36,075 results match your criteria vascular pattern

Correlation of laboratory parameters and Chest CT findings in young adults with COVID-19 and comparison of imaging findings with children.

Clin Imaging 2021 Jun 18;79:265-272. Epub 2021 Jun 18.

Istanbul University, Istanbul Medical Faculty, Radiology Department, Turkey.

Purpose: We aimed to compare COVID-19 imaging findings of young adults (19-35 years of age) with those of children (0-18 years) and to correlate imaging findings of young adults with their laboratory tests.

Materials And Methods: This retrospective study included Real Time-Polymerase Chain Reaction (RT-PCR) confirmed 130 young adults (mean age: 28.39 ± 4. Read More

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[Vascular, molecular and cellular mechanisms of development of cognitive impairments after occlusion of carotid arteries].

S M Guliaev

Angiol Sosud Khir 2021 ;27(2):11-16

Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences, Ulan-Ude, Russia.

Aim: The study was aimed at determining the role of vascular endothelial dysfunction in induction of molecular and cellular mechanisms of the development of cognitive impairments after occlusion of common carotid arteries.

Material And Methods: The experiments were carried out on Wistar rats. The animals were divided into 2 groups: group 1 - control, sham-operated animals; group 2 - rats with cerebral ischaemia-reperfusion. Read More

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January 2021

Patterns of Locoregional Recurrence after Radical Cystectomy for Stage T3-4 Bladder Cancer: A Radiation Oncologist's Point of View.

Yonsei Med J 2021 Jul;62(7):569-576

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Adjuvant radiotherapy (RT) has been performed to reduce locoregional failure (LRF) following radical cystectomy for locally advanced bladder cancer; however, its efficacy has not been well established. We analyzed the locoregional recurrence patterns of post-radical cystectomy to identify patients who could benefit from adjuvant RT and determine the optimal target volume.

Materials And Methods: We retrospectively reviewed 160 patients with stage ≥ pT3 bladder cancer who were treated with radical cystectomy between January 2006 and December 2015. Read More

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Lung ultrasound may help in the differential diagnosis of suspected oligosymptomatic COVID-19 patients on hemodialysis: A case report.

Hemodial Int 2021 Jun 24. Epub 2021 Jun 24.

Nephrology, Dialysis and Transplantation Unit, Careggi University Hospital, Florence, Italy.

Introduction: Considering that patients on dialysis showed a poor outcome during COVID-19 pandemic, and that COVID-19 symptoms in dialysis patients are often mild or absent, each dialysis unit should implement local strategies to early recognize patients affected by COVID-19. However, many available SARS-CoV-2 diagnostic tests demonstrated a moderate sensitivity, 70%-80% is probably a reasonable estimate. Consequently, having useful tools for differential diagnosis becomes essential. Read More

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Historical collections of vascular plants in the Korean Peninsula by three major collectors in the early 20th century: U. J. Faurie, E. J. Taquet and E. H. Wilson.

Biodivers Data J 2021 10;9:e66470. Epub 2021 Jun 10.

Mokpo National University, Muan, Republic of Korea Mokpo National University Muan Republic of Korea.

Background: The digitisation of historical collections aims to increase global access to scientific artifacts, especially those from currently inaccessible areas. Historical collections from North Korea deposited at foreign herbaria play a fundamental role in biodiversity transformation patterns. However, the biodiversity pattern distribution in this region remains poorly understood given the severe gaps in available geographic species distribution records. Read More

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Association of glomerular filtration rate slope with timely creation of vascular access in incident hemodialysis.

Sci Rep 2021 Jun 23;11(1):13137. Epub 2021 Jun 23.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100 Tzyou First Road, Sanmin District, Kaohsiung, 80708, Taiwan.

The factors associated with the timely creation of distal vascular access for hemodialysis initiation are unclear. We aimed to explore the association between the slope of estimated glomerular filtration rate (eGFR) and the successful usage of vascular access upon hemodialysis initiation. This single center retrospective cohort study enrolled chronic kidney disease patients who undertook a multidisciplinary care program from 2003 to 2016. Read More

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Influence of Surgical Methods on Hemodynamics in Supravalvular Aortic Stenosis: A Computational Hemodynamic Analysis.

Pediatr Cardiol 2021 Jun 23. Epub 2021 Jun 23.

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Shanghai, China.

We compared differences in the hemodynamic parameters of multiple surgical techniques for supravalvular aortic stenosis (SVAS). A three-dimensional model was reconstructed based on a patient's CT scan. Virtual McGoon, Doty, and Brom repairs were completed using computer-aided design (CAD). Read More

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COVID-19: Histopathological correlates of imaging patterns on chest computed tomography.

Respirology 2021 Jun 22. Epub 2021 Jun 22.

