46,471 results match your criteria vascular severity


A low aldosterone/renin ratio and high soluble ACE2 associate with COVID-19 severity.

J Hypertens 2021 Dec 1. Epub 2021 Dec 1.

Department of Intensive Care, Haga Teaching Hospital, The Hague, The Netherlands Department of Cardiology, Unit Heart Failure and Transplant Unit, Erasmus MC University Medical Center, Rotterdam Department of Pulmonology Department of Internal Medicine, Haga Teaching Hospital, The Hague Department of Internal Medicine, Division of Vascular Medicine and Pharmacology Erasmus MC University Medical Center, Rotterdam Department of Clinical Chemistry Department of Cardiology Department of Hospital Pharmacy, Haga Teaching Hospital, The Hague Department of Clinical Chemistry, Erasmus MC University Medical Center, Rotterdam Department of Haga Science Department of Radiology, Haga Teaching Hospital, The Hague, The Netherlands.

Background: The severity of COVID-19 after SARS-CoV-2 infection is unpredictable. Angiotensin-converting enzyme-2 (ACE2) is the receptor responsible for coronavirus binding, while subsequent cell entry relies on priming by the serine protease TMPRSS2 (transmembrane protease, serine 2). Although renin-angiotensin-aldosterone-system (RAAS) blockers have been suggested to upregulate ACE2, their use in COVID-19 patients is now considered well tolerated. Read More

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December 2021

Automatic Evaluation of Histological Prognostic Factors Using Two Consecutive Convolutional Neural Networks on Kidney Samples.

Clin J Am Soc Nephrol 2021 Dec 3. Epub 2021 Dec 3.

M Legendre, Department of Nephrology, CHU Dijon, Dijon, France

The prognosis of patients undergoing kidney tumor resection or kidney donation is linked to many histological criteria. These criteria notably include glomerular density, glomerular volume, vascular luminal stenosis, and severity of interstitial fibrosis/tubular atrophy. Automated measurements through a Deep Learning approach could save time and provide more precise data. Read More

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December 2021

Update on the thoracic outlet syndrome and plexus brachial syndrome: Specific clinical examination (for all) and rehabilitation protocol.

J Med Vasc 2021 Oct-Dec;46(5-6):232-240. Epub 2021 Nov 16.

INSERM, U1059 Sainbiose, Université de Lyon, Saint-Étienne, France; Département de Médecine Vasculaire et Thérapeutique, Centre Hospitalier Universitaire, Saint-Étienne, France; Campus Santé et Innovations, Université Jean Monnet, St-Priest-en-Jarez, France. Electronic address:

The diagnosis of uncomplicated forms of thoracobrachial outlet syndrome (TOS) and brachial plexus stretching syndrome (BPSS) is imprecise due to the lack of clear differentiation between dynamic vascular or neurological compression and brachial plexus stretching without vascular compression. After a review of literature, we propose and describe a simple way for clinical assessment of TOS, BPSS or association of both comprising 1 clinical sign and 2 manoeuvres. This clinical assessment can be performed by the medical doctor, the physiotherapist and the surgeon. Read More

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November 2021

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins.

PLoS Pathog 2021 Dec 3;17(12):e1010118. Epub 2021 Dec 3.

Institute of Neuropathology, University of Zurich, Zurich, Switzerland.

Antiphospholipid antibodies (aPL), assumed to cause antiphospholipid syndrome (APS), are notorious for their heterogeneity in targeting phospholipids and phospholipid-binding proteins. The persistent presence of Lupus anticoagulant and/or aPL against cardiolipin and/or β2 glycoprotein I have been shown to be independent risk factors for vascular thrombosis and pregnancy morbidity in APS. aPL production is thought to be triggered by-among other factors-viral infections, though infection-associated aPL have mostly been considered non-pathogenic. Read More

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December 2021

Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.

Am J Respir Crit Care Med 2021 Dec 3. Epub 2021 Dec 3.

QIMR Berghofer Medical Research Institute, 56362, Respiratory Immunology Laboratory, Brisbane, Queensland, Australia.

Rationale: The alarmins IL-33 and HMGB1 (high mobility group box 1) contribute to type-2 inflammation and asthma pathogenesis.

Objectives: To determine whether P2Y13 receptor (P2Y13-R), a purinergic G protein-coupled receptor (GPCR) and risk allele for asthma, regulates the release of IL-33 and HMGB1.

