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Factors associated with psychological distress for couples facing head and neck cancer: A systematic literature review.

Psychooncology 2021 Apr 9. Epub 2021 Apr 9.

King's Mill Hospital, Nottinghamshire Healthcare NHS Foundation Trust, Sutton-in-Ashfield, UK.

Objectives: Cancer patients in supportive relationships display improved health and survival outcomes. Identifying factors that might respond to intervention for Head and Neck Cancer (HNC) dyads is important as HNC patients and their partners experience heightened distress. This article systematically reviewed and evaluated the research findings and methodological quality of studies which identified factors influencing psychological distress for couples facing HNC. Read More

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Short-latency inhibition mitigates the relationship between conscious movement processing and overly cautious gait.

Age Ageing 2021 May;50(3):830-837

School of Sport and Health Sciences, University of Exeter, UK.

Background: Overly cautious gait is common in older adults. This is characterised by excessively slow gait, shortened steps, broadened base of support and increased double limb support. The current study sought to (1) evaluate if overly cautious gait is associated with attempts to consciously process walking movements, and (2) explore whether an individual's ability to rapidly inhibit a dominant motor response serves to mitigate this relationship. Read More

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Selective vulnerability to atrophy in sporadic Creutzfeldt-Jakob disease.

Ann Clin Transl Neurol 2021 May 5. Epub 2021 May 5.

Department of Neurology, Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco (UCSF), San Francisco, California.

Objective: Identification of brain regions susceptible to quantifiable atrophy in sporadic Creutzfeldt-Jakob disease (sCJD) should allow for improved understanding of disease pathophysiology and development of structural biomarkers that might be useful in future treatment trials. Although brain atrophy is not usually present by visual assessment of MRIs in sCJD, we assessed whether using voxel-based morphometry (VBM) can detect group-wise brain atrophy in sCJD.

Methods: 3T brain MRI data were analyzed with VBM in 22 sCJD participants and 26 age-matched controls. Read More

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Impact of environmental factors in predicting daily severity scores of atopic dermatitis.

Clin Transl Allergy 2021 Apr;11(2):e12019

Department of Bioengineering, Imperial College London, London, UK.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 20% of children worldwide. Environmental factors including weather and air pollutants have been shown to be associated with AD symptoms. However, the time-dependent nature of such a relationship has not been adequately investigated. Read More

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Clinical outcome of intradural extramedullary spinal cord tumors: A single-center retrospective analytical study.

Surg Neurol Int 2021 8;12:145. Epub 2021 Apr 8.

Department of Orthopaedic, Spine Division, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.

Background: Intradural extramedullary spinal cord tumors (IESCT) account for approximately two-thirds of largely benign intraspinal neoplasms. They occasionally present with acute neurological deterioration warranting emergent surgical intervention.

Methods: Here, we reviewed a series of 31 patients with intradural extramedullary spinal tumors who underwent surgery from 2012 to 2019. Read More

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The D*Phase-study: study protocol for a pragmatic two-phased, randomised controlled (non-inferiority) trial that addresses treatment non-response and compares cognitive behavioural therapy and short-term psychodynamic supportive psychotherapy for major depression.

BMC Psychiatry 2021 05 4;21(1):233. Epub 2021 May 4.

Dimence, Deventer, The Netherlands.

Background: Several evidence-based psychotherapeutic treatment options are available for depression, but the treatment results could be improved. The D*Phase study directly compares short-term psychodynamic supportive psychotherapy (SPSP) and cognitive behavioural therapy (CBT) for Major Depressive Disorder (MDD). The objectives are 1. Read More

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Long-term functional outcomes after an external femoral derotation osteotomy in individuals with cerebral palsy.

Gait Posture 2021 Apr 22;87:184-191. Epub 2021 Apr 22.

Gillette Children's Specialty Healthcare, 200 University Avenue East, Saint Paul, MN, 55101, United States; University of Minnesota, Orthopedic Surgery, 2450 Riverside Ave, Minneapolis, MN, 55454, United States. Electronic address:

Background: It is unknown how a femoral derotation osteotomy (FDO) during childhood affects functional outcomes in adulthood among individuals with bilateral cerebral palsy (CP).

