5,813 results match your criteria vascularization days

Microscopic features of the rat adrenal gland associated with chronic codeine phosphate administration.

Anat Cell Biol 2021 Apr 14. Epub 2021 Apr 14.

Department of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.

Codeine is an opioid analgesic and antitussive that has been widely abused. Some adverse effects noted with its abuse include adrenocortical insufficiency and activation of the hypothalamic-pituitary-adrenal axis. The structural basis for these dysfunctions is not clearly understood. Read More

View Article and Full-Text PDF

Effect of White Tea () Extract on Skin Wound Healing Process in Rats.

World J Plast Surg 2021 Jan;10(1):85-95

Medical Plants Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: White tea () has anti-inflammatory and antioxidant properties and a protective effect against wrinkles, sunburn and UV damages on the skin. Thus, we aimed to evaluate the effect of white tea extract on the healing process of skin wounds in rats.

Methods: This study was done in the Research Center of Shahrekord University of Medical Sciences, Shahrekord, Iran in 2019. Read More

View Article and Full-Text PDF
January 2021

The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats.

Sci Rep 2021 Apr 7;11(1):7672. Epub 2021 Apr 7.

Post-Graduation Program in Morfofuncional Sciences (PCMF), Departamento de Morfologia, Faculdade de Medicina, Medical School, Universidade Federal do Ceará (UFC), Rua Delmiro de Farias, s/n, Rodolfo Teófilo, Fortaleza, CE, 60441-750, Brazil.

Zoledronic acid (ZA) is often prescribed for osteoporosis or resorptive metabolic bone disease. This study aims to evaluate the effect of ZA on orthodontic tooth movement (OTM) and root and bone resorption and its repercussion on root, periodontal ligament and alveolar bone tissues. The experimental group consisted of 72 Wistar rats divided in four subgroups: Naive, Saline and Zoledronic Acid groups at the concentration of 0. Read More

View Article and Full-Text PDF

The Early Fragmentation of a Bovine Dermis-Derived Collagen Barrier Membrane Contributes to Transmembraneous Vascularization-A Possible Paradigm Shift for Guided Bone Regeneration.

Membranes (Basel) 2021 Mar 9;11(3). Epub 2021 Mar 9.

Department of Oral and Maxillofacial Plastic Surgery, Evangelic Johanniter Hospital Bethesda Mönchengladbach, 41061 Mönchengladbach, Germany.

Collagen-based barrier membranes are an essential component in Guided Bone Regeneration (GBR) procedures. They act as cell-occlusive devices that should maintain a micromilieu where bone tissue can grow, which in turn provides a stable bed for prosthetic implantation. However, the standing time of collagen membranes has been a challenging area, as native membranes are often prematurely resorbed. Read More

View Article and Full-Text PDF

A Reassessment of the Therapeutic Potential of a Dopamine Receptor 2 Agonist (D2-AG) in Endometriosis by Comparison against a Standardized Antiangiogenic Treatment.

Biomedicines 2021 Mar 8;9(3). Epub 2021 Mar 8.

Research Unit on Women's Health-Institute of Health Research, INCLIVA, 46010 Valencia, Spain.

Dopamine receptor 2 agonists (D2-ags) have been shown to reduce the size of tumors by targeting aberrant angiogenesis in pathological tissue. Because of this, the use of a D2-ag was inferred for endometriosis treatment. When assayed in mouse models however, D2-ags have been shown to cause a shift of the immature vessels towards a more mature phenotype but not a significant reduction in the amount of vascularization and size of lesions. Read More

View Article and Full-Text PDF

Reactive Changes in Elements of Stromal-Vascular Differons of Dysferlin-Deficient Skeletal Muscles after Procaine Injection.

Bull Exp Biol Med 2021 Mar 31;170(5):677-681. Epub 2021 Mar 31.

I. I. Mechnikov North-Western State Medical University, Ministry of Health if the Russian Federation, St. Petersburg, Russia.

The study assessed reactivity of stromal-vascular skeletal muscle differons to acute chemical injury. Dysferlin-deficient Bla/J mice and the wild-type С57BL/6 mice were intramuscularly injected with 100 μl of 0.5% procaine solution. Read More

View Article and Full-Text PDF

The Impact of Lower Limb Immobilization and Rehabilitation on Angiogenic Proteins and Capillarization in Skeletal Muscle.

