20,507 results match your criteria variable selection


A multi-pollutant assessment of preconception persistent endocrine disrupting chemicals and incident pregnancy loss.

Environ Int 2021 Jul 28;157:106788. Epub 2021 Jul 28.

Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Background: A few endocrine disrupting chemicals (EDCs) have been associated with pregnancy loss often as reported by women, though there has been no study of EDC mixtures and pregnancy loss in keeping with the nature of human exposure.

Objectives: To investigate preconception exposure to a mixture of EDCs to identify important drivers and inform multi-pollutant models of EDCs in relation to incident human gonadrophin chorionic (hCG) pregnancy loss.

Methods: A cohort of 501 couples were recruited from the general population and prospectively followed until a hCG-confirmed pregnancy or 12 months of trying to become pregnant. Read More

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Terahertz dual-band metamaterial absorber for trace indole-3-acetic acid and tricyclazole molecular detection based on spectral response analysis.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 24;263:120222. Epub 2021 Jul 24.

College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Sensors Sensing, Ministry of Agriculture, Zhejiang University, Hangzhou 310058, China. Electronic address:

A terahertz (THz) metamaterial absorber based on a split ring resonator (SRR) structure was used to realize the highly accurate detection of trace pesticides, including indole-3-acetic acid (IAA) and tricyclazole. The density functional theory (DFT) was used to analysis the THz fingerprint peaks of IAA and tricyclazole. According to the dual-band (0. Read More

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Development and Validation of a Simplified Risk Score for the Prediction of Critical COVID-19 Illness in Newly Diagnosed Patients.

J Med Virol 2021 Jul 31. Epub 2021 Jul 31.

Department of Nephrology, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Munich, Germany.

Objectives: Scores to identify patients at high risk of progression of coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may become instrumental for clinical decision-making and patient management.

Methods: We used patient data from the multicentre Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) and applied variable selection to develop a simplified scoring system to identify patients at increased risk of critical illness or death. A total of 1,946 patients who tested positive for SARS-CoV-2 were included in the initial analysis and assigned to derivation and validation cohorts (n=1,297 and n=649, respectively). Read More

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Steroid switch after progression on abiraterone plus prednisone in patients with metastatic castration-resistant prostate cancer: A systematic review.

Urol Oncol 2021 Jul 27. Epub 2021 Jul 27.

Department of Urology, Institute of Urology, Center of National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Background: Emerging evidence indicates that patients with metastatic castration-resistant prostate cancer could respond to steroid switch from prednisone (P) to dexamethasone (D) following progression on abiraterone acetate plus prednisone (AA+P).

Objectives: Conducting a systematic review to evaluate the efficacy, safety, and prognostic factors of steroid switch.

Materials And Methods: We systematically searched Pubmed, Web of Science, and American Society of Clinical Oncology annual meeting abstracts published up to October 2020. Read More

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[Prioritization by patients of a series of common components in the standard comprehensive geriatric assessment in Primary Care].

Rev Esp Geriatr Gerontol 2021 Jul 27. Epub 2021 Jul 27.

OSI Bilbao-Basurto, Bizkaia, España.

Objective: To know the prioritization by people aged ≥70 of a series of common components in the comprehensive geriatric assessment (CGA) in primary care (PC), according to the influence on health.

Method: Cross-sectional descriptive study through questionnaire to 109 people, have been excluded those at the end of life or with cognitive, sensory or mental/psychiatric impairment that made collaboration difficult. The main variable was a selection of 23 items of the physical/clinical, functional, mental and social/family, common components on a CGA in PC. Read More

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Cognitive impairment in euthymic patients with bipolar disorder: Prevalence estimation and model selection for predictors of cognitive performance.

J Affect Disord 2021 Jul 21;294:497-504. Epub 2021 Jul 21.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; South London & Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK.

Objectives Although cognitive dysfunction is a prominent feature of bipolar disorder (BD), previous research presents limitations in estimating the proportion of euthymic patients experiencing clinically relevant deficits and identifying predictors of cognitive difficulties. We explored the relevance of recommended definitions of clinically significant cognitive impairment for functional outcomes, estimated its prevalence, and identified patient characteristics associated with cognition. Methods We assessed cognitive performance across four domains in 80 euthymic participants with BD. Read More

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A meta-epidemiological study found lack of transparency and poor reporting of disproportionality analyses for signal detection in pharmacovigilance databases.

