386 results match your criteria vascular aggression

Recommendations of the Society of Thoracic Surgery and the Section of Cardiothoracic and Vascular Surgery of the Spanish Society of Anesthesia, Resuscitation and Pain Therapy, for patients undergoing lung surgery included in an intensified recovery program.

Rev Esp Anestesiol Reanim 2021 Jul 19. Epub 2021 Jul 19.

Servicio de Anestesia y Reanimación, Hospital Universitario 12 de Octubre, Madrid, España.

In recent years, multidisciplinary programs have been implemented that include different actions during the pre, intra and postoperative period, aimed at reducing perioperative stress and therefore improving the results of patients undergoing surgical interventions. Initially, these programs were developed for colorectal surgery and from there they have been extended to other surgeries. Thoracic surgery, considered highly complex, like other surgeries with a high postoperative morbidity and mortality rate, may be one of the specialties that most benefit from the implementation of these programs. Read More

View Article and Full-Text PDF

Opioid-Induced Psychosis in a Patient With Sickle Cell Disease.

Cureus 2021 Jun 9;13(6):e15557. Epub 2021 Jun 9.

Psychiatry, Interfaith Medical Center, Brooklyn, USA.

Sickle cell disease (SCD) is a common inherited hemoglobin disorder in which people have atypical hemoglobin, known as hemoglobin S. It is highly prevalent in non-Hispanic Blacks and people of Arab descent. It causes a distortion of the shape of red blood cells, leading to occlusion of blood vessels and thus tissue hypoxia and injury. Read More

View Article and Full-Text PDF

[Efficacy of combination of needle extract, hesperidin and vitamin C in treatment of chronic venous diseases].

Angiol Sosud Khir 2021 ;27(2):82-91

Laboratory of Physiology of Visceral Systems named after K.M. Bykov, Institute of Experimental Medicine, Saint Petersburg, Russia.

Background: In Russia, physicians are virtually unaware of drugs based on needle extract. However, abroad, saponins and, in particular, a combined preparation containing needle extract, hesperidin and vitamin C is one of drugs of choice, if not the leading medication in treatment of venous oedemas and other venous symptoms.

Aim: The authors conducted a systematic review of the Russian-and English-language literature using the following search terms: saponins, hesperidin, needle, ruscus, ruscogenin (and their Russian equivalents), each of which was entered in a combination with the word 'venous' or its Russian equivalent, respectively. Read More

View Article and Full-Text PDF

The Columbia Behavior Scale for Dementia (CBS-8): Validity and Reliability of a Rapidly Administered New Instrument for Dementia-Related Behaviors in Long-Term Care Settings.

Res Gerontol Nurs 2021 May-Jun;14(3):160-168. Epub 2021 May 1.

We developed and evaluated the psychometric properties of the Columbia Behavior Scale for Dementia (CBS-8), a rapid instrument that assesses positive symptoms, to enhance behavioral and psychological symptoms of dementia (BPSD) assessment and treatment in long-term care. Psychometric analyses were performed on CBS-8 data from residents ( = 350, age ≥50 years) in 47 Maryland long-term care facilities referred for neurocognitive and mood evaluation. The CBS-8 demonstrated acceptable internal consistency (α = 0. Read More

View Article and Full-Text PDF

Intermediate-risk thyroid carcinoma: indicators of a poor prognosis.

Arch Endocrinol Metab 2021 May;64(6):764-771

Unidade de Doenças da Tireoide, Divisão de Endocrinologia, Departamento de Medicina, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.

Objective: The intermediate-risk (IR) category includes tumors with different degrees of aggression. We aimed to identify the risk factors associated with unfavorable response to initial treatment and compare the effect of low/high radioactive iodine (RAI) therapy.

Methods: A total of 614 IR patients were selected from a database, during 1972-2015. Read More

View Article and Full-Text PDF

SHIRPA as a Neurological Screening Battery in Mice.