Med Sci Sports Exerc 2021 Mar 25. Epub 2021 Mar 25.

Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark Technical University of Munich, Germany. Sylvia Lawry Centre for Multiple Sclerosis Research, Munich, Germany.

Purpose: Skeletal muscle vascularization is important for tissue regeneration after injury and immobilization. We examined whether complete immobilization influences capillarization and oxygen delivery to the muscle and assessed the efficacy of rehabilitation by aerobic exercise training.

Methods: Young healthy males had one leg immobilized for 14 days and subsequently completed four weeks of intense aerobic exercise training. Read More

View Article and Full-Text PDF

Does hypoxia-inducible factor 1α play a role in regulating cutaneous oxygen flux in larval zebrafish (Danio rerio)?

J Comp Physiol B 2021 Mar 27. Epub 2021 Mar 27.

Department of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie Private, Ottawa, ON, K1N 6N5, Canada.

Previous studies have demonstrated that hypoxia tolerance is improved in zebrafish (Danio rerio) larvae after prior exposure to lowered ambient O levels. Such improved hypoxia performance was attributed in part, to increased levels of hypoxia-inducible factor 1α (Hif-1α) exerting downstream effects on various physiological processes including promotion of trunk skin angiogenesis. Since O uptake ([Formula: see text]) in larvae is facilitated largely by O diffusion across the skin, enhanced cutaneous vascularization is expected to enhance [Formula: see text] during hypoxia and thus contribute to improved hypoxia tolerance. Read More

View Article and Full-Text PDF

Evaluation of Clinical and Histological Outcomes of Adipose-Derived Mesenchymal Stem Cells in a Rabbit Corneal Alkali Burn Model.

Stem Cells Int 2021 7;2021:6610023. Epub 2021 Mar 7.

Laboratory of Experimental Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

To assess effects of adipose-derived mesenchymal stem cells (AMSCs) in corneal alkali injuries in an experimental animal model. Twenty white New Zealand rabbits were included in the study. The animal models were randomly divided into 2 groups. Read More

View Article and Full-Text PDF

The Application of a Bone Marrow Mesenchymal Stem Cell Membrane in the Vascularization of a Decellularized Tracheal Scaffold.

Stem Cells Int 2021 5;2021:6624265. Epub 2021 Mar 5.

Department of Neonatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510030, China.

Airway stenosis is a common problem in the neonatal intensive care unit (NICU) and pediatric intensive care unit (PICU). A tissue-engineered trachea is a new therapeutic method and a research hotspot. Successful vascularization is the key to the application of a tissue-engineered trachea. Read More

View Article and Full-Text PDF

Effects of sildenafil and tadalafil on skin flap viability.

Arch Dermatol Res 2021 Mar 14. Epub 2021 Mar 14.

University of Southern Santa Catarina, Florianópolis, Brazil.

Vascular complication is one of the causes of skin flap healing failure. Sildenafil and tadalafil, a type-5 phosphodiesterase inhibitor, can improve flap viability, however, the action mechanisms involved in this process are still unclear. To assess the effects of orally administered sildenafil and tadalafil on the healing kinetics and skin flap viability, sixty-two Wistar rats were divided into three groups: control (n = 22), sildenafil (n = 20), and tadalafil (n = 20). Read More

View Article and Full-Text PDF

Investigating the vascularization capacity of a decellularized dental pulp matrix seeded with human dental pulp stem cells: in vitro and preliminary in vivo evaluations.

Int Endod J 2021 Mar 11. Epub 2021 Mar 11.

Department of Oral Biology, School of Dentistry, University of Leeds, Leeds, UK.

Aim: To investigate the vascularization capacity of a decellularized dental pulp matrix (DDP) of bovine origin seeded with human dental pulp stem cells (hDPSCs) in vitro and to present preliminary in vivo findings.

Methodology: Bovine dental pulps were decellularized and then analysed using histological staining and DNA quantification. The resultant DDPs were characterized using immunohistochemical staining for the retention of vascular endothelial growth factor A (VEGF-A) and fibroblast growth factor 2 (FGF-2). Read More

View Article and Full-Text PDF

3D-microtissue derived secretome as a cell-free approach for enhanced mineralization of scaffolds in the chorioallantoic membrane model.