Methods: Bronchial biopsies were obtained from healthy and asthmatic subjects. Read More

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December 2021

The effect of extracorporeal shockwave myocardial revascularization therapy to myocardial perfusion and function in indicated CABG-stable angina pectoris patients: case series.

Eur Rev Med Pharmacol Sci 2021 Nov;25(22):6959-6966

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Dr. Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.

Objective: Many studies have found a beneficial effect of Extracorporeal Shockwave Myocardial Revascularization (ESMR) therapy for refractory angina patients. However, clinical studies ESMR therapy for indicated coronary artery bypass grafting (CABG)-stable angina pectoris (SAP) patients are limited.

Patients And Methods: Four indicated CABG-SAP patients CCS class I-III reviewed in this study. Read More

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November 2021

Retrospective Evaluation of Platelet-Leukocyte Indices and Cardiac Surgical Outcomes in Acyanotic Heart Disease Patients with Pulmonary Hypertension (REPLICA-PH).

Braz J Cardiovasc Surg 2021 Dec 2. Epub 2021 Dec 2.

Department of Cardiothoracic and Vascular Surgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, India.

Introduction: Acyanotic congenital heart disease (ACHD) patients with pulmonary hypertension (PH) are prone to postoperative complications, and characterization of the risk profile continues to fail in identifying inflammatory predilection. Our objective is to investigate the role of platelet-leukocyte indices (neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR], and systemic immune-inflammation index [SII] [neutrophil × platelet/lymphocyte]) in predicting poor outcomes following cardiac surgery in ACHD cohort with preoperative PH.

Methods: This single-center, retrospective risk-predictive study included ACHD patients undergoing surgical correction at our tertiary cardiac center between January 2015 and December 2019. Read More

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December 2021

Echocardiographic Global Longitudinal Strain Is Associated With Myocardial Fibrosis and Predicts Outcomes in Aortic Stenosis.

Front Cardiovasc Med 2021 10;8:750016. Epub 2021 Nov 10.

National Heart Research Institute Singapore, National Heart Center Singapore, Singapore, Singapore.

Left ventricular ejection fraction is the conventional measure used to guide heart failure management, regardless of underlying etiology. Left ventricular global longitudinal strain (LV-GLS) by speckle tracking echocardiography (STE) is a more sensitive measure of intrinsic myocardial function. We aim to establish LV-GLS as a marker of replacement myocardial fibrosis on cardiovascular magnetic resonance (CMR) and validate the prognostic value of LV-GLS thresholds associated with fibrosis. Read More

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November 2021

Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx.

Front Cell Dev Biol 2021 10;9:751251. Epub 2021 Nov 10.

Duke University School of Medicine and Durham VA Medical Centers, Durham, NC, United States.

Malaria caused by results in over 400,000 deaths annually, predominantly affecting African children. In addition, non-falciparum species including vivax and knowlesi cause significant morbidity and mortality. Vascular dysfunction is a key feature in malaria pathogenesis leading to impaired blood perfusion, vascular obstruction, and tissue hypoxia. Read More

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November 2021

fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy.

Biomed Opt Express 2021 Nov 29;12(11):7185-7198. Epub 2021 Oct 29.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

Anti-vascular endothelial growth factor (anti-VEGF) therapy is effective for reducing the severity level of diabetic retinopathy (DR). However, it is difficult to determine the spatial and temporal expression of VEGF in the DR retina at an early stage. Here, we report a quantitatively fluorescence molecular imaging and image analysis method by creating a VEGF targeted fluorescence imaging probe, which can potentially detect and predict anti-VEGF treatment response. Read More

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November 2021

Retinal vascular impairment in patients newly diagnosed with obstructive sleep apnea syndrome.

Multidiscip Respir Med 2021 Jan 2;16(1):773. Epub 2021 Nov 2.

Ophthalmology Department.

Background: To evaluate retinal morphological and vascular parameters in patients recently diagnosed with obstructive sleep apnea syndrome (OSAS) and determine the correlation between retinal vascular density and the severity of OSAS.

Methods: We performed a retrospective study on the retinal vasculature of patients with OSAS and age-match healthy controls. OSAS was confirmed by full-night cardiorespiratory polygraphy. Read More

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January 2021

Evolution of Late Right Heart Failure With Left Ventricular Assist Devices and Association With Outcomes.

