342 results match your criteria vascular-related diseases


Neurotrophin-3 and neurotrophin-4: The unsung heroes that lies behind the meninges.

Neuropeptides 2022 Jan 7;92:102226. Epub 2022 Jan 7.

Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia. Electronic address:

Neurotrophin is a growth factor that regulates the development and repair of the nervous system. From all factors, two pioneer groups, the nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), have been widely explored for their role in disease pathogenesis and potential use as therapeutic agents. Nonetheless, neurotrophin-3 (NT3) and neurotrophin-4 (NT4) also have promising potential, albeit less popular than their counterparts. Read More

View Article and Full-Text PDF
January 2022

Lung vessel volume evaluated with CALIPER software is an independent predictor of mortality in COVID-19 patients: a multicentric retrospective analysis.

Eur Radiol 2022 Jan 13. Epub 2022 Jan 13.

Department of Diagnosis and Treatment Services, Radiodiagnostics, Azienda Ospedaliero Universitaria Maggiore Della Carità, Novara, Italy.

Introduction: Computer-Aided Lung Informatics for Pathology Evaluation and Ratings (CALIPER) software has already been widely used in the evaluation of interstitial lung diseases (ILD) but has not yet been tested in patients affected by COVID-19. Our aim was to use it to describe the relationship between Coronavirus Disease 2019 (COVID-19) outcome and the CALIPER-detected pulmonary vascular-related structures (VRS).

Materials And Methods: We performed a multicentric retrospective study enrolling 570 COVID-19 patients who performed a chest CT in emergency settings in two different institutions. Read More

View Article and Full-Text PDF
January 2022

Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms.

Phytother Res 2022 Jan 13. Epub 2022 Jan 13.

Jilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. Read More

View Article and Full-Text PDF
January 2022

Mechanism of cell death of endothelial cells regulated by mechanical forces.

J Biomech 2022 Jan 20;131:110917. Epub 2021 Dec 20.

Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.

Cell death of endothelial cells (ECs) is a common devastating consequence of various vascular-related diseases. Atherosclerosis, hypertension, sepsis, diabetes, cerebral ischemia and cardiac ischemia/reperfusion injury, and chronic kidney disease remain major causes of morbidity and mortality worldwide, in which ECs are constantly subjected to a great amount of dynamic changed mechanical forces including shear stress, extracellular matrix stiffness, mechanical stretch and microgravity. A thorough understanding of the regulatory mechanisms by which the mechanical forces controlled the cell deaths including apoptosis, autophagy, and pyroptosis is crucial for the development of new therapeutic strategies. Read More

View Article and Full-Text PDF
January 2022

Novel Regulators of Retina Neovascularization: A Proteomics Approach.

J Proteome Res 2022 Jan 17;21(1):101-117. Epub 2021 Dec 17.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.

The purpose of this study was to identify proteins that regulate vascular remodeling in an ROP mouse model. Pups were subjected to fluctuating oxygen levels and retinas sampled during vessel regression (PN12) or neovascularization (PN17) for comparative SWATH-MS proteomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS). We developed a human retinal endothelial cell (HREC) ROP correlate to validate the expression of retina neovascular-specific markers. Read More

View Article and Full-Text PDF
January 2022

Treatment dilemmas: strategies for priapism, chronic leg ulcer disease, and pulmonary hypertension in sickle cell disease.

Hematology Am Soc Hematol Educ Program 2021 12;2021(1):411-417

The Ohio State University Wexner Medical Center, Department of Internal Medicine, Columbus, OH.

Sickle cell disease is a disorder characterized by chronic hemolytic anemia and multiorgan disease complications. Although vaso-occlusive episodes, acute chest syndrome, and neurovascular disease frequently result in complication and have well-documented guidelines for management, the management of chronic hemolytic and vascular-related complications, such as priapism, leg ulcers, and pulmonary hypertension, is not as well recognized despite their increasing reported prevalence and association with morbidity and mortality. This chapter therefore reviews the current updates on diagnosis and management of priapism, leg ulcers, and pulmonary hypertension. Read More

View Article and Full-Text PDF
December 2021

The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review.

Pharm Biol 2022 Dec;60(1):9-16

School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, Shanxi, China.

