288,339 results match your criteria vascular tissues

Experimental modeling of selective photodestruction of skin angiodysplasia by laser radiation with a wavelength of 525 nm.

Lasers Med Sci 2021 Jun 23. Epub 2021 Jun 23.

Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russian Federation.

Until now, the problem of effective treatment of skin angiodysplasia remains relevant. To solve it and improve the results of the treatment of this vascular pathology of the skin, photodestruction by laser radiation is considered, which provides a selective effect on the skin with minimal damage to the surrounding tissues. For selective photodestruction in the treatment of angiodysplasia of the skin, one can consider laser radiation with a wavelength of 520 ± 5 nm in the "green" spectral range, located close to the absorption peaks of hemoglobin and oxyhemoglobin chromophores. Read More

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T-cell responses and combined immunotherapy against human carbonic anhydrase 9-expressing mouse renal cell carcinoma.

Cancer Immunol Immunother 2021 Jun 23. Epub 2021 Jun 23.

Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan.

Renal cell carcinoma (RCC) is known to respond to immune checkpoint blockade (ICB) therapy, whereas there has been limited analysis of T-cell responses to RCC. In this study, we utilized human carbonic anhydrase 9 (hCA9) as a model neoantigen of mouse RENCA RCC. hCA9-expressing RENCA RCC (RENCA/hCA9) cells were rejected in young mice but grew in aged mice. Read More

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Co-Expression of LGR5 and CD133 Cancer Stem Cell Predicts a Poor Prognosis in Patients With Gastric Cancer.

Turk J Gastroenterol 2021 Mar;32(3):261-268

School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand;Translational Medicine Programs, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.

Background: The LGR5 and CD133 have been identified as cancer stem cells (CSCs) marker and prognostic marker in several cancers including gastric cancer. The purpose of the present study was to determine the association between co-expression of CSCs marker LGR5 and CD133 in patients with gastric cancer and their clinicopathological outcomes; to analyze the efficacy of co-expression of both markers in evaluating the prognosis of gastric cancer.

Methods: LGR5 and CD133 expression were investigated in a total of 400 patients by using immunohistochemistry. Read More

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Secretogranin II impairs tumor growth and angiogenesis by promoting degradation of hypoxia-inducible factor-1α in colorectal cancer.

Mol Oncol 2021 Jun 23. Epub 2021 Jun 23.

Institute of Digestive Surgery, Sichuan University, Department of Gastrointestinal Surgery, West China Hospital, School of Medicine, Sichuan University, West China, Chengdu, P.R. China.

Distant metastasis is a major cause of death in patients with colorectal cancer (CRC), but the management of advanced and metastatic CRC still remains problematic due to the distinct molecular alterations during tumor progression. Tumor angiogenesis is a key step in tumor growth, invasion, and metastasis. However, the signaling pathways involved in angiogenesis are poorly understood. Read More

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Pyruvate kinase M2 mediates fibroblast proliferation to promote tubular epithelial cell survival in acute kidney injury.

FASEB J 2021 Jul;35(7):e21706

Center for Kidney Disease, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Acute kidney injury (AKI) is a devastating condition with high morbidity and mortality rates. The pathological features of AKI are tubular injury, infiltration of inflammatory cells, and impaired vascular integrity. Pyruvate kinase is the final rate-limiting enzyme in the glycolysis pathway. Read More

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Cross-species comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma.

Dis Model Mech 2021 Jun 23. Epub 2021 Jun 23.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Angiosarcoma (AS) is a highly aggressive tumor of blood and lymphatic vessels in humans that carries a poor prognosis. The rarity of AS, together with its heterogeneous nature, and locations (skin, breast, visceral organs and deep soft tissues), makes understanding the pathogenesis of AS challenging. Dogs and cats spontaneously develop hemangiosarcoma (HSA), an aggressive tumor that shares many histopathological and clinical similarities to AS. Read More

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Glandular metastases from renal cell carcinoma show poor clinical responses to immune checkpoint inhibition but durable responses to angiogenesis inhibitors.