J Am Coll Cardiol 2021 Dec;78(23):2294-2308

Cardiovascular Medicine, Stanford University, Stanford, California, USA. Electronic address:

Background: A revised definition of right heart failure (RHF) for the Society of Thoracic Surgeons Intermacs database of left ventricular assist devices (LVADs) was introduced in June 2014.

Objectives: The purpose of this study was to determine the prevalence and severity of RHF over time and the association of RHF status at 3 months with 12-month outcomes after LVAD.

Methods: All patients in Society of Thoracic Surgeons Intermacs with follow-up and supported at least 3 months with a continuous flow LVAD implanted between June 2, 2014 and March 31, 2017 without a simultaneous RVAD. Read More

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December 2021

The Relationship Between Renal Function and Imaging Markers and Total Burden of Cerebral Small Vessel Disease.

Neurologist 2021 Nov 30. Epub 2021 Nov 30.

Department of Neurology, Stroke Center Department of Radiology, Ankara University Faculty of Medicine, Ankara, Turkey.

Background: Previous studies demonstrating the association between renal functions and cerebral small vessel diseases have usually focused on white matter hyperintensity in the general population or lacunar stroke patients. This study aimed to investigate the effects of renal function on imaging markers of cerebral small vessel disease and etiologic subtypes of stroke in patients with acute ischemic stroke or transient ischemic attack.

Materials And Methods: A total of 356 consecutive patients with acute ischemic stroke or transient ischemic attack who were admitted to the Stroke Unit and underwent brain magnetic resonance imaging were evaluated. Read More

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November 2021

Deep Learning-Based Approach to Automatically Assess Coronary Distensibility Following Kawasaki Disease.

Pediatr Cardiol 2021 Dec 2. Epub 2021 Dec 2.

Division of Pediatric Cardiology, CHU Ste-Justine, University of Montreal, 3175, Côte Sainte-Catherine, Montreal, QC, H3T 1C5, Canada.

Kawasaki disease is an acute vasculitis affecting children, which can lead to coronary artery (CA) aneurysms. Optical coherence tomography (OCT) has identified CA wall damage in KD patients, but it is unclear if these findings correlate with any distensibility changes in the CA and how these changes evolve over time. This paper seeks to establish the link between OCT findings and vessel distensibility with a novel deep learning coronary artery segmentation system and use the segmentation framework to automatically analyze the temporal evolution of coronary stiffness over many years. Read More

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December 2021

Identity and pathogenicity of fungi associated with root, crown and vascular symptoms related to winter squash yield decline.

Plant Dis 2021 Dec 2. Epub 2021 Dec 2.

Oregon State University, 2694, Botany & Plant Pathology, Corvallis, Oregon, United States;

Winter squash ( cv. 'Golden Delicious') produced in Oregon's Willamette Valley for edible seed production has experienced significant yield losses due to a soilborne disease. The symptoms associated with this disease problem include root rot, crown rot and vascular discoloration in the stems leading to a severe late season wilt and plant collapse. Read More

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December 2021

Risk factors for carotid plaque progression after optimising the risk factor treatment: substudy results of the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients with the carotid Bifurcation Plaque Study (ANTIQUE).

Stroke Vasc Neurol 2021 Dec 1. Epub 2021 Dec 1.

Department of Radiology, Military University Hospital Prague, Praha, Czech Republic.

Background And Aim: Carotid plaque progression contributes to increasing stroke risk. The study aims to identify factors influencing carotid plaque thickness progression after changing the preventive treatment to the 'treating arteries instead of risk factors' strategy, that is, change in treatment depending on the progression of atherosclerosis.

Methods: The study participants who completed sonographic controls over the course of 3 years were enrolled to the analysis. Read More

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December 2021

Association of Psoriasis With Incident Venous Thromboembolism and Peripheral Vascular Disease: A Systematic Review and Meta-analysis.

JAMA Dermatol 2021 Dec 1. Epub 2021 Dec 1.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Importance: Psoriasis, venous thromboembolism (VTE), and peripheral vascular disease (PVD) share similar mechanisms involving chronic inflammation. However, the associations between psoriasis and VTE or PVD are unclear.

Objective: To determine the association of psoriasis with incident VTE and PVD. Read More

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December 2021

LncRNA UCA1, miR-26a, and miR-195 in coronary heart disease patients: Correlation with stenosis degree, cholesterol levels, inflammatory cytokines, and cell adhesion molecules.

J Clin Lab Anal 2021 Dec 1:e24070. Epub 2021 Dec 1.

Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: Long noncoding RNA urothelial cancer-associated 1 (lnc-UCA1) targets microRNA-26a (miR-26a) and microRNA-195 (miR-195) to participate in coronary heart disease (CHD) progression via regulation of vascular smooth muscle cell and microvascular endothelial cell viability and mobility. Therefore, this study set out to further explore the relationship between lnc-UCA1 and miR-26a and miR-195, along with their roles in the management of patients with CHD.

Methods: One hundred and thirty-six CHD patients and 70 age-/gender-matched controls were recruited in this case-control study. Read More

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December 2021

Longitudinal assessment of adhesion to vascular cell adhesion molecule-1 at steady state and during vaso-occlusive crises in sickle cell disease.

Br J Haematol 2021 Dec 1. Epub 2021 Dec 1.

Functional Fluidics, Children's Hospital of Michigan, Detroit, MI, USA.

Sickle cell disease (SCD) is characterized by frequent and unpredictable vaso-occlusive crises (VOCs). Sickle erythrocytes (SSRBCs) contribute to VOCs by participating in a series of adhesive events with blood cells and the vascular endothelium. Adhesion assays have been used to evaluate the relationship between SSRBC adhesion and SCD severity. Read More

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December 2021

Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma.

Sci Rep 2021 Nov 30;11(1):23136. Epub 2021 Nov 30.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 4/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong SAR, The People's Republic of China.

To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Read More

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November 2021

Health Services Use and Functional Recovery Following Blunt Trauma in Older Persons - A National Multicentre Prospective Cohort Study.

J Am Med Dir Assoc 2021 Nov 27. Epub 2021 Nov 27.

Health Services and Systems Research, Duke-NUS Graduate Medical School, Singapore; Department of Emergency Medicine, Singapore General Hospital, Singapore.

Objective: Frailty is associated with morbidity and mortality in older injured patients. However, for older blunt-trauma patients, increased frailty may not manifest in longer length of stay at index admission. We hypothesized that owing to time spent in hospital from readmissions, frailty would be associated with less total time at home in the 1-year postinjury period. Read More

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November 2021

Variability in venous gas emboli following the same dive at 3,658 meters.

Undersea Hyperb Med 2021 Fourth Quarter;48(4):469-476

University at Buffalo, Department of Exercise and Nutrition Sciences, Center for Research and Education in Special Environments, Buffalo, New York U.S.

Exposure to a reduction in ambient pressure such as in high-altitude climbing, flying in aircrafts, and decompression from underwater diving results in circulating vascular gas bubbles (i.e., venous gas emboli [VGE]). Read More

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November 2021

Successful Profiling of Plasmodium falciparum Gene Expression in Clinical Samples via a Custom Capture Array.

mSystems 2021 Nov 30:e0022621. Epub 2021 Nov 30.

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.

genes encode Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens. These highly diverse antigens are displayed on the surface of infected erythrocytes and play a critical role in immune evasion and sequestration of infected erythrocytes. Studies of expression using non-leukocyte-depleted blood are challenging because of the predominance of host genetic material and lack of conserved segments. Read More

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November 2021

Ischemic stroke in COVID-19 patients: mechanisms, treatment and outcomes in a consecutive Swiss Stroke Registry analysis.

Eur J Neurol 2021 Nov 30. Epub 2021 Nov 30.

Stroke Unit, Cantonal Hospital of Baden, Baden, Switzerland.

Background: Most case series of patients with ischemic stroke (IS) and COVID-19 are limited to selected centers or lack 3-month outcome. Aim of this study is to describe frequency, clinical and radiological features, and 3-month outcomes of patients with IS and COVID-19 in a nationwide stroke registry.

Methods: From the Swiss Stroke Registry (SSR), we included all consecutive IS patients ≥18 years admitted to Swiss Stroke Centers or Stroke Units during the first wave of COVID-19 (25/02 to 08/06/2020). Read More

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November 2021

[Transcranial color Doppler ultrasonography: methodology and usefulness for the study of patent foramen ovale in cryptogenic stroke].

G Ital Cardiol (Rome) 2021 Dec;22(12):988-999

Dipartimento Cardiotoracovascolare "De Gasperis", ASST Grande Ospedale Metropolitano Niguarda, Milano.

