419,527 results match your criteria vasculature lipoprotein-associated

Differentiation of Brain Tumor Microvasculature From Normal Vessels Using Optical Coherence Angiography.

Lasers Surg Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Biomedical Engineering, The University of Texas Austin, Austin, Texas, 78712, USA.

Background And Objectives: Despite rapid advances and discoveries in medical imaging, monitoring therapeutic efficacy for malignant gliomas and monitoring tumor vasculature remains problematic. The purpose of this study is to utilize optical coherence angiography for vasculature characterization inside and surrounding brain tumors in a murine xenograft brain tumor model. Features included in our analysis include fractional blood volume, vessel tortuosity, diameter, orientation, and directionality. Read More

View Article and Full-Text PDF

USP22 regulates the formation and function of placental vasculature during the development of fetal growth restriction.

Placenta 2021 Jun 9;111:19-25. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China. Electronic address:

Introduction: Fetal growth restriction (FGR) is a common obstetric complication that can lead to a variety of adverse perinatal outcomes and is associated with chronic diseases in adulthood. Since ubiquitin-specific protease 22 (USP22) is closely related to cell growth, differentiation and proliferation, we aimed to investigate the role of USP22 in FGR development.

Methods: USP22 expression was detected in the placentas of eight normal and eight pregnant women with FGR. Read More

View Article and Full-Text PDF

Inhaled bronchodilators use and clinical course of adult inpatients with Covid-19 pneumonia in Spain: A retrospective cohort study.

Pulm Pharmacol Ther 2021 Jun 12:102007. Epub 2021 Jun 12.

Pneumology Department, La Paz University Hospital, IdiPAZ, Madrid.

Background: In the current coronavirus health crisis, inhaled bronchodilators(IB) have been suggested as a possible treatment for patients hospitalized. Patients with evidence of Covid-19 pneumonia worldwide have been prescribed these medications as part of therapy for the disease, an indication for which this medications could be ineffective taken on account the pathophysiology and mechanisms of disease progression.

Objective: The main objective was to evaluate whether there is an association between IB use and length of stay. Read More

View Article and Full-Text PDF

Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats.

Mech Ageing Dev 2021 Jun 12:111520. Epub 2021 Jun 12.

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Rende, Italy; Department of Obstetrics, Gynecology and Reproductive Science, University of Vermont, Burlington, VT, 05405, USA. Electronic address:

Vascular changes of tone and biomechanical properties induced by ageing increase the risk for cardiovascular diseases. Caloric restriction (CR) has been shown to protect against cardiovascular diseases and improve endothelial dysfunction in cerebral resistance arteries. We hypothesise that CR will enhance vascular tone and structural properties of cerebral resistance arteries and exert comparable beneficial effects on the systemic vasculature of aged rat model. Read More

View Article and Full-Text PDF

Basement Membrane Extracellular Matrix Proteins in Pulmonary Vascular and Right Ventricular Remodeling in Pulmonary Hypertension.

Am J Respir Cell Mol Biol 2021 Jun 15. Epub 2021 Jun 15.

Johns Hopkins University School of Medicine, 1500, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States;

The extracellular matrix (ECM), a highly organized network of structural and non-structural proteins, plays a pivotal role in cellular and tissue homeostasis. Changes in the ECM are critical for normal tissue repair, while dysregulation contributes to aberrant tissue remodeling. Pulmonary arterial hypertension (PAH) is a severe disorder of the pulmonary vasculature characterized by pathologic remodeling of the pulmonary vasculature and right ventricle (RV), increased production and deposition of structural and non-structural proteins, and altered expression of ECM growth factors and proteases. Read More

View Article and Full-Text PDF

Simulation of Fluid-Structure Interaction in Extracorporeal Membrane Oxygenation Circulatory Support Systems.