Research Questions: How do long-term functional outcomes after an FDO compare to matched individuals who did not have an FDO? How do outcomes change over time?

Methods: We queried the gait laboratory database for individuals who underwent an external FDO in childhood and were currently ≥25 years old. Participants returned for a long-term analysis (gait, physical examination, functional tests, imaging, questionnaires). Read More

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Timeliness and completeness of laboratory-based surveillance of COVID-19 cases in England.

Public Health 2021 Apr 1;194:163-166. Epub 2021 Apr 1.

Epidemiology Cell, Public Health England National Infection Service, London, UK.

Objectives: The aim of the study was to evaluate completeness and timeliness of the rapidly developed surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in England using patient-level data.

Study Design: This is an observational study wherein public health surveillance systems are evaluated.

Methods: Data were collected in the Public Health England's Second-Generation Surveillance System through routine laboratory reporting processes, as well as via enhanced testing in collaboration with commercial partners. Read More

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Chronic stress in practice assistants: An analytic approach comparing four machine learning classifiers with a standard logistic regression model.

PLoS One 2021 4;16(5):e0250842. Epub 2021 May 4.

Institute of General Practice and Family Medicine, University Hospital Bonn, University of Bonn, Bonn, Germany.

Background: Occupational stress is associated with adverse outcomes for medical professionals and patients. In our cross-sectional study with 136 general practices, 26.4% of 550 practice assistants showed high chronic stress. Read More

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Project20: Does continuity of care and community-based antenatal care improve maternal and neonatal birth outcomes for women with social risk factors? A prospective, observational study.

PLoS One 2021 4;16(5):e0250947. Epub 2021 May 4.

Department of Women and Children's Health, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.

Background: Social factors associated with poor childbirth outcomes and experiences of maternity care include minority ethnicity, poverty, young motherhood, homelessness, difficulty speaking or understanding English, migrant or refugee status, domestic violence, mental illness and substance abuse. It is not known what specific aspects of maternity care work to improve the maternal and neonatal outcomes for these under-served, complex populations.

Methods: This study aimed to compare maternal and neonatal clinical birth outcomes for women with social risk factors accessing different models of maternity care. Read More

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Nomogram to predict survival outcome of patients with veno-arterial extracorporeal membrane oxygenation after refractory cardiogenic shock.

Postgrad Med 2021 May 4. Epub 2021 May 4.

The Second School of Clinical Medicine, Southern Medical University, Department of Critical Care Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China.

Objective: This study aims to develop a nomogram model to predict the survival of refractory cardiogenic shock (RCS) patients that received veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

Methods: A total of 235 and 209 RCS patients were supported with VA-ECMO from January 2018 to December 2019 in Guangdong Provincial People's Hospital, and from January 2020 to December 2020 in four third-grade and class-A hospitals were a development cohort (DC) and validation cohort (VC), respectively. Finally, 137 and 98 patients were included in the DC and VC. Read More

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The influence of motivation and emotion on sensorimotor rhythm-based brain-computer interface performance.

Psychophysiology 2021 May 4:e13832. Epub 2021 May 4.

Institute of Psychology, University of Würzburg, Würzburg, Germany.

While decades of research have investigated and technically improved brain-computer interface (BCI)-controlled applications, relatively little is known about the psychological aspects of brain-computer interfacing. In 35 healthy students, we investigated whether extrinsic motivation manipulated via monetary reward and emotional state manipulated via video and music would influence behavioral and psychophysiological measures of performance with a sensorimotor rhythm (SMR)-based BCI. We found increased task-related brain activity in extrinsically motivated (rewarded) as compared with nonmotivated participants but no clear effect of emotional state manipulation. Read More

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Is There a Role for Perioperative Pelvic Radiotherapy in Surgically Resected Stage IV Rectal Cancer?: A Propensity Score-matched Analysis.

Am J Clin Oncol 2021 May 4. Epub 2021 May 4.

