39,614 results match your criteria vasculitis patients


New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review.

Vaccines (Basel) 2021 Oct 29;9(11). Epub 2021 Oct 29.

Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

Introduction: The introduction of COVID-19 vaccination programs has become an integral part of the major strategy to reduce COVID-19 numbers worldwide. New-onset and relapsed kidney histopathology have been reported following COVID-19 vaccination, sparking debate on whether there are causal associations. How these vaccines achieve an immune response to COVID-19 and the mechanism that this triggers kidney pathology remains unestablished. Read More

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October 2021

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.

Viruses 2021 Nov 9;13(11). Epub 2021 Nov 9.

Clinical Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.

Extrahepatic manifestations are a feature of chronic hepatitis C virus (HCV) infection. In the course of chronic HCV infection, about 70% of patients have one or more extrahepatic manifestations. The latter are often the first and only clinical sign of infection. Read More

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November 2021

Lupus Vasculitis: An Overview.

Biomedicines 2021 Nov 5;9(11). Epub 2021 Nov 5.

Department of Biomedical Sciences and Human Oncology, "Aldo Moro" University of Bari Medical School, 70124 Bari, Italy.

Lupus vasculitis (LV) is one of the secondary vasculitides occurring in the setting of systemic lupus erythematosus (SLE) in approximately 50% of patients. It is most commonly associated with small vessels, but medium-sized vessels can also be affected, whereas large vessel involvement is very rare. LV may involve different organ systems and present in a wide variety of clinical manifestations according to the size and site of the vessels involved. Read More

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November 2021

Whole-Body [F]FDG PET/CT Can Alter Diagnosis in Patients with Suspected Rheumatic Disease.

Diagnostics (Basel) 2021 Nov 9;11(11). Epub 2021 Nov 9.

Comprehensive Heart Failure Center, Department of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.

The 2-deoxy-d-[F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is widely utilized to assess the vascular and articular inflammatory burden of patients with a suspected diagnosis of rheumatic disease. We aimed to elucidate the impact of [F]FDG PET/CT on change in initially suspected diagnosis in patients at the time of the scan. Thirty-four patients, who had undergone [F]FDG PET/CT, were enrolled and the initially suspected diagnosis prior to [F]FDG PET/CT was compared to the final diagnosis. Read More

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November 2021

Increased Expression of Pyroptosis in Leukocytes of Patients with Kawasaki Disease.

Diagnostics (Basel) 2021 Nov 3;11(11). Epub 2021 Nov 3.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Background: Kawasaki disease (KD) is a form of febrile vasculitis that primarily occurs in children. It can cause inflammation of the coronary arteries, which leads to aneurysms. The pathogenesis of coronary arteries may be associated with apoptosis or pyroptosis mediated by caspases activity, but this idea has not been discussed much in KD. Read More

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November 2021

Intracranial Involvement in Takayasu's Arteritis.

Diagnostics (Basel) 2021 Oct 27;11(11). Epub 2021 Oct 27.

Division of Rheumatology, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Takayasu's arteritis (TAK) is a large-vessel vasculitis that targets the aorta and its major branches. Although extracranial vascular involvement is uniformly present in this disease, the frequency of intracranial involvement in TAK has not been well studied. We retrospectively reviewed the clinical and imaging records of patients diagnosed with TAK at a single Canadian university medical centre to determine the prevalence of intracranial vascular involvement. Read More

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October 2021

Vascular Imaging Techniques to Diagnose and Monitor Patients with Takayasu Arteritis: A Review of the Literature.

Diagnostics (Basel) 2021 Oct 27;11(11). Epub 2021 Oct 27.

Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba-Cho, Shiwa-Gun, Morioka 028-3695, Japan.

Takayasu arteritis (TA) is a large vessel vasculitis that causes stenosis, occlusion, and sometimes the aneurysm of the aorta and its major branches. TA often occurs in young women, and because the symptoms are not obvious in the early stages of the disease, diagnosis is difficult and often delayed. In approximately 10% to 20% of patients, TA is reportedly complicated by ischemic stroke or transient ischemic attack. Read More

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October 2021

Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies.

Diagnostics (Basel) 2021 Oct 26;11(11). Epub 2021 Oct 26.

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests, while linear correlation analyses were used for age, fat mass, FBGL, and eGFR. Read More

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October 2021

Avacopan: First Approval.

