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The effect of different calcium silicate-based pulp capping materials on tooth discoloration: an in vitro study.

BMC Oral Health 2021 07 2;21(1):330. Epub 2021 Jul 2.

Department of Public Health and Community Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Variation in the composition of calcium silicate-based pulp capping materials could influence the discoloration potential of some of these materials, thus affecting the color and aesthetic appearance of the coronal tooth structure. Furthermore, contact with blood if hemostasis is not fully achieved may enhance this discoloration for some materials. Therefore the aim of this study was to evaluate in vitro the color change of coronal tooth structure after placing various calcium silicate-based materials in the pulp chamber in the presence or absence of blood. Read More

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A Comparative Study of Biocompatibility in Rat Connective Tissue of a New Mineral Trioxide Compound (Theracal) versus MTA and a Bioactive G3 Glass.

J Clin Med 2021 Jun 8;10(12). Epub 2021 Jun 8.

Department of Veterinary, Faculty of Veterinary, Alfonso X El Sabio University, 28691 Madrid, Spain.

The aim of this paper was to assess the differences in tissue response to implantation during 15, 30 and 45 days in the subcutaneous connective tissue of Wistar rats from three biomaterials: Angelus MTA, Theracal LC, and Angelus MTA to which 25% bioglass G3 was added. Twenty-four Wistar rats were used, the materials were inserted into the rat's dorsal area in silicone tubes 5 mm long by 1.5 mm diameter. Read More

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Investigation of a modified hydraulic calcium silicate-based material - Bio-C Pulpo.

Braz Oral Res 2021 16;35:e077. Epub 2021 Jun 16.

Universidade Estadual de Campinas - Unicamp, Piracicaba Dental School, Department of Restorative Dentistry, Piracicaba, SP, Brazil.

This study evaluated the physicochemical, biological, and antimicrobial properties of a new hydraulic calcium silicate-based modified material, and compared it with MTA Repair HP and MTA Angelus. The materials were assessed regarding color luminosity (L), color change, radiopacity, setting time, and ISO 6876:2012 linear flow. Volumetric filling and volume change were evaluated using microcomputed-tomography (µCT). Read More

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The effect of different chelators on the dislodgement resistance of MTA Repair HP, MTA Angelus, and MTA Flow.

Odontology 2021 Jun 15. Epub 2021 Jun 15.

Department of Endodontics, Faculty of Dentistry, Antalya Bilim University, Antalya, Turkey.

The aim of this study was to investigate the influence of various irrigants on the dislodgement resistance of MTA Repair HP, MTA Angelus, and MTA Flow to root dentin. Three slices (1.0 ± 0. Read More

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Biological assessment of a new ready-to-use hydraulic sealer.

Restor Dent Endod 2021 May 24;46(2):e21. Epub 2021 Mar 24.

Department of Preventive and Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.

Objectives: This study compared the cytotoxicity, biocompatibility, and tenascin immunolabeling of a new ready-to-use hydraulic sealer (Bio-C Sealer) with MTA-Fillapex and white MTA-Angelus.

Materials And Methods: L929 fibroblasts were cultivated and exposed to undiluted and diluted material extracts. Polyethylene tubes with or without (the control) the materials were implanted into the dorsa of rats. Read More

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Comparison of Postobturation Pain Experience after Apical Extrusion of Calcium Silicate- and Resin-Based Root Canal Sealers.

J Endod 2021 Aug 29;47(8):1278-1284. Epub 2021 May 29.

Department of Restorative Dentistry, Division of Endodontics, São Leopoldo Mandic Dental School, Campinas, São Paulo, Brazil.

Introduction: This study compared the intensity of postobturation pain after unintentional apical extrusion of calcium silicate-based root canal sealers (EndoSequence BC Sealer [Brasseler USA, Savannah, GA] and Bio-C Sealer [Angelus, Londrina, PR, Brazil]) with a resin-based sealer (AH Plus; Dentsply Sirona, York, PA).

Methods: A total of 330 patients referred for root canal treatment on molar teeth with asymptomatic irreversible pulpitis were recruited. Root canals were prepared using WaveOne Gold instruments (Dentsply Sirona) in a crown-down technique and irrigated with 2% chlorhexidine gel and saline solution. Read More

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Tooth Discoloration Induced by Different Calcium Silicate-Based Cements: A Two-Year Spectrophotometric and Photographic Evaluation in Vitro.