Department of Radiation Oncology, Chungnam National University School of Medicine, Daejeon Department of Radiation Oncology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, 20, Seoul, Republic of Korea.

Objectives: This study aimed to determine whether perioperative pelvic radiotherapy (RT) improves outcomes in stage IV rectal cancer patients treated with primary surgical resection and systemic chemotherapy and to identify predictive factors for selection of patients for these approaches.

Materials And Methods: We searched the Surveillance, Epidemiology, and End Results (SEER) database for patients diagnosed between 2010 and 2015 with stage IV rectal cancer, but without brain or bone metastases. After applying the exclusion criteria, a total of 26,132 patients were included in the analysis; propensity score matching was used to balance their individual characteristics. Read More

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Salivary Porphyromonas gingivalis predicts outcome in oral squamous cell carcinomas: a cohort study.

BMC Oral Health 2021 May 3;21(1):228. Epub 2021 May 3.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospita1 of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, People's Republic of China.

Background: Studies suggest Porphyromonas gingivalis (Pg) increased the incidence of oral squamous cell carcinoma (OSCC). However, fimA genotypes distribution of Pg, the origination of Pg in tissue, and its prognostic value are inconclusive. We aimed to investigate the frequency of fimA genotypes in OSCC patients, study the association between Pg and OSCC, and explore the prognostic value of Pg. Read More

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Conditions associated with worse acceptance of a simplified accelerated recovery after surgery protocol in laparoscopic colorectal surgery.

BMC Surg 2021 May 3;21(1):229. Epub 2021 May 3.

Hospital FelicioRocho, Belo Horizonte, Brazil.

Background: Enhanced Recovery Surgical Programs were initially applied to colorectal procedures and used as multimodal approach to relieve the response to surgical stress. An important factor that negatively impacts the success of these programs is the poor tolerance of these patients to certain items in the adopted protocol, especially with regard to post-operative measures. The identification of these factors may help to increase the success rate of such programs, ensuring that benefits reach a greater number of patients and that resources are better allocated. Read More

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Prognostic impact of additive chemotherapy after curative resection of metachronous colorectal liver metastasis: a single-centre retrospective study.

BMC Cancer 2021 May 3;21(1):490. Epub 2021 May 3.

Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital of Würzburg, Oberdürrbacherstr. 6, 97080, Würzburg, Germany.

Background: A prognostic benefit of additive chemotherapy in patients following resection of metachronous colorectal liver metastases (CRLM) remains controversial. Therefore, the goal of this retrospective study was to investigate the impact of perioperative chemotherapy on disease-free survival (DFS) and overall survival (OS) of patients after curative resection of metachronous CRLM.

Methods: In a retrospective single-centre study, patients after curative resection of metachronous CRLM were included and analysed for DFS and OS with regard to the administration of additive chemotherapy. Read More

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Radiographic and plantar pressure assessment of pes planovalgus severity in children with cerebral palsy.

Clin Biomech (Bristol, Avon) 2021 Apr 27;85:105364. Epub 2021 Apr 27.

Department of Orthopedic Surgery, University of Colorado, Aurora, CO, USA; Center for Gait and Movement Analysis (CGMA), Children's Hospital Colorado, Aurora, CO, USA; Orthopedics Institute, Children's Hospital Colorado, Aurora, CO, USA.

Background: Pes planovalgus is common in children with cerebral palsy. Although severity influences treatment, there still lacks standard clinical measurements to objectively quantify pes planovalgus in this population. The comparison of pedobarographic data and radiographic measurements to clinical evaluation has not been reported in this population. Read More

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The effect of a brief mindfulness intervention on perception of bodily signals of satiation and hunger.

Appetite 2021 Apr 30:105280. Epub 2021 Apr 30.

Marketing and Consumer Behaviour Group, Wageningen University and Research, Hollandseweg 1, 6706 KN, The Netherlands.