Context: Farrerol, a typical natural flavanone isolated from the traditional Chinese herb 'Man-shan-hong' [ L. (Ericaceae)] with phlegm-reducing and cough-relieving properties, is widely used in China for treating bronchitis and asthma.

Objective: To present the anti-inflammatory, antioxidant, vasoactive, antitumor, and antimicrobial effects of farrerol and its underlying molecular mechanisms. Read More

View Article and Full-Text PDF
December 2022

Retinal Imaging Techniques Based on Machine Learning Models in Recognition and Prediction of Mild Cognitive Impairment.

Neuropsychiatr Dis Treat 2021 6;17:3267-3281. Epub 2021 Nov 6.

Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, People's Republic of China.

Background And Purpose: Mild Cognitive Impairment (MCI) is thought to be the signal of many progressive diseases but is easily ignored. Therefore, a simple and easy screening method for recognizing and predicting MCI is urgently needed. The study aimed to establish machine learning models of retinal vascular features to categorize and predict MCI. Read More

View Article and Full-Text PDF
November 2021

Leadless pacemaker implant, anticoagulation status, and outcomes: Results from the Micra Transcatheter Pacing System Post-Approval Registry.

Heart Rhythm 2021 Oct 29. Epub 2021 Oct 29.

Department of Cardiologic Medicine, Centre Hospitalier Régional Universitaire de Tours-Hôpital Trousseau, Tours, France.

Background: Early results from the Micra investigational trial and Micra Post-Approval Registry (PAR) demonstrated excellent safety and device performance; however, outcomes based on anticoagulation (AC) status at implant have not been evaluated.

Objective: The purpose of this study was to report implant characteristics, perforation rate, and vascular-related events based on perioperative oral AC strategy in patients undergoing Micra implant.

Methods: We compared procedure characteristics, major complications, and vascular events, including pericardial effusion, stratified by any adverse event (including major complications, minor complications, and observations) or major complication only according to AC status in the Micra PAR. Read More

View Article and Full-Text PDF
October 2021

Using three-dimensional visualization as an optimal tool to plan and validate an aortopexy in a congenital heart disease patient with severe tracheal stenosis.

Interact Cardiovasc Thorac Surg 2021 Nov 5. Epub 2021 Nov 5.

Clinic for Children's Heart Medicine, University Heart & Vascular Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

We present a patient with severe tracheal stenosis resulting from a compression by the innominate artery 6 months after an arterial switch operation in a dextro-transposition of the great arteries. Segmentation and three-dimensional (3D) visualization were derived from a contrast-enhanced dual-source computed tomography and post-processing was performed using a dedicated open-source platform (3D Slicer). Post-processing allowed a comprehensible visualization of the relationship of the innominate artery to the trachea when compared to standard computer tomography reformations. Read More

View Article and Full-Text PDF
November 2021

Self-reported cataract surgery and 10-year all-cause and cause-specific mortality: findings from the National Health and Nutrition Examination Survey.

Br J Ophthalmol 2021 Oct 25. Epub 2021 Oct 25.

Guangdong Eye Institute, Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China

Purpose: To investigate the association of self-reported cataract surgery with all-cause and cause-specific mortality using a large-scale population-based sample.

Methods: Data from the 1999-2008 cycles of the National Health and Nutrition Examination Survey were used. A self-reported history of cataract surgery was considered a surrogate for the presence of clinically significant cataract surgery. Read More

View Article and Full-Text PDF
October 2021

Nailfold capillaries and myositis specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis.

Rheumatology (Oxford) 2021 Sep 8. Epub 2021 Sep 8.

Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Kasumi, Minami-ku, Hiroshima, Japan.

Objectives: This study aimed to quantify nailfold capillary (NFC) abnormalities in anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) patients and to evaluate the association with clinical parameters, including serum biomarkers. In addition, we aimed to clarify the period leading to remission of NFC abnormalities during immunosuppressive treatment in patients with DM.

Methods: A prospective observational study was conducted including patients (n = 10) who first visited Hiroshima University Hospital and were diagnosed with DM or clinically amyopathic dermatomyositis (CADM) with anti-MDA5 antibodies. Read More

View Article and Full-Text PDF
September 2021

From remodeling to quiescence: The transformation of the vascular network.

