51,379 results match your criteria variability observed


In-vivo kinematic assessment of alloplastic temporomandibular joint replacements by means of helical axis: A cohort study with historical control.

J Biomech 2021 May 5;122:110494. Epub 2021 May 5.

Clinic of Masticatory Disorders, Center of Dental Medicine, University of Zurich, Switzerland. Electronic address:

Alloplastic total temporomandibular joint replacement (TJR) is a surgical procedure used to restore normal mandibular function when conservative therapies fail. The instantaneous helical axis (HA), is a mathematical model used to visualize globally rigid body kinematics. It can be applied to mandibular motion for quantification of movement patterns and irregularities. Read More

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Increasing cognitive load attenuates the moderating effect of attentional inhibition on the relationship between posttraumatic stress symptoms and threat-related attention bias variability.

J Anxiety Disord 2021 May 9;81:102416. Epub 2021 May 9.

Westfield State University, United States.

Theory and empirical evidence suggest that those with higher posttraumatic stress (PTS) symptoms and better attentional control (i.e., the strategic control of higher-order executive attention in regulating bottom-up, stimulus driven responses to prepotent stimuli; Sarapas et al. Read More

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Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study.

Diabetologia 2021 May 15. Epub 2021 May 15.

CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands.

Aims: CVD is the main cause of morbidity and mortality in individuals with diabetes. It is currently unclear whether daily glucose variability contributes to CVD. Therefore, we investigated whether glucose variability is associated with arterial measures that are considered important in CVD pathogenesis. Read More

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Real life Study on the Pharmacokinetic of Remdesivir in ICU patients admitted for Severe COVID-19 Pneumonia.

Br J Clin Pharmacol 2021 May 14. Epub 2021 May 14.

Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Italy.

Remdesivir is one of the most encouraging treatments against SARS-CoV-2 infection. After intravenous infusion, RDV is rapidly metabolized (T 1h) within the cells to its active adenosine triphosphate analogue form (GS-443902) and, then, it can be found in plasma in its nucleoside analogue form (GS-441524). In this real life study we describe the Remdesivir and GS-441524 concentrations at 3 time points in nine ICU patients, through a validated UHPLC-MS/MS method. Read More

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Molecular identification of triticale introgression lines carrying leaf rust resistance genes transferred from Aegilops kotschyi Boiss. and Ae. tauschii Coss.

J Appl Genet 2021 May 14. Epub 2021 May 14.

Department of Genomics, Institute of Plant Genetics of the Polish Academy of Sciences, Strzeszyńska 34, 60-479, Poznań, Poland.

Triticale (× Triticosecale Wittmack) is a commercial hybrid harboring wheat (Triticum sp.) and rye (Secale cereale L.) genomes. Read More

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Cervical mucus patterns and the fertile window in women without known subfertility: a pooled analysis of three cohorts.

Hum Reprod 2021 May 15. Epub 2021 May 15.

Office of Cooperative Reproductive Health, Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA.

Study Question: What is the normal range of cervical mucus patterns and number of days with high or moderate day-specific probability of pregnancy (if intercourse occurs on a specific day) based on cervical mucus secretion, in women without known subfertility, and how are these patterns related to parity and age?

Summary Answer: The mean days of peak type (estrogenic) mucus per cycle was 6.4, the mean number of potentially fertile days was 12.1; parous versus nulliparous, and younger nulliparous (<30 years) versus older nulliparous women had more days of peak type mucus, and more potentially fertile days in each cycle. Read More

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PARSIMONIOUS MECHANISTIC MODELING OF BACTERIAL RUNOFF TO INFORM FOOD SAFETY MANAGEMENT OF AGRICULTURAL WATER QUALITY.

Appl Environ Microbiol 2021 May 14. Epub 2021 May 14.

Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.

Pond irrigation water comprises a major pathway of pathogenic bacteria to fresh produce. Current regulatory methods have been shown to be ineffective assessing this risk when variability of bacterial concentrations is large. This paper proposes using mechanistic modeling of bacterial transport as a way to identify improved strategies for mitigating this risk pathway. Read More

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Sleep assessment in cystic fibrosis patients using a minimal-impact biomotion system.

Sleep Med 2021 Apr 22;83:21-25. Epub 2021 Apr 22.

Department of Pneumology, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Tüschener Weg 40, 45239, Essen, Germany. Electronic address:

Purpose: In our study we aimed to analyze sleep variability and activity in patients with cystic fibrosis (CF) during their hospital stay.

Methods: Forty-three CF patients were recruited and have been divided into two subgroups: exacerbated (n = 18) and non-exacerbated (n = 25). During the course of their hospital stay we used VitaLog, a minimal-impact biomotion device, in order to determine total sleep time (TST), time in bed (TIB), sleep efficiency (SE) and intra patient standard deviation (IPSD) of TST. Read More

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Prospective and retrospective timing in mild cognitive impairment and Alzheimer's disease patients: A systematic review and meta-analysis.