J Clin Epidemiol 2021 Jul 27. Epub 2021 Jul 27.

Pharmacovigilance Unit, Grenoble Alpes University Hospital, F-38000 Grenoble, France; HP2 Laboratory, INSERM U1300, Univ. Grenoble Alpes, F-38000 Grenoble, France.

Objective: To review and appraise methods and reporting characteristics of pharmacovigilance disproportionality analyses.

Study Design And Setting: We randomly selected 100 disproportionality analyses indexed in Medline found during a systematic literature search. We then extracted and synthetized methodological and reporting characteristics using 7 key items: 1) title transparency; 2) protocol pre-registration; 3) date of data extraction and analysis; 4) outcome, population, exposure and comparator definitions; 5) adjustment and stratification of results; 6) method and threshold for signal detection; 7) secondary and sensitivity analyses. Read More

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Predicting zebrafish (Danio rerio) embryo developmental toxicity through a non-conformational QSAR approach.

Sci Total Environ 2021 Jul 3;796:148820. Epub 2021 Jul 3.

Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CONICET, UNLP, Diag. 113 y 64, C.C. 16, Sucursal 4, 1900 La Plata, Argentina. Electronic address:

For many years, the frequent use of synthetic chemicals in the manufacture of veterinary drugs and plague control products has raised negative effects on human health and other non-target organisms, promoting the need to employ a practical and suitable methodology for early risk identification of several thousand commercial compounds. The zebrafish (Danio rerio) embryo has been emerged as one sustainable animal model for measuring developmental toxicity, an endpoint that is included in the regulatory procedures to approve chemicals, avoiding conventional and costly toxicity assays based on animal testing. In this context, the Quantitative Structure-Activity Relationships (QSAR) theory is applied to develop a predictive model based on a well-defined zebrafish embryo developmental toxicity database reported by the ToxCast™ Phase I chemical library of the Environmental Protection Agency (U. Read More

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Using knockoffs for controlled predictive biomarker identification.

Stat Med 2021 Jul 30. Epub 2021 Jul 30.

Advanced Methodology and Data Science, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.

One of the key challenges of personalized medicine is to identify which patients will respond positively to a given treatment. The area of subgroup identification focuses on this challenge, that is, identifying groups of patients that experience desirable characteristics, such as an enhanced treatment effect. A crucial first step towards the subgroup identification is to identify the baseline variables (eg, biomarkers) that influence the treatment effect, which are known as predictive variables. Read More

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Identifying Safety Thresholds for Immunosuppressive Drugs: Applying Insights from Primary Antibody Deficiencies to Mitigate Adverse Events in Secondary Antibody Deficiencies Using Mathematical Modeling of Preclinical and Early Clinical Data.

Eur J Drug Metab Pharmacokinet 2021 Jul 30. Epub 2021 Jul 30.

Merck Institute for Pharmacometrics (an affiliate of Merck KGaA, Darmstadt, Germany), Lausanne, Switzerland.

Immunosuppressive drugs can alleviate debilitating symptoms of autoimmune diseases, but, by the same token, excessive immune suppression can result in an increased risk of infection. Despite the dangers of a compromised immune system, clear definitions of what constitutes excessive suppression remain elusive. Here we review the most common infections associated with primary antibody deficiencies (PADs), such as agammaglobulinemia, common variable immunodeficiency (CVID), and IgA deficiency, as well as infections that are associated with drug-induced or secondary antibody immunodeficiencies (SADs). Read More

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Fast and flexible estimation of effective migration surfaces.

Elife 2021 Jul 30;10. Epub 2021 Jul 30.

Department of Human Genetics, University of Chicago, Chicago, United States.

Spatial population genetic data often exhibits 'isolation-by-distance,' where genetic similarity tends to decrease as individuals become more geographically distant. The rate at which genetic similarity decays with distance is often spatially heterogeneous due to variable population processes like genetic drift, gene flow, and natural selection. Petkova et al. Read More

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Risk assessment models for venous thromboembolism in hospitalised adult patients: a systematic review.

BMJ Open 2021 Jul 29;11(7):e045672. Epub 2021 Jul 29.

Emergency Department, Salford Royal NHS Foundation Trust, Salford, UK.