Cells Dev 2021 Aug 21:203735. Epub 2021 Aug 21.

Instituto de Medicina Molecular - João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. Electronic address:

The vascular system is essential for embryogenesis, healing, and homeostasis. Dysfunction or deregulated blood vessel function contributes to multiple diseases, including diabetic retinopathy, cancer, hypertension, or vascular malformations. A balance between the formation of new blood vessels, vascular remodeling, and vessel quiescence is fundamental for tissue growth and function. Read More

View Article and Full-Text PDF

Effect of late-onset epilepsy on cognitive functioning in patients with small vessel disease.

Epilepsy Behav 2021 10 7;123:108238. Epub 2021 Aug 7.

Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain; School of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Rationale: Late-onset epilepsy (LOE) often has underlying cerebrovascular cause and has been associated with neurocognitive deficits and dementia. Nevertheless, the interplay between these factors has not been studied thus far. Hence, we conducted a retrospective cross-sectional study aimed to explore how unprovoked epileptic seizures along with vascular-related factors contribute to neurocognitive impairments in patients with cerebral small vessel disease. Read More

View Article and Full-Text PDF
October 2021

Examining the causal mediating role of brain pathology on the relationship between diabetes and cognitive impairment: the Cardiovascular Health Study.

J R Stat Soc Ser A Stat Soc 2020 Oct 8;183(4):1705-1726. Epub 2020 May 8.

Johns Hopkins University, Baltimore, and Johns Hopkins Center on Aging and Health, Baltimore, USA.

The paper examines whether leads to incident mild cognitive impairment and dementia through brain hypoperfusion and white matter disease. We performed inverse odds ratio weighted causal mediation analyses to decompose the effect of diabetes on cognitive impairment into direct and indirect effects, and we found that approximately a third of the total effect of diabetes is mediated through vascular-related brain pathology. Our findings lend support for a common aetiological hypothesis regarding incident cognitive impairment, which is that diabetes increases the risk of clinical cognitive impairment in part by impacting the vasculature of the brain. Read More

View Article and Full-Text PDF
October 2020

Cystatin C predicts the risk of incident cerebrovascular disease in the elderly: A meta-analysis on survival date studies.

Medicine (Baltimore) 2021 Jul;100(28):e26617

Department of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong.

Background: Stroke is the third leading cause of global year of life lost in all-age and second-ranked cause of disability adjusted life years in middle-aged and elder population. Therefore, it is critical to study the relationship between vascular-related risk factors and cerebrovascular diseases. Several cross-sectional studies have shown that Cystatin C (Cys C) is an independent risk factor for cerebrovascular diseases and levels of Cys C are significantly higher in stroke patients than in healthy individuals. Read More

View Article and Full-Text PDF

Jujuboside B Inhibits Neointimal Hyperplasia and Prevents Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration Activation of AMPK/PPAR-γ Signaling.

Front Pharmacol 2021 24;12:672150. Epub 2021 Jun 24.

Department of Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

The uncontrolled proliferation and migration of vascular smooth muscle cells is a critical step in the pathological process of restenosis caused by vascular intimal hyperplasia. Jujuboside B (JB) is one of the main biologically active ingredients extracted from the seeds of Zizyphus jujuba (SZJ), which has the properties of anti-platelet aggregation and reducing vascular tension. However, its effects on restenosis after vascular intervention caused by VSMCs proliferation and migration remain still unknown. Read More

View Article and Full-Text PDF

Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors.

Bioengineering (Basel) 2021 Jun 9;8(6). Epub 2021 Jun 9.

Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 15-21, 08028 Barcelona, Spain.

Tumor vessel-on-a-chip systems have attracted the interest of the cancer research community due to their ability to accurately recapitulate the multiple dynamic events of the metastatic cascade. Vessel-on-a-chip microfluidic platforms have been less utilized for investigating the distinctive features and functional heterogeneities of tumor-derived vascular networks. In particular, vascular tumors are characterized by the massive formation of thrombi and severe bleeding, a rare and life-threatening situation for which there are yet no clear therapeutic guidelines. Read More

View Article and Full-Text PDF

Circulating MicroRNA Responses to Postprandial Lipemia with or without Prior Exercise.

Int J Sports Med 2021 Dec 11;42(14):1260-1267. Epub 2021 Jun 11.