Curr Protoc 2021 May;1(5):e135

Laboratory of Stress, Immunity, Pathogens, Medical School, University of Lorraine, Vandœuvre-les-Nancy, France.

The SmithKline, Harwell, Imperial College, Royal Hospital, Phenotype Assessment (SHIRPA) is a rapid battery of tests comprising 42 measurements of motor activity, coordination, postural control, muscle tone, autonomic functions, and emotional reactivity, as well as reflexes dependent on visual, auditory, and tactile modalities. Individual scores in SHIRPA are sensitive in detecting phenotypes of several experimental models of neural disease, especially cerebellar degeneration and Alzheimer disease, and combined subscores have been useful in estimating the impact of vascular anomalies and exposure to infectious agents. In cerebellar degeneration, weak forelimb grip, impaired wire maneuver and air righting, and negative geotaxis appear as prevalent features. Read More

View Article and Full-Text PDF

Natural disaster stress during pregnancy is linked to reprogramming of the placenta transcriptome in relation to anxiety and stress hormones in young offspring.

Mol Psychiatry 2021 May 12. Epub 2021 May 12.

Department of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, Addiction Institute of Mount Sinai, New York, NY, USA.

Prenatal stress can lead to long-term adverse effects that increase the risk of anxiety and other emotional disorders in offspring. The in utero underpinnings contributing to such phenotypes remain unknown. We profiled the transcriptome of placental specimens from women who lived through Hurricane Sandy during pregnancy compared to those pregnant during non-Sandy conditions. Read More

View Article and Full-Text PDF

Workplace physical aggressions in Italy and Emilia Romagna region.

Med Lav 2021 Apr 20;112(2):130-140. Epub 2021 Apr 20.

Department of Psychology, University of Bologna.

Background: Workplace physical aggressions determine severe consequences for people and organizations. Previous studies reported their spread in organizations and described factors related to their occurrence (e.g. Read More

View Article and Full-Text PDF

Angiogenesis as a hallmark of solid tumors - clinical perspectives.

Cell Oncol (Dordr) 2021 Apr 9. Epub 2021 Apr 9.

Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: Angiogenesis is a key and early step in tumorigenesis, and is known as a hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue vessels, the architecture of the tumor vasculature is abnormal, being leaky, tortuous, fragile and blind-ended. Perivascular cells are either detached or absent, causing reduction of vascular integrity, an increase in vessel immaturity, incoherent perfusion, defective functionality and enhanced tumor dissemination and metastasis. Read More

View Article and Full-Text PDF

Auto-aggressive CXCR6 CD8 T cells cause liver immune pathology in NASH.

Nature 2021 Apr 24;592(7854):444-449. Epub 2021 Mar 24.

Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University Innsbruck, Innsbruck, Austria.

Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease related to obesity, and causes liver disease and cancer. The accumulation of metabolites leads to cell stress and inflammation in the liver, but mechanistic understandings of liver damage in NASH are incomplete. Here, using a preclinical mouse model that displays key features of human NASH (hereafter, NASH mice), we found an indispensable role for T cells in liver immunopathology. Read More

View Article and Full-Text PDF

Correlation of Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment: A Memory Clinic Experience.

Front Aging Neurosci 2021 5;13:595758. Epub 2021 Mar 5.

Unit of Behavioral Neurology, IRCCS Mondino Foundation, Pavia, Italy.

: Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in terms of cerebrospinal fluid (CSF) tau and brain atrophy. : One-hundred patients with mild cognitive impairment (MCI) or dementia (Alzheimer's disease, AD; Lewy-body disease, LBD; frontotemporal dementia, FTD; vascular dementia, VD) underwent a complete diagnostic workup, including 3T-MRI and/or CT and CSF. Read More

View Article and Full-Text PDF

Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth.

Cureus 2021 Jan 13;13(1):e12687. Epub 2021 Jan 13.

Psychiatry, Thomas Jefferson University Hospital, Philadelphia, USA.