Behav Brain Res 2021 May 11:113354. Epub 2021 May 11.

Université Paul Valéry Montpellier 3, EPSYLON EA 4556, F34000, Montpellier, France.

Performance on timing tasks changes with age. Whether these changes reflect a real "clock" problem due to aging or a secondary effect of the reduced cognitive resources of older adults still remains an unsettled question. Research on processing of time in aged populations marked by severe mnemonic and/or attentional deficits, such as patients with Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI), may help elucidate the role of cognitive resources in age-related temporal distortions. Read More

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Occupational exposure risk during spraying of biocidal paint containing silver nanoparticles.

J Occup Environ Hyg 2021 May 14:1-15. Epub 2021 May 14.

CPWR - The Center for Construction Research and Training, Silver Spring, Maryland.

The study assessed potential to exceed occupational exposure limits while spraying paint with and without a silver nanoparticle biocidal additive. A tradesperson performed the tasks in a sealed chamber with filtered air supply. Integrated air sampling entailed transmission electron microscopy with energy dispersive X-ray analysis, direct-reading of particle number concentrations, and determination of silver mass concentration by NIOSH Method 7300. Read More

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Exploring Plant Performance, Fruit Physicochemical Characteristics, Volatile Profiles, and Sensory Properties of Day-Neutral and Short-Day Strawberry Cultivars Grown in Texas.

J Agric Food Chem 2021 May 14. Epub 2021 May 14.

Department of Nutrition and Food Sciences, Texas Woman's University, 304 Administration Drive, Denton, Texas 76204, United States.

To assist increasing annual acreage of Texas-grown (U.S.A. Read More

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Development and Validation of a Large Synthetic Cohort for the Study of Cardiovascular Health across the Lifespan.

Am J Epidemiol 2021 May 12. Epub 2021 May 12.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine.

We developed and validated a synthetic cohort approach to examine lifespan cardiovascular risk factors (CRFs) and events, including cardiovascular disease (CVD) and death from ages 20-90 years. This study included 40,875 participants from 7 large, population-based longitudinal epidemiology studies (1948-2016). We multiply imputed the participant's lifespan CRFs and events using the available records based on a joint multi-level imputation model. Read More

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Genetic assessment of BoLA-DRB3 polymorphisms by comparing Bangladesh, Ethiopian, and Korean cattle.

J Anim Sci Technol 2021 Mar 31;63(2):248-261. Epub 2021 Mar 31.

Ethiopian Biotechnology Institute, Addis Ababa 5954, Ethiopia.

Attributable to their major function in pathogen recognition, the use of bovine leukocyte antigens (BoLA) as disease markers in immunological traits in cattle is well established. However, limited report exists on polymorphism of the BoLA gene in zebu cattle breeds by high resolution typing methods. Thus, we used a polymerase chain reaction sequence-based typing (PCR-SBT) method to sequence exon 2 of the BoLA class II DRB3 gene from 100 animals (Boran, n = 13; Sheko, n = 20; Fogera, n = 16; Horro, n = 19), Hanwoo cattle (n = 18) and Bangladesh Red Chittagong zebu (n = 14). Read More

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Erythrocyte transfusion restored heart rate variability in children with thalassemia major.

Transfus Apher Sci 2021 May 10:103156. Epub 2021 May 10.

Department of Pediatric Hematology and Oncology, Inonu University, Faculty of Medicine, Malatya, Turkey.

Thalassemia major (TM) is a severe transfusion-dependent anemia. Regular erytrocyte transfusion is required for the treatment of thalassemia patients. However, repeated transfusion may result in impairements in heart function. Read More

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Printed artificial sweat as replacement for natural fingermarks: Qualitative and quantitative approach considering an amino acid reagent.

Sci Justice 2021 May 3;61(3):249-259. Epub 2021 Feb 3.

École des Sciences Criminelles (School of Criminal Justice), Faculté de Droit, des Sciences Criminelles et d'Administration Publique, University of Lausanne, Quartier Sorge, Building Batochime, CH-1015 Lausanne, Switzerland. Electronic address:

The study presented in this paper aims at assessing how printed fingermarks can be used to generate realistic latent marks bearing varying quantities of materials to be detected. Considering dilution series of artificial sweat (eccrine secretion) and 1,2-indanedione/zinc as amino acid reagent, we assessed how printed marks behave in comparison to natural fingermarks provided by a set of 30 donors. The results were assessed in terms of relative intensity (contrast, luminescence) and expert grading (ridge details, overall quality). Read More

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Gender Disparity in Surgical Society Leadership and Annual Meeting Programs.

J Surg Res 2021 May 10;266:69-76. Epub 2021 May 10.

