33,795 results match your criteria vast majority

Reactivation of latent infections in solid organ transplant recipients from sub-Saharan Africa: What should be remembered?

Transplant Rev (Orlando) 2021 Jun 2;35(4):100632. Epub 2021 Jun 2.

Unit of Infectious Diseases, University Hospital "12 de Octubre", Research Institute Hospital "12 de Octubre" (imas12), Madrid, Spain; Department of Medicine, Universidad Complutense, Madrid, Spain.

International migration from Sub-Saharan African countries to the European Union and the United States has significantly increased over the past decades. Although the vast majority of these immigrants are young and healthy people, a minority can be affected by chronic conditions eventually leading to solid organ transplantation (SOT). Importantly, these candidates can bear geographically restricted fungal and parasitic latent infections that can reactivate after the procedure. Read More

View Article and Full-Text PDF

Comparison of injectable filler locations in men and women: An age-matched case analysis.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Laser & Skin Surgery Center of New York, New York, NY, USA.

In recent years, the popularity of fillers has risen significantly. Traditionally, women have undergone the vast majority of cosmetic procedures, but men have steadily shown increasing interest. Recently, significant research has been dedicated to understanding the anatomic differences between male and female facial structures and their clinical aesthetic implications, especially for filler placement. Read More

View Article and Full-Text PDF

Pyridine moiety: An insight into recent advances in treatment of cancer.

Mini Rev Med Chem 2021 Jun 14. Epub 2021 Jun 14.

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-II, Greater Noida-201306, India.

The incidence of cancer is increasing worldwide, affecting a vast majority of the human population. As new different anticancer agents are being developed now, the requirement is to deal somehow with them and evaluate their safety. Among them, pyridine based drugs are contributing a lot, as it is one of the imperative pharmacophores occurring synthetically as well as naturally in heterocyclic compounds, and having a wide range of therapeutic applications in the area of drug discovery, thereby offering many chances for further improvement in antitumor agents via acting onto numerous receptors of extreme prominence. Read More

View Article and Full-Text PDF

Demographic profile, clinical characteristics and medical management patterns of Indian coronary artery disease patients: a nationwide urban-based, real-world, retrospective, observational electronic medical record study - report of baseline data.

Expert Rev Cardiovasc Ther 2021 Jun 14. Epub 2021 Jun 14.

Healthplix Technologies, Bengaluru, India.

: This is the first detailed Indian electronic medical record (EMR) based real-world observational study to understand the clinical characteristics, associated comorbidities/risk factors and treatment(s) of CAD patients across India.: EMR data of adult Indians (aged ≥ 18 years) diagnosed with CAD was retrospectively analyzed.: Majority of the participants had stable IHD (93%), were men (68. Read More

View Article and Full-Text PDF

RGBT Tracking via Multi-Adapter Network with Hierarchical Divergence Loss.

IEEE Trans Image Process 2021 Jun 14;PP. Epub 2021 Jun 14.

RGBT tracking has attracted increasing attention since RGB and thermal infrared data have strong complementary advantages, which could make trackers all-day and all-weather work. Existing works usually focus on extracting modality-shared or modality-specific information, but the potentials of these two cues are not well explored and exploited in RGBT tracking. In this paper, we propose a novel multi-adapter network to jointly perform modality-shared, modality-specific and instance-aware target representation learning for RGBT tracking. Read More

View Article and Full-Text PDF

Metastatic Liver Tumors in Surgical Pathology: Impact of Contemporary Diagnostic and Therapeutic Paradigms in a Tertiary Care Center.

Int J Surg Pathol 2021 Jun 14:10668969211022708. Epub 2021 Jun 14.

12250Indiana University School of Medicine, Indianapolis, IN, USA.

We analyzed metastatic liver tumors received in the department of pathology in a tertiary care center over a 3-year period. There were 509 metastatic liver tumors; counterintuitively, there were as many resections (235 cases) as biopsies (274 cases). This unexpected finding reflects contemporaneous organ-specific paradigms for diagnosis and management of metastatic liver disease in oncologic practice, and the association of our practice with a National Cancer Institute-designated comprehensive cancer center with expertise and specialization in liver surgery. Read More

View Article and Full-Text PDF

Advanced Oxidation Processes for Water and Wastewater Viral Disinfection. A Systematic Review.

Food Environ Virol 2021 Jun 14. Epub 2021 Jun 14.

Department of Chemical Engineering, University of Patras, University Campus, Caratheodory 1, 26504, Patras, Greece.

