18 results match your criteria vasopressin misoprostol

  • Page 1 of 1

Misoprostol vs vasopressin as a single hemostatic agent in laparoscopic myomectomy: Comparable, or just better than nothing?

J Obstet Gynaecol Res 2020 Nov 10;46(11):2356-2365. Epub 2020 Sep 10.

1st Department of Obstetrics & Gynecology, Medical School, National and Kapodistrian University of Athens, "Alexandra" Hospital, Athens, Greece.

Aim: Laparoscopic myomectomy may be associated with considerable blood loss, especially in patients in whom no specific hemostatic measures are used. We conducted this retrospective comparative study to investigate whether misoprosol is an effective and safe alternative to vasopressin when used as single hemostatic agent in laparoscopic myomectomy.

Methods: Two hundred cases undergoing laparoscopic myomectomy (-ies), were included. Read More

View Article and Full-Text PDF
November 2020

Measures to Reduce Perioperative and Intraoperative Blood Loss at Myomectomy: A Survey of Obstetrician-Gynaecologists.

J Obstet Gynaecol Can 2020 05 18;42(5):550-555. Epub 2019 Dec 18.

Division of Gynaecologic Surgery and Pelvic Medicine, Department of Obstetrics and Gynaecology, St. Michael's Hospital, University of Toronto, Toronto, ON. Electronic address:

Objective: This study sought to determine current techniques used by Canadian obstetrician-gynaecologists (OB/GYNs) to medically optimize patients undergoing myomectomy during the perioperative and intraoperative periods and to identify gaps in knowledge or barriers to access of blood conservation methods.

Methods: From September to December 2016, a self-administered electronic questionnaire was distributed to 120 Canadian OB/GYNs who perform myomectomies and who practise in either academic, community, or community academic-affiliated hospitals.

Results: A total of 68 of 120 (57%) completed responses were analyzed. Read More

View Article and Full-Text PDF

Perioperative nonhormonal pharmacological interventions for bleeding reduction during open and minimally invasive myomectomy: a systematic review and network meta-analysis.

Fertil Steril 2020 01 18;113(1):224-233.e6. Epub 2019 Nov 18.

Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Objective: To synthesize evidence on the most effective pharmacological interventions for bleeding reduction during open and minimally invasive myomectomy.

Design: Systematic review and network meta-analysis of randomized controlled trials (RCTs).

Setting: Not applicable. Read More

View Article and Full-Text PDF
January 2020

Comparison of intramyometrial vasopressin plus rectal misoprostol with intramyometrial vasopressin alone to decrease blood loss during laparoscopic myomectomy: Randomized clinical trial.

Eur J Obstet Gynecol Reprod Biol 2018 Sep 5;228:279-283. Epub 2018 Jul 5.

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

Objective: To compare the efficacy and safety of intramyometrial vasopressin plus rectal misoprostol with intramyometrial vasopressin alone to reduce blood loss during laparoscopic myomectomy.

Study Design: A randomized, single-blind, controlled trial was conducted at All India Institute of Medical Sciences, New Delhi, India. Sixty women with symptomatic leiomyoma scheduled for laparoscopic myomectomy were recruited for the study. Read More

View Article and Full-Text PDF
September 2018

Use of medications to decrease bleeding during surgical abortion: a survey of abortion providers' practices in the United States.

Contraception 2018 06 25;97(6):500-503. Epub 2018 Feb 25.

University of Hawaii, John A. Burns School of Medicine, Department of Obstetrics, Gynecology & Women's Health, 1319 Punahou St., Ste. 824, Honolulu, HI 96826, USA.

Objective: Our objective was to document current practices of abortion providers on the use of medications to decrease bleeding during surgical abortion.

Study Design: We emailed surveys to 336 abortion providers through a professional listserv to elicit information on their use of medications to prevent and treat bleeding during first- and second-trimester surgical abortion.

Results: One hundred sixty-eight (50%) providers responded to our survey. Read More

View Article and Full-Text PDF

Intramyometrial Injection of Vasopressin: A Novel Method for Hemostasis at Laparoscopic Management of Cornual Ectopic.

