29,690 results match your criteria venous thromboembolism

Sex-Based Differences in COVID-19 Outcomes.

J Womens Health (Larchmt) 2021 Apr;30(4):492-501

Division of Cardiology, Lenox Hill Hospital, Northwell Health, New York, New York, USA.

Smaller studies suggest lower morbidity and mortality associated with coronavirus disease 2019 (COVID-19) in women. Our aim is to assess the impact of female sex on outcomes in a large cohort of patients hospitalized with COVID-19. This is a retrospective observational cohort study of 10,630 adult patients hospitalized with a confirmed COVID-19 polymerase chain reaction between March 1, 2020 and April 27, 2020, with follow-up conducted through June 4, 2020. Read More

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Use of Pharmacologic Prophylaxis Against Venous Thromboembolism in Hospitalized Injured Children.

J Pediatr Hematol Oncol 2021 Apr 21. Epub 2021 Apr 21.

Division of Hematology CHOC Children's Hospital, Orange, CA Division of Pediatric Surgery Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, NC Section of Critical Care, Department of Pediatrics Children's Wisconsin/Medical College of Wisconsin, Milwaukee, WI Section of General Pediatrics, Department of Pediatrics Section of Pediatric Critical Care, Department of Pediatrics, Yale School of Medicine, New Haven, CT.

Despite a practice management guideline and risk prediction model for venous thromboembolism (VTE), pediatric-specific evidence on pharmacologic prophylaxis is lacking. In a retrospective study, we characterized receipt of prophylaxis and explored its effectiveness in hospitalized injured patients below 18 years old using data from the Trauma Quality Improvement Program. Concordance of receipt of prophylaxis with guideline and predicted risk of VTE was estimated using κ statistic. Read More

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Predictors of Length of Hospital Stay, Mortality, and Outcomes Among Hospitalised COVID-19 Patients in Saudi Arabia: A Cross-Sectional Study.

J Multidiscip Healthc 2021 15;14:839-852. Epub 2021 Apr 15.

Department of Internal Medicine, Al Noor Specialist Hospital, Mecca, Saudi Arabia.

Background: COVID-19 pandemic is a major strain on health and economic systems, with rapidly increasing demand for in patients' facilities. Disease diagnosis and estimating patients at higher risk is important for the optimal management during the pandemic. This study aimed to identify the predictors of mortality and length of hospital stay in COVID-19 patients. Read More

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Venous Thromboembolism in Trauma: The Role of Anticoagulation and Inferior Vena Cava Filters.

Semin Intervent Radiol 2021 Mar 15;38(1):40-44. Epub 2021 Apr 15.

Division of Interventional Radiology, Department of Radiology, Northwestern University, Chicago, Illinois.

Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality among patients with severe trauma. Historically, prophylactic inferior vena cava filters (IVCFs) were used in high-risk trauma patients with suspected risk factors for VTE, including prolonged immobilization, and concurrent contraindication to anticoagulation. Mounting data regarding the efficacy of IVCF in this cohort, as well as concerns regarding morbidity of an in situ IVCF, have challenged this practice paradigm. Read More

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Thromboelastography-Guided Anticoagulant Therapy for the Double Hazard of Thrombohemorrhagic Events in COVID-19: A Report of 3 Cases.

Am J Case Rep 2021 Apr 1;22:e931080. Epub 2021 Apr 1.

Indiana University School of Medicine South Bend Campus, Notre Dame, IN, USA.

BACKGROUND The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), often manifests a coagulopathy in severely ill patients, which may cause hemorrhage and/or thrombosis of varying severity. This report comprises the cases of 3 patients with COVID-19-associated coagulopathy who were evaluated with thromboelastography (TEG) and activated partial thromboplastin time (aPTT) to enable personalized anticoagulant therapy. CASE REPORT Three patients presented with COVID-19 pneumonia, confirmed by reverse transcription-polymerase chain reaction, who developed thrombohemorrhagic coagulopathy. Read More

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Peripheral thrombosis causing simultaneous saddle pulmonary embolism and paradoxical ST elevation myocardial infarction resulting in cardiovascular collapse.