Water and wastewater virological quality is a significant public health issue. Viral agents include emerging and re-emerging pathogens characterized by extremely small size, and high environmental stability. Since the mainly used conventional disinfection methods are usually not able to achieve complete disinfection of viral and other microbial targets, in real water and wastewater matrices, effective strategies for the treatment, use and reuse of water and the development of next-generation water supply systems are required. Read More

View Article and Full-Text PDF

Acute Lymphoblastic Leukaemia Survival in Children Covered by Seguro Popular in Mexico: A National Comprehensive Analysis 2005-2017.

Health Syst Reform 2021 Jan;7(1):e1914897

Centre for Research on Population Health, INSP (Instituto Nacional de Salud Pública), Cuernavaca, Mexico.

The aim of the study was to measure survival of children with acute lymphoblastic leukemia (ALL) under Mexico's public health insurance for the population treated under . A retrospective cohort study using claims data from Mexico's program, covering cancer treatment from 2005 to 2015 was conducted. Overall 5-year national and state-specific survival for children with ALL across Mexico who initiated cancer treatment under this program was estimated. Read More

View Article and Full-Text PDF
January 2021

Multiplex technologies for the assessment of minimal residual disease and low-level mutation detection in leukaemia: mass spectrometry versus next-generation sequencing.

Br J Haematol 2021 Jun 14. Epub 2021 Jun 14.

Department of Genetics and Molecular Pathology and Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia.

With the focus of leukaemia management shifting to the implications of low-level disease burden, increasing attention is being paid on the development of highly sensitive methodologies required for detection. There are various techniques capable of identification of measurable residual disease (MRD) either evidencing as relevant mutation detection [e.g. Read More

View Article and Full-Text PDF

Spectral decision for cognitive radio networks in a multi-user environment.

Heliyon 2021 May 29;7(5):e07132. Epub 2021 May 29.

Technological Faculty, Universidad Distrital Francisco José de Caldas, Bogotá D.C 111931, Colombia.

Cognitive radio networks promote better spectral efficiency of the electric radio spectrum. The vast majority of current spectral decision models for cognitive radio networks evaluate their performance based on a single secondary user. In reality, the network can experience multiple requests from spectral opportunities. Read More

View Article and Full-Text PDF

Assessing Swarming of Aerobic Bacteria from Human Fecal Matter.

Bio Protoc 2021 May 5;11(9):e4008. Epub 2021 May 5.

Department of Medicine, Genetics, and Molecular Pharmacology, Albert Einstein College of Medicine Bronx, NY, USA.

Swarming - swift movement across a surface via flagella propulsion - is a unique property of many bacteria. The role of swarming, particularly among bacterial populations of the human gut microbiome, is not yet fully understood; although, it is becoming an area of increased scientific and clinical inquiry. To further characterize bacterial swarming in human health, an effective assay for swarming that utilizes complex material, such as fecal matter, is necessary. Read More

View Article and Full-Text PDF

Additive Value of Preoperative Sarcopenia and Lymphopenia for Prognosis Prediction in Localized Pancreatic Ductal Adenocarcinoma.

Front Oncol 2021 27;11:683289. Epub 2021 May 27.

Department of Medical Oncology, University Hospital of Besançon, Besançon, France.

Background: Surgical resection with adjuvant chemotherapy is the only treatment that can provide long term survival in localized pancreatic ductal adenocarcinoma (LPDAC). Notwithstanding, recurrence occurs in the vast majority of patients and a better stratification of preoperative therapies is required. This study aimed to investigate preoperative immunological and nutritional factors to predict relapse-free survival (RFS) in patients with LPDAC. Read More

View Article and Full-Text PDF

Symptoms, antibody levels and vaccination attitude after asymptomatic to moderate COVID-19 infection in 200 healthcare workers.

GMS Hyg Infect Control 2021 19;16:Doc15. Epub 2021 Apr 19.

MVZ DIANOVIS, Greiz, Germany.

In Germany, the willingness to be vaccinated against COVID-19 is rather low among medical staff. We collected data on symptoms, antibody titers and vaccination readiness from clinic employees at a municipal clinic who had already been through a COVID-19 infection (asymptomatic to moderate). We also examined the antibody titers for their possible importance as an individual decision-making aid with regard to vaccination. Read More

View Article and Full-Text PDF

Arteriovenous Malformation of the Upper Eyelid: A Case Report.

Plast Reconstr Surg Glob Open 2021 Jun 10;9(6):e3609. Epub 2021 Jun 10.

Division of Plastic Surgery, Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Arteriovenous malformations (AVMs) are rare lesions formed by direct connection of arteries and veins bypassing capillary beds. AVM locations can vary; however, extracranial AVMs remain the least common. The vast majority of these malformations are congenital and can be triggered by hormonal changes. Read More

View Article and Full-Text PDF

Development of an inexpensive matrix-assisted laser desorption-time of flight mass spectrometry method for the identification of endophytes and rhizobacteria cultured from the microbiome associated with maize.

PeerJ 2021 28;9:e11359. Epub 2021 May 28.