Introduction: Hospital-acquired thrombosis accounts for a large proportion of all venous thromboembolism (VTE), with significant morbidity and mortality. This subset of VTE can be reduced through accurate risk assessment and tailored pharmacological thromboprophylaxis. This systematic review aimed to determine the comparative accuracy of risk assessment models (RAMs) for predicting VTE in patients admitted to hospital. Read More

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Metabolic surgery may protect against admission for COVID-19 in persons with nonalcoholic fatty liver disease.

Surg Obes Relat Dis 2021 Jun 29. Epub 2021 Jun 29.

Department of Surgery, University of Minnesota, Division of Surgical Oncology, Minneapolis, Minnesota.

Background: SARS-CoV-2 (COVID-19) disease causes significant morbidity and mortality through increased inflammation and thrombosis. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are states of chronic inflammation and indicate advanced metabolic disease.

Objective: The purpose of this observational study was to characterize the risk of hospitalization for COVID-19 in patients with NAFLD/NASH and evaluate the mitigating effect of various metabolic treatments. Read More

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Variable selection for longitudinal zero-inflated power series transition model.

J Biopharm Stat 2021 Jul 30:1-18. Epub 2021 Jul 30.

Department of Statistics, Faculty of Mathematical Sciences, Tarbiat Modares University, Tehran, Iran.

In modeling many longitudinal count clinical studies, the excess of zeros is a common problem. To take into account the extra zeros, the zero-inflated power series (ZIPS) models have been applied. These models assume a latent mixture model consisting of a count component and a degenerated zero component that has a unit point mass at zero. Read More

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To comply or not comply? A latent profile analysis of behaviours and attitudes during the COVID-19 pandemic.

PLoS One 2021 29;16(7):e0255268. Epub 2021 Jul 29.

Department of Psychology, University of Saskatchewan, Saskatoon, Canada.

How and why do people comply with protective behaviours during COVID-19? The emerging literature employs a variable-centered approach, typically using a narrow selection of constructs within a study. This study is the first to adopt a person-centred approach to identify complex patterns of compliance, and holistically examine underlying psychological differences, integrating multiple psychology paradigms and epidemiology. 1575 participants from Australia, US, UK, and Canada indicated their behaviours, attitudes, personality, cognitive/decision-making ability, resilience, adaptability, coping, political and cultural factors, and information consumption during the pandemic's first wave. Read More

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Patient and public involvement in numerical aspects of trials (PoINT): exploring patient and public partners experiences and identifying stakeholder priorities.

Trials 2021 Jul 28;22(1):499. Epub 2021 Jul 28.

Health Services Research Unit, University of Aberdeen, Aberdeen, UK.

Background And Aims: Patient and public involvement is increasingly common in trials, but its quality remains variable in a lot of settings. Many key decisions in trials involve numbers, but patients are rarely involved in those discussions. We aimed to understand patient and public partners' experiences and opinions regarding their involvement in numerical aspects of research and discuss and identify priorities, according to multiple stakeholders, around the most important numerical aspects in trials to involve patients and the public in. Read More

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Validity of a method for identifying disease subtypes that are etiologically heterogeneous.

Stat Methods Med Res 2021 Jul 28:9622802211032704. Epub 2021 Jul 28.

Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

A focus of cancer epidemiologic research has become the identification of risk factors that influence specific subtypes of disease, a phenomenon known as etiologic heterogeneity. In previous work we developed a novel strategy to cluster tumor markers and identify disease subtypes that differ maximally with respect to known risk factors for use in the context of case-control studies. The method relies on the premise that unsupervised -means clustering will find candidate solutions that are closely aligned with the sought-after etiologically distinct clusters, which may not be true in the presence of clusters of tumor markers that are not related to risk of disease. Read More

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Bayesian variable selection for the Cox regression model with spatially varying coefficients with applications to Louisiana respiratory cancer data.

Biom J 2021 Jul 28. Epub 2021 Jul 28.

Department of Statistics, University of Missouri - Columbia, Columbia, MO, USA.

The Cox regression model is a commonly used model in survival analysis. In public health studies, clinical data are often collected from medical service providers of different locations. There are large geographical variations in the covariate effects on survival rates from particular diseases. Read More

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SSR marker-based genetic diversity analysis and SNP haplotyping of genes associating abiotic and biotic stress tolerance, rice growth and development and yield across 93 rice landraces.

Mol Biol Rep 2021 Jul 28. Epub 2021 Jul 28.

