1,555 results match your criteria variants concern

Impact of SARS-CoV-2 variant-associated RBD mutations on the susceptibility to serum antibodies elicited by COVID-19 infection or vaccination.

Clin Infect Dis 2021 Jul 26. Epub 2021 Jul 26.

State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.

Background: Several SARS-CoV-2 lineages with mutations at the spike protein receptor binding domain (RBD) have reduced susceptibility to antibody neutralization, and have been classified as Variants of Concern (VOCs) or Variants of Interest (VOIs). Here, we systematically compared the neutralization susceptibility and RBD binding of different VOCs/VOIs, including B.1. Read More

View Article and Full-Text PDF

Understanding COVID-19 dynamics and the effects of interventions in the Philippines: A mathematical modelling study.

Lancet Reg Health West Pac 2021 Sep 14;14:100211. Epub 2021 Jul 14.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Background: COVID-19 initially caused less severe outbreaks in many low- and middle-income countries (LMIC) compared with many high-income countries, possibly because of differing demographics, socioeconomics, surveillance, and policy responses. Here, we investigate the role of multiple factors on COVID-19 dynamics in the Philippines, a LMIC that has had a relatively severe COVID-19 outbreak.

Methods: We applied an age-structured compartmental model that incorporated time-varying mobility, testing, and personal protective behaviors (through a "Minimum Health Standards" policy, MHS) to represent the first wave of the Philippines COVID-19 epidemic nationally and for three highly affected regions (Calabarzon, Central Visayas, and the National Capital Region). Read More

View Article and Full-Text PDF
September 2021

Trajectory of Growth of SARS-CoV-2 Variants in Houston, Texas, January through May 2021 Based on 12,476 Genome Sequences.

Am J Pathol 2021 Jul 22. Epub 2021 Jul 22.

Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, 6565 Fannin Street, Houston, Texas, 77030; Departments of Pathology and Laboratory Medicine, and Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, New York, 10065. Electronic address:

Certain genetic variants of SARS-CoV-2 are of substantial concern because they may be more transmissible or detrimentally alter the pandemic course and disease features in individual patients. We report SARS-CoV-2 genome sequences from 12,476 patients in the Houston Methodist healthcare system diagnosed from January 1 through May 31, 2021. Prevalence of the B. Read More

View Article and Full-Text PDF

Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.

Science 2021 Jul 22. Epub 2021 Jul 22.

Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.

Understanding the causes and consequences of the emergence of SARS-CoV-2 variants of concern is crucial to pandemic control yet difficult to achieve, as they arise in the context of variable human behavior and immunity. We investigate the spatial invasion dynamics of lineage B.1. Read More

View Article and Full-Text PDF

Structural Evaluation of the Spike Glycoprotein Variants on SARS-CoV-2 Transmission and Immune Evasion.

Int J Mol Sci 2021 Jul 10;22(14). Epub 2021 Jul 10.

Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Malaysia.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents significant social, economic and political challenges worldwide. SARS-CoV-2 has caused over 3.5 million deaths since late 2019. Read More

View Article and Full-Text PDF

SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational bursts.

PLoS One 2021 23;16(7):e0255169. Epub 2021 Jul 23.

San Diego Biomedical Research Institute (SDBRI), San Diego, CA, United States of America.

Since the first case of COVID-19 in December 2019 in Wuhan, China, SARS-CoV-2 has spread worldwide and within a year and a half has caused 3.56 million deaths globally. With dramatically increasing infection numbers, and the arrival of new variants with increased infectivity, tracking the evolution of its genome is crucial for effectively controlling the pandemic and informing vaccine platform development. Read More

View Article and Full-Text PDF

Appraising screening, making risk in/visible. The medical debate over Non-Rare Thrombophilia (NRT) testing before prescribing the pill.

Sociol Health Illn 2021 Jul 22. Epub 2021 Jul 22.


Non-rare thrombophilia (NRT) are hereditary predispositions to thromboembolism, the most severe side effect of combined hormonal contraception. In the mid-1990s, the identification of NRT stirred up a controversy over the possibility of investigating these genetic variants in women wishing to use contraception. Through a review of literature, this article reconstructs the debate over whether and how this genetic test should be prescribed as a way to reconfigure the risk visibility on pharmacological contraception. Read More

View Article and Full-Text PDF

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice.