Sci Rep 2021 Mar 8;11(1):5418. Epub 2021 Mar 8.

Division of Surgical Research, University Hospital of Zurich, Zurich, Switzerland.

Bone regeneration is a complex process and the clinical translation of tissue engineered constructs (TECs) remains a challenge. The combination of biomaterials and mesenchymal stem cells (MSCs) may enhance the healing process through paracrine effects. Here, we investigated the influence of cell format in combination with a collagen scaffold on key factors in bone healing process, such as mineralization, cell infiltration, vascularization, and ECM production. Read More

View Article and Full-Text PDF

Picturing Breast Cancer Brain Metastasis Development to Unravel Molecular Players and Cellular Crosstalk.

Cancers (Basel) 2021 Feb 22;13(4). Epub 2021 Feb 22.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.

With breast cancer (BC) therapy improvements, the appearance of brain metastases has been increasing, representing a life-threatening condition. Brain metastasis formation involves BC cell (BCC) extravasation across the blood-brain barrier (BBB) and brain colonization by unclear mechanisms. We aimed to disclose the actors involved in BC brain metastasis formation, focusing on BCCs' phenotype, growth factor expression, and signaling pathway activation, correlating with BBB alterations and intercellular communication. Read More

View Article and Full-Text PDF
February 2021

Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8.

Angiogenesis 2021 Mar 2. Epub 2021 Mar 2.

Institute for Clinical & Experimental Surgery, Saarland University, 66421, Homburg, Saarland, Germany.

Angiogenesis crucially contributes to various diseases, such as cancer and diabetic retinopathy. Hence, anti-angiogenic therapy is considered as a powerful strategy against these diseases. Previous studies reported that the acyclic monoterpene linalool exhibits anticancer, anti-inflammatory and anti-oxidative activity. Read More

View Article and Full-Text PDF

The Effect of Apocynin on Fat Graft Survival.

Aesthetic Plast Surg 2021 Mar 1. Epub 2021 Mar 1.

ENT Department, Taksim Training and Education Hospital, Istanbul, Turkey.

Background: In this study, we investigated the effect of apocynin on fat graft survival in a rat model.

Methods: Twenty-one Wistar albino male rats were included in the study. The grafts taken from the inguinal area were applied to the nape of each rat. Read More

View Article and Full-Text PDF

Effects of diode low-level laser therapy on healing of tooth extraction sockets: a histopathological study in diabetic rats.

Lasers Med Sci 2021 Mar 1. Epub 2021 Mar 1.

Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Diabetes mellitus is mostly interrelated to deficiency in wound healing. Low-level laser therapy has been shown to exert reliable effects on the acceleration of wound healing process. This study aimed to determine the potential influence of low-level laser therapy (LLLT) on the healing of extraction sockets in diabetic rats. Read More

View Article and Full-Text PDF

Diagnostic accuracy of Quantitative Colour Doppler Flow imaging in distinguishing Persistent Fetal Vasculature from Retinal Detachment.

Acta Ophthalmol 2021 Feb 24. Epub 2021 Feb 24.

Department of Neuroradiology, Foundation Adolphe de Rothschild Hospital, Paris, France.

Purpose: Distinguishing posterior persistent fetal vasculature (PFV) from retinal detachment (RD) may be very challenging clinically and ultrasonographically, as they share common morphological features. However, it is crucial, considering their substantially distinct management and treatment. We aimed to assess the relevance of quantitative colour Doppler flow imaging to distinguish PFV from RD in children. Read More

View Article and Full-Text PDF
February 2021

Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues.

Adv Funct Mater 2020 Nov 25;30(48). Epub 2020 Jun 25.

Biological Design Center, Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

Formation of capillary blood vasculature is a critical requirement for native as well as engineered organs and can be induced in vitro by co-culturing endothelial cells with fibroblasts. However, whether these fibroblasts are required only in the initial morphogenesis of endothelial cells or needed throughout is unknown, and the ability to remove these stromal cells after assembly could be useful for clinical translation. In this study, we introduce a technique termed CAMEO (Controlled Apoptosis in Multicellular Tissues for Engineered Organogenesis), whereby fibroblasts are selectively ablated on demand, and utilize it to probe the dispensability of fibroblasts in vascular morphogenesis. Read More

View Article and Full-Text PDF
November 2020

Molecular mechanisms underlying fructose-induced cardiovascular disease: exercise, metabolic pathways and microRNAs.

