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Neonatal Lymphopenia Screening Is Important For Early Diagnosis of Severe Combined Immunodeficiency.

Am J Perinatol 2021 Jun 11. Epub 2021 Jun 11.

Division of Hematology and Oncology, Immunology, Department of Pediatrics, Erciyes University, School of Medicine, Kayseri, Turkey.

Objective:  T-cell receptor excision circles are expensive for neonatal severe combined immunodeficiency screening in developing countries. We aimed to detect immunodeficiencies presenting with lymphopenia to enable screening in the general population and to improve awareness regarding lymphopenia among clinicians.

Study Design:  This study was conducted prospectively. Read More

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The interaction effect between comorbidity and venous thromboembolism on mortality rates after venous thromboembolism: A 5-year cohort study.

Thromb Haemost 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Background: Comorbidity influences venous thromboembolism (VTE) mortality, but it is unknown whether this is due to comorbidity alone or whether biological interaction exists.

Objectives: We examined whether comorbidity and VTE interact to increase VTE mortality beyond their individual effects.

Methods: This register-based 5-year cohort study included all VTE patients ≥18 years during 2000-2016, and an age-, sex-, and comorbidity-matched comparison cohort of individuals without VTE. Read More

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[Validity of the "Structured Inventory of Malingered Symptomatology" [SIMS] in the Assessment of Healthy Individuals and Patients with Psychiatric Disorders Outside the Forensic Context].

Fortschr Neurol Psychiatr 2021 Jun 11. Epub 2021 Jun 11.

Forensische Psychiatrie, Zentralinstitut für Seelische Gesundheit, Mannheim, Germany.

Objective: Assessment of the rate of false-positive results of the Structured Inventory of Malingered Symptomatology (SIMS) in healthy controls and authentic patients outside the forensic or rehabilitative context.

Methods: Beyond the SIMS scores, further variables (PANSS, Hamilton scale, MMSE) were obtained. SIMS scores of healthy individuals were compared with the SIMS scores of the different groups of patients. Read More

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[Modern Treatment Options for Postoperative Chylothorax: a Systematic Review].

Pneumologie 2021 Jun 11;75(6):439-446. Epub 2021 Jun 11.

Klinik für Thoraxchirurgie, Regiomed Kliniken GmbH, Sonneberg/Coburg.

Background:  Chylothorax is a multifactorial complication, usually caused by surgery or traumatic injury, and more rarely by malignant disease. Because of the lack of prospective, randomised trials, the evidence-based treatment rests upon personal experience, but ideally taking into account retrospective analysis.

Material And Methods:  The aim of this review is to provide a comprehensive overview of the currently available modern treatment options. Read More

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C677T and A1298C MTHFR gene polymorphisms and response to fluoropyrimidine-based chemotherapy in Mestizo patients with metastatic colorectal cancer.

Pharmacogenet Genomics 2021 Jun 9. Epub 2021 Jun 9.

Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain Centro de Investigaciones en Hematología y Trastornos Afines, CIHATA, Universidad de Costa Rica Departamento de Patología, Hospital Calderón Guardia, Caja Costarricense de Seguro Social, San José, San Pedro, Costa Rica.

Objective: To assess the association between C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) single-nucleotide polymorphisms (SNPs) and response to first-line fluoropyrimidine-based chemotherapy for metastatic colorectal adenocarcinoma.

Methods: A total of 68 patients were prospectively followed up in San Juan de Dios Hospital (San José, Costa Rica) from January 2019 to November 2020. Patients received first-line therapy with capecitabine or 5-fluorouracil in combination with oxaliplatin or irinotecan. Read More

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Trends in Operative Treatment of Pediatric and Adolescent Forearm Fractures Among American Board of Orthopaedic Surgery Part II Candidates.

J Pediatr Orthop 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopaedic Surgery, Brown University/Warren Alpert School of Medicine Warren Alpert School of Medicine at Brown University Brown University, Providence, RI Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA.