Non-invasive Doppler ultrasonographic study of cerebral arteries (transcranial Doppler, TCD) has been extensively applied on both outpatient and inpatient settings. It is performed placing a low-frequency (≤2 MHz) transducer on the scalp of the patient over specific acoustic windows, in order to visualize the intracranial arterial vessels and to evaluate the cerebral blood flow velocity and its alteration in many different conditions. Nowadays a valid indication for TCD in the outpatient setting is the research of right-to-left shunting, responsible for the so-called "paradoxical embolism", most often due to patency of foramen ovale, which is responsible for the majority of cryptogenic strokes occurring in patients younger than 55 years. Read More

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December 2021

Cognitive Predictors of Delirium on Long-Term Follow-Up after TIA and Stroke: Population-Based Cohort Study.

Cerebrovasc Dis 2021 Nov 29:1-8. Epub 2021 Nov 29.

Wolfson Centre for Prevention of Stroke and Dementia, Wolfson Building, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom.

Introduction: TIA and stroke cause cognitive impairment with a typical "vascular" pattern, including prominent frontal/executive deficits. Cognitive impairment is associated with increased delirium risk and the few available data suggest that executive dysfunction is important. We therefore determined the predictive value of both severity and pattern of cognitive deficits for delirium on long-term follow-up after TIA/stroke. Read More

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November 2021

Differences between Atrial Fibrillation Detected before and after Stroke and TIA: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis 2021 Nov 29:1-6. Epub 2021 Nov 29.

Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Background: Preliminary evidence suggests that patients with atrial fibrillation (AF) detected after stroke (AFDAS) may have a lower prevalence of cardiovascular comorbidities and lower risk of stroke recurrence than AF known before stroke (KAF).

Objective: We performed a systematic search and meta-analysis to compare the characteristics of AFDAS and KAF.

Methods: We searched PubMed, Scopus, and EMBASE for articles reporting differences between AFDAS and KAF until June 30, 2021. Read More

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November 2021

Factor XII deficiency evaluated by thrombin generation assay.

Clin Biochem 2021 Nov 26. Epub 2021 Nov 26.

Normandie Univ, UNIROUEN, INSERM U1096, Rouen University Hospital, Vascular Hemostasis Unit, F 76000 Rouen, France. Electronic address:

Introduction: Coagulation factor XII (FXII) plays a role in thrombin generation, fibrinolysis, inflammation, angiogenesis, chemotaxis and diapedesis. FXII deficiency is not associated with bleeding risk unlike other coagulation factors.

Materials/methods: We investigated thrombin generation assay (TGA) profile modification in FXII deficiency and the correlation with TGA and deficiency severity. Read More

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November 2021

The Predictive Role of Artificial Intelligence-Based Chest CT Quantification in Patients with COVID-19 Pneumonia.

Tomography 2021 11 1;7(4):697-710. Epub 2021 Nov 1.

Medical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary.

We sought to analyze the prognostic value of laboratory and clinical data, and an artificial intelligence (AI)-based algorithm for Coronavirus disease 2019 (COVID-19) severity scoring, on CT-scans of patients hospitalized with COVID-19. Moreover, we aimed to determine personalized probabilities of clinical deterioration. Data of symptomatic patients with COVID-19 who underwent chest-CT-examination at the time of hospital admission between April and November 2020 were analyzed. Read More

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November 2021

Rationale and Design of the Orencia Atherosclerosis and Rheumatoid Arthritis Study (ORACLE Arthritis Study): Implications of Biologics against Rheumatoid Arthritis and the Vascular Complications, Subclinical Atherosclerosis.

Methods Protoc 2021 Nov 15;4(4). Epub 2021 Nov 15.

Department of Medical Science and Cardio-Renal Medicine, Graduate School of Medicine, Yokohama City University, Fukuura, Kanazawa-Ku, Yokohama 236-0004, Japan.

To explore the biological and immunological basis of human rheumatoid arthritis and human atherosclerosis, we planned and reported a detailed design and rationale for Orencia Atherosclerosis and Rheumatoid Arthritis Study (ORACLE Arthritis Study) using highly sensitive, high-throughput, human autoantibody measurement methods with cell-free protein synthesis technologies. Our previous study revealed that subjects with atherosclerosis had various autoantibodies in their sera, and the titers of anti-Th2 cytokine antibodies were correlated with the severity of atherosclerosis. Because rheumatoid arthritis is a representative autoimmune disease, we hypothesized that both rheumatoid arthritis and atherosclerosis are commonly developed by autoantibody-mediated autoimmune processes, leading to incessant inflammatory changes in both articular joint tissues and vessel walls. Read More

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November 2021