BMJ Case Rep 2021 Apr 21;14(4). Epub 2021 Apr 21.

Department of Cardiology, St Vincent Hospital, Worcester, Massachusetts, USA.

Paradoxical coronary artery embolism is often an underdiagnosed cause of acute myocardial infarction (MI). It should always be considered in patient with acute MI and a low risk profile for atherosclerotic coronary artery disease. We describe a patient with simultaneous acute saddle pulmonary embolism (PE) and acute ST segment elevation MI due to paradoxical coronary artery embolism. Read More

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Diagnosis of venous thromboembolism using clinical pretest probability rules, D-dimer assays, and imaging techniques.

Joanne Thanavaro

Nurse Pract 2021 May;46(5):15-22

Joanne Thanavaro is Associate Dean for Graduate Education at St. Louis University Trudy Busch Valentine School of Nursing, St. Louis, Mo.

Abstract: Venous thromboembolism is a significant clinical entity that includes two associated medical disorders: deep vein thrombosis and pulmonary embolism. The goal of this article is to describe the optimal approach to evaluating venous thromboembolism including pretest probability clinical decision rules and appropriate testing to ensure an accurate diagnosis. Read More

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Lupus anticoagulant single positivity at acute phase is not associated with venous thromboembolism or in-hospital mortality in COVID-19.

Arthritis Rheumatol 2021 Apr 21. Epub 2021 Apr 21.

Université de Paris, Innovative Therapies in Haemostasis, INSERM, F-75006 Paris, France, Hematology department and Biosurgical research lab (Carpentier Foundation), Assistance Publique Hôpitaux de Paris.Centre-Université de Paris (APHP-CUP), F-75015, Paris, France.

Introduction: Antiphospholipid antibodies (APA) clinical relevance in COVID-19 is controversial. We aimed to investigate the prevalence and prognostic value of conventional and non-conventional APA in COVID-19 patients.

Methods: This study was a multi-centric, prospective observational French cohort of patients hospitalized for COVID-19 suspicion. Read More

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Pulmonary complications of sickle cell disease: a narrative clinical review.

Adv Respir Med 2021 Apr 21. Epub 2021 Apr 21.

Division of Pulmonary, Critical Care and Sleep Medicine Wayne State University School of Medicine Detroit, United States.

Sickle cell disease (SCD) is associated with vaso-occlusive episodes that affect different organs. Pulmonary involvement is a major cause of morbidity and mortality in this patient population. We performed a literature search in the PubMed database for articles addressing SCD and pulmonary diseases. Read More

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An Unexpected Factor to Wellens Syndrome.

Cureus 2021 Apr 14;13(4):e14489. Epub 2021 Apr 14.

Cardiology, Upstate University Hospital, Syracuse, USA.

Factor V Leiden deficiency, the most common inherited thrombophilia, is a risk factor for venous thromboembolism in both the heterozygous and homozygous forms. An autosomal dominant genetic condition, the pattern of incomplete penetrance leads to variable manifestations of the disease. The association with arterial thromboembolism remains controversial, with studies indicating modest increases in risk of coronary artery disease, stroke. Read More

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Submassive Pulmonary Embolism in Mild COVID-19 Without Lung Infiltrates.

Cureus 2021 Mar 18;13(3):e13978. Epub 2021 Mar 18.

Department of Pulmonary, Critical Care and Sleep Medicine, University of Connecticut Health, Farmington, USA.

A 66-year-old man who had been diagnosed with mild coronavirus 2019 (COVID-19) infection nine days prior presented to the emergency room with acute-onset chest pain and shortness of breath. Chest CT angiogram (CTA) revealed pulmonary emboli (PE) in the right and left pulmonary arteries with right heart strain; lung parenchyma showed no infiltrates. Although severe COVID-19 infection is associated with thrombotic complications, data regarding the occurrence of PE in mild cases of COVID-19 is scarce. Read More

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Thromboembolic Disease in COVID-19.

