114,941 results match your criteria vasculitis


Leukocytoclastic vasculitis after exposure to COVID-19 vaccine.

An Bras Dermatol 2021 Nov 10. Epub 2021 Nov 10.

Department of Hematology, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

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November 2021

New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review.

Vaccines (Basel) 2021 Oct 29;9(11). Epub 2021 Oct 29.

Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

Introduction: The introduction of COVID-19 vaccination programs has become an integral part of the major strategy to reduce COVID-19 numbers worldwide. New-onset and relapsed kidney histopathology have been reported following COVID-19 vaccination, sparking debate on whether there are causal associations. How these vaccines achieve an immune response to COVID-19 and the mechanism that this triggers kidney pathology remains unestablished. Read More

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October 2021

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.

Viruses 2021 Nov 9;13(11). Epub 2021 Nov 9.

Clinical Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.

Extrahepatic manifestations are a feature of chronic hepatitis C virus (HCV) infection. In the course of chronic HCV infection, about 70% of patients have one or more extrahepatic manifestations. The latter are often the first and only clinical sign of infection. Read More

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November 2021

Equine Arteritis Virus (EAV) Outbreak in a Show Stallion Population.

Viruses 2021 Oct 24;13(11). Epub 2021 Oct 24.

MH Gluck Equine Research Center, Department of Veterinary Science, College of Agriculture, Food & Environment, University of Kentucky, Lexington, KY 40546-0099, USA.

(1) Background: Equine arteritis virus (EAV) infection causes reproductive losses and systemic vasculitis in susceptible . The intact male becomes the virus' reservoir upon EAV infection, as it causes a chronic-persistent infection of the accessory sex glands. Infected semen is the main source of virus transmission. Read More

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October 2021

Hygiene Hypothesis as the Etiology of Kawasaki Disease: Dysregulation of Early B Cell Development.

Authors:
Jong-Keuk Lee

Int J Mol Sci 2021 Nov 15;22(22). Epub 2021 Nov 15.

Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 05505, Korea.

Kawasaki disease (KD) is an acute systemic vasculitis that occurs predominantly in children under 5 years of age. Despite much study, the etiology of KD remains unknown. However, epidemiological and immunological data support the hygiene hypothesis as a possible etiology. Read More

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November 2021

Lupus Vasculitis: An Overview.

Biomedicines 2021 Nov 5;9(11). Epub 2021 Nov 5.

Department of Biomedical Sciences and Human Oncology, "Aldo Moro" University of Bari Medical School, 70124 Bari, Italy.

Lupus vasculitis (LV) is one of the secondary vasculitides occurring in the setting of systemic lupus erythematosus (SLE) in approximately 50% of patients. It is most commonly associated with small vessels, but medium-sized vessels can also be affected, whereas large vessel involvement is very rare. LV may involve different organ systems and present in a wide variety of clinical manifestations according to the size and site of the vessels involved. Read More

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November 2021

Whole-Body [F]FDG PET/CT Can Alter Diagnosis in Patients with Suspected Rheumatic Disease.

Diagnostics (Basel) 2021 Nov 9;11(11). Epub 2021 Nov 9.

Comprehensive Heart Failure Center, Department of Nuclear Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.

The 2-deoxy-d-[F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is widely utilized to assess the vascular and articular inflammatory burden of patients with a suspected diagnosis of rheumatic disease. We aimed to elucidate the impact of [F]FDG PET/CT on change in initially suspected diagnosis in patients at the time of the scan. Thirty-four patients, who had undergone [F]FDG PET/CT, were enrolled and the initially suspected diagnosis prior to [F]FDG PET/CT was compared to the final diagnosis. Read More

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November 2021

Increased Expression of Pyroptosis in Leukocytes of Patients with Kawasaki Disease.

Diagnostics (Basel) 2021 Nov 3;11(11). Epub 2021 Nov 3.

Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Background: Kawasaki disease (KD) is a form of febrile vasculitis that primarily occurs in children. It can cause inflammation of the coronary arteries, which leads to aneurysms. The pathogenesis of coronary arteries may be associated with apoptosis or pyroptosis mediated by caspases activity, but this idea has not been discussed much in KD. Read More

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November 2021

Intracranial Involvement in Takayasu's Arteritis.