Background: Pediatric and adolescent forearm fractures are among the most common injuries treated by orthopaedic surgeons. Recent literature shows that there has been an increased interest in operative management for these injuries. The purpose of the current study was to examine the trends in case volume, patient age, surgeon fellowship training, and postoperative complications of surgically treated pediatric forearm fractures over >15-year period of American Board of Orthopaedic Surgery (ABOS) Part II Oral Examination candidates. Read More

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Characterization of arrhythmias, evaluation of cardiac biomarkers and their association with survival in calves suffering from foot-and-mouth disease.

J Vet Cardiol 2021 Apr 18;36:64-76. Epub 2021 Apr 18.

Indian Veterinary Research Institute, Regional Campus, Hebbal, Bengaluru, Karnataka, 560024, India.

Introduction: Foot-and-mouth disease (FMD) causes mortality in calves due to myocarditis; however, the effects of FMD virus on cardiac arrhythmogenesis and Purkinje cells are unknown. Identifying diagnostic and prognostic markers in FMD-affected calves may be useful in disease management in the endemic countries.

Materials And Methods: A total of 81 FMD-affected calves were prospectively monitored till death or recovery. Read More

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The effectiveness of natalizumab vs fingolimod-A comparison of international registry studies.

Mult Scler Relat Disord 2021 May 8;53:103012. Epub 2021 May 8.

KTU Medical Faculty Farabi Hospital, Trabzon, Turkey.

Background: Natalizumab and fingolimod were the first preparations recommended for disease breakthrough in priorly treated relapsing-remitting multiple sclerosis. Of three published head-to-head studies two showed that natalizumab is the more effective to prevent relapses and EDSS worsening.

Methods: By re-analyzing original published results from MSBase, France, and Denmark using uniform methodologies, we aimed at identifying the effects of differences in methodology, in the MS-populations, and at re-evaluating the differences in effectiveness between the two drugs. Read More

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A non-parametric propensity score for estimating the effect of interferon-beta or glatiramer acetate on long-term outcomes of multiple sclerosis.

Mult Scler Relat Disord 2021 May 30;53:103050. Epub 2021 May 30.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada; Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada.

Background: The few observational studies that investigated the long-term effects of interferon-beta and glatiramer acetate were usually focused on progression to irreversible disability and other outcomes such as number of relapses and transition to secondary-progressive multiple sclerosis (SPMS) have been rarely studied. The objective of this paper is to estimate the effect of interferon-beta/glatiramer acetate on progression to irreversible disability, transition from relapsing-remitting multiple sclerosis (RRMS) to SPMS and the rate of relapses over 10 years.

Methods: Analyses included 2498 patients with confirmed diagnosis of RRMS followed in Montréal from 1977 to 2016. Read More

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Improved oxygen activation over metal-organic-frameworks derived and zinc-modulated [email protected] catalyst for boosting indoor gaseous formaldehyde oxidation at room temperature.

J Colloid Interface Sci 2021 May 30;601:833-842. Epub 2021 May 30.

College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China; Engineering Research Center of Alternative Energy Materials & Devices, Ministry of Education, Chengdu 610065, China. Electronic address:

The indoor low-concentration formaldehyde (HCHO) removal in cobalt-based catalysts is still a "hot potato". In this work, metal-organic-frameworks (MOF)-derived and Zinc (Zn)-modulated new cobalt nanoparticles catalyst ([email protected]) was designed and prepared. The [email protected] performed outstanding elimination activities for ~1 ppm HCHO at 25 °C. Read More

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Monte Carlo determination of dose coefficients at different developmental stages of zebrafish (Danio rerio) in experimental condition.

J Environ Radioact 2021 Jun 8;237:106667. Epub 2021 Jun 8.

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions. Electronic address:

The release of liquid effluent of nuclear power into aquatic system increases with the rapid development of nuclear facilities in coastal and inland regions. Aquatic model animals are very important for the study of the radiation hazards to non-human biota in water environment and its extrapolation of dose-effect relationship to human models. However, the study of the radiation dose rate calculation model of the aquatic animal zebrafish is still on the homogeneous isotropic model used for the protection of the environment. Read More

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Spatial and temporal changes in bomb radiocarbon in the northern Indian Ocean.

J Environ Radioact 2021 Jun 8;237:106680. Epub 2021 Jun 8.