J Cardiovasc Transl Res 2021 Jun 14. Epub 2021 Jun 14.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

Extracorporeal membrane oxygenation (ECMO) is a vital mechanical circulatory support modality capable of restoring perfusion for the patient in circulatory failure. Despite increasing adoption of ECMO, there is incomplete understanding of its effects on systemic hemodynamics and how the vasculature responds to varying levels of continuous retrograde perfusion. To gain further insight into the complex ECMO:failing heart circulation, computational fluid dynamics simulations focused on perfusion distribution and hemodynamic flow patterns were conducted using a patient-derived aorta geometry. Read More

View Article and Full-Text PDF

Technical standardization of ICG near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy for duplex kidney in pediatric patients.

World J Urol 2021 Jun 14. Epub 2021 Jun 14.

Division of Pediatric Surgery, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy.

Purpose: This study aimed to standardize the operative technique of indocyanine green (ICG) near-infrared fluorescence (NIRF) laparoscopic partial nephrectomy (LPN) and compare it with the standard technique.

Methods: In the last 4 years, we performed 22 LPN (14 right-sided, 8 left-sided) in children with non-functioning moiety of duplex kidney. Patients included 12 girls and 10 boys with a median age of 3. Read More

View Article and Full-Text PDF

Hypertension-induced cognitive impairment: from pathophysiology to public health.

Nat Rev Nephrol 2021 Jun 14. Epub 2021 Jun 14.

Vascular Cognitive Impairment and Neurodegeneration Program, Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Hypertension affects two-thirds of people aged >60 years and significantly increases the risk of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises the structural and functional integrity of the cerebral microcirculation, promoting microvascular rarefaction, cerebromicrovascular endothelial dysfunction and neurovascular uncoupling, which impair cerebral blood supply. In addition, hypertension disrupts the blood-brain barrier, promoting neuroinflammation and exacerbation of amyloid pathologies. Read More

View Article and Full-Text PDF

Kirigami-inspired stents for sustained local delivery of therapeutics.

Nat Mater 2021 Jun 14. Epub 2021 Jun 14.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Implantable drug depots have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential systemic side effects. Tubular organs including the gastrointestinal tract, respiratory tract and vasculature all manifest with endoluminal disease. The anatomic distribution of localized drug delivery for these organs using existing therapeutic modalities is limited. Read More

View Article and Full-Text PDF

At a crossroads: coronavirus disease 2019 recovery and the risk of pulmonary vascular disease.

Curr Opin Pulm Med 2021 Jun 11. Epub 2021 Jun 11.

Frankel Cardiovascular Center, Michigan Medicine, University of Michigan, Ann Arbor, Michigan Department of Medicine, Indiana University, Indianapolis, Indiana Laboratory of Vascular Thrombosis and Inflammation, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA.

Purpose Of Review: The coronavirus disease 2019 (COVID-19) pandemic has led to almost 3,000,000 deaths across 139 million people infected worldwide. Involvement of the pulmonary vasculature is considered a major driving force for morbidity and mortality. We set out to summarize current knowledge on the acute manifestations of pulmonary vascular disease (PVD) resulting from COVID-19 and prioritize long-term complications that may result in pulmonary hypertension (PH). Read More

View Article and Full-Text PDF

Discovering Non-Invasive Biomarkers Predictive of Opioid Use Disorder Treatment Response.

CNS Spectr 2021 Apr;26(2):173

University of Pennsylvania, Philadelphia, PA, USA.

Background: Opioid use disorder (OUD) continues to be the driving force behind drug overdoses in the United States, killing nearly 47,000 people in 2018 alone. The increasing presence of deadlier fentanyl analogues in the heroin drug supply are putting users at a greater risk for overdose than ever before. Admissions to treatment programs for OUD have also nearly doubled since 2006, yet relapse rates remain high. Read More

View Article and Full-Text PDF

[Clinical value of left ventricular strain analysis by cardiovascular magnetic resonance in patients with coronary chronic total occlusion].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):601-609

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029,China.