Division of Vascular Surgery, Stanford University School of Medicine, Stanford, California; Stanford-Surgery Policy Improvement Research & Education Center, Department of Surgery, Stanford University School of Medicine, Stanford, California; Vascular Surgery Section, Department of Surgery, Palo Alto Veterans Affairs Medical Center, Palo Alto, California. Electronic address:

Introduction: Prior work suggests women surgical role models attract more female medical students into surgical training. We investigate recent trends of women in surgical society leadership and national conference moderator and plenary speaker roles.

Methods: Gender distribution was surveyed at 15 major surgical societies and 14 conferences from 2014 to 2018 using publicly reported data. Read More

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Variability in real-world emissions and fuel consumption by diesel construction vehicles and policy implications.

Sci Total Environ 2021 Apr 22;786:147256. Epub 2021 Apr 22.

Research Center for Eco-Environmental Engineering, Dongguan University of Technology, Dongguan 523830, China. Electronic address:

Strategically reducing the emission of non-road mobile source especially diesel construction vehicle (DCV) has a large potential in improving air quality and has attracted much scientific and public attention in recent years around the world. In this study, we explored real-world fuel consumption rate and gaseous emissions factors for multiple pollutants of three typical DCVs in China. The sampling campaign considered the operation mode, cumulative operation hour, emission standard stage and engine power. Read More

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A new typology of human hair medullas based on lipid composition analysis by synchrotron FTIR microspectroscopy.

Analyst 2021 May 13. Epub 2021 May 13.

SMIS beamline, SOLEIL Synchrotron, BP48, l'Orme des Merisiers, 91192 Gif-sur-Yvette CEDEX, France.

Human hair is an organ that connects fundamental and applied research with everyday life through the cosmetic industry. Yet, the accurate compositional description of the human hair medulla is lacking due to their small size and difficulty with microextraction. Medullas are thus generally classified based on morphology. Read More

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High-throughput genotype-based population structure analysis of selected buffalo breeds.

Transl Anim Sci 2021 Apr 7;5(2):txab033. Epub 2021 May 7.

Department of Animal Biotechnology, College of Veterinary Science and Animal Husbandry, Anand Agriculture University, Anand 388001, India.

India is considered as the home tract of some of the best buffalo breeds. However, the genetic structure of the Indian river buffalo is poorly understood. Hence, there is a need to characterize the populations and understand the genetic structure of various buffalo breeds for selection and to design breeding strategies. Read More

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Protein Conjugated with Glucose via Maillard Reaction: Antioxidant and Techno-Functional Properties.

Int J Food Sci 2021 23;2021:5572554. Epub 2021 Apr 23.

Department of Food Science and Technology, Cape Peninsula University of Technology, Bellville 7535, South Africa.

The food industry is considering novel sources of proteins with enhanced functionalities to meet the increasing demand and population growth. Edible insect proteins have emerged as an alternative that is environmentally friendly and economically viable and thus could make a significant contribution to global food security. This study was aimed to establish the effect of conjugation via the Maillard reaction on the antioxidant and techno-functional properties of black soldier fly larvae protein concentrate. Read More

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Monitoring Individual Sleep and Nocturnal Heart Rate Variability Indices: The Impact of Training and Match Schedule and Load in High-Level Female Soccer Players.

Front Physiol 2021 26;12:678462. Epub 2021 Apr 26.

Portugal Football School, Portuguese Football Federation (FPF), Oeiras, Portugal.

Purpose: To describe individual sleep habits and nocturnal heart rate variability (HRV) responses, and to explore intra-individual associations of workload with sleep and nocturnal HRV indices in high-level female soccer players throughout a 2-week competitive period.

Materials And Methods: The study followed a descriptive, observational design. Thirty-four high-level female soccer players (aged 20. Read More

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Danshen () on the Global Market: What Are the Implications for Products' Quality?

Front Pharmacol 2021 26;12:621169. Epub 2021 Apr 26.

Pharmacognosy and Phytotherapy, UCL School of Pharmacy, London, United Kingdom.

Danshen (Radix et rhizoma ; Bunge, Lamiaceae) is commonly used in Asia, including China, Japan, and Korea with markets in America and Europe growing substantially. It is included in multiple pharmacopeias and salvianolic acid B and tanshinone IIA are used as quality markers. However, on the markets, substitutes and different processing methods often are a concern. Read More

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Dynamic functional connectivity and its anatomical substrate reveal treatment outcome in first-episode drug-naïve schizophrenia.

Transl Psychiatry 2021 May 12;11(1):282. Epub 2021 May 12.

Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Zhejiang, China.