J Clin Imaging Sci 2021 26;11:16. Epub 2021 Mar 26.

Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States.

Coronavirus disease 2019 (COVID-19) was initially recognized in late December 2019 and has quickly spread globally with over 114 million reported cases worldwide at the time of this publication. For the majority of patients infected with COVID-19, the clinical manifestations are absent or mild. In more advanced cases, severe respiratory dysfunction is the leading cause of morbidity and mortality. Read More

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Rationales and uncertainties for aspirin use in COVID-19: a narrative review.

Fam Med Community Health 2021 Apr;9(2)

Department of Family Medicine, Suez Canal University Faculty of Medicine, Ismailia, Egypt.

Objectives: To review the pathophysiology of COVID-19 disease, potential aspirin targets on this pathogenesis and the potential role of aspirin in patients with COVID-19.

Design: Narrative review.

Setting: The online databases PubMed, OVID Medline and Cochrane Library were searched using relevant headlines from 1 January 2016 to 1 January 2021. Read More

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Audit and Feedback to Surgery Interns and Residents on Prescribing Risk-Appropriate Venous Thromboembolism Prophylaxis.

J Surg Educ 2021 Apr 17. Epub 2021 Apr 17.

Russell H. Morgan Department of Radiology and Radiological Science; Division of Health Sciences Informatics; Armstrong Institute for Patient Safety and Quality, Johns Hopkins University School of Medicine; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Objective: To evaluate the effectiveness of feedback using an emailed scorecard and a web-based dashboard on risk-appropriate VTE prophylaxis prescribing practices among general surgery interns and residents.

Design: Prospective cohort study.

Setting: The Johns Hopkins Hospital, an urban academic medical center. Read More

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An evaluation of venous thromboembolism by whole-body enhanced CT scan for critical COVID-19 pneumonia with markedly rises of coagulopathy related factors: a case series study.

Thromb J 2021 Apr 20;19(1):26. Epub 2021 Apr 20.

Department of Emergency Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.

Background: Coronavirus disease (COVID-19) pneumonitis associated with severe respiratory failure has a high mortality rate. Based on recent reports, the most severely ill patients present with coagulopathy, and disseminated intravascular coagulation (DIC)-like massive intravascular clot formation is frequently observed. Coagulopathy has emerged as a significant contributor to thrombotic complications. Read More

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Consensus on thromboprophylaxis in gynecological surgery

Rev Colomb Obstet Ginecol 2021 03 30;72(1):53-68. Epub 2021 Mar 30.


Objective: To draw a synthesis of the available evidence regarding interventions for the prevention of venous thromboembolic events during the perioperative care of women with benign gynecological pathology, with the aim of reducing the associated morbidity and mortality. Materials and methods: The development group included healthcare professionals, decision-makers and one patient representative. All the participants stated their disclosures. Read More

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Failure of the Ottawa Score to Predict the Risk of Recurrent Venous Thromboembolism in Cancer Patients: The Prospective PREDICARE Cohort Study.

Thromb Haemost 2021 Apr 20. Epub 2021 Apr 20.

Georges Pompidou European Hosp, Paris, France.

Introduction: Recurrent venous thromboembolism (VTE) despite curative anticoagulation is frequent in patients with cancer. Identifying patients with a high risk of recurrence could have therapeutic implications. A prospective study was designed to validate the Ottawa risk score of recurrent VTE in cancer patients. Read More

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Fibrinolysis in Venous Thromboembolism.

Anetta Undas

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.