BMJ Case Rep 2021 Jun 22;14(6). Epub 2021 Jun 22.

Department of Medicine, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

While half of the metastatic clear cell renal cell carcinomas (ccRCCs) involve the lungs, metastatic lesions have been described in various other organs, including glandular tissues such as the pancreas. Recent evidence suggests that ccRCC lesions affecting the pancreas are poorly responsive to immune checkpoint inhibition (ICI) but show superior responses to tyrosine kinase inhibitors (TKIs) targeting the vascular endothelial growth factor (VEGF) signalling pathway. However, this has yet to be explored in ccRCC spreading to other glandular tissues. Read More

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Bilateral macular drusen in acquired partial lipodystrophy with type 2 membranoproliferative glomerulonephritis.

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Moorfields Eye Hospital NHS Foundation Trust, London, UK

A 35-year-old woman with acquired partial lipodystrophy (PLD) and features of type 2 membranoproliferative glomerulonephritis (MPGN-II), presented with difficulty in her fine detailed vision over the past year. She had right amblyopia from a hypermetropic anisometropia with astigmatism, displaying a best-corrected visual acuity of 0.50 and 0. Read More

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Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening.

SLAS Discov 2021 Jun 21:24725552211019409. Epub 2021 Jun 21.

Bayer AG, Global Drug Discovery, Berlin, Germany.

SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase that was initially described as an H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has been reported to methylate and regulate several nonhistone proteins relevant to cancer, including mitogen-activated protein kinase kinase kinase 2 (MAP3K2), vascular endothelial growth factor receptor 1 (VEGFR1), and the human epidermal growth factor receptor 2 (HER2). In addition, overexpression of SMYD3 has been linked to poor prognosis in certain cancers, suggesting SMYD3 as a potential oncogene and attractive cancer drug target. Read More

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Albumin Neutralizes Hydrophobic Toxins and Modulates Pathogenicity.

mBio 2021 Jun 22:e0053121. Epub 2021 Jun 22.

Junior Research Group Adaptive Pathogenicity Strategies, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.

Albumin is abundant in serum but is also excreted at mucosal surfaces and enters tissues when inflammation increases vascular permeability. Host-associated opportunistic pathogens encounter albumin during commensalism and when causing infections. Considering the ubiquitous presence of albumin, we investigated its role in the pathogenesis of infections with the model human fungal pathogen, Candida albicans. Read More

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Effects of sporadic transthyretin amyloidosis frequently on the gallbladder and the correlation between amyloid deposition in the gallbladder and heart: A forensic autopsy-based histopathological evaluation.

Pathol Int 2021 Jun 21. Epub 2021 Jun 21.

Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.

The aim of the study is to evaluate the clinicopathological features of cholecystic ATTR deposition in patients with cardiac involvement, investigate the correlation of amyloid deposition severity in the gallbladder and the heart, and compare its prevalence in the gallbladder and other organs. Fifty patients with sporadic ATTR amyloidosis were identified. Of these, we evaluated 15 patients who underwent gallbladder sampling accurately. Read More

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Management of Refractory Mandibular Kaposiform Hemangioendothelioma with Sirolimus: A Case Report and Review of the Literature.

J Oral Maxillofac Surg 2021 May 18. Epub 2021 May 18.

Consultant, Department of Maxillofacial and Oral Surgery, Faculty of Dentistry, Taif University, Alhawiah, Saudi Arabia.

Kaposiform Hemangio-endothelioma (KHE) is a rare vascular neoplasm of intermediate malignancy that generally occurs in infancy and early childhood. Typically, the lesion arises from superficial or deep soft tissues of the extremities, trunk and retroperitoneum. The paucity of reported cases of head and neck KHEs is evidence of the rarity of the disease in this region. Read More

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HASTY, the Arabidopsis EXPORTIN5 ortholog, regulates cell-to-cell and vascular microRNA movement.