Department of Natural Sciences, University of Houston, Downtown, Houston, Texas, United States.

Many endophytes and rhizobacteria associated with plants support the growth and health of their hosts. The vast majority of these potentially beneficial bacteria have yet to be characterized, in part because of the cost of identifying bacterial isolates. Matrix-assisted laser desorption-time of flight (MALDI-TOF) has enabled culturomic studies of host-associated microbiomes but analysis of mass spectra generated from plant-associated bacteria requires optimization. Read More

View Article and Full-Text PDF

Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells.

Oncoimmunology 2021 Jun 6;10(1):1932061. Epub 2021 Jun 6.

Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, China.

The vast majority (>90%) of glioblastoma (GBM) patients belong to the isocitrate dehydrogenase 1 wild type (IDH1) group which exhibits a poor prognosis with a median survival of less than 15 months. This study demonstrated numerous immunosuppressive genes as well as β-catenin gene, pivotal for Wnt/β-catenin signaling, were upregulated in 206 IDH1 glioma patients using the Chinese Glioma Genome Atlas (CGGA) database. The increase in microglia with an immunosuppressive phenotype and the overexpression of β-catenin protein were further verified in IDH1 GBM patients and IDH1 GL261 glioma allografts. Read More

View Article and Full-Text PDF

Knowledge and Attitudes of Future Healthcare Professionals Toward Rare Diseases.

Front Genet 2021 28;12:639610. Epub 2021 May 28.

Department of Organization and Management in Health Care, Poznan University of Medical Sciences, Poznań, Poland.

Caring for patients suffering from a rare disease (RD) requires the special and combined efforts of different healthcare professionals, including nurses, physiotherapists and physicians. Nevertheless, Poland still lacks a national plan for RDs and the undergraduate and postgraduate education of future healthcare professionals on RDs is also inadequate. Thus, the aim of this study was to assess the awareness of RDs among nursing, physiotherapy and medical students in Poland. Read More

View Article and Full-Text PDF

Autoantibody Discovery, Assay Development and Adoption: Death Valley, the Sea of Survival and Beyond.

Front Immunol 2021 27;12:679613. Epub 2021 May 27.

Research and Development, Inova Diagnostics, San Diego, CA, United States.

Dating to the discovery of the Lupus Erythematosus (LE) cell in 1948, there has been a dramatic growth in the discovery of unique autoantibodies and their cognate targets, all of which has led to the availability and use of autoantibody testing for a broad spectrum of autoimmune diseases. Most studies of the sensitivity, specificity, commutability, and harmonization of autoantibody testing have focused on widely available, commercially developed and agency-certified autoantibody kits. However, this is only a small part of the spectrum of autoantibody tests that are provided through laboratories world-wide. Read More

View Article and Full-Text PDF

Modular Molecular Weaponry Plays a Key Role in Competition Within an Environmental Population.

Front Microbiol 2021 21;12:671092. Epub 2021 May 21.

Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.

The type VI secretion system (T6SS) operons of contain extraordinarily diverse arrays of toxic effector and cognate immunity genes, which are thought to play an important role in the environmental lifestyle and adaptation of this human pathogen. Through the T6SS, proteinaceous "spears" tipped with antibacterial effectors are injected into adjacent cells, killing those not possessing immunity proteins to these effectors. Here, we investigate the T6SS-mediated dynamics of bacterial competition within a single environmental population of . Read More

View Article and Full-Text PDF

Psychoeducational Challenges in Spanish Children With Dyslexia and Their Parents' Stress During the COVID-19 Pandemic.

Front Psychol 2021 28;12:648000. Epub 2021 May 28.

Department of Special Education, University of Azuay, Cuenca, Ecuador.

Background: Research during 2020 has been rapidly attending to the impact of COVID-19 on various dimensions of wellbeing (e.g., physical, psychological, lifestyle and routines) on adults and children around the world. Read More

View Article and Full-Text PDF

Telemedicine in Spine Surgery: Global Perspectives and Practices.

Global Spine J 2021 Jun 14:21925682211022311. Epub 2021 Jun 14.

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Study Design: Cross-sectional, anonymous, international survey.

Objectives: The COVID-19 pandemic has resulted in the rapid adoption of telemedicine in spine surgery. This study sought to determine the extent of adoption and global perspectives on telemedicine in spine surgery. Read More

View Article and Full-Text PDF

The impact of additional payments on functional decline among long-term care health facility residents in Japan.

Age Ageing 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Epidemiology and Health Economics, School of Public Health, Graduate School of Medicine, University of Tokyo, Tokyo City, Japan.

Background: Additional payment approach has been one of the most important incentives in long-term care (LTC) systems for the past 20 years in Japan.