Fibrinolysis is of paramount importance in maintaining or regaining the patency of veins and pulmonary arteries obstructed by thrombi. Growing experimental and clinical evidence indicates that impaired fibrinolysis mediated by multiple complex mechanisms is involved in venous thromboembolism (VTE). Global plasma fibrin clot lysis markers, especially clot lysis time, have been reported to predict recurrent deep-vein thrombosis and pulmonary embolism. Read More

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Guideline No. 417: Prevention of Venous Thromboembolic Disease in Gynaecological Surgery: (En français : Prévention de la maladie thromboembolique veineuse en chirurgie gynécologique).

J Obstet Gynaecol Can 2021 Apr 17. Epub 2021 Apr 17.

Hamilton, ON.

Objective: The primary objective of this clinical practice guideline is to provide gynaecologists with an algorithm and evidence to guide the use of thromboprophylaxis in gynaecological surgery.

Target Population: All patients undergoing gynaecological surgery for benign or malignant indications.

Benefits, Harms, And Costs: The implementation of this guideline will benefit patients undergoing gynaecological surgery and provide physicians with a standard algorithm for the use of perioperative thromboprophylaxis. Read More

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Case of right ventricular and aortic thrombi in a patient with severe COVID-19.

BMJ Case Rep 2021 Apr 19;14(4). Epub 2021 Apr 19.

Department of Hematology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Emerging evidence suggests that novel COVID-19 is associated with increased prothrombotic state and risk of thromboembolic complications, particularly in severe disease. COVID-19 is known to predispose to both venous and arterial thrombotic disease. We describe a case of a 61-year-old woman with history of type II diabetes, hypertension and hyperlipidaemia who presented with dry cough and acute abdominal pain. Read More

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Prevalence of proximal deep vein thrombosis in hospitalized COVID-19 patients.

Eur J Intern Med 2021 Apr 8. Epub 2021 Apr 8.

Service de pneumologie B, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris; Inserm UMR1152, Université Paris7 Denis Diderot, 75018Paris, France. Electronic address:

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Economic Evaluation of New Oral Anticoagulants in Prevention of Venous Thrombosis Following Joint Replacement Surgery: A Systematic Review.

Clin Ther 2021 Apr 16. Epub 2021 Apr 16.

Health Management and Economics Research Center, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

Purpose: The main purpose of prescribing oral anticoagulants in patients undergoing total knee and total hip replacement surgery is to prevent venous thromboembolism (VTE). The present study aimed to summarize evidence from economic evaluations regarding new oral anticoagulants (NOACs) used in VTE prophylaxis after joint replacement surgery.

Methods: To obtain relevant literature on economic evaluations of NOACs used in the prevention of VTE following joint replacement surgery, we searched the Cochrane Library, PubMed, Web of Science, Embase, and Scopus, as well as specialized economic evaluation databases, for articles published from January 2008 to December 2019. Read More

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Single center experience of inferior vena cava filter retrieval in trauma patients: contrast-enhanced CT-based retrieval within hospital stay.

Clin Imaging 2021 Apr 13;79:43-47. Epub 2021 Apr 13.

Department of Orthopedic Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea. Electronic address:

Purpose: To assess the safety and retrieval rate of a predischarge inferior vena cava (IVC) filter retrieval strategy based on contrast computed tomography (CT).

Methods: IVC filter insertion for trauma patients from 2010 to 2018 were reviewed. An active filter retrieval strategy was established in March 2017. Read More

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Cause of death based on systematic postmortem studies in patients with positive SARS-CoV2 tissue PCR during the COVID-19 pandemic.

J Intern Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.

Importance: Assessment of the causative association between the COVID-19 and cause of death has been hampered by limited availability of systematically performed autopsies. We aimed to present autopsy-confirmed causes of death in patients who died with COVID-19 and to assess the association between thrombosis and diffuse alveolar damage consistent with COVID-19 (DAD).

Methods: Consecutive forensic (n=60) and clinical (n=42) autopsies with positive postmortem SARS-CoV2 PCR in lungs (age 73±14 years, 50% men) were included. Read More

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Is Obesity Associated With an Increased Risk of Complications After Surgical Management of Acetabulum and Pelvis Fractures? A Systematic Review.