Perinatal hypoxia due to obstetric complications has been known to cause neurodevelopmental impairments in infants and children. The severity of the impairments and recovery depends on the degree of hypoxia. There have been some studies which focuses on understanding the effects of perinatal hypoxia on cognitive and behavioral functioning like attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disorders, or aggression. Read More

View Article and Full-Text PDF
January 2021

Wnt Signaling Plays a Key Role in the Regulation of the Immune Response and Cardiac Damage during Infection.

ACS Infect Dis 2021 03 11;7(3):566-578. Epub 2021 Feb 11.

Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Córdoba, Argentina.

Chagas cardiomyopathy is the consequence of a compromised electrical and mechanical cardiac function, with parasite persistence, unbalanced inflammation, and pathological tissue remodelling, being intricately related to myocardial aggression and impaired function. Recent studies have shown that Wnt signaling pathways play a critical role in the pathogenesis of cardiac and vascular diseases. In addition, we have reported that infection activates Wnt signaling to promote intracellular replication of the parasites in macrophages, with the treatment of mice with IWP-L6 (an inhibitor of the -acyl-transferase, PORCN, responsible for the post-translational modifications necessary for Wnt protein secretion) being able to diminish parasitemia and tissue parasitism. Read More

View Article and Full-Text PDF

Psychological characteristics are associated with healthcare worker adherence to infection control practices.

Am J Infect Control 2021 Jul 16;49(7):879-884. Epub 2021 Jan 16.

Department of Infectious Diseases and LIM54, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Infection Control Department, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil. Electronic address:

Background: Most bloodstream infections related to vascular catheters can be avoided if evidence-based practices are applied during insertion and maintenance. In practice, adherence by health care workers (HCWs) is unsatisfactory and is the main current challenge. The objective of this study is to investigate associations between adherence to infection control practices and performance in psychological tests. Read More

View Article and Full-Text PDF

Seizure symptoms and ambulatory EEG findings: incidence of epileptiform discharges.

Epileptic Disord 2020 Dec;22(6):752-758

Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Aims: Ambulatory video-EEG monitoring has been utilized as a cost-effective alternative to inpatient video-EEG monitoring for non-surgical diagnostic evaluation of symptoms suggestive of epileptic seizures. We aimed to assess incidence of epileptiform discharges in ambulatory video-EEG recordings according to seizure symptom history obtained during clinical evaluation.

Methods: This was a retrospective cohort study. Read More

View Article and Full-Text PDF
December 2020

Nomograms and risk score models for predicting survival in rectal cancer patients with neoadjuvant therapy.

World J Gastroenterol 2020 Nov;26(42):6638-6657

Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union College, Beijing 100021, China.

Background: Colorectal cancer is a common digestive cancer worldwide. As a comprehensive treatment for locally advanced rectal cancer (LARC), neoadjuvant therapy (NT) has been increasingly used as the standard treatment for clinical stage II/III rectal cancer. However, few patients achieve a complete pathological response, and most patients require surgical resection and adjuvant therapy. Read More

View Article and Full-Text PDF
November 2020

Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells.

Chin J Cancer Res 2020 Oct;32(5):564-579

Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China.

Objective: Although T-cell immunoglobulin and mucin-domain containing molecule-3 (Tim-3) has been recognized as a promising target for cancer immunotherapy, its exact role in breast cancer has not been fully elucidated.

Methods: gene expression in breast cancer and its prognostic significance were analyzed. Associated mechanisms were then explored by establishing Tim-3-overexpressing breast cancer cells. Read More

View Article and Full-Text PDF
October 2020

Use of Patient-Reported Symptoms from an Online Symptom Tracking Tool for Dementia Severity Staging: Development and Validation of a Machine Learning Approach.

J Med Internet Res 2020 11 11;22(11):e20840. Epub 2020 Nov 11.

DGI Clinical Inc, Halifax, NS, Canada.

