Am J Physiol Heart Circ Physiol 2021 May 7. Epub 2021 May 7.
Department of Biomechanics, University of Nebraska Omaha, Omaha, NE, United Statesgrid.266815.e.
Vascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized Tomography Angiography scans from 211 subjects 5-93 years old (mean age 47±24 years, 127M/84F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thoracic aorta to the pelvic arteries. A machine learning random forest algorithm was used to determine the associations between calcification in each zone with demographics, risk factors, and vascular morphometry. Read More