Exp Physiol 2021 Feb 19. Epub 2021 Feb 19.

National Institute for Science and Technology - INCT Physical (In)activity and Exercise, CNPq -, Niterói, Rio de Janeiro, Brazil.

New Findings: What is the central question of this study? What are the mechanisms underlying the cardiac protective effect of aerobic training in the progression of a high fructose-induced cardiometabolic disease in Wistar rats? What is the main finding and its importance? At the onset of cardiovascular disease, aerobic training activates the p-p70S6K, ERK and IRβ-PI3K-AKT pathways, without changing the miR-126 and miR-195 levels, thereby providing evidence that aerobic training modulates the insulin signalling pathway. These data contribute to the understanding of the molecular cardiac changes that are associated with physiological left ventricular hypertrophy during the development of a cardiovascular disease.

Abstract: During the onset of cardiovascular disease (CVD), disturbances in myocardial vascularization, cell proliferation and protein expression are observed. Read More

View Article and Full-Text PDF
February 2021

Voluntary exercise does not improve muscular properties or functional capacity during C26-induced cancer cachexia in mice.

J Muscle Res Cell Motil 2021 Feb 19. Epub 2021 Feb 19.

Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Tervuursevest 101, box 1500, 3001, Leuven, Belgium.

Exercise training is considered as a potential intervention to counteract muscle degeneration in cancer cachexia. However, evidence to support such intervention is equivocal. Therefore, we investigated the effect of exercise training, i. Read More

View Article and Full-Text PDF
February 2021

Effects of atorvastatin and resveratrol against the experimental endometriosis; evidence for glucose and monocarboxylate transporters, neoangiogenesis.

Life Sci 2021 May 16;272:119230. Epub 2021 Feb 16.

Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

The current study was conducted to investigate the therapeutic effects of atorvastatin (ATV) and resveratrol (RVT) in sole and simultaneous forms of administration against the symbiosis between glucose transporters 1 and 3 (GLUT-1 and GLUT-3), monocarboxylate transporters 1 a and 4 (MCT-1 and MCT-4) and neovascularization in ectopic endometrial tissue (EET). For this purpose, the experimental endometriosis was induced in 24 virgin female Wistar rats, and then the rats were divided into non-treated endometriosis-induced (ENDO-sole), AVT-treated (5 mg kg-1), RVT-treated (40 mg kg-1) and AVT +RVT-treated groups (n = 6 rats in each group). Following 28 days from the experimental endometriosis induction, the EETs were collected and the EETs size, neovascularization ratio, and expression levels of GLUT-1, GLUT-3, MCT-1, and MCT-4 were analyzed by qRT-PCR and immunohistochemistry (IHC). Read More

View Article and Full-Text PDF

Coculture of Endothelial and Stromal Cells to Promote Concurrent Osteogenesis and Vasculogenesis.

Tissue Eng Part A 2021 Mar 30. Epub 2021 Mar 30.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.

A key challenge in the treatment of large bone defects is the need to provide an adequate and stable vascular supply as new tissue develops. Bone tissue engineering applies selected biomaterials and cell types to create an environment that promotes tissue formation, maturation, and remodeling. Mesenchymal stromal cells (MSCs) have been widely used in these strategies because of their established effects on bone formation, and their ability to act as stabilizing pericytes that support vascular regeneration by endothelial cells (ECs). Read More

View Article and Full-Text PDF

Regenerative Wound Healing by Open Grafting of Autologous Fat and PRP-Gel - A New Concept and Potential Alternative to Flaps.

Mohan Rangaswamy

Plast Reconstr Surg Glob Open 2021 Jan 25;9(1):e3349. Epub 2021 Jan 25.

American Academy of Cosmetic Surgery Hospital, Dubai, United Arab Emirates.