Convergent evidence has suggested a significant effect of antipsychotic exposure on brain structure and function in patients with schizophrenia, yet the characteristics of favorable treatment outcome remains largely unknown. In this work, we aimed to examine how large-scale brain networks are modulated by antipsychotic treatment, and whether the longitudinal changes could track the improvements of psychopathologic scores. Thirty-four patients with first-episode drug-naïve schizophrenia and 28 matched healthy controls were recruited at baseline from Shanghai Mental Health Center. Read More

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Microbiome Analysis Reveals Diversity and Function of Associated with the Eastern Oyster, .

mSphere 2021 May 12;6(3). Epub 2021 May 12.

Department of Cell and Molecular Biology, University of Rhode Island, Kingston, Rhode Island, USA

Marine invertebrate microbiomes play important roles in diverse host and ecological processes. However, a mechanistic understanding of host-microbe interactions is currently available for a small number of model organisms. Here, an integrated taxonomic and functional analysis of the microbiome of the eastern oyster, , was performed using 16S rRNA gene-based amplicon profiling, shotgun metagenomics, and genome-scale metabolic reconstruction. Read More

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Sensitivity of a widespread groundwater copepod to different contaminants.

Chemosphere 2021 Jul 12;274:129911. Epub 2021 Feb 12.

Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark; Centre for Ecology, Evolution and Environmental Changes (cE3c), and Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal. Electronic address:

Groundwater is an indispensable resource for humankind and sustainable biomes functioning. Anthropogenic disturbance threatens groundwater ecosystems globally, but to which extent groundwater organisms respond to stressors remains poorly understood. Groundwater animals are rare, with small populations, difficult to find and to breed in the lab, which poses a main challenge to the assessment of their responses to pollutants. Read More

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Determination of "Fitness-for-Purpose" of Quantitative Structure-Activity Relationship (QSAR) Models to Predict (Eco-)Toxicological Endpoints for Regulatory Use.

Regul Toxicol Pharmacol 2021 May 9:104956. Epub 2021 May 9.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK. Electronic address:

In silico models are used to predict toxicity and molecular properties in chemical safety assessment, gaining widespread regulatory use under a number of legislations globally. This study has rationalised previously published criteria to evaluate quantitative structure-activity relationships (QSARs) in terms of their uncertainty, variability and potential areas of bias, into ten assessment components, or higher level groupings. The components have been mapped onto specific regulatory uses (i. Read More

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Auditory evoked potentials: Differences by sex, race, and menstrual cycle and correlations with common psychoacoustical tasks.

PLoS One 2021 12;16(5):e0251363. Epub 2021 May 12.

Department of Speech, Language, and Hearing Sciences, University of Texas, Austin, Texas, United States of America.

Auditory brainstem responses (ABRs) and auditory middle-latency responses (AMLRs) to a click stimulus were measured in about 100 subjects. Of interest were the sex differences in those auditory evoked potentials (AEPs), the correlations between the various AEP measures, and the correlations between the AEP measures and measures of otoacoustic emissions (OAEs) and behavioral performance also measured on the same subjects. Also of interest was how the menstrual cycle affected the various AEP measures. Read More

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Modeling the influence of 0.03%, 0.05% and 0.08% blood alcohol concentrations on lane positioning and steering control of Indian drivers.

Traffic Inj Prev 2021 May 12:1-11. Epub 2021 May 12.

Transportation Systems Engineering, Department of Civil Engineering, Indian Institute of Technology (IIT) Bombay, Mumbai, Maharashtra, India.

Objective: Alcohol-impairment of drivers has significant influence on road traffic safety; however, no experimental research has been conducted on the lateral driving control of Indian drivers. Therefore, the present study investigates the effects of different Blood Alcohol Concentration (BAC) levels (0%, 0.03%, 0. Read More

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Emergence of complex dynamics of choice due to repeated exposures to extinction learning.

Anim Cogn 2021 May 12. Epub 2021 May 12.

Institute for Neural Computation, Ruhr-Universität Bochum, Universitätstr. 150, 44801, Bochum, Germany.

Extinction learning, the process of ceasing an acquired behavior in response to altered reinforcement contingencies, is not only essential for survival in a changing environment, but also plays a fundamental role in the treatment of pathological behaviors. During therapy and other forms of training involving extinction, subjects are typically exposed to several sessions with a similar structure. The effects of this repeated exposure are not well understood. Read More

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A multi-omics approach for understanding the effects of moderate wine consumption on human intestinal health.

Food Funct 2021 May;12(9):4152-4164

Institute of Food Science Research (CIAL), CSIC-UAM, C/Nicolás Cabrera 9, 28049-Madrid, Spain.

The human gut is a highly diverse microbial ecosystem. Although showing a well-defined core of dominant taxa, an interindividual variability exists in microbiome arrangement patterns, and the presence and proportion of specific species, determining individual metabolic features-metabotypes-which govern the health effects of dietary interventions (i.e. Read More

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