Diagnostics (Basel) 2021 Oct 27;11(11). Epub 2021 Oct 27.

Division of Rheumatology, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Takayasu's arteritis (TAK) is a large-vessel vasculitis that targets the aorta and its major branches. Although extracranial vascular involvement is uniformly present in this disease, the frequency of intracranial involvement in TAK has not been well studied. We retrospectively reviewed the clinical and imaging records of patients diagnosed with TAK at a single Canadian university medical centre to determine the prevalence of intracranial vascular involvement. Read More

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October 2021

Vascular Imaging Techniques to Diagnose and Monitor Patients with Takayasu Arteritis: A Review of the Literature.

Diagnostics (Basel) 2021 Oct 27;11(11). Epub 2021 Oct 27.

Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, 2-1-1 Idaidori, Yahaba-Cho, Shiwa-Gun, Morioka 028-3695, Japan.

Takayasu arteritis (TA) is a large vessel vasculitis that causes stenosis, occlusion, and sometimes the aneurysm of the aorta and its major branches. TA often occurs in young women, and because the symptoms are not obvious in the early stages of the disease, diagnosis is difficult and often delayed. In approximately 10% to 20% of patients, TA is reportedly complicated by ischemic stroke or transient ischemic attack. Read More

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October 2021

Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies.

Diagnostics (Basel) 2021 Oct 26;11(11). Epub 2021 Oct 26.

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests, while linear correlation analyses were used for age, fat mass, FBGL, and eGFR. Read More

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October 2021

Autoantibodies and Rheumatologic Manifestations in Hepatitis C Virus Infection.

Biology (Basel) 2021 Oct 20;10(11). Epub 2021 Oct 20.

Rheumatology Unit, Department of General and Specialistic Medicine, Azienda Ospedaliero Universitaria Città Della Salute e Della Scienza di Torino, 10126 Turin, Italy.

HCV is a virus that can cause chronic infection which can result in a systemic disease that may include many rheumatologic manifestations such as arthritis, myalgia, sicca syndrome, cryoglobulinemia vasculitis as well as other non-rheumatological disorders (renal failure, onco-haematological malignancies). In this population, the high frequency of rheumatoid factor (45-70%), antinuclear (10-40%) and anticardiolipin (15-20%) antibodies is a B-cell mediated finding sustained by the infection. However, the possibility that a primitive rheumatic pathology may coexist with the HCV infection is not to be excluded thus complicating a differential diagnosis between primitive and HCV-related disorders. Read More

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October 2021

[Large vessel vasculitis: update 2021].

Dtsch Med Wochenschr 2021 Nov 26;146(23):1516-1519. Epub 2021 Nov 26.

Sektion Angiologie - Gefäßzentrum, Med. Klinik und Poliklinik IV, LMU-Klinikum.

In recent years, clinically significant advances have been made in the management of giant cell arteritis and Takayasu arteritis. This concise review article highlights important aspects of the diagnostic workup and imaging-based treatment surveillance of the large vessel vasculitides. Read More

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November 2021

Multisystem Imaging Manifestations of Kawasaki Disease.

Radiographics 2021 Nov 26:210070. Epub 2021 Nov 26.

From the Departments of Radiology (Y.T., T.K.) and Cardiology (M.M.), Tokyo Metropolitan Children's Medical Center, Tokyo, Japan; Department of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.T., M.J.); Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa (A.H.); Department of Radiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115 (A.H.); Center for Intractable Diseases, Saitama University Hospital, Saitama, Japan (G.N.); Department of Pediatrics, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan (K.Y.); Department of Radiology, Saiseikai Yokohama Tobu Hospital, Kanagawa, Japan (K.S.); Department of Neurology, Chiba University School of Medicine, Chiba, Japan (H.H.); and Department of Radiology, National Center for Child Health and Development, Tokyo, Japan (S.N.).

Kawasaki disease (KD) is a common pediatric vasculitis syndrome involving medium- and small-sized arteries that is especially prevalent in early childhood (ie, age 6 months to 5 years). The diagnosis of KD is made on the basis of clinical features, such as fever, characteristic mucocutaneous changes, and nonsuppurative cervical lymphadenopathy. However, early diagnosis is often challenging because many children with KD present with atypical symptoms. Read More

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November 2021

The innate immune system in human kidney inflammaging.