An increasing number of studies investigate the effects of mindfulness on food intake and weight outcomes, while the underlying mechanisms by which mindfulness exerts its effects have received less attention. We conducted two pre-registered studies to shed light on the frequently proposed yet largely understudied hypothesis that mindfulness improves awareness of bodily signals of satiation and hunger. We assessed the ability to perceive the onset of bodily signals of satiation with the two-step water load test (Study 1) and the ability to perceive the onset of bodily signals of hunger with the preload test (Study 2). Read More

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Facial Injuries Due to Cycling are Prevalent: Improved Helmet Design Offering Facial Protection is Recommended.

J Oral Maxillofac Surg 2021 Mar 26. Epub 2021 Mar 26.

Professor, Division of Plastic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN; Attending Surgeon, Department of Plastic and Hand Surgery, Regions Hospital, Saint Paul, MN.

Purpose: Safety equipment for recreational cycling is commonly designed to protect the calvarium, but not the face, in the event of a crash. The purpose of this study is to identify the prevalence of facial injuries and their most common subcategories due to cycling injuries and to serve as an anatomical guide of what facial structures most need protection.

Methods: We report a cross-sectional study of consecutive patients reported to the National Electronic Injury Surveillance System from January 1, 2010 to December 31, 2019. Read More

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Formulation of diets for pigs based on a ratio between digestible calcium and digestible phosphorus results in reduced excretion of calcium in urine without affecting retention of calcium and phosphorus compared with formulation based on values for total calcium.

J Anim Sci 2021 May 3. Epub 2021 May 3.

Division of Nutritional Sciences, University of Illinois, Urbana, USA.

An experiment was conducted to test the hypothesis that formulating diets for pigs based on a ratio between standardized total tract digestible (STTD) Ca and STTD P instead of total Ca and STTD P does not decrease Ca retention, but increases P utilization. Forty barrows (59.4 ± 3. Read More

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Nonlaboratory-based risk assessment model for type 2 diabetes mellitus screening in Chinese rural population: a joint bagging-boosting model.

IEEE J Biomed Health Inform 2021 May 3;PP. Epub 2021 May 3.

Diabetes mellitus is one of the major public health problems in the world due to its high prevalence and medical costs. The prevention effort necessitates reliable risk assessment models which can effectively identify high-risk individuals and enable healthcare practitioners to initiate appropriate preventive interventions. However, diabetes risk assessment models based on data analysis face multiple challenges, such as class imbalance and low identification rate. Read More

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Effects of moderate intensity endurance training and high-intensity interval training on the reproductive parameters of wistar rats overfed in infancy.

Chin J Physiol 2021 Mar-Apr;64(2):106-114

Department of Medicine, Postgraduate Health Program, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.

Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development of obesity, cardiovascular diseases, and diabetes in the long term. In addition to metabolic changes during adulthood, overweight/obesity may influence reproductive function. Human and animal studies suggest that lifestyle changes through exercise and/or controlled diet result in improved semen quality in obese individuals. Read More

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Total intrapartum fetal reperfusion time (fetal resilience) and neonatal acidemia.

J Matern Fetal Neonatal Med 2021 May 2:1-10. Epub 2021 May 2.

Department of Obstetrics and Gynecology, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Objective: The main objective is to study the predictive capacity of intrapartum total fetal reperfusion (fetal resilience) by itself or in combination with other parameters as a predictor of neonatal acidemia.

Study Design: A retrospective case-control study was carried out at the Miguel Servet University Hospital (Zaragoza, Spain) on a cohort of 5694 pregnant women between June 2017 and October 2018. Maternal, perinatal, and cardiotocographic records were collected. Read More

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A Nomogram Model to Predict Prognosis of Patients With Genitourinary Sarcoma.

Front Oncol 2021 16;11:656325. Epub 2021 Apr 16.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Objectives: The aim of this study is to evaluate the significant factors influencing the overall survival (OS) and recurrence free survival (RFS) and make an attempt to develop a nomogram for predicting the prognosis of patients with genitourinary sarcoma (GS).

Methods: Data on adult GS from 1985 to 2010 were collected. The impact of clinical factors on OS and RFS were estimated by Kaplan-Meier (KM) analysis, and differences between groups were analyzed by the log-rank test. Read More

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Snake Bite Management: A Scoping Review of the Literature.