Department of Pathology, Cancer Centre Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Background And Objective: Patients with coronavirus disease 2019 (COVID-19) pneumonia present with typical findings on chest computed tomography (CT), but the underlying histopathological patterns are unknown. Through direct regional correlation of imaging findings to histopathological patterns, this study aimed to explain typical COVID-19 CT patterns at tissue level.

Methods: Eight autopsy cases were prospectively selected of patients with PCR-proven COVID-19 pneumonia with varying clinical manifestations and causes of death. Read More

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Semi-Automatic Planning and Three-dimensional Electrospinning of Patient-Specific Grafts for Fontan Surgery.

IEEE Trans Biomed Eng 2021 Jun 22;PP. Epub 2021 Jun 22.

This paper proposes a semi-automatic Fontan surgery planning method for designing and manufacturing hemodynamically optimized patient-specific grafts. Fontan surgery is a palliative procedure for patients with a single ventricle heart defect by creating a new path using a vascular graft for the deoxygenated blood to be directed to the lungs, bypassing the heart. However, designing patient-specific grafts with optimized hemodynamic performance is a complex task due to the variety of patient-specific anatomies, confined surgical planning space, and the requirement of simultaneously considering multiple design criteria for vascular graft optimization. Read More

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Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses.

Sci Rep 2021 Jun 21;11(1):12927. Epub 2021 Jun 21.

Dyson School of Design Engineering, Imperial College London, London, UK.

Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still unclear. A key question is whether the complex anatomy of vasculature plays a role in increasing forces in cerebral vessels and producing damage. Read More

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Young stroke due to pulmonary arteriovenous malformation.

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Young patients presenting with cryptogenic stroke should be investigated for cardiac and extra-cardiac sources of emboli. We present a patient who was investigated for a cardiac source of emboli, following multiple ischaemic strokes and migraine with aura over a period of 17 years. The events were initially thought to be related to a patent foramen ovale (PFO) on bubble contrast echocardiography, however, due to an unusual flow pattern to the left heart, she underwent a CT angiogram to exclude intrapulmonary shunting. Read More

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Bilateral macular drusen in acquired partial lipodystrophy with type 2 membranoproliferative glomerulonephritis.

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Moorfields Eye Hospital NHS Foundation Trust, London, UK

A 35-year-old woman with acquired partial lipodystrophy (PLD) and features of type 2 membranoproliferative glomerulonephritis (MPGN-II), presented with difficulty in her fine detailed vision over the past year. She had right amblyopia from a hypermetropic anisometropia with astigmatism, displaying a best-corrected visual acuity of 0.50 and 0. Read More

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Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening.

SLAS Discov 2021 Jun 21:24725552211019409. Epub 2021 Jun 21.

Bayer AG, Global Drug Discovery, Berlin, Germany.

SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase that was initially described as an H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has been reported to methylate and regulate several nonhistone proteins relevant to cancer, including mitogen-activated protein kinase kinase kinase 2 (MAP3K2), vascular endothelial growth factor receptor 1 (VEGFR1), and the human epidermal growth factor receptor 2 (HER2). In addition, overexpression of SMYD3 has been linked to poor prognosis in certain cancers, suggesting SMYD3 as a potential oncogene and attractive cancer drug target. Read More

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CD34-negative Solitary Fibrous Tumor: A Clinicopathologic Study of 25 Cases and Comparison With Their CD34-positive Counterparts.

Am J Surg Pathol 2021 Apr 7. Epub 2021 Apr 7.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH.

CD34-negative solitary fibrous tumors (SFTs) are rare and have not been comprehensively studied. We retrospectively reviewed all cases of SFT confirmed with STAT6 immunohistochemistry and/or STAT6 gene fusion between 2013 and 2020 and collected pertinent clinicopathologic parameters. Of a total of 244 cases, 25 (10%) lacked CD34 expression by immunohistochemistry. Read More

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How we approach hemangiomas in infants.

Pediatr Blood Cancer 2021 Jun 20:e29077. Epub 2021 Jun 20.

Hemangioma and Vascular/Lymphatic Malformations Program, New York University Langone Health, New York, New York, USA.

Pediatric oncologists are increasingly involved in the management of benign vascular tumors and their associated life-threatening complications. Hemangiomas are the most common referring diagnosis to multidisciplinary vascular anomalies clinics. However, as contemporary research has revealed, hemangiomas are not a single, easily defined entity but rather a diverse set of related vascular tumors, each having a unique natural history, growth pattern, and response to therapy. Read More

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Common tendinopathies around the elbow; what does current evidence say?

J Clin Orthop Trauma 2021 Aug 21;19:216-223. Epub 2021 May 21.

Shoulder & Elbow Unit, University Hospitals of Leicester, Leicester, UK.