Cell Rep 2021 Jul 10:109452. Epub 2021 Jul 10.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally administered spike protein-based chimpanzee adenovirus-vectored vaccine (ChAd-SARS-CoV-2-S) in animals, which has advanced to human trials. Here, we assessed its durability, dose response, and cross-protective activity in mice. Read More

View Article and Full-Text PDF

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice.

Cell Rep 2021 Jul 10:109450. Epub 2021 Jul 10.

Department of Epidemiology, READDI Initiative, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Improving clinical care for individuals infected with SARS-CoV-2 variants is a global health priority. Small-molecule antivirals like remdesivir (RDV) and biologics such as human monoclonal antibodies (mAbs) have demonstrated therapeutic efficacy against SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19). It is not known whether combination RDV/mAb will improve outcomes over single-agent therapies or whether antibody therapies will remain efficacious against variants. Read More

View Article and Full-Text PDF

Breakthrough Infections of SARS-CoV-2 Gamma Variant in Fully Vaccinated Gold Miners, French Guiana, 2021.

Emerg Infect Dis 2021 Jul 21;27(10). Epub 2021 Jul 21.

An outbreak of severe acute respiratory syndrome coronavirus 2 caused by the Gamma variant of concern infected 24/44 (55%) employees of a gold mine in French Guiana (87% symptomatic, no severe forms). The attack rate was 60% (15/25) among fully vaccinated miners and 75% (3/4) among unvaccinated miners without a history of infection. Read More

View Article and Full-Text PDF

A Simple RT-PCR Melting temperature Assay to Rapidly Screen for Widely Circulating SARS-CoV-2 Variants.

J Clin Microbiol 2021 Jul 21:JCM0084521. Epub 2021 Jul 21.

Public Health Research Institute; Center for Emerging Pathogens, Rutgers New Jersey Medical School; Institute of Genomic Medicine, Rutgers New Jersey Medical School, Newark, NJ.

. The increased transmission of SARS-CoV-2 variants of concern (VOC) which originated in the United Kingdom (B.1. Read More

View Article and Full-Text PDF

Characterisation of a novel ACE2-based therapeutic with enhanced rather than reduced activity against SARS-CoV-2 variants.

J Virol 2021 Jul 21:JVI0068521. Epub 2021 Jul 21.

Autolus Limited, The MediaWorks, 191 Wood Lane, London, W12 7FP.

The human angiotensin-converting enzyme 2 acts as the host cell receptor for SARS-CoV-2 and the other members of the family SARS-CoV-1 and HCoV-NL63. Here we report the biophysical properties of the SARS-CoV-2 spike variants D614G, B.1. Read More

View Article and Full-Text PDF

Amplicon Sequence Variants Artificially Split Bacterial Genomes into Separate Clusters.

mSphere 2021 Jul 21:e0019121. Epub 2021 Jul 21.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.

Amplicon sequencing variants (ASVs) have been proposed as an alternative to operational taxonomic units (OTUs) for analyzing microbial communities. ASVs have grown in popularity, in part because of a desire to reflect a more refined level of taxonomy since they do not cluster sequences based on a distance-based threshold. However, ASVs and the use of overly narrow thresholds to identify OTUs increase the risk of splitting a single genome into separate clusters. Read More

View Article and Full-Text PDF

Potency of BNT162b2 and mRNA-1273 vaccine-induced neutralizing antibodies against severe acute respiratory syndrome-CoV-2 variants of concern: A systematic review of in vitro studies.

Rev Med Virol 2021 Jul 19:e2277. Epub 2021 Jul 19.

Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

BNT162b2 and mRNA-1273 are two types of mRNA-based vaccine platforms that have received emergency use authorization. The emergence of novel severe acute respiratory syndrome (SARS-CoV-2) variants has raised concerns of reduced sensitivity to neutralization by their elicited antibodies. We aimed to systematically review the most recent in vitro studies evaluating the effectiveness of BNT162b2 and mRNA-1273 induced neutralizing antibodies against SARS-CoV-2 variants of concern. Read More

View Article and Full-Text PDF

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.

Science 2021 Jul 20. Epub 2021 Jul 20.

Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.

There is an urgent need for antiviral agents that treat SARS-CoV-2 infection. We screened a library of 1,900 clinically safe drugs against OC43, a human beta-coronavirus that causes the common cold and evaluated the top hits against SARS-CoV-2. Twenty drugs significantly inhibited replication of both viruses in vitro. Read More

View Article and Full-Text PDF

Elucidating causes of COVID-19 infection and related deaths after vaccination.