Plast Reconstr Surg Glob Open 2021 Apr 29;9(4):e3506. Epub 2021 Apr 29.

Department of Plastic and Reconstructive Surgery, The Ohio State University College of Medicine, Columbus, Ohio.

Background: Around the world, snake bite envenomation remains an underreported human health hazard. Envenomation can cause local and systemic complications, especially when there is a lack of antivenom availability. Although there are established guidelines regarding snake bite management acute care, there is a paucity of data regarding surgical intervention and the plastic surgeon's role treating this unique patient population. Read More

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Reduced circulating exosomal miR-382 predicts unfavorable outcome in non-small cell lung cancer.

Int J Clin Exp Pathol 2021 15;14(4):469-474. Epub 2021 Apr 15.

Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu, China.

Circulating microRNAs (miRNAs) have been demonstrated as robust and promising biomarkers for non-small cell lung cancer (NSCLC). Our aim was to determine the significance of serum exosomal miR-382 in NSCLC. Circulating exosomes were collected from 126 patients with NSCLC and 60 normal controls before treatment and one month after surgery. Read More

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Patient Perspectives on a Digital Mobile Health Application for RA.

Open Access Rheumatol 2021 23;13:63-71. Epub 2021 Apr 23.

B2 Consulting, Kelowna, British Columbia, Canada.

Background: Emerging evidence suggests that patients are increasingly willing to use digital mobile health applications for rheumatoid arthritis (RA apps). The development and diffusion of RA apps open the possibility of improved management of the disease and better physician-patient interactions. However, adoption rates among apps have been lower than hoped, and research shows that many available RA apps lack key features. Read More

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Aflatoxicosis in Pekin duckling and the effects of treatments with lycopene and silymarin.

Vet World 2021 Mar 29;14(3):788-793. Epub 2021 Mar 29.

Department of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Egypt.

Background And Aim: Aflatoxins (AFs) are potent toxic metabolites produced from species. Whose existence in poultry ration leads to drastic economic losses, notably in duck, as the most susceptible poultry species. This study aimed to determine tissue residues of AFs, alterations in selected clinical chemistry variables in serum, mainly during the exposure period, and lycopene and silymarin's possible roles as herbal treatments against aflatoxicosis in Pekin duckling. Read More

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The Human Muscle Size and Strength Relationship: Effects of Architecture, Muscle Force, and Measurement Location.

Med Sci Sports Exerc 2021 Apr 27. Epub 2021 Apr 27.

Versus Arthritis, Centre for Sport, Exercise and Osteoarthritis, Loughborough University, Leicestershire, United Kingdom School of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, United Kingdom Academy of Sport and Physical Activity, Faculty of Health and Wellbeing, Collegiate Campus, Sheffield Hallam University, Sheffield, United Kingdom School of Sport and Health Sciences, University of Exeter, United Kingdom.

Purpose: This study aimed to determine the best muscle size index of muscle strength by establishing if incorporating muscle architecture measurements improved the human muscle size-strength relationship. The influence of calculating muscle force, and the location of anatomical cross-sectional area (ACSA) measurements on this relationship were also examined.

Methods: Fifty-two recreationally active males completed unilateral isometric knee extension strength assessments and MRI scans of the dominant thigh and knee to determine quadriceps femoris (QF) size variables (ACSA along the length of the femur, maximum ACSA [ACSAMAX] and volume [VOL]) and patellar tendon moment arm. Read More

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Implications of Guideline-based, Risk-stratified Restaging Transurethral Resection of High-grade Ta Urothelial Carcinoma on Bacillus Calmette-Guérin Therapy Outcomes.

Eur Urol Oncol 2021 Apr 29. Epub 2021 Apr 29.

Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Guideline indications for restaging transurethral resection (reTUR) for high-grade (HG) Ta bladder tumors vary due to a paucity of data.

Objective: To investigate guideline-based, risk-adapted approaches to reTUR for HG Ta lesions.

Design, Setting, And Participants: An institutional review of HG Ta patients who received adequate bacillus Calmette-Guérin (BCG) from 2000 to 2019 was conducted. Read More

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