EMBO J 2021 Jun 21:e107455. Epub 2021 Jun 21.

Department of Biology, ETH Zürich, Zürich, Switzerland.

Plant microRNAs (miRNAs) guide cytosolic post-transcriptional gene silencing of sequence-complementary transcripts within the producing cells, as well as in distant cells and tissues. Here, we used an artificial miRNA-based system (amiRSUL) in Arabidopsis thaliana to explore the still elusive mechanisms of inter-cellular miRNA movement via forward genetics. This screen identified many mutant alleles of HASTY (HST), the ortholog of mammalian EXPORTIN5 (XPO5) with a recently reported role in miRNA biogenesis in Arabidopsis. Read More

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How Do Trees Grow in Girth? Controversy on the Role of Cellular Events in the Vascular Cambium.

Acta Biotheor 2021 Jun 21. Epub 2021 Jun 21.

Department of Botany, Hamdard University, Tughlaqabad, New Delhi, 110 062, India.

Radial growth has long been a subject of interest in tree biology research. Recent studies have brought a significant change in the understanding of some basic processes characteristic to the vascular cambium, a meristem that produces secondary vascular tissues (phloem and xylem) in woody plants. A new hypothesis regarding the mechanism of intrusive growth of the cambial initials, which has been ratified by studies of the arrangement of cambial cells, negates the influence of this apical cell growth on the expansion of the cambial circumference. Read More

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Circular RNA circ_0084927 regulates proliferation, apoptosis, and invasion of breast cancer cells via miR-142-3p/ERC1 pathway.

Am J Transl Res 2021 15;13(5):4120-4136. Epub 2021 May 15.

Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System Tongliao, Inner Mongolia Autonomous Region, China.

Objective: We aimed to investigate the mechanism of circular RNA circ_0084927 in the progression of breast cancer (BC).

Methods: The levels of circ_0084927, miR-142-3p, and ELKS/RAB6-interacting/CAST family member-1 (ERC1) mRNA in the BC tissues and cells were detected by qRT-PCR. CCK8, colony formation, Transwell, and flow cytometry assays were performed to examine the cell proliferation, colony formation, cell invasion, and apoptosis, respectively, in the BC cells with regulated expressions of circ_0084927, miR-142-3p, and ERC1. Read More

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CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression.

Oncol Lett 2021 Aug 4;22(2):587. Epub 2021 Jun 4.

Institute of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Jiangsu, Yangzhou 225001, P.R. China.

Metastasis is the main cause of poor prognosis of patients with gastric cancer (GC). Thus, current research is focused on identifying biomarkers that can predict the prognosis of patients with GC. C-X-C motif chemokine receptor 4 (CXCR4) and vascular endothelial growth factor (VEGF) have been reported to play important roles in different types of malignancies; however, their role in the prognosis of GC remains unknown. Read More

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Horizontal MicroRNA Transfer by Platelets - Evidence and Implications.

Front Physiol 2021 3;12:678362. Epub 2021 Jun 3.

Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

For decades, platelets have been known for their central role in hemostasis and their ability to release bioactive molecules, allowing inter-platelet communication and crosstalk with the immune system and vascular cells. However, with the detection of microRNAs in platelets and platelet-derived microvesicles (MVs), a new level of inter-cellular regulation was revealed. By shedding MVs from their plasma membrane, platelets are able to release functional microRNA complexes that are protected from plasma RNases. Read More

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Association between single nucleotide polymorphisms of tropoelastin gene and aortic dissection.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 May;46(5):458-466

Department of Vascular Surgery, Hainan General Hospital, Haikou 570311.

Objectives: To evaluate the relation between single nucleotide polymorphisms (SNPs) of tropoelastin gene and aortic dissection (AD) via identifying SNPs in the tropoelastin gene, and to detect the level of tropoelastin mRNA, elastin and elastic fibers.