J Clin Pediatr Dent 2021 Apr;45(2):112-116

Objective: Calcium silicate-based cements (CSCs) may lead to coronal staining in young permanent teeth over the time. The purpose of this study was to evaluate and compare the long-term tooth discoloration induced by different CSCs.

Study Design: Ninety freshly-extracted human molars were assigned randomly into 6 groups (n=15/group) according to the CSC used as a pulpotomy material: ProRoot MTA, MTA Angelus, NeoMTA, EndoSequence Putty, Biodentine and Negative control (No cement). Read More

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Biocompatibility of NeoMTA Plus® versus MTA Angelus as delayed furcation perforation repair materials in a dog model.

BMC Oral Health 2021 04 13;21(1):192. Epub 2021 Apr 13.

Department of Endodontic, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Background: The biocompatibility of NeoMTA Plus® (Avlon BioMed Inc., Bradenton, Fl) as a furcal perforation repair material is not fully understood. This study compares the biocompatibility of Mineral Trioxide Aggregate (MTA Angelus) and NeoMTA Plus® as delayed furcation perforation repair materials. Read More

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Fracture resistance of endodontically treated teeth restored with resin post reinforced with glass fiber.

J Med Life 2021 Jan-Mar;14(1):81-85

Department of Endodontics, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

This study aims to determine whether the design of resin posts reinforced with glass fiber (FRC) and Reporfost (Angelus, Londrina, PR, Brazil) significantly improves the fracture resistance of endodontically treated teeth restored through this method.A batch of 30 maxillary monoradicular teeth (15 central incisors, 15 canines) were treated endodontically by step-back technique (apical enlargement 40-K file) sealed with Sealapex (Kerr Corporation, Orange, US) and gutta-percha by lateral condensation, cold. They were divided into two equal groups, prepared for cementing the FRC posts. Read More

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Sealing Ability of Calcium Silicate-based Materials in the Repair of Furcal Perforations: A Laboratory Comparative Study.

J Contemp Dent Pract 2020 Oct 1;21(10):1091-1097. Epub 2020 Oct 1.

Department of Endodontics, Faculty of Dentistry, Saint Joseph University, Beirut, Lebanon.

Aim: To assess the sealing ability of two calcium silicate-based materials in the treatment of iatrogenic furcal perforations using a dye-penetration leakage model.

Materials And Methods: Furcation perforations were performed using a size 12 round burr on the pulp chamber floor of 20 first mandibular molars. The teeth were then randomly divided into two groups, two additional molars served as negative controls. Read More

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October 2020

A micro-computed tomographic study using a novel test model to assess the filling ability and volumetric changes of bioceramic root repair materials.

Restor Dent Endod 2021 Feb 8;46(1):e2. Epub 2020 Dec 8.

Department of Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil.

Objectives: New premixed bioceramic root repair materials require moisture for setting. Using micro-computed tomography (micro-CT), this study evaluated the filling ability and volumetric changes of calcium silicate-based repair materials (mineral trioxide aggregate repair high-plasticity [MTA HP] and Bio-C Repair, Angelus), in comparison with a zinc oxide and eugenol-based material (intermediate restorative material [IRM]; Dentsply DeTrey).

Materials And Methods: Gypsum models with cavities 3 mm deep and 1 mm in diameter were manufactured and scanned using micro-CT (SkyScan 1272. Read More

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February 2021

Cytocompatibility and bioactive properties of the new dual-curing resin-modified calcium silicate-based material for vital pulp therapy.

Clin Oral Investig 2021 Feb 27. Epub 2021 Feb 27.

Cellular Therapy and Hematopoietic Transplant Research Group, Biomedical Research Institute, Virgen de la Arrixaca Clinical University Hospital, IMIB-Arrixaca, University of Murcia, 30120, Murcia, Spain.

Objective: The aim of the present study was to evaluate the in vitro biocompatibility of Theracal PT, Theracal LC, and MTA Angelus, considered as bioactive materials used for vital pulp treatment, on human dental pulp stem cells (hDPSCs).

Materials And Methods: Human dental pulp stem cells (hDPSCs) were isolated from third molars, and material eluates were prepared (undiluted, 1:2, and 1:4 ratios). The hDPSC cytotoxicity, adhesion, morphology, viability, and cell migration were assessed. Read More

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February 2021

Impact of Warm Vertical Compaction on the Sealing Ability of Calcium Silicate-Based Sealers: A Confocal Microscopic Evaluation.

Materials (Basel) 2021 Jan 14;14(2). Epub 2021 Jan 14.