Tendinopathies are common causes of pain around the elbow resulting in significant functional impairment in athletes or the working-age population. Patients complain of a gradual onset pain with or without any specific trauma. Tissue histology shows chronic fibroblast and vascular proliferation, with a disorganized collagen pattern and absence of inflammatory mediators. Read More

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Primaquine Diphosphate, a Known Antimalarial Drug, Blocks Vascular Leakage Acting Through Junction Stabilization.

Front Pharmacol 2021 4;12:695009. Epub 2021 Jun 4.

Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.

Endothelial barrier integrity is important for vascular homeostasis, and hyperpermeability participates in the progression of many pathological states, such as diabetic retinopathy, ischemic stroke, chronic bowel disease, and inflammatory disease. Here, using drug repositioning, we discovered that primaquine diphosphate (PD), previously known as an antimalarial drug, was a potential blocker of vascular leakage. PD inhibited the linear pattern of vascular endothelial growth factors (VEGF)-induced disruption at the cell boundaries, blocked the formation of VEGF-induced actin stress fibers, and stabilized the cortactin actin rings in endothelial cells. Read More

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Identification of VEGFA-centric temporal hypoxia-responsive dynamic cardiopulmonary network biomarkers.

Life Sci 2021 Jun 17:119718. Epub 2021 Jun 17.

Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Lucknow Road, Timarpur, Delhi, India. Electronic address:

Aims: Hypoxia, a pathophysiological condition, is profound in several cardiopulmonary diseases (CPD). Every individual's lethality to a hypoxia state differs in terms of hypoxia exposure time, dosage units and dependent on the individual's genetic makeup. Most of the proposed markers for CPD were generally aim to distinguish disease samples from normal samples. Read More

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Mediterranean Diet is Associated with Reduced Risk of Abdominal Aortic Aneurysm in Smokers: Results of Two Prospective Cohort Studies.

Eur J Vasc Endovasc Surg 2021 Jun 15. Epub 2021 Jun 15.

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Objective: Smoking is a strong risk factor for the development of abdominal aortic aneurysm (AAA). It was hypothesised that a Mediterranean diet via its anti-oxidative properties would decrease the risk of AAA, particularly among smokers.

Methods: The study population included the Cohort of Swedish Men (45 072 men) and the Swedish Mammography Cohort (36 632 women), aged 45 - 83 years at baseline. Read More

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Disturbance interval modulates the starting point for vegetation succession.

Ecology 2021 Jun 18:e03439. Epub 2021 Jun 18.

Department of Ecology and Genetics, Uppsala University, Uppsala, Sweden.

Increased frequency and new types of disturbances due to global change calls for deepened insights into possible alterations of successional pathways. Despite current interest in disturbance interactions there is a striking lack of studies focusing on the implication of decreasing times between disturbances. We surveyed forest-floor vegetation (vascular plants and bryophytes) in a Pinus sylvestris-dominated, even-aged production forest landscape, unique due to presence of stands under a precisely dated disturbance interval gradient, ranging 0-123 yr between clearcutting and a subsequent mega-fire. Read More

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Cerebrofacial vascular metameric syndrome associated with Moyamoya syndrome: a rare case report.

Childs Nerv Syst 2021 Jun 18. Epub 2021 Jun 18.

Graduated in Medicine, CESMAC University Center, Maceió, Alagoas, Brazil.

Introduction: Neural crest and mesoderm cell dysfunction of certain metameric level result in vascular malformations, i.e., cerebrofacial arteriovenous metameric syndrome (CAMS) and cerebrofacial venous metameric syndrome (CVMS). Read More

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Sleep behavior of infants with infantile hemangioma treated with propranolol-a cohort study.

Eur J Pediatr 2021 Jun 18. Epub 2021 Jun 18.

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Sleep problems are frequently reported in infants treated with propranolol for infantile hemangiomas, possibly serving as a marker for a negative impact on central nervous system function. In this cohort study, we objectively investigate the sleep behavior of infants with infantile hemangiomas on propranolol compared to a healthy, untreated control group. Sleep of propranolol-treated infants and controls was investigated using ankle actigraphy and a 24-h diary for 7-10 days at ages 3 and 6 months. Read More

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Stomach serosal arteries distinguish gastric regions of the rat.

J Anat 2021 Jun 17. Epub 2021 Jun 17.

Department of Psychological Sciences, Purdue University, West Lafayette, Indiana, USA.

Because the stomach in situ has few distinctive surface features and changes shape dramatically with food intake, we have used micro-CT imaging combined with two distinct contrast agents to (1) characterize the pattern of arteries, potential landmarks, on the stomach wall and (2) evaluate how meal-related shape changes affect the size of the different regions. Images generated with a contrast agent injected directly into the heart during perfusion enabled a thorough look at the organizational features of the stomach angioarchitecture. The stomach receives its blood supply primarily from two pairs of vessels, the gastric and gastroepiploic arteries. Read More

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Revisiting the anatomy of the monocot cambium, a novel meristem.