Authors:
Arnold Lee

Drugs 2021 Nov 26. Epub 2021 Nov 26.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Avacopan (TAVNEOS™) is a complement 5a receptor (C5aR) antagonist developed by ChemoCentryx for the treatment of autoimmune diseases including anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis. The therapeutic effects of avacopan are attributed to the inhibition of C5aR activity on neutrophils, however, the exact mechanism of therapeutic efficacy in patients with ANCA-associated vasculitis has not been established. In September 2021, avacopan received its first approval in Japan for the treatment of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), the two most common forms of ANCA-associated vasculitis, where it is being commercialized by Kissei Pharmaceutical through a partnership with Vifor Pharma. Read More

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November 2021

The Network of Pro-Inflammatory Factors CD147, DcR3, and IL33 in the Development of Kawasaki Disease.

J Inflamm Res 2021 19;14:6043-6053. Epub 2021 Nov 19.

Department of Cardiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, People's Republic of China.

Introduction: Kawasaki disease (KD) is an acute febrile systemic vasculitis, but the etiology remains unknown. We studied serum levels of CD147, DcR3, and IL33 in different stages of KD to explore the value of CD147, DcR3, and IL33 in the pathophysiology of KD.

Methods: We measured serum levels of CD147, DcR3, and IL33 by enzyme-linked immunosorbent assay (ELISA) at different stages with 71 KD patients and 66 healthy control children. Read More

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November 2021

Antibody response to COVID-19 booster vaccine in rituximab treated patients with ANCA associated vasculitis.

Kidney Int 2021 Nov 22. Epub 2021 Nov 22.

Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:

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November 2021

Fulminant Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis After 10 Years of Hydralazine Use.

Cureus 2021 Oct 22;13(10):e18974. Epub 2021 Oct 22.

Rheumatology, Nassau University Medical Center, East Meadow, USA.

Vasculitis, by definition, causes changes in the walls of blood vessels, including thickening, weakening, narrowing, and scarring, leading to inflammation and necrosis of the blood vessel walls. Small-vessel vasculitis is commonly associated with anti-neutrophil cytoplasmic antibodies (ANCA), which activate cytokine-primed neutrophils and monocytes that express ANCA antigens proteinase 3 (PR3) and myeloperoxidase (MPO) on their surface. The continuous injury and inflammation of these small vessels characterized by circulating immune complexes and antinuclear antibodies result in clinical features standard in all types of vasculitis. Read More

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October 2021

Differences in the Clinical Manifestations and Mortality of Systemic Lupus Erythematosus Onset in Children and Adults: A Systematic Review and Meta-Analysis.

Int Arch Allergy Immunol 2021 Sep 27:1-11. Epub 2021 Sep 27.

Experiment Center, Capital Institute of Pediatrics, Beijing, China.

Introduction: The aim of this study was to assess the differences between childhood-onset and adult-onset systemic lupus erythematosus (cSLE and aSLE) for clinical manifestations and mortality using a meta-analytic approach.

Methods: The PubMed, EMBASE, and the Cochrane library were searched for eligible studies published between January 1982 and March 2021. The odds ratio (OR) with 95% confidence interval was used to calculate the pooled effect estimates using the random-effects model. Read More

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September 2021

Causes of acute respiratory failure in patients with small-vessel vasculitis admitted to intensive care units: a multicenter retrospective study.

Ann Intensive Care 2021 Nov 24;11(1):158. Epub 2021 Nov 24.

Service de Médecine Intensive Réanimation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Sorbonne Université, 4 rue de la chine, 75020, Paris, France.

Rationale: Acute respiratory failure (ARF) in patients admitted to the intensive care unit (ICU) with known or de novo small-vessel vasculitis (Svv) may be secondary to the underlying immune disease or to other causes. Early identification of the cause of ARF is essential to initiate the most appropriate treatment in a timely fashion.

Methods: A retrospective multicenter study in 10 French ICUs from January 2007 to January 2018 to assess the clinical presentation, main causes and outcome of ARF associated with Svv, and to identify variables associated with non-immune etiology of ARF in patients with known Svv. Read More

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November 2021

Safety Outcomes of Brolucizumab in Neovascular Age-Related Macular Degeneration: Results From the IRIS Registry and Komodo Healthcare Map.

JAMA Ophthalmol 2021 Nov 24. Epub 2021 Nov 24.

Department of Ophthalmology at Rush University Medical Center, Chicago, Illinois.

Importance: Limited data exist on the real-world safety outcomes of patients with neovascular age-related macular degeneration treated with brolucizumab (Beovu).

Objective: To determine the real-world incidence of intraocular inflammation (IOI), including retinal vasculitis (RV) and/or retinal vascular occlusion (RO), for patients with neovascular age-related macular degeneration who underwent brolucizumab treatment. Additionally, potential risk factors associated with these adverse events were evaluated. Read More

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November 2021

Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis.

Pathobiology 2021 Nov 23:1-6. Epub 2021 Nov 23.

Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan.