To explore the clinical value of quantitatively assessment of left ventricular strain in patients with coronary chronic total occlusion (CTO) by cardiac magnetic resonance imaging (CMR)-feature tracking (CMR-FT) technique. In this retrospective and observation study, patients with single CTO, who underwent CMR examination in Beijing Anzhen Hospital from November 2014 to January 2019, were selected as case group (CTO group), and those without cardiovascular diseases defined by echocardiography, electrocardiogram (ECG) and clinical history and with normal CMR results were selected as healthy control group (control group). General clinical data including age, gender, discharge diagnosis, and the examination results of echocardiography and ECG were obtained from the electronic medical record system. Read More

View Article and Full-Text PDF

Understanding the Role of Blood Vessels in the Neurological Manifestations of COVID-19.

Am J Pathol 2021 Jun 11. Epub 2021 Jun 11.

Schepens Eye Research Institute of Massachusetts Eye and Ear and the Department of Ophthalmology at Harvard Medical School, Boston, United States. Electronic address:

SARS-CoV-2 was originally identified as an outbreak in Wuhan, China towards the end of 2019 and quickly became a global pandemic, with a large death toll. Originally identified as a respiratory disease, similar to previously discovered SARS and MERS type viruses, concern has since been raised about the effects of SARS-CoV-2 infection on the vasculature. This viral-vascular involvement is of particular concern with regards to the small vessels present in the brain, with mounting evidence demonstrating that SARS-CoV-2 is capable of crossing the blood-brain-barrier. Read More

View Article and Full-Text PDF

Immune cells in lens injury repair and fibrosis.

Exp Eye Res 2021 Jun 11;209:108664. Epub 2021 Jun 11.

Department of Pathology, Anatomy and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Department of Ophthalmology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA. Electronic address:

Immune cells, both tissue resident immune cells and those immune cells recruited in response to wounding or degenerative conditions, are essential to both the maintenance and restoration of homeostasis in most tissues. These cells are typically provided to tissues by their closely associated vasculatures. However, the lens, like many of the tissues in the eye, are considered immune privileged sites because they have no associated vasculature. Read More

View Article and Full-Text PDF

Sheehan syndrome.

J Pak Med Assoc 2021 Apr;71(4):1282-12568

Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.

Sheehan syndrome is an underestimated cause of hypopituitarism, which can be either partial or complete. It results from ischaemic necrosis of anterior pituitary during peripartum period leading to loss of one or more pituitary cell lines. Hyperplasia of pituitary gland during pregnancy increases demand for blood supply and at the same time compresses the pituitary gland. Read More

View Article and Full-Text PDF

Transplacental transfer of congenital B-cell acute lymphoblastic leukemia to the maternal vasculature.

Pediatr Blood Cancer 2021 Jun 14:e29142. Epub 2021 Jun 14.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.

View Article and Full-Text PDF

Dietary nutrient restrictions in the post-weaning period change Santa Inês ewe lamb nutritional metabolic profile.

Trop Anim Health Prod 2021 Jun 14;53(3):359. Epub 2021 Jun 14.

Animal Science Department, Federal University of Tocantins, BR-153, Km 112, s/no, Caixa Postal 132, 77.804-970, Araguaina, Tocantins, Brazil.

The objective of this study was to evaluate the metabolic profile of Santa Inês ewe lambs fed diets for early or late-maturing diets with or without nutrient restrictions. The experiment consisted of a 2 × 2 completely randomized factorial experiment with either early- or late-maturity feed formulation according to "Nutrient Requirements of Small Ruminants" with or without 15% crude protein (CP) and total digestible nutrients (TDN) restrictions in diets formulated, five replications, and 20 ewe lambs averaging 15.1±2. Read More

View Article and Full-Text PDF

Accuracy of registration techniques and vascular imaging modalities in fusion imaging for aortic endovascular interventions: a phantom study.

CVIR Endovasc 2021 Jun 14;4(1):51. Epub 2021 Jun 14.

Department for Radiology and Neuroradiology, Sana Hospital, Lübeck, Germany.

Background: This study aimed to assess the error of different registration techniques and imaging modalities for fusion imaging of the aorta in a standardized setting using a anthropomorphic body phantom.