Department of Kinesiology, University of Maryland School of Public Health, College Park, United States.

Repeated exposure to a high-fat meal triggers inflammation and oxidative stress, contributing to the onset of cardiometabolic diseases. Regular exercise prevents cardiometabolic diseases and a prior bout of acute endurance exercise can counteract the detrimental cardiovascular effects of a subsequent high-fat meal. Circulating microRNAs (ci-miRs) are potential mediators of these vascular effects through regulation of gene expression at the posttranscriptional level. Read More

View Article and Full-Text PDF
December 2021

The role of SIRT2 in vascular-related and heart-related diseases: A review.

J Cell Mol Med 2021 07 24;25(14):6470-6478. Epub 2021 May 24.

Department of Cardiology, The First Hospital of China Medical University, Shenyang, China.

At present, cardiovascular disease is one of the important factors of human death, and there are many kinds of proteins involved. Sirtuins family proteins are involved in various physiological and pathological activities of the human body. Among them, there are more and more studies on the relationship between sirtuin2 (SIRT2) protein and cardiovascular diseases. Read More

View Article and Full-Text PDF

Effects of the Vertebral Artery Ostium/Subclavian Artery Angle on In-Stent Restenosis after Vertebral Artery Ostium Stenting.

Biomed Res Int 2021 27;2021:5527988. Epub 2021 Apr 27.

Department of Neurology, Chinese PLA General Hospital, First Medical Center, Beijing, China.

Methods: Between January 2016 and October 2018, sixty-four consecutive patients who underwent a total of 66 stenting procedures were screened for symptomatic and asymptomatic atherosclerotic VAOS. Of these patients, 57 had complete follow-up data. The baseline patient demographics and morphological features of the VAO were recorded. Read More

View Article and Full-Text PDF

Vessel segmentation from volumetric images: a multi-scale double-pathway network with class-balanced loss at the voxel level.

Med Phys 2021 Jul 31;48(7):3804-3814. Epub 2021 May 31.

Xi'an Key Lab of Radiomics and Intelligent Perception, School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi, 710069, China.

Purpose: Vessel segmentation from volumetric medical images is becoming an essential pre-step in aiding the diagnosis, guiding the therapy, and patient management for vascular-related diseases. Deep learning-based methods have drawn many attentions, but most of them did not fully utilize the multi-scale spatial information of vessels. To address this shortcoming, we propose a multi-scale network similar to the well-known multi-scale DeepMedic. Read More

View Article and Full-Text PDF

Protective effects and molecular mechanisms of polypeptide k on Schwann cells.

Ann Transl Med 2021 Mar;9(5):381

Key Laboratory of Neuroregeneration of Jiangsu, Ministry of Education, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China.

Background: polypeptide k (ABPPk) is an active ingredient used in traditional Chinese medicine separated from polypeptides. So far, the role of ABPPk in peripheral nerve protection has not been comprehensively studied.

Methods: In this study, primary Schwann cells exposed to serum deprivation were treated with ABPPk or nerve growth factor (NGF) . Read More

View Article and Full-Text PDF

Vascular Abnormalities Detected with Chest CT in COVID-19: Spectrum, Association with Parenchymal Lesions, Cardiac Changes, and Correlation with Clinical Severity (COVID-CAVA Study).

Diagnostics (Basel) 2021 Mar 29;11(4). Epub 2021 Mar 29.

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland.

Although vascular abnormalities are thought to affect coronavirus disease 2019 (COVID-19) patients' outcomes, they have not been thoroughly characterized in large series of unselected patients. The Swiss national registry coronavirus-associated vascular abnormalities (CAVA) is a multicentric cohort of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who underwent a clinically indicated chest computed tomography (CT) aiming to assess the prevalence, severity, distribution, and prognostic value of vascular and non-vascular-related CT findings. Clinical outcomes, stratified as outpatient treatment, inpatient without mechanical ventilation, inpatient with mechanical ventilation, or death, will be correlated with CT and biological markers. Read More

View Article and Full-Text PDF

Multiscale Risk Factors of Cardiovascular Disease: CLSA Analysis of Genetic and Psychosocial Factors.

Front Cardiovasc Med 2021 16;8:599671. Epub 2021 Mar 16.

