive nutritional factors influencing the mechanical ventilation duration. Read More

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Post-COVID-19 rehabilitation - a Polish pilot program.

Med Pr 2021 Jun 10. Epub 2021 Jun 10.

Opole University of Technology, Opole, Poland (Faculty of Physical Education and Physiotherapy).

The current spread of SARS-CoV-2 indicates a long-term fight against the widespread and exponential increase in morbidity and mortality across the globe. A variety of non-pharmacological strategies to mitigate and suppress virus transmission have been investigated and introduced. Currently, emerging studies focus mostly on the management of hospital-treated patients in the acute phase of the disease, including the legitimacy of using physiotherapeutic procedures. Read More

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SARS-CoV-2 and the role of fomite transmission: a systematic review.

F1000Res 2021 24;10:233. Epub 2021 Mar 24.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, UK.

SARS-CoV-2 RNA has been detected in fomites which suggests the virus could be transmitted via inanimate objects. However, there is uncertainty about the mechanistic pathway for such transmissions. Our objective was to identify, appraise and summarise the evidence from primary studies and systematic reviews assessing the role of fomites in transmission. Read More

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Review of biological risks associated with the collection of municipal wastes.

Sci Total Environ 2021 Jun 5;791:148287. Epub 2021 Jun 5.

HSE Science and Research Centre, Harpur Hill, Buxton, Derbyshire SK17 9JN, UK.

In many countries, the management of household waste has recently changed with an increased focus upon waste sorting resulting in lower collection frequency for some waste fractions. A consequence of this is the potential for increased growth of microorganisms in the waste before collection, which can lead to an increased exposure via inhalation for waste collection workers. Through a review of the literature, we aimed to evaluate risks caused by waste collecting workers' exposure to bioaerosols and to illuminate potential measures to reduce the exposure. Read More

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Clinical outcome, risk assessment, and seasonal variation in hospitalized COVID-19 patients-Results from the CORONA Germany study.

PLoS One 2021 17;16(6):e0252867. Epub 2021 Jun 17.

Semmelweis University, Budapest, Hungary.

Background: After one year of the pandemic and hints of seasonal patterns, temporal variations of in-hospital mortality in COVID-19 are widely unknown. Additionally, heterogeneous data regarding clinical indicators predicting disease severity has been published. However, there is a need for a risk stratification model integrating the effects on disease severity and mortality to support clinical decision-making. Read More

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Early prediction of lung lesion progression in COVID-19 patients with extended CT ventilation imaging.

Eur J Nucl Med Mol Imaging 2021 Jun 17. Epub 2021 Jun 17.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Wuhan, 430071, China.

Purpose: In the prediction of COVID-19 disease progression, a clear illustration and early determination of an area that will be affected by pneumonia remain great challenges. In this study, we aimed to predict and visualize the progression of lung lesions in COVID-19 patients in the early stage of illness by using chest CT.

Methods: COVID-19 patients who underwent three chest CT scans in the progressive phase were retrospectively enrolled. Read More

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Factors Influencing the Length of Hospital Stay Among Patients with Chronic Obstructive Pulmonary Disease (COPD) in Macao Population: A Retrospective Study of Inpatient Health Record.

Int J Chron Obstruct Pulmon Dis 2021 9;16:1677-1685. Epub 2021 Jun 9.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.

Purpose: This study aims to identify the effects of patient and clinical therapy factors on the length of hospital stay (LOS) for admission due to chronic obstructive pulmonary disease (COPD) in Macao.

Patients And Methods: Health record of patients with COPD admitted to Kiang Wu Hospital from January 2017 to December 2019 was retrospectively analyzed. Demographic information, blood test results, clinical therapies, and LOS were described and analyzed by multivariable regression. Read More

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Evolution of the nutritional status of COVID-19 critically-ill patients: A prospective observational study from ICU admission to three months after ICU discharge.

Clin Nutr 2021 May 24. Epub 2021 May 24.

Université de Paris, F-75015, Paris, France; Assistance Publique-Hôpitaux de Paris (AP-HP), Service de Réanimation Médicale, Hôpital Européen Georges Pompidou, Paris, France; Institut Du Cerveau et de La Moelle épinière - ICM, Inserm U1127, CNRS UMR 7225, F-75015, Paris, France.

Background & Aims: Malnutrition following intensive care unit (ICU) stay is frequent and could be especially prominent in critically ill Coronavirus Disease 2019 (COVID-19) patients as they present prolonged inflammatory state and long length stay. We aimed to determine the prevalence of malnutrition in critically ill COVID-19 patients both at the acute and recovery phases of infection.

Methods: We conducted a prospective observational study including critically ill COVID-19 patients requiring invasive mechanical ventilation discharged alive from a medical ICU of a university hospital. Read More

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