Introduction: IgA vasculitis is a systemic disease that results from the entrapment of circulating IgA-containing immune complexes in small-vessel walls in the skin, kidneys, and gastrointestinal tract. An excessive formation of neutrophil extracellular traps (NETs) is involved in the pathogenesis of vasculitis, especially in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This study aimed to clarify whether NETs are implicated in IgA vasculitis. Read More

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November 2021

Contrast-enhanced Magnetic Resonance Imaging, Perfusion Magnetic Resonance Imaging 1H-Magnetic Resonance Spectroscopy Distinguish Primary Central Nervous System Vasculitis from Glioblastoma.

World Neurosurg 2021 Nov 20. Epub 2021 Nov 20.

Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan.

Background: We investigated the ability of magnetic resonance imaging (MRI) to distinguish primary central nervous system vasculitis (PCNSV) from glioblastoma to facilitate the development of an appropriate treatment for PCNSV.

Methods: We enrolled patients who were treated for PCNSV or glioblastoma at our center between January 2007 and August 2018. We compared the diagnoses of the two conditions by retrospectively reviewing patients' data for contrast-enhanced MRI, perfusion MRI, flow-sensitive black-blood (FSBB) imaging, and H-magnetic resonance spectroscopy (MRS). Read More

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November 2021

Polymyalgia Rheumatica in a Patient with Pseudogout and Dementia.

Am J Case Rep 2021 Nov 23;22:e933926. Epub 2021 Nov 23.

Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

BACKGROUND The differential diagnosis of generalized pain includes reactivity associated with bacterial and viral infections, autoimmune rheumatic disease, and orthopedic diseases. Obtaining a detailed medical history and establishing an accurate diagnosis are difficult in elderly patients with dementia. In addition, the differential diagnosis between polymyalgia rheumatica and pseudogout is often difficult. Read More

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November 2021

Vasculitis in a patient with mevalonate kinase deficiency (MKD): a case report.

Pediatr Rheumatol Online J 2021 Nov 22;19(1):161. Epub 2021 Nov 22.

Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.

Background: Mevalonate kinase deficiency (MKD) is a rare autoinflammatory condition caused by biallelic loss-of-function (LOF) mutations in mevalonate kinase (MVK) gene encoding the enzyme mevalonate kinase. Patients with MKD display a variety of non-specific clinical manifestations, which can lead to diagnostic delay. We report the case of a child presenting with vasculitis that was found by genetic testing to be caused by MKD, and now add this autoinflammatory disease to the ever-expanding list of causes of monogenic vasculitides. Read More

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November 2021

Molecular diagnosis of in culture negative endocarditis and vascular infection in South Korea.

Ann Med 2021 Dec;53(1):2256-2265

Department of Infectious Diseases, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Q fever endocarditis is a major cause of culture-negative endocarditis. The role of is underestimated because it is difficult to diagnose. We investigated the significance of as the cause of culture-negative endocarditis and vascular infection by examining blood and tissue specimens using serological testing and polymerase chain reaction (PCR). Read More

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December 2021

Levamisole-induced and COVID-19-induced retiform purpura: two overlapping, emerging clinical syndromes.

Arch Dermatol Res 2021 Nov 22. Epub 2021 Nov 22.

Infectious Diseases, Rutgers New Jersey Medical School, MSB H-576, 185 South Orange Ave, Newark, NJ, 07103, USA.

Levamisole exposure in cocaine users is a well-recognized cause of retiform purpura, a distinctive net-like maculopapular patch. Prolonged exposure to levamisole can lead to a serious systemic syndrome known as levamisole-induced vasculitis, most commonly involving the kidneys and lungs. More recently, retiform purpura has been observed in patients with the novel coronavirus disease of 2019 (COVID-19). Read More

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November 2021

Rituximab-Associated Flare of Cryoglobulinemic Vasculitis.

Kidney Int Rep 2021 Nov 4;6(11):2840-2849. Epub 2021 Sep 4.

Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Background: Patients with cryoglobulinemic vasculitis (CV) can develop disease flare after rituximab administration. The objective of our study was to describe the prevalence, clinical characteristics, predisposing factors, and outcomes of patients with rituximab-associated flare of CV.

Methods: We conducted a retrospective study in a tertiary referral center until March 25, 2020. Read More

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November 2021

Rheumatic Manifestations and Diseases From Immune Checkpoint Inhibitors in Cancer Immunotherapy.

Front Med (Lausanne) 2021 4;8:762247. Epub 2021 Nov 4.

Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

Immune checkpoint inhibitors (ICIs), which can enhance antitumor immunity and inhibit cancer growth, have revolutionized the treatment of multiple cancers and dramatically decreased mortality. However, treatment with ICIs is directly associated with immune-related adverse events (irAEs) because of inflammation in off-target organs and autoimmunity resulting from non-specific immune activation. These irAEs can cause rheumatic diseases and manifestations such as inflammatory arthritis, polymyalgia rheumatica, myositis, vasculitis, Sicca and Sjogen's syndrome, and systemic lupus erythematosus. Read More

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November 2021

VEXAS within the spectrum of rheumatologic disease.

Semin Hematol 2021 Oct 9;58(4):218-225. Epub 2021 Oct 9.

Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN.

The identification of the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome as a myeloid-driven inflammatory disease resulting from somatic mutations in the UBA1 gene further exposes the increasingly recognized overlap between hematologic disturbances and auto-immunity and/or auto-inflammatory presentations. Although single or multi-lineage cytopenias are a unifying aspect of VEXAS, patients with this condition can present with a wide array of inflammatory findings affecting the skin, lung, joints, eye, vascular system, and cartilaginous structures. As such, it is paramount that generalists, and subspecialty providers familiarize themselves with the clinical characteristics of this condition. Read More

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October 2021

The Quantification of Extracellular Trap Cell Death-Derived Products as Diagnostic Biomarkers for Otitis Media with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and Eosinophilic Otitis Media.

Otol Neurotol 2021 Nov 19. Epub 2021 Nov 19.

Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objective: This study aimed to quantify the cell-free deoxyribonucleic acid (DNA), citrullinated-histone H3 (cit-H3)-DNA complex, and myeloperoxidase (MPO)-DNA complex as extracellular trap cell death (ETosis)-derived products in the middle ear fluid, and to identify diagnostic biomarkers for the discrimination of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) from eosinophilic otitis media (EOM).

Study Design: Prospective study.

Setting: Tertiary referral center. Read More

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November 2021

The predictive value of the Kobayashi and Kawanet score systems regarding immunoglobulin resistance and cardiac complications in patients with Kawasaki disease: A pilot study

Orv Hetil 2021 11 21;162(47):1885-1890. Epub 2021 Nov 21.

1 Fejér Megyei Szent György Egyetemi Oktató Kórház, Újszülött-, Csecsemő- és Gyermekosztály, Székesfehérvár, Seregélyesi út 3., 8000.

Összefoglaló. Bevezetés: A Kawasaki-szindróma immunvasculitis, amely kezeletlenül kardiológiai szövődményekhez vezethet. A korai intravénás immunglobulin-terápia mérsékli a szövődményeket, de az esetek 10-20%-a rezisztens a kezelésre. Read More

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November 2021

Facial nerve paresis in the course of masked mastoiditis as a revelator of GPA.

Eur Arch Otorhinolaryngol 2021 Nov 19. Epub 2021 Nov 19.

Department of Otolaryngology, Head and Neck Surgery, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, Poland.

Purpose: The aim of this study was to present a series of 6 patients with facial nerve palsy and masked mastoiditis which constituted as revelators of localized granulomatosis with polyangiitis (GPA) and to evaluate the utility of the ACR/EULAR 2017 provisional classification criteria for GPA in such cases.

Methods: Study group included 58 patients with GPA. Cases with facial nerve palsy and masked mastoiditis were thoroughly analyzed. Read More

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November 2021

Incidence and risk factors of COVID-19 in patients with vasculitis in the first year of the pandemic: a Danish nationwide cohort study.

Clin Exp Rheumatol 2021 Oct 28. Epub 2021 Oct 28.

Department of Rheumatology, Aalborg University Hospital, Aalborg, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

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October 2021

Practice patterns and outcomes for pediatric ANCA vasculitis transplant recipients in a national cohort.

Pediatr Nephrol 2021 Nov 18. Epub 2021 Nov 18.

Maria Fareri Children's Hospital, Westchester Medical Center, Boston Children's Health Physicians, New York Medical College, Valhalla, NY, USA.

Background: Anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis is a rare condition in pediatric patients. Little is known about practice patterns and outcomes of pediatric transplant patients. The purpose of our study was to examine differences in patient characteristics, immunosuppression, and long-term graft outcomes between ANCA and non-ANCA vasculitis recipients. Read More

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November 2021

Predictive Value of Laboratory Indexes on Renal Involvement in Children with Henoch-Schönlein Purpura.

Int J Gen Med 2021 9;14:7951-7959. Epub 2021 Nov 9.

Department of Pediatrics, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China.

Objective: Henoch-Schönlein purpura (HSP) is the most common vasculitis in children. Renal involvement is the main long-term complication of HSP, and presently there is no way to predict which children may have irreversible renal damage from the outset. This study aimed to explore the prediction value of laboratory indexes on renal involvement in children with HSP, which could help the early identification and intervention. Read More

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November 2021