Physical Research Laboratory, Ahmedabad, India.

For improved understanding of ocean circulation in the northern Indian Ocean region, long term continuous record of radiocarbon measurement is required. Limited radiocarbon records from the region demands investigations of natural archives. Coral core records along with some literature data were analysed to study the temporal changes in C values over the northern Indian Ocean. Read More

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Systematic review of reproductive outcomes after High Intensity Focused Ultrasound treatment of uterine fibroids.

Eur J Radiol 2021 May 27;141:109801. Epub 2021 May 27.

Department of Radiology, Isala hospital, Dokter van Heesweg 2, 8025 AB, Zwolle, the Netherlands.

Purpose: Myomectomy is currently the gold standard for the treatment of uterine fibroids in women who desire pregnancy. However, this surgical fibroid removal has a long convalescence. Promising alternatives may be non-invasive High Intensity Focused Ultrasound (HIFU) under either MRI (MR-HIFU) or ultrasound guidance (USgHIFU). Read More

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Mechanical property characterization of partially crystalline Poly-Ether-Ether-Ketone.

J Mech Behav Biomed Mater 2021 Jun 1;121:104600. Epub 2021 Jun 1.

CAS Key Laboratory for Mechanical Behavior and Design of Materials, Department of Modern Mechanics. University of Science and Technology of China, Hefei, Anhui, 230027, China.

The present study investigates the mechanical properties of partially crystalline Poly-Ether-Ether-Ketone between the glass transition and the cold crystallization. Biaxial tension, uniaxial tension, and DMA experiments were conducted to investigate the influence of temperature-induced crystallization on mechanical properties, and three stiffening behaviors are observed. Firstly, a 'U' type mechanical property is observed for all three experiments with first softening and then significant stiffening behavior with increasing temperature. Read More

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Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2).

Nutrition 2021 May 7;89:111340. Epub 2021 May 7.

Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address:

Objectives: The viral entry of SARS-CoV-2 requires host-expressed TMPRSS2 to facilitate the viral spike protein priming. This study aims to test the hypothesis that magnesium (Mg) treatment leads to DNA methylation changes in TMPRSS2.

Methods: This study is nested within the Personalized Prevention of Colorectal Cancer Trial, a double-blind 2 × 2 factorial randomized controlled trial, which enrolled 250 participants from Vanderbilt University Medical Center. Read More

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A higher percentage of leukemic blasts with vacuoles predicts unfavorable outcomes in patients with acute myeloid leukemia.

Leuk Res 2021 Jun 6;109:106638. Epub 2021 Jun 6.

Department of Hematology, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Henan, People's Republic of China. Electronic address:

Cytoplasmic vacuoles, which are a morphological feature of dysplasia, can be observed under a microscope at initial diagnosis. Recently, this typical morphological feature has been found to be associated with impaired survival. To investigate the clinical significance of the grading of blasts with vacuoles in acute myeloid leukemia (AML), we retrospectively studied 152 patients newly diagnosed with non-M3 AML. Read More

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Effect of azithromycin on bronchial wall thickness in severe persistent asthma: A double-blind placebo-controlled randomized clinical trial.

Respir Med 2021 Jun 2;185:106494. Epub 2021 Jun 2.

Department of Radiology, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran. Electronic address:

Background: Azithromycin reduced airway remodeling in animal models of asthma. However, its effect on human subjects has not been studied yet. This study aimed to investigate the effect of long-term treatment with azithromycin on airways wall thickness in patients with severe persistent asthma. Read More

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Expression of the Vitreoscilla hemoglobin gene in Nannochloropsis oceanica regulates intracellular oxygen balance under high-light.

J Photochem Photobiol B 2021 Jun 4;221:112237. Epub 2021 Jun 4.

Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Engineering Laboratory of Single Cell Oil, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China,; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China. Electronic address:

Nannochloropsis oceanica is widely used as a model photosynthetic chassis to produce fatty acids and carotenoid pigments. However, intense light typically causes excessive generation of reactive oxygen species (ROS) and photorespiration in microalgal cells, which results in decreased cell growth rate and unsaturated fatty acid content. In this study, the Vitreoscilla hemoglobin gene (vgb) was introduced into N. Read More

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Enhancing stability and resilience of electromethanogenesis system by acclimating biocathode with intermittent step-up voltage.