Department of Genomic Science, Central University of Kerala, Periye, Kasaragod, Kerala, 671316, India.

Background: As rice is the staple food for more than half of the world's population, enhancing grain yield irrespective of the variable climatic conditions is indispensable. Many traditionally cultivated rice landraces are well adapted to severe environmental conditions and have high genetic diversity that could play an important role in crop improvement.

Methods And Results: The present study revealed a high level of genetic diversity among the unexploited rice landraces cultivated by the farmers of Kerala. Read More

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Serum proteome modulations upon treatment provides biological insight on response to treatment in relapsed mantle cell lymphoma.

Cancer Rep (Hoboken) 2021 Jul 28:e1524. Epub 2021 Jul 28.

Department of Immunotechnology, Lund University, Lund, Sweden.

Background: The possibility to monitor patient's serum proteome during treatment can provide deepened understanding of the biology associated with response to specific drugs. Non-invasive serum sampling provides an opportunity for sustainable repetitive sampling of patients, which allows for more frequent evaluation of the biological response and enhanced flexibility in treatment selection in contrast to tissue biopsies.

Aim: To pin-point biologically relevant changes in pre- and on-treatment serum proteome samples in relapsed mantle cell lymphoma (MCL) patients, leading to insight into mechanisms behind response to treatment in sub-groups of patients. Read More

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Comprehensive analysis of KCS gene family in Citrinae reveals the involvement of CsKCS2 and CsKCS11 in fruit cuticular wax synthesis at ripening.

Plant Sci 2021 Sep 10;310:110972. Epub 2021 Jun 10.

National R&D Center for Citrus Postharvest Technology, Wuhan, 430070, China; Key Laboratory of Horticultural Plant Biology, Ministry of Education, Wuhan, 430070, China; College of Horticulture & Forestry Sciences, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address:

Cuticular wax covers the surface of fleshy fruit and plays a protective role in fruit development and postharvest storage, including reducing fruit water loss, resisting biotic and abiotic stress and affecting fruit glossiness. The β-ketoacyl-CoA synthase (KCS) is the rate-limiting enzyme of very long chain fatty acids (VLCFAs) synthesis, which provides precursors for the synthesis of cuticular wax. In this study, a total of 96 KCS genes were identified in six Citrinae species, including 13, 16, 21, 14, 16 and 16 KCS genes in the primitive species (Atalantia buxifolia), the wild species (Citrus ichangensis), and four cultivated species (Citrus medica, Citrus grandis, Citrus sinensis and Citrus clementina), respectively. Read More

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September 2021

Gender dimensions of the impact of HIV/AIDS on stunting in children under five years in Zimbabwe.

BMC Public Health 2021 Jul 27;21(1):1461. Epub 2021 Jul 27.

Department of Economics, Bindura University of Science Education, P. Bag 1020, Bindura, Zimbabwe.

Background: HIV/AIDS can have a disastrous effect on household food and nutrition security outcomes such as stunting in children under 5. However, stunting and HIV/AIDS are highly gendered phenomena that need to be explored in order to get an in-depth understanding of the interrelationship. This study was therefore aimed at investigating gender dimensions of the impact of HIV/AIDS on stunting in children under 5 years in Zimbabwe. Read More

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Self-assessment of attitudes towards conditions to provide safe abortion among new medical graduates in Thailand, 2018: an application of cross-sectional survey with factor analysis.

BMC Womens Health 2021 Jul 27;21(1):273. Epub 2021 Jul 27.

International Health Policy Program, Ministry of Public Health, Nonthaburi, 11000, Thailand.

Background: Unsafe abortion is one of the major public health problems in Thailand. Although the penal code of Thailand and the Thai Medical Council permit doctors to perform safe abortion in certain conditions, little is known about the attitudes that new medical doctors have towards abortion. The objectives of this article are to explore the attitudes towards abortion in certain conditions among new medical graduates and to identify factors related to those attitudes. Read More

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Manual Therapy with Neural Mobilization: Immediate Effect on the Vocal Quality of Women with Dysphonia.

J Voice 2021 Jul 23. Epub 2021 Jul 23.

Department of Speech Therapy, Federal University of Minas Gerais - UFMG, Minas Gerais, Brazil. Electronic address:

Objective: To evaluate the immediate effect of neural mobilization on the voice quality, self-perceived phonatory effort, and laryngeal muscles of women with behavioral dysphonia.