Department of Endodontics, Faculty of Dentistry, Saint Joseph University, Beirut BP 17-5208, Lebanon.

The aim of this in vitro study was to evaluate the dentinal tubule penetration of two calcium silicate-based sealers used in warm vertical compaction (WVC) obturation technique in comparison with the single cone (SC) technique by confocal laser scanning microscopy (CLSM). The null hypothesis was that both obturation techniques produced similar sealer penetration depths at 1 and 5 mm from the apex. Forty-four mandibular single-rooted premolars were randomly divided into four equally experimental groups (n = 10) and two control groups (n = 2) according to the type of sealer (Bio-C Angelus, Londrína, PR, Brazil or HiFlow Brasseler, Savannah, GA, USA) with either SC or WVC. Read More

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January 2021

Intentional replantation and Biodentine root reconstruction. A case report with 10-year follow-up.

Int Endod J 2021 Jun 3;54(6):988-1000. Epub 2021 Feb 3.

Dental School, National and Kapodistrian University of Athens, Athens, Greece.

Aim: To describe the innovative use of intentional replantation for Biodentine root reconstruction of a previously treated immature maxillary central incisor with vertically extended crown root fracture and root detachment.

Summary: In the present case, the intentional replantation of a failing, previously treated maxillary central incisor with a vertical crown/root fracture in a 12-year-old male patient is reported. The gross extrusion of gutta-percha points beyond the apex and the pre-existing extensive, trauma related, distal cervical dentinal detachment justified the intentional replantation treatment plan as an option for tooth retention. Read More

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In vitro comparison of physical, chemical, and mechanical properties of graphene nanoplatelet added Angelus mineral trioxide aggregate to pure Angelus mineral trioxide aggregate and calcium hydroxide.

Microsc Res Tech 2021 May 7;84(5):929-942. Epub 2021 Jan 7.

Department of Metallurgical and Materials Engineering, Faculty of Technology, Firat University, Elazig, Turkey.

It is important to cover the pulp surface with a biocompatible material that is physically, mechanically, and chemically adequate. Graphene has the potential to form hard tissue, but at high doses, it shows toxic effects. It can be added to biocompatible materials at low doses to enhance their hard tissue forming potential. Read More

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Biological evaluation of hesperidin for direct pulp capping in dogs' teeth.

Int J Exp Pathol 2021 Feb 6;102(1):32-44. Epub 2021 Jan 6.

Department of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

This study compared the biological effect of Hesperidin, Mineral Trioxide Aggregate (MTA)-Angelus and calcium hydroxide for direct pulp capping. A total of 126 dogs teeth were divided according to the post-treatment evaluation period into three groups (42 teeth each), group I: 2 weeks, group II: 4 weeks and group III: 8 weeks. Each group was further subdivided according to the pulp capping material into three subgroups (14 teeth each), subgroup A (Hesperidin), subgroup B (MTA-Angelus) and subgroup C (Dycal). Read More

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February 2021

The effect of current pulp capping materials against intrapulpal temperature increase in primary teeth. An in-vitro study by pulpal microcirculation simulation model.

J Dent Sci 2021 Jan 22;16(1):85-90. Epub 2020 Jul 22.

Department of Endodontics, Faculty of Dentistry, Pamukkale University, Denizli, Turkey.

Background/purpose: Widespread use of light-cured materials has raised the issue of possible thermal effects on pulp tissue. It was aimed to investigate the effectiveness of pulp capping materials (PCM) against intrapulpal temperature increases (ITI) in primary teeth during light-curing of compomers in this study.

Materials And Methods: A Class-I cavity was prepared on the primary mandibular second molar tooth. Read More

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January 2021

Evaluation of indirect pulp capping using pozzolan-based cement (ENDOCEM-Zr®) and mineral trioxide aggregate - A randomized controlled trial.

J Conserv Dent 2020 Mar-Apr;23(2):152-157. Epub 2020 Nov 5.

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Affiliated to Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Background: Pulp capping should always be considered as the primary treatment of choice for teeth without irreversible pulpitis in lesions approaching dental pulp. The predictability of vital pulp therapy has improved with the introduction of newer bioceramic materials.

Aim: The purpose of this randomized controlled trial was to compare the outcomes of mineral trioxide aggregate (MTA) (Angelus, Londrina, Brazil) and a pozzolan-based cement (ENDOCEM-Zr [Maruchi, Wonju, Korea]) as an indirect pulp capping (IPC) material. Read More

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November 2020

Physicochemical, biological, and antibacterial evaluation of tricalcium silicate-based reparative cements with different radiopacifiers.