Bioresour Technol 2021 Jun 4;337:125376. Epub 2021 Jun 4.

State Key Laboratory of Clean Energy, Department of Energy Engineering, Zhejiang University, Hangzhou 310027, PR China.

Electromethanogenesis (EMG) system could efficiently convert CO to CH by using excess renewable electricity. However, the fluctuation and interruption of renewable electricity will adversely affect the biocathode and therefore the CH production of the EMG system. In this work, a novel biocathode acclimation strategy with intermittent step-up voltage (ISUV) was proposed to improve the stability and resilience of the EMG system against the unstable input of renewable power. Read More

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Rapid and highly selective electrochemical sensor based on ZnS/Au-decorated f-multi-walled carbon nanotube nanocomposites produced via pulsed laser technique for detection of toxic nitro compounds.

J Hazard Mater 2021 Jun 1;418:126269. Epub 2021 Jun 1.

Core-Facility Center for Photochemistry & Nanomaterials, Department of Chemistry (BK21 FOUR), Research Institute of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address:

Novel ZnS/Au/f-multi-walled carbon nanotube (MWCNT) nanostructures were produced via a pulsed laser-assisted technique followed by a wet chemical process. ZnS nanospheres were synthesized via pulsed laser ablation of a Zn target in DMSO, which was used as a solvent and sulfur source. Notably, no additional sulfur sources, surfactants, or reducing agents were used during the synthesis. Read More

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The promotions on radical formation and micropollutant degradation by the synergies between ozone and chemical reagents (synergistic ozonation): A review.

J Hazard Mater 2021 Jun 8;418:126327. Epub 2021 Jun 8.

Key Laboratory of Microorganism Application and Risk Control of Shenzhen, Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental Safety, Institute of Environment and Ecology, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China. Electronic address:

The combination of ozone (O) and chemical reagents (such as HO) shows synergies on the radical formation and micropollutant degradation. The promoting performance was associated with various parameters including chemical reagents, micropollutants, solution pH, and the water matrix. In this review, we summarized existing knowledge on radical formation pathways, radical yields, and radical oxidation for different synergistic ozonation processes in various water matrices (such as groundwater, surface water, and wastewater). Read More

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Facile green synthesis of zero-valent iron nanoparticles using barberry leaf extract ([email protected]) for photocatalytic reduction of hexavalent chromium.

Bioorg Chem 2021 Jun 3;114:105051. Epub 2021 Jun 3.

Department of Environmental Health Engineering, School of Public Health and Center for Water Quality Research (CWQR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran.

In this study, zero-valent iron (GnZVI) was synthesized using barberry leaf extract ([email protected]). The physicochemical properties of the final products were characterized by FT-IR, SEM, TEM, and EDS techniques. The results of TEM analysis showed that the obtained iron zero-valent nanoparticles with a diameter between 20 and 40 nm and shell-core structures were successfully synthesized. Read More

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Function and distribution of the conjugative plasmid pLM1686 in foodborne Listeria monocytogenes in China.

Int J Food Microbiol 2021 May 30;352:109261. Epub 2021 May 30.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Institute of Pathogenic Biology, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China. Electronic address:

Listeria monocytogenes, a fatal foodborne pathogen has the extraordinary capacity to survive in harsh conditions and is a potential threat to public health. A novel 91 kb plasmid pLM1686 was found in the prevalent L. monocytogenes sequence type (ST) 87 strain in China. Read More

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Prediction of false positive SARS-CoV-2 molecular results in a high-throughput open platform system.

J Mol Diagn 2021 Jun 8. Epub 2021 Jun 8.

Department of Laboratory Medicine & Pathology, Division of Molecular Pathology and Genomics, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Widespread high-throughput testing for identification of SARS-CoV-2 infection by RT-PCR has been a foundation in the response to the COVID-19 pandemic. Quality assurance metrics for these RT-PCR tests are still evolving as testing becomes widely implemented. As testing increases, it is important to understand performance characteristics and the errors associated with these tests. Read More

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Epidemiology and clinical features of intestinal protozoan infections detected by Real-Time PCR in non-native children within an Italian tertiary care children's hospital: a cross-sectional study.