J Minim Invasive Gynecol 2017 Nov - Dec;24(7):1071-1072. Epub 2017 Apr 18.

Department of Obstetrics and Gynaecology, Advanced Laparoscopy Division, Altius Hospital, Bangalore, India. Electronic address:

Study Objective: Although all ectopic pregnancies are associated with risk of hemorrhage, cornual pregnancies are feared for catastrophic hemorrhage and uncontrollable bleeding. The maternal mortality rate can be as high as 2.5%, which is 7 times higher than the mortality rate for ectopic pregnancies in general. Read More

View Article and Full-Text PDF

The management of uterine leiomyomas.

J Obstet Gynaecol Can 2015 Feb;37(2):157-178

Hamilton ON.

Objectives: The aim of this guideline is to provide clinicians with an understanding of the pathophysiology, prevalence, and clinical significance of myomata and the best evidence available on treatment modalities.

Options: The areas of clinical practice considered in formulating this guideline were assessment, medical treatments, conservative treatments of myolysis, selective uterine artery occlusion, and surgical alternatives including myomectomy and hysterectomy. The risk-to-benefit ratio must be examined individually by the woman and her health care provider. Read More

View Article and Full-Text PDF
February 2015

Interventions to reduce haemorrhage during myomectomy for fibroids.

Cochrane Database Syst Rev 2014 Aug 15(8):CD005355. Epub 2014 Aug 15.

Reproductive Health Solutions, 43 Fowler's Rd, Salisbury, UK, SP1 2QP.

Background: Benign smooth muscle tumours of the uterus, known as fibroids or myomas, are often symptomless. However, about one-third of women with fibroids will present with symptoms that are severe enough to warrant treatment. The standard treatment of symptomatic fibroids is hysterectomy (that is surgical removal of the uterus) for women who have completed childbearing, and myomectomy for women who desire future childbearing or simply want to preserve their uterus. Read More

View Article and Full-Text PDF

A trial comparing the use of rectal misoprostol plus perivascular vasopressin with perivascular vasopressin alone to decrease myometrial bleeding at the time of abdominal myomectomy.

Fertil Steril 2013 Oct 19;100(4):1044-9. Epub 2013 Jul 19.

Hugh Wynter Fertility Management Unit, University of the West Indies, Mona, Kingston, Jamaica; Department of Obstetrics and Gynaecology, University of the West Indies, Mona, Kingston, Jamaica. Electronic address:

Objective: To compare the efficacy of rectal misoprostol plus perivascular vasopressin with perivascular vasopressin alone as hemostatic agents for the reduction of blood loss during myomectomies.

Design: Prospective, randomized, double-blind, controlled study.

Setting: University of the West Indies and Andrews Memorial Hospital. Read More

View Article and Full-Text PDF
October 2013

Interventions to reduce haemorrhage during myomectomy for fibroids.

Cochrane Database Syst Rev 2011 Nov 9(11):CD005355. Epub 2011 Nov 9.

United Nations Population Fund, New York, USA.

Background: Uterine myomas (fibroids) are benign tumours of the uterus. Myomectomy, the surgical removal of myomas, can be associated with life-threatening bleeding and prolonged postoperative stay. Knowledge of the effectiveness of the interventions to reduce bleeding during myomectomy is essential to enable evidence-based clinical decisions. Read More

View Article and Full-Text PDF
November 2011

Interventions to reduce haemorrhage during myomectomy for fibroids.

Cochrane Database Syst Rev 2009 Jul 8(3):CD005355. Epub 2009 Jul 8.

Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA.

Background: Uterine myomas (fibroids) are benign tumours of the uterus. Myomectomy, the surgical removal of myomas, is an important treatment option especially for women who wish to preserve their uteri. The major problem with myomectomy is excessive bleeding, which can be life-threatening and prolong postoperative stay. Read More

View Article and Full-Text PDF

A systematic review of randomized controlled trials to reduce hemorrhage during myomectomy for uterine fibroids.