Planta 2021 Jun 17;254(1). Epub 2021 Jun 17.

Uruwhenua Botanicals, 51 Falconer Rd, Pohara RD 1, Takaka, New Zealand.

Main Conclusion: The monocot cambium is semi-storied, and its cells do not undergo rearrangement. The monocot cambium is a lateral meristem responsible for secondary growth in some monocotyledons of Asparagales. It is an unusual meristem, not homologous with the vascular cambia of gymnosperms and non-monocotyledonous angiosperms. Read More

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Hemodynamic Abnormalities in the Aorta of Turner Syndrome Girls.

Front Cardiovasc Med 2021 1;8:670841. Epub 2021 Jun 1.

Department of Biomedical Engineering, University of Strathclyde, Glasgow, United Kingdom.

Congenital abnormalities in girls and women with Turner syndrome (TS), alongside an underlying predisposition to obesity and hypertension, contribute to an increased risk of cardiovascular disease and ultimately reduced life expectancy. We observe that children with TS present a greater variance in aortic arch morphology than their healthy counterparts, and hypothesize that their hemodynamics is also different. In this study, computational fluid dynamic (CFD) simulations were performed for four TS girls, and three age-matched healthy girls, using patient-specific inlet boundary conditions, obtained from phase-contrast MRI data. Read More

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Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy.

J Am Soc Nephrol 2021 Jun 16. Epub 2021 Jun 16.

L Lerman, Division of Nephrology and Hypertension, Mayo Clinic Minnesota, Rochester, United States

Background: Peripheral vascular diseases may induce chronic ischemia and cellular injury distal to the arterial obstruction. Cellular senescence involves proliferation arrest in response to stress, which can damage neighboring cells. Renal artery stenosis (RAS) induces stenotic-kidney dysfunction and injury, but whether these arise from cellular senescence and their temporal pattern remain unknown. Read More

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Association of vaping with decreased vascular endothelial growth factor expression and decreased microvessel density in cutaneous wound healing tissue in rats.

Wound Repair Regen 2021 Jun 15. Epub 2021 Jun 15.

Boston University School of Medicine, Boston, Massachusetts, USA.

Vaping is suggested to be a risk factor for poor wound healing akin to smoking. However, the molecular and histologic mechanisms underlying this postulation remain unknown. Our study sought to compare molecular and histologic changes in cutaneous flap and non-flap tissue between vaping, smoking and control cohorts. Read More

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Study of the Protocol Used to Evaluate Skin-Flap Perfusion in Mastectomy Based on the Characteristics of Indocyanine Green.

Photodiagnosis Photodyn Ther 2021 Jun 11:102401. Epub 2021 Jun 11.

Department of Specialized Surgeries, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.

Background: Indocyanine green angiography enables real-time visualization of blood vessels at depths of up to 10 mm beneath the body surface, thereby aiding the evaluation of the viability of skin flaps and predicting necrosis in surgical fields requiring good tissue perfusion. Although skin-flap necrosis also occurs in mastectomy without reconstruction, most studies have focused on reconstructive plastic surgery. Several patients undergoing mastectomy are eligible for postoperative adjuvant therapy, but complications can lead to delays in treatment and thus require prevention. Read More

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The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADMET studies.

RSC Med Chem 2021 Apr 23;12(5):779-790. Epub 2021 Apr 23.

School of Pharmacy, University of Birmingham Edgbaston B15 2TT UK +44(0)121 414 7288.

The conceptual technology of small molecule glycomimetics, exemplified by compounds , has shown promising protective effects against lipid-induced endothelial dysfunction, restorative effects on diabetic endothelial colony forming cells, and preventative effects on downstream vascular calcification amongst other important and studies. We report the optimised synthesis of an array of 17 small molecule glycomimetics, including the regio-, enantio- and diastereo-meric sulfated scaffolds of a hit structure along with novel desulfated examples. For the first time, the absolute stereochemical configurations of have been clarified based on an identified and consistent anomaly with the Sharpless asymmetric dihydroxylation reaction. Read More

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Interpretation of coronary steal syndrome and haemodynamic changes after surgical closure of coronary fistula using Doppler wire and computational fluid dynamics analysis: a case report.

Eur Heart J Case Rep 2021 Apr 24;5(4):ytab069. Epub 2021 Apr 24.

School of Mechanical Engineering, University of Ulsan, 93, Daehak-ro, Nam-gu, Ulsan 44610, Republic of Korea.

Background: Coronary arteriovenous fistulas (CAFs) are rare but can cause myocardial ischaemia and other complications. However, the haemodynamic and physiologic characteristics of significant CAFs requiring treatment are poorly described. We report a case of CAF causing coronary steal syndrome in which haemodynamic changes were assessed before and after surgical closure using a Doppler wire and computational fluid dynamics (CFD) technique. Read More

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