Travel Med Infect Dis 2021 Jun 8:102107. Epub 2021 Jun 8.

Infectious Diseases Unit, Meyer Children's University Hospital, Florence, Italy; Department of Health Sciences, University of Florence, Italy. Electronic address:

Background: Enteric parasite infections are underestimated due to the limited sensitivity and specificity of microscopy, which remains the diagnostic gold standard in routine clinical practice. This could be a major problem in high-income countries, where the burden of parasitic diseases is low. In recent years, Multiplex Real-Time polymerase chain reaction (RT-PCR) based methods have been implemented. Read More

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Fluid-structure interaction modeling of lactating breast: Newtonian vs. non-Newtonian milk.

J Biomech 2021 May 13;124:110500. Epub 2021 May 13.

Department of Mechanical Engineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA. Electronic address:

Breastfeeding is a highly dynamic and complex mechanism. The suckling process by the infant involves compression and intra-oral vacuum pressure, leading to milk expression from breast. The accumulated milk from the nipple varies depending on the milk properties and transient flow rate during the suckling cycle. Read More

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Assessment of Morbidity and Mortality after Periprosthetic Hip Fracture. Influence of Vancouver Stage in a Retrospective Single-Centre Study of 88 Patients.

Orthop Traumatol Surg Res 2021 Jun 8:102985. Epub 2021 Jun 8.

Service de Chirurgie de l'Arthrose et du Sport, Urgences Traumatiques des Membres. CHU de Grenoble-Alpes, Hôpital Sud, Avenue de Kimberley, BP 338, 38434 Echirolles Cedex, France.

Background: Peri-prosthetic hip fractures (PPHFs) are serious complications whose treatment is generally difficult due to their predominance in elderly patients with bone frailty and other comorbidities. The Vancouver classification is the most widely used and is helpful for assisting treatment decisions. However, its value for predicting morbidity and mortality has not been assessed. Read More

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Gefitinib with concurrent thoracic radiotherapy in unresectable locally advanced non-small cell lung cancer with EGFR mutation; West Japan Oncology Group 6911L.

J Thorac Oncol 2021 Jun 8. Epub 2021 Jun 8.

Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osakasayama, Japan.

Introduction: About 10% of locally-advanced non-small cell lung cancer (LA-NSCLC) patients harbor epidermal growth factor receptor (EGFR) mutation and recent reports suggested the declined benefit with immune-checkpoint inhibitor in this population. The attempt that introduces EGFR-tyrosine kinase inhibitor (TKI) into the treatment of LA-NSCLC with EGFR mutation has been warranted.

Methods: Chemotherapy-naïve, unresectable LA-NSCLC patients with sensitive EGFR mutation (exon 19 deletion or exon 21 L858R point mutation) were enrolled. Read More

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Tuberculosis of the spine in children - Does drug resistance affect surgical outcomes?

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Paediatric TB Clinic, Bai Jerbai Wadia Hospital for Children, Mumbai, India. Electronic address:

Background Context: The emergence of drug resistance has complicated the management of spinal tuberculosis (TB). While it is well known that the medical management of drug-resistant spinal TB is more difficult, the surgical outcomes of the same have not been studied sufficiently, particularly in children.

Purpose: To analyze the surgical outcomes in a cohort of children treated for spinal TB, and to thus assess whether drug resistant (DR) disease is associated with poorer surgical outcomes. Read More

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Brivanib alaninate inhibited dengue virus proliferation through VEGFR2/AMPK pathway.

Pharmacol Res 2021 Jun 8:105721. Epub 2021 Jun 8.

State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China. Electronic address:

Dengue virus (DENV) is the most prevalent arthropod-borne viral disease of humans and has a major impact on global public health. There is no clinically approved drugs for DENV infection. Since intracellular VEGFR2 is increased in DENV infected patients, we thus hypothesized that VEGFR2 participated DENV proliferation and its inhibitors could be served as antivirals against DENV. Read More

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