Dent Mater 2021 02 13;37(2):311-320. Epub 2020 Dec 13.

Department of Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil. Electronic address:

Objective: To evaluate tricalcium silicate-based (TCS) experimental materials, associated with zirconium oxide (ZrO), calcium tungstate (CaWO) or niobium oxide (NbO) radiopacifiers, in comparison with MTA Repair HP (Angelus).

Methods: Physicochemical tests: setting time, radiopacity, pH and solubility. In vitro assays: cytotoxicity: MTT and Neutral Red - NR; cell bioactivity: alkaline phosphatase activity (ALP), Alzarin red staining (ARS) and real time PCR (qPCR). Read More

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February 2021

Retention of Provisional Intraradicular Retainers Using Fiberglass Pins.

J Int Soc Prev Community Dent 2020 Sep-Oct;10(5):666-673. Epub 2020 Sep 28.

Postgraduate Program in Dentistry, School of Dentistry, University of Taubate, Taubate, São Paulo, Brazil.

Objectives: The purpose of this study was to compare the retention properties between fiberglass pins with chemically activated acrylic resin and metallic intraradicular retainers often used for the purpose of temporary prosthetic retention.

Materials And Methods: Two mechanical tests, pushout and traction, were performed on specimens distributed in three groups ( = 10) for each test; two metal pins G1: Metalpin Ângelus and G2: Provisional Pivot Jon in addition to one fiberglass pin G3: Whitepost DC-E, FGM. One-way analysis of variance (ANOVA) followed by Tukey's test was used at the level of significance α = 0. Read More

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September 2020

Antibacterial Activity of a New Ready-To-Use Calcium Silicate-Based Sealer.

Braz Dent J 2020 Nov-Dec;31(6):611-616

UNAERP - Universidade de Ribeirão Preto, Ribeirão Preto, SP, Brazil.

The aim of this study was to evaluate the antibacterial potential of a calcium silicate-based sealer (Bio-C Sealer, Angelus) against common bacteria in primary and secondary endodontic infections. Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus mutans were exposed to fresh Bio-C Sealer for 24 h by the agar diffusion method (n=5). Additionally, the antibacterial activity was investigated against E. Read More

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November 2020

Sealing ability of three different root repair materials for furcation perforation repair: An study.

J Conserv Dent 2020 Jan-Feb;23(1):62-65. Epub 2020 Oct 10.

Malla Reddy Dental College for Women, Hyderabad, Telangana, India.

Aim: The present study aimed to evaluate and compare the sealing ability of mineral trioxide aggregate (MTA)-Angelus, Biodentine™, and EndoSequence cement in furcation perforations using protein leakage assessment.

Materials And Methods: The present study was conducted using seventy extracted human maxillary and mandibular molars with intact furcation. The samples were randomly allocated into three groups ( = 20) based on repair material used: Group 1 - MTA-Angelus, Group 2 - Biodentine™, and Group 3 - EndoSequence. Read More

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October 2020

Physicochemical Properties of a Bioceramic Repair Material - BioMTA.

Braz Dent J 2020 Sep-Oct;31(5):511-515

Department of Restorative Dentistry, School of Dentistry, UNESP - Universidade Estadual Paulista, Araraquara, SP, Brazil.

This study aimed to assess the physicochemical properties of a repair material in the Brazilian market, BioMTA, in comparison to other two materials currently in use (Biodentine and MTA Angelus). The initial setting time was evaluated using Gillmore needle. The pH was measured with a pH-meter after 24 h, 3, 7, 14 and 21 days. Read More

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November 2020

Marginal adaptation, solubility and biocompatibility of TheraCal LC compared with MTA-angelus and biodentine as a furcation perforation repair material.

BMC Oral Health 2020 10 29;20(1):298. Epub 2020 Oct 29.

Department of Endodontic, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Background: This study evaluated the marginal adaptation, solubility and biocompatibility of TheraCal LC compared with mineral trioxide aggregate (MTA-Angelus) and Biodentine when used as a furcation perforation repair material.

Methods: The marginal adaptation was assessed by scanning electronic microscope and presence of any gap between the dentin surface and filling material in each quadrant of the sample was analyzed at 1000 X magnification. The solubility was measured after one week by the ISO standard method. Read More

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October 2020

An Comparative Evaluation of the Sealing Ability of Five Different Root-end Filling Materials under Confocal Laser Microscopy.