Background: SymptomGuide Dementia (DGI Clinical Inc) is a publicly available online symptom tracking tool to support caregivers of persons living with dementia. The value of such data are enhanced when the specific dementia stage is identified.

Objective: We aimed to develop a supervised machine learning algorithm to classify dementia stages based on tracked symptoms. Read More

View Article and Full-Text PDF
November 2020

What is the Role of Image-Guided Endovascular Surgery in Postbariatric Surgery Bleeding Complications?

J Laparoendosc Adv Surg Tech A 2021 Feb 16;31(2):146-151. Epub 2020 Sep 16.

DAICIM Foundation (Teaching, Research, Assistance in Minimal Invasive Surgery), Buenos Aires, Argentina.

Obesity treatment requires surgical procedures included in bariatric surgery. Bleeding complications are reported in 1%-4%. Image-guided surgery (IGS) includes minimally invasive procedures that have the advantage of less aggression to the patient, fewer complications, and a quick recovery. Read More

View Article and Full-Text PDF
February 2021

Behavioural Disturbances in Patients with Diagnosis of Neurocognitive Disorder in Bogotá (Colombia).

Rev Colomb Psiquiatr (Engl Ed) 2020 Jul - Sep;49(3):136-141. Epub 2018 Dec 10.

Centro de Memoria y cognición Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia; Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia; Departamento de Fisiología, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.

Introduction: The main aim of this study is to determine the prevalence of behavioural disturbances (BD) in a group of patients with diagnosis of neurocognitive disorders assessed by a memory clinic in a referral assessment centre in Bogotá, Colombia, in 2015.

Material And Methods: This is an observational, retrospective descriptive study of 507 patients with a diagnosis of neurocognitive disorder (according to DSM-5 criteria) evaluated in a referral centre in Bogotá, Colombia, in 2015.

Results: Among the group of patients assessed, analyses reveal mean age for minor neurocognitive disorders of 71. Read More

View Article and Full-Text PDF

Intermediate-risk thyroid carcinoma: indicators of a poor prognosis.

Arch Endocrinol Metab 2020 Aug 28. Epub 2020 Aug 28.

Divisão de Endocrinologia, Departamento de Medicina, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.

Objective: The intermediate-risk (IR) category includes tumors with different degrees of aggression. We aimed to identify the risk factors associated with unfavorable response to initial treatment and compare the effect of low/high radioactive iodine (RAI) therapy.

Subjects And Methods: A total of 614 IR patients were selected from a database, during 1972-2015. Read More

View Article and Full-Text PDF

Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.

Front Immunol 2020 7;11:1772. Epub 2020 Aug 7.

Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.

Intravascular hemolysis of any cause can induce acute kidney injury (AKI). Hemolysis-derived product heme activates the innate immune complement system and contributes to renal damage. Therefore, we explored the role of the master complement regulator Factor H (FH) in the kidney's resistance to hemolysis-mediated AKI. Read More

View Article and Full-Text PDF

Clinical and laboratory peculiarities of children's state with chronic tonsilitis on type 1 diabetes.

Wiad Lek 2020 ;73(7):1465-1469

National Pedagogical Dragomanov University, Kyiv, Ukraine.

Objective: The aim: Improvement of early diagnostics quality and efficiency of chronic pharyngeal diseases (CPD) treatment in children with DM-1 by studying the clinical and laboratory features of the disease course and complex therapy administration.

Patients And Methods: Materials and methods: A comprehensive examination of 707 children with diabetes mellitus-1, aged 3 to 18, was conducted, which determined clinical and laboratory features of their state in the presence and absence of chronic tonsillitis (CT).

Results: Results: Using microbiological and cytological examination of the palatine tonsils (PT) crypts, the leading role of microbial associations in the pathogenesis of HT in the formation of immune inflammation was determined, their influence on the local immunity indices was defined. Read More

View Article and Full-Text PDF

The zebrafish histamine H3 receptor modulates aggression, neural activity and forebrain functional connectivity.