Method: This is an intrasubject comparative study. The research included 21 women aged 18 to 59 years with vocal complaints. Read More

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Predicting clinically significant response to primary care treatment for depression from electronic health records of veterans.

J Affect Disord 2021 Jul 16;294:337-345. Epub 2021 Jul 16.

VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Objective: To reduce delays in referral to specialty mental health care, we evaluated clinical prediction models estimating the likelihood of response to primary care treatment of depression in the VA healthcare system.

Methods: We included patients with a primary care depression diagnosis between October 1, 2015 and December 31, 2017, an initial PHQ-9 score ≥ 10 within 30 days, a follow-up PHQ-9 score within 2-8 months, and no specialty mental health care within three months prior to depression diagnosis. We evaluated eight ordinary least squares regression models, each with a different procedure for selecting predictors of percentage change in PHQ-9 score from baseline to follow-up. Read More

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Dipeptidyl peptidase III as a DNA marker to investigate epidemiology and taxonomy of Old World Leishmania species.

PLoS Negl Trop Dis 2021 Jul 26;15(7):e0009530. Epub 2021 Jul 26.

Laboratory of Molecular Epidemiology and Experimental Pathology, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunisia.

Background: Dipeptidyl peptidase III (DPPIII) member of M49 peptidase family is a zinc-dependent metallopeptidase that cleaves dipeptides sequentially from the N-terminus of its substrates. In Leishmania, DPPIII, was reported with other peptidases to play a significant role in parasites' growth and survival. In a previous study, we used a coding sequence annotated as DPPIII to develop and evaluate a PCR assay that is specific to dermotropic Old World (OW) Leishmania species. Read More

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Predicting the efficacy of COVID-19 convalescent plasma donor units with the Lumit Dx anti-receptor binding domain assay.

PLoS One 2021 26;16(7):e0253551. Epub 2021 Jul 26.

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.

Background: The novel coronavirus SARS-CoV2 that causes COVID-19 has resulted in the death of more than 2.5 million people, but no cure exists. Although passive immunization with COVID-19 convalescent plasma (CCP) provides a safe and viable therapeutic option, the selection of optimal units for therapy in a timely fashion remains a barrier. Read More

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Generalized Equations for Predicting Percent Body Fat from Anthropometric Measures Using a Criterion Five-Compartment Model.

Med Sci Sports Exerc 2021 Jul 23. Epub 2021 Jul 23.

Department of Exercise Science, Shenandoah University, Winchester, VA Department of Kinesiology, University of Alabama, Tuscaloosa, AL College of Nursing and Health Sciences, Texas A&M International University, Laredo, TX Department of Education, Ewha Womans University, Seoul, South Korea Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO.

Introduction: Anthropometric-based equations are used to estimate percent body fat (%BF) when laboratory methods are impractical or not available. However, because these equations are often derived from two-compartment models, they are prone to error due to assumptions regarding fat-free mass composition. The purpose of this study was to develop a new anthropometric-based equation for the prediction of %BF, using a five-compartment (5C) model as the criterion measure. Read More

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Making the case for the collection of a minimal dataset for children with speech sound disorder.

Int J Lang Commun Disord 2021 Jul 26. Epub 2021 Jul 26.

Bristol Speech and Language Therapy Research Unit, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol, UK.

Background: NHS case note data are a potential source of practice-based evidence which could be used to investigate the effectiveness of different interventions for individuals with a range of speech, language and communication needs. Consistency in pre- and post-intervention data as well as the collection of relevant variables would need to be demonstrated as a precursor to adopting this approach in future investigations of speech and language therapy intervention.

Aims: To explore whether routine clinical data collection for children with speech sound disorder (SSD) could be a potential source for examining the effectiveness of intervention(s). Read More

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High Definition Lipoplasty in Male Patients: A Systematic Review of Surgical Techniques and Outcomes.

Aesthet Surg J 2021 Jul 26. Epub 2021 Jul 26.

Division of Plastic and Reconstructive Surgery, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, NY.

Background: Lipoplasty has undergone a series of refinements throughout history. It is now possible to apply superficial suction to enhance the outline of a muscle in order to improve the results of aesthetic lipoplasty.

Objectives: Herein, we aimed to summarize the available evidence on the techniques and surgical outcomes of high definition lipoplasty (HDL) in male patients. Read More

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