Contemp Clin Dent 2020 Jan-Mar;11(1):51-54. Epub 2020 Jul 13.

Department of Conservative Dentistry and Endodontics, Genesis Institute of Dental Sciences and Research, Faridkot, Punjab, India.

Aim: The purpose of this study was to compare and evaluate the best sealing ability of five different root end filling materials i.e. Silver Amalgam, RMGIC, Cermet Cement, MTA Angelus and Biodentine using ConFocal Laser Scanning Microscope. Read More

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Tissue response to white mineral aggregate-based cement containing barium sulfate as alternative radiopacifier: A randomized controlled animal study.

Microsc Res Tech 2021 Apr 21;84(4):705-711. Epub 2020 Oct 21.

Department of Dentistry, Endodontics and Dental Materials, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil.

The purpose of this study was to investigate the tissue reaction stimulated by BaSO - and Bi O -containing White MTA Angelus, in comparison with Bi O -containing white Portland cement, and white ProRoot MTA. Thirty-six adult male Wistar rats (Rattus norvegicus), weighing between 250 and 300 g, were distributed into three groups (n = 12) in accordance with the period of sacrifice (15, 30, and 60 days). Four polyethylene tubes filled with the tested cements were implanted into the dorsum of each rat. Read More

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Three new species of the genus Poeciloderrhis Stål, 1874 from Brazil (Blattodea, Blaberidae, Epilamprinae) and neotype designation for Poeciloderrhis imperialis Rocha e Silva amp; Jurberg, 1978.

Zootaxa 2020 Jul 13;4810(3):zootaxa.4810.3.8. Epub 2020 Jul 13.

Department of Entomology, Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista s/nº, São Cristóvão, RJ, Brazil..

Three new species of Poeciloderrhis are described: P. angelus sp. nov. Read More

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Micro-computed Tomographic Assessment of Supplementary Cleaning Techniques for Removing Bioceramic Sealer and Gutta-percha in Oval Canals.

J Endod 2020 Dec 19;46(12):1901-1906. Epub 2020 Sep 19.

Faculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Endodontia, Campinas, São Paulo, Brazil. Electronic address:

Introduction: The aim of this study was to conduct a micro-computed tomographic assessment of the effectiveness of 3 supplementary cleaning techniques in reducing the residual volume of gutta-percha and a bioceramic sealer after performing endodontic retreatment procedures in teeth with oval canals.

Methods: Thirty-six mandibular premolars were instrumented with the ProTaper Next system (instruments X1-X3; Dentsply Maillefer, Ballaigues, Switzerland) and filled with gutta-percha and Bio-C Sealer (Angelus, Londrina, PR, Brazil) using the single-cone technique. The teeth were reinstrumented with the Reciproc R40 instrument (VDW, Munich, Germany) and divided into 3 groups according to the supplementary cleaning technique used (n = 12): ultrasonic-assisted irrigation (UAI), EndoActivator (Dentsply Tulsa Dental Specialties, Tulsa, OK) irrigation (EAI), or the XP-endo Finisher R system (XPR; FKG Dentaire, La Chaux-de-Fonds, Switzerland). Read More

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December 2020

Post preparation: cleanness achieved by different irrigating protocols.

Acta Odontol Latinoam 2020 Sep;33(2):117-124

Universidad de Buenos Aires, Facultad de Odontología, Cátedra de Materiales Dentales, Buenos Aires, Argentina.

The aim of this study was to evaluate the ability of different irrigation protocols to remove from the walls of the root canal and entrance to dentinal tubules the smear layer produced during preparation for a fiber post. Fifty decoronated human lower premolars were treated endodontically and the apical third of the canal was filled with a single gutta-percha point using warm vertical compaction. Ten millimeters were left free for post preparation, which was done by sequential use of a Largo #1 drill and Exacto #3 pilot drill (Angelus, Brazil), with irrigation with distilled water upon each instrument change. Read More

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September 2020

Evaluation of the adhesion of human dental pulp stem cells to different endodontic biomaterials before and after setting.

J Dent Res Dent Clin Dent Prospects 2020 17;14(2):97-103. Epub 2020 Jun 17.

General Dental Practitioner, Tabriz, Iran.

Stem cell-based treatment modalities have been potential strategies for tissue regeneration in many conditions. Several studies have evaluated the biologic properties of DPSCs and their efficacy in the treatment of a variety of diseases. The present study was undertaken to evaluate the adhesion behavior of DPSCs on different endodontic materials before and after setting. Read More

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