J Nephrol 2021 Nov 26. Epub 2021 Nov 26.

Unit of Nephrology, Dialysis, Transplantation, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy.

Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Read More

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November 2021

Avacopan: First Approval.

Authors:
Arnold Lee

Drugs 2021 Nov 26. Epub 2021 Nov 26.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Avacopan (TAVNEOS™) is a complement 5a receptor (C5aR) antagonist developed by ChemoCentryx for the treatment of autoimmune diseases including anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis. The therapeutic effects of avacopan are attributed to the inhibition of C5aR activity on neutrophils, however, the exact mechanism of therapeutic efficacy in patients with ANCA-associated vasculitis has not been established. In September 2021, avacopan received its first approval in Japan for the treatment of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), the two most common forms of ANCA-associated vasculitis, where it is being commercialized by Kissei Pharmaceutical through a partnership with Vifor Pharma. Read More

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November 2021

The Network of Pro-Inflammatory Factors CD147, DcR3, and IL33 in the Development of Kawasaki Disease.

J Inflamm Res 2021 19;14:6043-6053. Epub 2021 Nov 19.

Department of Cardiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, People's Republic of China.

Introduction: Kawasaki disease (KD) is an acute febrile systemic vasculitis, but the etiology remains unknown. We studied serum levels of CD147, DcR3, and IL33 in different stages of KD to explore the value of CD147, DcR3, and IL33 in the pathophysiology of KD.

Methods: We measured serum levels of CD147, DcR3, and IL33 by enzyme-linked immunosorbent assay (ELISA) at different stages with 71 KD patients and 66 healthy control children. Read More

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November 2021

Antibody response to COVID-19 booster vaccine in rituximab treated patients with ANCA associated vasculitis.

Kidney Int 2021 Nov 22. Epub 2021 Nov 22.

Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:

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November 2021

[Giant cell arteritis: a case report with scalp necrosis and sudden blindness].

Laeknabladid 2021 Dec;107(12):597-602

Laboratory of Rheumatology, Faculty of Medicine, University of Iceland.

In the summer of 2020, an elderly woman in her eighties sought medical attention due to headache and visual disturbances. The diagnosis was unclear, she became blind on both eyes and developed extended scalp necrosis. Later it was clear that these symptoms were due to accelerating symptoms of giant cell arteritis (GCA). Read More

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December 2021

Fulminant Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis After 10 Years of Hydralazine Use.

Cureus 2021 Oct 22;13(10):e18974. Epub 2021 Oct 22.

Rheumatology, Nassau University Medical Center, East Meadow, USA.

Vasculitis, by definition, causes changes in the walls of blood vessels, including thickening, weakening, narrowing, and scarring, leading to inflammation and necrosis of the blood vessel walls. Small-vessel vasculitis is commonly associated with anti-neutrophil cytoplasmic antibodies (ANCA), which activate cytokine-primed neutrophils and monocytes that express ANCA antigens proteinase 3 (PR3) and myeloperoxidase (MPO) on their surface. The continuous injury and inflammation of these small vessels characterized by circulating immune complexes and antinuclear antibodies result in clinical features standard in all types of vasculitis. Read More

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October 2021

Editorial: Introduction, Vasculitis 2021.

Curr Opin Rheumatol 2022 Jan;34(1):1-3

Department of Medicine, New York University School of Medicine, New York, New York, USA.

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January 2022

Differences in the Clinical Manifestations and Mortality of Systemic Lupus Erythematosus Onset in Children and Adults: A Systematic Review and Meta-Analysis.

Int Arch Allergy Immunol 2021 Sep 27:1-11. Epub 2021 Sep 27.

Experiment Center, Capital Institute of Pediatrics, Beijing, China.

Introduction: The aim of this study was to assess the differences between childhood-onset and adult-onset systemic lupus erythematosus (cSLE and aSLE) for clinical manifestations and mortality using a meta-analytic approach.

Methods: The PubMed, EMBASE, and the Cochrane library were searched for eligible studies published between January 1982 and March 2021. The odds ratio (OR) with 95% confidence interval was used to calculate the pooled effect estimates using the random-effects model. Read More

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September 2021

Causes of acute respiratory failure in patients with small-vessel vasculitis admitted to intensive care units: a multicenter retrospective study.