Diabetes Metab Syndr 2021 Jul 15;15(5):102212. Epub 2021 Jul 15.

Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, New Delhi, India. Electronic address:

Background And Aims: Symptomatic or asymptomatic COVID-19 infection has been reported in vaccination. In the current article, we try to elucidate various causes behind COVID-19 infection and mortality following COVID-19 vaccination and suggest possible strategies to counteract this threat.

Methods: We carried out a comprehensive review of the literature using suitable keywords such as 'COVID-19', 'Pandemics', 'Vaccines', 'Mortality', 'deaths', 'infections', and 'India' on the search engines of PubMed, SCOPUS, Google Scholar, and ResearchGate in from January to May 2021. Read More

View Article and Full-Text PDF

Broad sarbecovirus neutralization by a human monoclonal antibody.

Nature 2021 Jul 19. Epub 2021 Jul 19.

Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

The recent emergence of SARS-CoV-2 variants of concern (VOC) and the recurrent spillovers of coronaviruses in the human population highlight the need for broadly neutralizing antibodies that are not affected by the ongoing antigenic drift and that can prevent or treat future zoonotic infections. Here, we describe a human monoclonal antibody (mAb), designated S2X259, recognizing a highly conserved cryptic receptor-binding domain (RBD) epitope and cross-reacting with spikes from all sarbecovirus clades. S2X259 broadly neutralizes spike-mediated entry of SARS-CoV-2 including the B. Read More

View Article and Full-Text PDF

SARS-CoV-2 Vaccine Effectiveness in a High-Risk National Population in a Real-World Setting.

Ann Intern Med 2021 Jul 20. Epub 2021 Jul 20.

VA Pittsburgh Healthcare System, University of Pittsburgh School of Medicine, and University of Pittsburgh, Pittsburgh, Pennsylvania (F.B.M.).

Background: With the emergency use authorization of multiple vaccines against SARS-CoV-2 infection, data are urgently needed to determine their effectiveness in a real-world setting.

Objective: To evaluate the short-term effectiveness of vaccines in preventing SARS-CoV-2 infection.

Design: Test-negative case-control study using conditional logistic regression. Read More

View Article and Full-Text PDF

Short Report: Early genomic detection of SARS-CoV-2 P.1 variant in Northeast Brazil.

PLoS Negl Trop Dis 2021 Jul 19;15(7):e0009591. Epub 2021 Jul 19.

Laboratório Central de Saúde Pública da Bahia-LACEN-BA, Salvador, Bahia, Brazil.

Tracking the spread of SARS-CoV-2 variants of concern is crucial to inform public health efforts and control the ongoing pandemic. Here, we report genetic evidence for circulation of the P.1 variant in Northeast Brazil. Read More

View Article and Full-Text PDF

SARS-CoV-2 Variants in Rhode Island.

R I Med J (2013) 2021 Sep 1;104(7):16-20. Epub 2021 Sep 1.

Rhode Island Department of Health, State Health Laboratories, Providence, RI.

COVID-19 is a worldwide public health emergency caused by SARS-CoV-2. Genomic surveillance of SARS-CoV-2 emerging variants is important for pandemic monitoring and informing public health responses. Through an interstate academic-public health partnership, we established Rhode Island's capacity to sequence SARS-CoV-2 genomes and created a systematic surveillance program to monitor the prevalence of SARS-CoV-2 variants in the state. Read More

View Article and Full-Text PDF
September 2021

Lentil lectin derived from exhibit broad antiviral activities against SARS-CoV-2 variants.

Emerg Microbes Infect 2021 Jul 19:1-31. Epub 2021 Jul 19.

Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing 102629, China.

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutated continuously and newly emerging variants escape from antibody-mediated neutralization raised great concern. S protein is heavily glycosylated and the glycosylation sites are relatively conserved, thus glycans on S protein surface could be a target for development of anti-SARS-CoV-2 strategies against variants. Here, we collected twelve plant-derived lectins with different carbohydrate specificity and evaluated their anti-SARS-CoV-2 activity against mutant strains and epidemic variants using a pseudovirus based neutralization assay. Read More

View Article and Full-Text PDF

Improving the phishing website detection using empirical analysis of Function Tree and its variants.

Heliyon 2021 Jul 29;7(7):e07437. Epub 2021 Jun 29.

School of Built Environment, Engineering and Computing, Leeds Beckett University, Headingley Campus, Leeds, LS6 3QS, United Kingdom.