Objective: To estimate the effect of additional payments on functional decline in long-term care health facility (LTCHF) residents of Japan.

Design: A 24-month retrospective cohort study. Read More

View Article and Full-Text PDF

Bioleaching for environmental remediation of toxic metals and metalloids: A review on soils, sediments, and mine tailings.

Chemosphere 2021 Jun 4;282:131108. Epub 2021 Jun 4.

Department of Microbiology, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

Owing to industrial evolution, a huge mass of toxic metals, including Co, Cu, Cr, Mn, Ni, Pb, and Zn, and metalloids, such as As and Sb, has inevitably been released into the natural environment and accumulated in soils or sediments. Along with modern industrialization, many mineral mines have been explored and exploited to provide materials for industries. Mining industries also generate a vast amount of waste, such as mine tailings, which contain a high concentration of toxic metals and metalloids. Read More

View Article and Full-Text PDF

The squirrel monkey model in clinical neuroscience.

Neurosci Biobehav Rev 2021 Jun 9. Epub 2021 Jun 9.

Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France; Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, France. Electronic address:

Clinical neuroscience research relying on animal models brought valuable translational insights into the function and pathologies of the human brain. The anatomical, physiological, and behavioural similarities between humans and mammals have prompted researchers to study cerebral mechanisms at different levels to develop and test new treatments. The vast majority of biomedical research uses rodent models, which are easily manipulable and have a broadly resembling organisation to the human nervous system but cannot satisfactorily mimic some disorders. Read More

View Article and Full-Text PDF

The immune landscape of common CNS malignancies: implications for immunotherapy.

Nat Rev Clin Oncol 2021 Jun 11. Epub 2021 Jun 11.

Department of Neurosurgery, Northwestern University, Chicago, IL, USA.

Immunotherapy has enabled remarkable therapeutic responses across cancers of various lineages, albeit with some notable exceptions such as glioblastoma. Several previous misconceptions, which have impaired progress in the past, including the presence and role of the blood-brain barrier and a lack of lymphatic drainage, have been refuted. Nonetheless, a subset of patients with brain metastases but, paradoxically, not the vast majority of those with gliomas are able to respond to immune-checkpoint inhibitors. Read More

View Article and Full-Text PDF

Exploring polyps to colon carcinoma voyage: can blocking the crossroad halt the sequence?

Abdul Arif Khan

J Cancer Res Clin Oncol 2021 Jun 11. Epub 2021 Jun 11.

Division of Microbiology, Indian Council of Medical Research-National AIDS Research Institute, Pune, Maharashtra, India.

Colorectal cancer is an important public health concern leading to significant cancer associate mortality. A vast majority of colon cancer arises from polyp which later follows adenoma, adenocarcinoma, and carcinoma sequence. This whole process takes several years to complete and recent genomic and proteomic technologies are identifying several targets involved in each step of polyp to carcinoma transformation in a large number of studies. Read More

View Article and Full-Text PDF

Attitudes, beliefs and practice of Egyptian healthcare workers towards seasonal influenza vaccination.

Influenza Other Respir Viruses 2021 Jun 11. Epub 2021 Jun 11.

World Health Organization Country Office, Cairo, Egypt.

Background: Seasonal influenza vaccination is highly recommended for healthcare workers (HCWs) every year to protect them and reduce the risk of disease transmission at workplaces. Relatively few studies addressed influenza vaccination in the Eastern Mediterranean Region.

Objectives: The main objective of this study was to explore the attitudes, beliefs and practice of Egyptian HCWs towards seasonal influenza vaccine. Read More

View Article and Full-Text PDF

C=C Bond Oxidative Cleavage of BODIPY Photocages by Visible Light.

Chemistry 2021 Jun 10. Epub 2021 Jun 10.

Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Institute of Biomedicine and Biotechnology, Xuyuan Road, 518055, Shenzhen, CHINA.

Photocages for protection and controlled release of bioactive compounds have been widely investigated. However, the vast majority of these photocages have employed the cleavage of single bonds and high-energy ultraviolet light. The construction of a photoactivation system that uses a visible light to cleave unsaturated bonds still remains a challenge. Read More

View Article and Full-Text PDF

A snapshot of HIV-1 capsid-host interactions.

Curr Res Struct Biol 2020 19;2:222-228. Epub 2020 Oct 19.

Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT, 06511, USA.

From cellular deposition of the HIV-1 capsid to integration of the viral genome, the capsid constitutes a primary target of a variety of host proteins that work to either promote or inhibit HIV-1 infection. Successful progression of HIV-1 infection depends on interactions between the capsid and host factors involved in stability, cellular transport, nuclear import, and genome integration. The virus must also guard its reverse-transcribing genome inside the capsid from host restriction factors that bind the capsid and suppress infection. Read More

View Article and Full-Text PDF
October 2020