Materials And Methods: A phantom with the 3D printed vasculature of a patient suffering from an infrarenal aortic aneurysm was constructed. Pulsatile flow was generated via an external pump. Read More

View Article and Full-Text PDF

The Cardiovascular Cost of Silence: Relationships Between Self-silencing and Carotid Atherosclerosis in Midlife Women.

Ann Behav Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Individuals engage in a range of behaviors to maintain close relationships. One behavior is self-silencing or inhibiting self-expression to avoid relationship conflict or loss. Self-silencing is related to poor mental health and self-reported physical health in women but has not been examined in relation to cardiovascular health, particularly using direct measures of the vasculature. Read More

View Article and Full-Text PDF

Ageing, hypertension and aortic valve stenosis - Understanding the series circuit using cardiac magnetic resonance and applanation tonometry.

Int J Cardiol Hypertens 2021 Jun 28;9:100087. Epub 2021 May 28.

Department of Cardiology, St Vincent's Hospital, Sydney, Australia.

Background: Aortic stenosis (AS) is no longer considered to be a disease of fixed left ventricular (LV) afterload, but rather, functions as a series circuit, with important contributions from both the valve and vasculature. Patients with AS are typically elderly, with hypertension and a markedly remodelled aorta. The arterial component is sizeable, and yet, quantifying this to-date has been difficult to determine. Read More

View Article and Full-Text PDF

Age, Wound Size, and Position of Injury - Dependent Vascular Regeneration Assay in Growing Leaves.

Bio Protoc 2021 May 5;11(9):e4010. Epub 2021 May 5.

School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram, Kerala 695551, India.

Recurring damage to the aerial organs of plants necessitates their prompt repair, particularly their vasculature. While vascular regeneration assays for aerial plant parts such as the stem and inflorescence stalk are well established, those for leaf vasculature remain unexplored. Recently, we established a new vascular regeneration assay in growing leaves and discovered the underlying molecular mechanism. Read More

View Article and Full-Text PDF

Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology.

Front Cell Dev Biol 2021 26;9:688388. Epub 2021 May 26.

Department of Pathology and Translational Pathobiology, Louisiana State University Health - Shreveport, Shreveport, LA, United States.

The Nck family of modular adaptor proteins, including Nck1 and Nck2, link phosphotyrosine signaling to changes in cytoskeletal dynamics and gene expression that critically modulate cellular phenotype. The Nck SH2 domain interacts with phosphotyrosine at dynamic signaling hubs, such as activated growth factor receptors and sites of cell adhesion. The Nck SH3 domains interact with signaling effectors containing proline-rich regions that mediate their activation by upstream kinases. Read More

View Article and Full-Text PDF

Spontaneous Intracranial Hemorrhage: A Sign of Cavernous Angioma Diagnosis in Pediatric Age Group.

Cureus 2021 May 9;13(5):e14917. Epub 2021 May 9.

Department of Neuroscience, Salmaniya Medical Complex, Manama, BHR.

Cerebral cavernous malformation (CCM) is a developmental abnormality of blood vessels that supply the brain. It is composed of large, adjacent capillaries which contain little or no neural tissue. They mostly occur in the supratentorial region. Read More

View Article and Full-Text PDF

Bilateral Pulmonary Emboli and Deep Venous Thrombi in Association With Chronic Inflammatory Demyelinating Polyneuropathy.

Cureus 2021 May 2;13(5):e14802. Epub 2021 May 2.

Department of Neurology, Cleveland Clinic, Cleveland, USA.

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune neurological disorder primarily affecting the peripheral nervous system. It is important to recognize because treatment with immunomodulators can improve symptoms. We present the case of a 61-year-old man who developed a saddle pulmonary embolus as well as right-sided deep venous thrombi following left knee arthroplasty. Read More

View Article and Full-Text PDF

Tuning molecular aggregation to achieve highly bright AIE dots for NIR-II fluorescence imaging and NIR-I photoacoustic imaging.