The phishing attack is one of the most complex threats that have put internet users and legitimate web resource owners at risk. The recent rise in the number of phishing attacks has instilled distrust in legitimate internet users, making them feel less safe even in the presence of powerful antivirus apps. Reports of a rise in financial damages as a result of phishing website attacks have caused grave concern. Read More

View Article and Full-Text PDF

Management and Thinking on the Treatment of Cancer Patients During the COVID-19.

Front Mol Biosci 2021 1;8:673360. Epub 2021 Jul 1.

Center of Oncology, Department of Medical Oncology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Coronavirus disease-2019 (COVID-19) has spread rapidly around the world and has become a public health emergency of international concern. The weekly epidemiological report issued by the WHO pointed out that new coronavirus variants have appeared in 131 countries and regions, which demonstrates that the current epidemic situation is still severe. As of now, the severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been widespread worldwide for more than one year and poses a serious threat to the health of vulnerable groups such as those with malignancies, the elderly, and the immunocompromised. Read More

View Article and Full-Text PDF

[SARS-CoV-2 variants, a still unfinished story].

Vacunas 2021 Jul 13. Epub 2021 Jul 13.

Unidad de Microbiología Clínica. Laboratorio Regional de Salud Pública de la Comunidad de Madrid. Dirección General de Salud Pública, Consejería de Sanidad, Comunidad de Madrid, Madrid, España.

Mutations in the SARS-CoV-2 genome can affect the gene encoding the Spike (S) antigen, which interacts with the host cell specific receptor, selecting mutant variants with changes in their infective capacity, pathogenic potential and resistance to neutralizing antibodies. The nomenclature to design the variants uses a colloquial form referred to the country or place of detection, a code from the "Pangolin" database and one from the "Nextstrain" page. New variants that have spread include the British B. Read More

View Article and Full-Text PDF

Is diffusion of SARS-CoV-2 variants of concern associated with different symptoms?

J Infect 2021 Jul 15. Epub 2021 Jul 15.

Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University Hospita of Verona, Piazzale LA Scuro, Verona 37134, Italy. Electronic address:

View Article and Full-Text PDF

HAVoC, a bioinformatic pipeline for reference-based consensus assembly and lineage assignment for SARS-CoV-2 sequences.

BMC Bioinformatics 2021 Jul 17;22(1):373. Epub 2021 Jul 17.

Department of Virology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Background: SARS-CoV-2 related research has increased in importance worldwide since December 2019. Several new variants of SARS-CoV-2 have emerged globally, of which the most notable and concerning currently are the UK variant B.1. Read More

View Article and Full-Text PDF

RT-PCR based SARS-CoV-2 variant screening assays require careful quality control.

J Clin Virol 2021 Aug 7;141:104905. Epub 2021 Jul 7.

Center for Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria. Electronic address:

Background: Distinctive genotypes of SARS-CoV-2 have emerged that are or may be associated with increased transmission, pathogenicity, and/or antibody escape. In many countries, clinical and diagnostic laboratories are under mandate to identify and report these so-called variants of concern (VOC).

Objectives: We used an external quality assessment scheme to determine the scope, accuracy, and reliability of laboratories using various molecular diagnostic assays to identify current VOC (03 March 2021). Read More

View Article and Full-Text PDF

An Update on SARS-CoV-2 Diversity in the United States National Capital Region: Evolution of Novel and Variants of Concern.

Clin Infect Dis 2021 Jul 17. Epub 2021 Jul 17.

Johns Hopkins Hospital, Department of Pathology, Division of Medical Microbiology, Baltimore, Maryland, USA.

Background: SARS-CoV-2 Variants concerning for enhanced transmission, evasion of immune responses, or associated with severe disease have motivated the global increase in genomic surveillance. In this study, large scale whole genome sequencing was performed between November 2020 and end of March 2021 to provide a phylodynamic analysis of circulating variants over-time. In addition, we compared the viral genomic features of March 2020 and March 2021. Read More

View Article and Full-Text PDF

Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration.

Sci Rep 2021 07 16;11(1):14604. Epub 2021 Jul 16.

The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.

While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings as "self-tests". Multidisciplinary evaluation of the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW, a widely used rapid antigen test, included limit of detection, variant detection, test performance across different age-groups, and usability with self/caregiver-administration. While BinaxNOW detected the highly infectious variants, B. Read More

View Article and Full-Text PDF