Acta Physiol (Oxf) 2020 12 12;230(4):e13543. Epub 2020 Aug 12.

Department of Neuroscience, Psychology and Behaviour, College of Life Sciences, University of Leicester, Leicester, UK.

Aim: Aggression is a behavioural trait characterized by the intention to harm others for offensive or defensive purposes. Neurotransmitters such as serotonin and dopamine are important mediators of aggression. However, the physiological role of the histaminergic system during this behaviour is currently unclear. Read More

View Article and Full-Text PDF
December 2020

A European Academy of Neurology guideline on medical management issues in dementia.

Eur J Neurol 2020 10 26;27(10):1805-1820. Epub 2020 Jul 26.

Department of Neurology, Danish Dementia Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background And Purpose: Dementia is one of the most common disorders and is associated with increased morbidity, mortality and decreased quality of life. The present guideline addresses important medical management issues including systematic medical follow-up, vascular risk factors in dementia, pain in dementia, use of antipsychotics in dementia and epilepsy in dementia.

Methods: A systematic review of the literature was carried out. Read More

View Article and Full-Text PDF
October 2020

Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society.

J Hypertens 2020 09;38(9):1682-1698

Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité.

: Inflammation is a physiological response to aggression of pathogenic agents aimed at eliminating the aggressor agent and promoting healing. Excessive inflammation, however, may contribute to tissue damage and an alteration of arterial structure and function. Increased arterial stiffness is a well recognized cardiovascular risk factor independent of blood pressure levels and an intermediate endpoint for cardiovascular events. Read More

View Article and Full-Text PDF
September 2020

The compelling arguments for the need of microvascular investigation in COVID-19 critical patients.

Romeo Martini

Clin Hemorheol Microcirc 2020 ;75(1):27-34

Unità Operativa di Angiologia, Azienda Ospedaliera Universitaria di Padova, Padova, Italy.

The burden of pandemic COVID-19 is growing worldwide, as the continuous increases of contagion. Only 10-15% of the entire infected population has the necessity of intensive care unit (ICU) treatments. But, this relatively low rate of patients has absorbed almost the whole availability of ICU during few days, becoming at least in Italy, an emergency for the national health system. Read More

View Article and Full-Text PDF

Multidimensional hydrogel models reveal endothelial network angiocrine signals increase glioblastoma cell number, invasion, and temozolomide resistance.

Integr Biol (Camb) 2020 06;12(6):139-149

Dept. Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Glioblastoma (GBM) is the most common primary malignant brain tumor. The tissue microenvironment adjacent to vasculature, termed the perivascular niche, has been implicated in promoting biological processes involved in glioblastoma progression such as invasion, proliferation, and therapeutic resistance. However, the exact nature of the cues that support tumor cell aggression in this niche is largely unknown. Read More

View Article and Full-Text PDF

Statins for Smith-Lemli-Opitz syndrome.

Cochrane Database Syst Rev 2020 ;2020(1)

Division of Translational Research, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA.

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: 1. To evaluate the efficacy of statin therapy in reducing the frequency or severity of the neurobehavioral abnormalities seen in people with SLOS (e. Read More

View Article and Full-Text PDF
January 2020

Integrin β4 Is an Effective and Efficient Marker in Synchronously Highlighting Lymphatic and Blood Vascular Invasion, and Perineural Aggression in Malignancy.

Am J Surg Pathol 2020 05;44(5):681-690

Department of Pathology, Peking University Shenzhen Hospital.

Lymphovascular invasion (LVI) and perineural invasion (PNI) are 2 important pathologic parameters and need to be accurately assessed in multiple malignancies. Integrin β4, a member of the integrin family, has been reported to be positively expressed in vascular endothelia, peripheral nerves, and a collection of epithelia. However, little is known about the effectiveness of β4 immunostaining on the recognition of LVI and PNI. Read More

View Article and Full-Text PDF