A new regenerative technique is described that enabled in situ formation of soft tissue bridge for difficult wounds, which otherwise needed flaps, resulting in complete healing in 3/3 cases. The wounds were debrided till healthy bleeding and covered with a triple-layer matrix of platelet-rich fibrin gel, condensed liposuctioned autologous fat, and porous collagen dressing. Negative pressure wound therapy was applied after 48 hours for 4-5 days in 2 cases and after 11 days for 3 weeks in the third case. Read More

View Article and Full-Text PDF
January 2021

New Insights Into the Role of β-NGF/TrKA System in the Endometrium of Alpacas During Early Pregnancy.

Front Vet Sci 2020 22;7:583369. Epub 2021 Jan 22.

Instituto Superior de Investigaciones Biológicas (INSIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas - Universidad Nacional de Tucumán (CONICET-UNT), and Instituto de Biología "Dr. Francisco D. Barbieri", Facultad de Bioquímica, Química y Farmacia, UNT, San Miguel de Tucumán, Argentina.

One striking reproductive feature in South American camelids is that more than 90% of gestations are established in the left uterine horn (LUH). This phenomenon could be related to a differential vascular irrigation of the LUH. An increase of vascularization in llama endometrium was observed after systemic administration of Beta Nerve Growth Factor (β-NGF), a neurotrophin present in the uterus and placenta of various mammals that is involved in pregnancy development. Read More

View Article and Full-Text PDF
January 2021

Letrozole Versus Clomiphene Citrate and Natural Cycle: Endometrial Receptivity During Implantation Window in Women With Polycystic Ovary Syndrome.

Front Endocrinol (Lausanne) 2020 18;11:532692. Epub 2021 Jan 18.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Objective: Numerous studies have reported on ovulation and pregnancy rates in patients with polycystic ovary syndrome (PCOS). However, relevant data on endometrial receptivity are limited. This study was conducted to compare endometrial receptivity during implantation windows among letrozole (LE), clomiphene citrate (CC), and natural cycle, and to assess the predictive value for pregnancy of observed indicators. Read More

View Article and Full-Text PDF
January 2021

Sexual dimorphisms in brain gene expression in the growth-restricted guinea pig can be modulated with intra-placental therapy.

Pediatr Res 2021 Feb 2. Epub 2021 Feb 2.

Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

Background: Fetal responses to adverse pregnancy environments are sex-specific. In fetal guinea pigs (GPs), we assessed morphology and messenger RNA (mRNA) expression in fetal growth-restricted (FGR) tissues at midpregnancy.

Methods: Female GPs were assigned either an ad libitum diet (C) or 30% restricted diet (R) prior to pregnancy to midpregnancy. Read More

View Article and Full-Text PDF
February 2021

Ultra-high-frequency ultrasound monitoring of plaque psoriasis during ixekizumab treatment.

Skin Res Technol 2021 Mar 2;27(2):277-282. Epub 2021 Feb 2.

Department of Dermatology, University of Pisa, Pisa, Italy.

Background: High-frequency ultrasound (HFUS) is a non-invasive method that detects superficial skin features. Ultra-high frequencies (50-100 MHz) can reveal epidermis and dermis structures.

Objectives: In this study, we describe the psoriatic plaque using a new device equipped with a 70 MHz probe (VEVO MD, Fujifilm, VisualSonics) and we assess the lesion before and after ixekizumab. Read More

View Article and Full-Text PDF

Application of Deproteinized Bovine Bone Mineral as Proangiogenic Scaffold for Alveolar Bone Formation in Beagle Dogs.

Microscopy (Oxf) 2021 Feb 2. Epub 2021 Feb 2.

Division of Dental Anatomy, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan.

Alveolar bone repair after tooth extraction is essential after oral surgeries. Various grafting materials are used to promote the regeneration of lost alveolar bone. This study analysed the morphological features of the tissue regeneration process using deproteinized bovine bone mineral (DBBM). Read More

View Article and Full-Text PDF
February 2021

Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing.

ACS Biomater Sci Eng 2021 03 1;7(3):1147-1158. Epub 2021 Feb 1.

Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States.

Dysangiogenesis and chronic inflammation are two critical reasons for diabetic foot ulcers. Desferrioxamine (DFO) was used clinically in the treatment of diabetic foot ulcers by repeated injections because of its capacity to induce vascularization. Biocompatible carriers that release DFO slowly and facilitate healing simultaneously are preferable options to accelerate the healing of diabetic wounds. Read More

View Article and Full-Text PDF