Ann Intensive Care 2021 Nov 24;11(1):158. Epub 2021 Nov 24.

Service de Médecine Intensive Réanimation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Sorbonne Université, 4 rue de la chine, 75020, Paris, France.

Rationale: Acute respiratory failure (ARF) in patients admitted to the intensive care unit (ICU) with known or de novo small-vessel vasculitis (Svv) may be secondary to the underlying immune disease or to other causes. Early identification of the cause of ARF is essential to initiate the most appropriate treatment in a timely fashion.

Methods: A retrospective multicenter study in 10 French ICUs from January 2007 to January 2018 to assess the clinical presentation, main causes and outcome of ARF associated with Svv, and to identify variables associated with non-immune etiology of ARF in patients with known Svv. Read More

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November 2021

Safety Outcomes of Brolucizumab in Neovascular Age-Related Macular Degeneration: Results From the IRIS Registry and Komodo Healthcare Map.

JAMA Ophthalmol 2021 Nov 24. Epub 2021 Nov 24.

Department of Ophthalmology at Rush University Medical Center, Chicago, Illinois.

Importance: Limited data exist on the real-world safety outcomes of patients with neovascular age-related macular degeneration treated with brolucizumab (Beovu).

Objective: To determine the real-world incidence of intraocular inflammation (IOI), including retinal vasculitis (RV) and/or retinal vascular occlusion (RO), for patients with neovascular age-related macular degeneration who underwent brolucizumab treatment. Additionally, potential risk factors associated with these adverse events were evaluated. Read More

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November 2021

Nodular vasculitis during treatment with vedolizumab in a patient with ulcerative colitis.

Australas J Dermatol 2021 Nov 24. Epub 2021 Nov 24.

Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

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November 2021

Erythema Induratum of Bazin Accompanied by Atrophy of the Subcutaneous Fat.

Int Med Case Rep J 2021 15;14:777-781. Epub 2021 Nov 15.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, Indonesia.

Erythema induratum of Bazin (EIB) is a predominantly lobular panniculitis with or without vasculitis due to (MTB) infection. Atrophic scars may remain after EIB was healed. Rare cases of EIB showing sharp skin depression may mimic deep morphea and lupus profundus. Read More

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November 2021

Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis.

Pathobiology 2021 Nov 23:1-6. Epub 2021 Nov 23.

Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan.

Introduction: IgA vasculitis is a systemic disease that results from the entrapment of circulating IgA-containing immune complexes in small-vessel walls in the skin, kidneys, and gastrointestinal tract. An excessive formation of neutrophil extracellular traps (NETs) is involved in the pathogenesis of vasculitis, especially in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This study aimed to clarify whether NETs are implicated in IgA vasculitis. Read More

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November 2021

Contrast-enhanced Magnetic Resonance Imaging, Perfusion Magnetic Resonance Imaging 1H-Magnetic Resonance Spectroscopy Distinguish Primary Central Nervous System Vasculitis from Glioblastoma.

World Neurosurg 2021 Nov 20. Epub 2021 Nov 20.

Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan.

Background: We investigated the ability of magnetic resonance imaging (MRI) to distinguish primary central nervous system vasculitis (PCNSV) from glioblastoma to facilitate the development of an appropriate treatment for PCNSV.

Methods: We enrolled patients who were treated for PCNSV or glioblastoma at our center between January 2007 and August 2018. We compared the diagnoses of the two conditions by retrospectively reviewing patients' data for contrast-enhanced MRI, perfusion MRI, flow-sensitive black-blood (FSBB) imaging, and H-magnetic resonance spectroscopy (MRS). Read More

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November 2021

Polymyalgia Rheumatica in a Patient with Pseudogout and Dementia.

Am J Case Rep 2021 Nov 23;22:e933926. Epub 2021 Nov 23.

Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

BACKGROUND The differential diagnosis of generalized pain includes reactivity associated with bacterial and viral infections, autoimmune rheumatic disease, and orthopedic diseases. Obtaining a detailed medical history and establishing an accurate diagnosis are difficult in elderly patients with dementia. In addition, the differential diagnosis between polymyalgia rheumatica and pseudogout is often difficult. Read More

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November 2021