Chem Sci 2020 Jul 17;11(31):8157-8166. Epub 2020 Jul 17.

School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiao Tong University Xi'an 710049 P. R. China

Currently, bright aggregation-induced emission luminogens (AIEgens) with high photoluminescence quantum yields (PLQYs) in the NIR-II region are still limited, and thus an efficient strategy to enhance NIR-II fluorescence performance through tuning molecular aggregation is proposed here. The synthesized donor-acceptor tailored AIEgen (DTPA-TBZ) not only exhibits an excellent absorptivity in the NIR-I region, but also good fluorescence signals in the NIR-II region with an emission extending to 1200 nm. Benefiting from such improved intramolecular restriction and aggregation, a significant absolute PLQY value of 8. Read More

View Article and Full-Text PDF

The Application Potential and Advance of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Infarction.

Stem Cells Int 2021 1;2021:5579904. Epub 2021 Jun 1.

Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Myocardial infarction (MI) is a devastating disease with high morbidity and mortality caused by the irreversible loss of functional cardiomyocytes and heart failure (HF) due to the restricted blood supply. Mesenchymal stem cells (MSCs) have been emerging as lead candidates to treat MI and subsequent HF mainly through secreting multitudinous factors of which exosomes act as the most effective constituent to boost the repair of heart function through carrying noncoding RNAs and proteins. Given the advantages of higher stability in the circulation, lower toxicity, and controllable transplantation dosage, exosomes have been described as a wonderful and promising cell-free treatment method in cardiovascular disease. Read More

View Article and Full-Text PDF

Therapeutic Induction of Tertiary Lymphoid Structures in Cancer Through Stromal Remodeling.

Front Immunol 2021 27;12:674375. Epub 2021 May 27.

Cancer Microenvironment Laboratory, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, Australia.

Improving the effectiveness of anti-cancer immunotherapy remains a major clinical challenge. Cytotoxic T cell infiltration is crucial for immune-mediated tumor rejection, however, the suppressive tumor microenvironment impedes their recruitment, activation, maturation and function. Nevertheless, solid tumors can harbor specialized lymph node vasculature and immune cell clusters that are organized into tertiary lymphoid structures (TLS). Read More

View Article and Full-Text PDF

Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance.

Front Immunol 2021 27;12:656364. Epub 2021 May 27.

Department of Cancer Diagnostics and Immunology, Greater Poland Cancer Center, Poznań, Poland.

The tumor microenvironment (TME) is a complex and ever-changing "rogue organ" composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells and extracellular matrix (ECM). These complex components, utilizing both benign and malignant cells, nurture the harsh, immunosuppressive and nutrient-deficient environment necessary for tumor cell growth, proliferation and phenotypic flexibility and variation. An important aspect of the TME is cellular crosstalk and cell-to-ECM communication. Read More

View Article and Full-Text PDF

Quantitative Assessment of the Intracranial Vasculature of Infants and Adults Using iCafe (Intracranial Artery Feature Extraction).

Front Neurol 2021 28;12:668298. Epub 2021 May 28.

University of Washington, Seattle, WA, United States.

Comprehensive quantification of intracranial artery features may help to assess and understand regional variations of blood supply during early brain development and aging. We analyzed vasculature features of 27 healthy infants during natural sleep, 13 infants at 7-months (7.3 ± 1. Read More

View Article and Full-Text PDF

Improving endovascular access to the target vessel for thrombus aspiration -Use of the wedge device to overcome anatomic hurdles.

Interv Neuroradiol 2021 Jun 14:15910199211024794. Epub 2021 Jun 14.

Department of Radiology, Beaumont Hospital, Dublin, Ireland.

Background And Purpose: Aspiration is a successful technique used in thrombectomy for acute stroke. It is contingent upon the appropriate position of the aspiration catheter, so that it is in contact with the thrombus. However, navigating the craniocervical vasculature is challenging is some patients. Read More

View Article and Full-Text PDF