Methods: The specimens of the AD group (=96) and the control group (=95), including their blood and aortic wall tissues, were collected. DNA was extracted from the blood samples in the 2 groups, and the SNPs in the tropoelastin gene were examined by the MassARRAY genotyping technique, and their haplotypes were constructed by PHASE software. Read More

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Oxidative stress in neutrophils: Implications for diabetic cardiovascular complications.

Antioxid Redox Signal 2021 Jun 19. Epub 2021 Jun 19.

The Ohio State University Wexner Medical Center, 12306, Surgery, 473 W 12th Ave, DHLRI 611A, Columbus, Ohio, United States, 43210-1240;

Significance: Neutrophil behavior and function is altered by hyperglycemia associated with diabetes. Aberrant activation by hyperglycemia causes neutrophils to respond with increased production of reactive oxidative species (ROS). Excess ROS, a signature of primed neutrophils, can intracellularly induce neutrophils to undergo NETosis, flooding surrounding tissues with ROS and damage-associated molecular patterns (DAMPs) such as S100 calcium binding proteins (S100A8/A9). Read More

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Targeting tumor vascularization: promising strategies for vascular normalization.

J Cancer Res Clin Oncol 2021 Jun 19. Epub 2021 Jun 19.

Department of Cell Biology, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212003, Jiangsu, China.

Tumor recurrence after the clinical cure of tumor often results from the presence of an abnormal microenvironment, including an aberrant vasculature. The tumor microenvironment is rich in pro-angiogenic factors but lacks pro-maturation factors. Pro-angiogenic conditions in the tumor microenvironment, such as hypoxia, are double-edged swords, promoting both the repair of normal tissues and the development of an abnormal blood vessel network. Read More

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Serum Apo J as a potential marker of conversion from mild cognitive impairment to dementia.

J Neurol Sci 2021 Jun 15;427:117537. Epub 2021 Jun 15.

Department of Translational Medicine and for Romagna, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.

Background: Apolipoprotein J (ApoJ) is present in both plasma and tissues, including brain. Growing evidence suggest that this protein may play an early role on the development of the two most common forms of dementia, Alzheimer's disease (AD) and vascular dementia (VD).

Objective: To evaluate whether serum ApoJ levels might be able to predict the progression to AD, VD, or mixed dementia (AD&VD) in individuals with mild cognitive impairment (MCI). Read More

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Identification of VEGFA-centric temporal hypoxia-responsive dynamic cardiopulmonary network biomarkers.

Life Sci 2021 Jun 17:119718. Epub 2021 Jun 17.

Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Lucknow Road, Timarpur, Delhi, India. Electronic address:

Aims: Hypoxia, a pathophysiological condition, is profound in several cardiopulmonary diseases (CPD). Every individual's lethality to a hypoxia state differs in terms of hypoxia exposure time, dosage units and dependent on the individual's genetic makeup. Most of the proposed markers for CPD were generally aim to distinguish disease samples from normal samples. Read More

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Old and new biomarkers for volumetric muscle loss.

Curr Opin Pharmacol 2021 Jun 16;59:61-69. Epub 2021 Jun 16.

Bone-Muscle Collaborative Sciences, College of Nursing & Health Innovation, The University of Texas at Arlington, Arlington, TX 76010, USA. Electronic address:

Volumetric muscle loss (VML) impacts skeletal muscles and causes damage to associated tissues such as blood vessels and other structural tissues. Despite progress in the VML field, current preclinical approaches are often ineffective at restoring muscle volume. Additional research is paramount to develop strategies that improve muscle mass and function, while restoring supporting tissues. Read More

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Posterior superior alveolar nerves contribute to sensation in the anterior teeth.

Ann Anat 2021 Jun 16:151784. Epub 2021 Jun 16.