Int J Gynaecol Obstet 2008 Jan 25;100(1):4-9. Epub 2007 Sep 25.

Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK.

Objective: To assess the effectiveness and safety of interventions to reduce blood loss during myomectomy.

Methods: Electronic searches of the Cochrane Library, MEDLINE, and EMBASE, between 1966 and 2006 for randomized controlled trials (RCTs).

Results: We found significant reductions in blood loss with vaginal misoprostol (weighted mean difference [WMD] -149. Read More

View Article and Full-Text PDF
January 2008

Interventions to reduce haemorrhage during myomectomy for fibroids.

Cochrane Database Syst Rev 2007 Jan 24(1):CD005355. Epub 2007 Jan 24.

University of Yaounde 1,PO Box 1364, Yaounde, Cameroon.

Background: Uterine myomas (fibroids) are benign tumours of the uterus. Myomectomy, the surgical removal of the myomas, is an important treatment option especially for women who desire to preserve their uteri. The major problem with myomectomy is excessive bleeding from increased uterine blood supply, and this can be life-threatening and prolong postoperative stay. Read More

View Article and Full-Text PDF
January 2007

Expression of the oxytocin and V1a vasopressin receptors in human myometrium in differing physiologic states and following misoprostol administration.

Gynecol Obstet Invest 2006 29;62(4):181-5. Epub 2006 May 29.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine College of Medicine, Orange, CA 92868, USA.

Objective: To assess relative expression levels of mRNA for the oxytocin receptor (OTR) and the V1a vasopressin receptor (V1aR) in human myometrium in various physiologic states and to determine if misoprostol exposure affects the expression of mRNA for these receptors.

Study Design: Using semiquantitative reverse transcription-polymerase chain reaction, we analyzed myometrial samples from 37 women (10 menopausal, 10 nongravid premenopausal, 10 gravidae, 7 premenopausal misoprostol-treated nongravid women) for the specific expression of mRNA messages for OTR and V1aR. The presence of the OTR and V1aR protein was confirmed by immunohistochemistry. Read More

View Article and Full-Text PDF
February 2007

Methods for induced abortion.

Obstet Gynecol 2004 Jul;104(1):174-85

Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA.

We describe present methods for induced abortion used in the United States. The most common procedure is first-trimester vacuum curettage. Analgesia is usually provided with a paracervical block and is not completely effective. Read More

View Article and Full-Text PDF

EP3 receptors inhibit antidiuretic-hormone-dependent sodium transport across frog skin epithelium.

Pflugers Arch 1999 Jan;437(2):213-8

Biochemical Department, August Krogh Institute, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.

We examined the effect of prostaglandin E2 (PGE2) on antidiuretic hormone (ADH)-dependent Na+ transport and cAMP production in isolated frog skin epithelium. ADH caused an increase in transepithelial Na+ transport and a decrease in cellular potential, indicating an increase in apical Na+ permeability. Subsequent addition of PGE2 decreased Na+ transport and repolarised the cells. Read More

View Article and Full-Text PDF
January 1999

Cerebroventricular calcitonin gene-related peptide inhibits rat duodenal bicarbonate secretion by release of norepinephrine and vasopressin.

Authors:
H J Lenz M R Brown

J Clin Invest 1990 Jan;85(1):25-32

Department of Medicine, University of Hamburg, Federal Republic of Germany.

Proximal duodenal bicarbonate secretion is an important factor in humans and animals protecting the mucosa against acid-peptic damage. This study examined the mechanisms responsible for the central nervous system regulation of duodenal bicarbonate secretion by calcitonin gene-related peptide (CGRP) in unrestrained rats. Cerebroventricular administration of rat CGRP significantly inhibited basal duodenal bicarbonate secretion as well as the stimulatory effects of vasoactive intestinal peptide, neurotensin, a luminal PGE1 analogue, misoprostol, and hydrochloric acid. Read More

View Article and Full-Text PDF
January 1990
  • Page 1 of 1