J Am Acad Orthop Surg Glob Res Rev 2021 04 19;5(4). Epub 2021 Apr 19.

From the Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA (Dr. Mittwede, Dr. Gibbs, and Dr. Tarkin); the Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI (Dr. Ahn); and the Department of Orthopaedic Surgery, University of Mississippi Medical Center, Jackson, MS (Dr. Bergin).

Background: When considering surgical fixation of acetabulum and pelvis fractures in patients with obesity, a thorough understanding of the risks of potential complications is important. We performed a systematic review to evaluate whether obesity is associated with an increased risk of complications after surgical management of acetabulum and pelvis fractures.

Methods: We searched PubMed/MEDLINE, EMBASE, and the Cochrane Library for studies published through December 2020 that reported the effect of increased body mass index (BMI) or obesity on the risk of complications after surgical treatment of acetabulum and pelvis fractures. Read More

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Do Inpatients Receive Risk-Based Prophylactic Treatment for Thrombotic Events?

Clin Appl Thromb Hemost 2021 Jan-Dec;27:1076029621995563

568072University Heart Center Freiburg - Bad Krozingen, Department of Cardiology and Angiology I, Faculty of Medicine, University of Freiburg, Germany.

Background: Current guidelines recommend risk-based use of prophylaxis for preventing medical inpatients from venous thromboembolism (VTE). Little is known about the current prescription practice, and even less whether differences between subspecialists like cardiologists, usually treating patients with thrombotic or thromboembolic diseases, and gastroenterologists, treating more patients with gastrointestinal bleeding complications, exist.

Methods: We performed a retrospective chart review of patients on cardiology and gastroenterology wards of our university hospital. Read More

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Cardiovascular Events in Men with Prostate Cancer Receiving Hormone Therapy: An Analysis of the FDA Adverse Event Reporting System (FAERS).

J Urol 2021 Apr 19:101097JU0000000000001785. Epub 2021 Apr 19.

Harrington Heart and Vascular Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Purpose: The comparative cardiovascular risk profiles of available hormone therapies for the treatment of prostate cancer is not known.

Materials And Methods: We queried the FDA Adverse Event Reporting System (FAERS), a retrospective, pharmacovigilance database, for cardiovascular adverse event reports in men with prostate cancer receiving gonadotropin releasing hormone (GnRH) agonists, GnRH antagonists, androgen receptor antagonists, and/or androgen synthesis inhibitors from January 2000 to April 2020.

Results: Cardiovascular adverse events accounted for 6,231 reports (12. Read More

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Treatment of pulmonary artery stump thrombosis after lobectomy: a case report and literature review.

Adv Respir Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgery, National Research Institute of Tuberculosis and Lung Diseases, Warsaw, Poland, Warsaw, Poland.

Introduction: Lung cancer surgery is a well-known risk factor for venous thromboembolism. Thus, standard care involves the use of pharmacological and mechanical prophylaxis until discharge from the hospital. Pulmonary artery stump thrombosis (PAST) is a rare condition which can develop months to years after lung cancer surgery. Read More

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Rare and Underestimated Association of Pulmonary Embolism and Olanzapine Therapy; Report of Two Cases.

Arch Acad Emerg Med 2021 5;9(1):e17. Epub 2021 Feb 5.

Department of Cardiology, Mohammed VI University Hospital of Oujda, Mohammed First University of Oujda, Morocco.

Venous thromboembolic disease (VTD) is a very common and severe pathological condition in which there are many predisposing factors. Olanzapine is a drug frequently used in psychiatric practises; it is thought to increase the risk of VTD. Here, we report two cases, a young man and a woman, with a medical history of schizophrenia treated by olanzapine who developed pulmonary embolism and we did not find any aetiologies of VTD in them. Read More

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February 2021