Division of Anatomy and Cell Biology of the Hard Tissues, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan. Electronic address:

Background: There is no available data on the occurrence rate of a converged alveolar canal, the detailed three-dimensional (3D) courses of alveolar canals/grooves (ACGs), or the contribution of each superior alveolar nerve to each area in the maxilla. This study aimed to clarify the 3D courses of ACGs, the relationship between ACGs and superior alveolar nerves, and the contribution of posterior superior alveolar nerves (PSANs) using computed tomography (CT) with histological analysis.

Methods: During the gross anatomy course at Niigata University, we investigated nine human cadavers. Read More

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Niches that regulate stem cells and hematopoiesis in adult bone marrow.

Dev Cell 2021 Jun 12. Epub 2021 Jun 12.

Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult life within the bone marrow, where they produce the mature cells necessary to maintain blood cell counts and immune function. In the bone marrow and spleen, HSCs are sustained in perivascular niches (microenvironments) associated with sinusoidal blood vessels-specialized veins found only in hematopoietic tissues. Endothelial cells and perivascular leptin receptor stromal cells produce the known factors required to maintain HSCs and many restricted progenitors in the bone marrow. Read More

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Endothelial ontogeny and the establishment of vascular heterogeneity.

Bioessays 2021 Jul;43(7):e2100036

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

The establishment of distinct cellular identities was pivotal during the evolution of Metazoa, enabling the emergence of an array of specialized tissues with different functions. In most animals including vertebrates, cell specialization occurs in response to a combination of intrinsic (e.g. Read More

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Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models.

J Artif Organs 2021 Jun 18. Epub 2021 Jun 18.

Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Incorporation of surrounding tissues after implantation of synthetic vascular prostheses potentially varies in accordance with implanted prostheses. To evaluate post-implant tissue incorporation, we examined surgical, histological and ultrastructural findings after implantation in animal models. Three types of commercially available prostheses were tested (Gelweave™; Group G, J Graft SHIELD NEO; Group J and Triplex; Group T). Read More

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Cancer environmental immunotherapy: starving tumor cell to death by targeting TGFB on immune cell.

J Immunother Cancer 2021 Jun;9(6)

Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

The blockage of intersectional communication between tumor and its metabolic and immune microenvironment is now considered a promising solution in treating cancer. Tumors have been identified as a special type of "wounds" that do not heal. Recent studies demonstrate that the lack of the transforming growth factor beta (TGFB) signaling pathway in CD4 helper T cells induces the remodeling of the intratumoral vascular tissue, like healing "wounds" in damaged tissues caused by tumor overgrowth, which consequently prevents tumor cells from receiving the required nutrients in their microenvironment. Read More

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Geometrical confinement controls cell, ECM and vascular network alignment during the morphogenesis of 3D bioengineered human connective tissues.

Acta Biomater 2021 Jun 15. Epub 2021 Jun 15.

Interdisciplinary Research Centre on Biomaterials (CRIB), University of Napoli Federico II, P.le Tecchio 80, 80125 Napoli, Italy; Department of Chemical, Materials and Industrial Production Engineering (DICMAPI), University of Napoli Federico II, P.le Tecchio 80, 80125 Napoli, Italy.

Engineered tissues featuring aligned ECM possess superior regenerative capabilities for the healing of damaged aligned tissues. The morphofunctional integration in the host's injury site improves if the aligned ECM elicits the unidirectional growth of vascular network. In this work we used a bottom-up tissue engineering strategy to produce endogenous and highly aligned human connective tissues with the final aim to trigger the unidirectional growth of capillary-like structures. Read More

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Luteolin, an aryl hydrocarbon receptor antagonist, alleviates diabetic retinopathy by regulating the NLRP/NOX4 signalling pathway: Experimental and molecular docking study.

Y Yang M Zhou H Liu

Physiol Int 2021 Jun 18. Epub 2021 Jun 18.

Department of Ophthalmology, Affiliated Zhongshan Hospital of Dalian University, 116001, Dalian, Liaoning, China.

Objective: The present report evaluates the protective effects of luteolin against diabetic retinopathy (DR).

Materials And Methods: Diabetes was induced in rats by i.p. Read More

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