School of Human Nutrition, McGill University, Montreal, QC, Canada.

Cardiovascular disease (CVD) is a complex disease resulting from multiscale risk factors including genetics, age, and psychosocial factors (PSFs) such as depression and social isolation. However, previous research has lacked in operationalizing multiscale risk factors to determine individual and interactive associations over the life course. Therefore, this study aimed to evaluate individual and interactive associations of multiscale risk factors for CVD outcomes including genetics and PSFs at middle and older-aged stages of the life course. Read More

View Article and Full-Text PDF

What is 'Alzheimer's disease'? The neuropathological heterogeneity of clinically defined Alzheimer's dementia.

Curr Opin Neurol 2021 04;34(2):237-245

Rush Alzheimer's Disease Center, Chicago, Illinois, USA.

Purpose Of Review: Beta-amyloid with paired helical filaments (PHF)-tau neurofibrillary tangles define hallmark Alzheimer's disease neuropathologic changes (AD-NC). Yet persons with Alzheimer's dementia, defined broadly as an amnestic multidomain progressive dementia, often exhibit postmortem evidence of other neuropathologies including other neurodegenerative (Lewy body disease and transactive response DNA-binding protein disease) and vascular-related brain lesions. Clinicopathologic and epidemiologic analyses demonstrate the significance of these substrates, as coinciding neuropathologies mitigate the threshold for diagnosis of Alzheimer's dementia. Read More

View Article and Full-Text PDF

Vascular surgery-related violations of the Emergency Medical Treatment and Labor Act.

J Vasc Surg 2021 08 4;74(2):599-604.e1. Epub 2021 Feb 4.

Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston University School of Medicine, Boston, Mass. Electronic address:

Objective: The Emergency Medical Treatment and Labor Act (EMTALA) is a federal law established in 1986 to ensure that patients who present to an emergency department receive medical care regardless of means. Violations are reported to the Centers for Medicare and Medicaid Services and can result in significant financial penalties. Our objective was to assess all available EMTALA violations for vascular-related issues. Read More

View Article and Full-Text PDF

Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective.

Int J Environ Res Public Health 2021 02 3;18(4). Epub 2021 Feb 3.

Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vanvitelli", Piazza L. Miraglia 2, 80138 Naples, Italy.

Background: Neuroinvasive properties of SARS-CoV-2 have allowed the hypothesis of several pathogenic mechanisms related to acute and chronic neurological sequelae. However, neuropathological correlates have been poorly systematically investigated, being retrieved from reports of single case or limited case series still.

Methods: A PubMed search was carried out to review all publications on autopsy in subjects with "COronaVIrus Disease-19" (COVID-19). Read More

View Article and Full-Text PDF
February 2021

Pre-clinical investigation of mesenchymal stromal cell-derived extracellular vesicles: a systematic review.

Cytotherapy 2021 04 2;23(4):277-284. Epub 2021 Feb 2.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran, Iran; Department of Biology, University of Science and Culture, Tehran, Iran. Electronic address:

The therapeutic potential of naturally secreted micro- and nanoscale extracellular vesicles (EVs) makes them attractive candidates for regenerative medicine and pharmaceutical science applications. To date, the results of numerous publications have shown the practicality of using EVs to replace mesenchymal stromal cells (MSCs) or liposomes. This article presents a systematic review of pre-clinical studies conducted over the past decade of MSC-derived EVs (MSC-EVs) used in animal models of disease. Read More

View Article and Full-Text PDF

Pulmonary arterial hypertension in a patient with multiple myeloma during carfilzomib treatment: in search of better management.

Tumori 2021 Dec 1;107(6):NP37-NP40. Epub 2021 Feb 1.

Haematology Unit, ASL ROMA 1, Santo Spirito Hospital of Rome, Italy.

Background: Multiple myeloma is a plasma cell dyscrasia accounting for 1% of neoplastic diseases and is the second most common hematologic malignancy after lymphoma. Pulmonary arterial hypertension is characterized by increased blood pressure in the pulmonary circulation and the development of pulmonary vascular remodeling. Increased resistance in the pulmonary vessels strains the right ventricle, leading to right heart failure. Read More

View Article and Full-Text PDF
December 2021