23,219 results match your criteria valvular heart


A Network Meta-Analysis Comparing Osteoporotic Fracture among Different Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Atrial Fibrillation.

J Bone Metab 2021 May 31;28(2):139-150. Epub 2021 May 31.

Department of Cardiology, Sri Jayadeva Institute of Cardiac Sciences and Research, Bengaluru, India.

Background: There are limited studies comparing the risk of osteoporosis and fractures between different direct oral anticoagulants (DOACs) and vitamin K antagonists (VKA) in non-valvular atrial fibrillation (AF). Using a network meta-analysis (NMA), we compared osteoporotic fractures among 5 different treatment arms, viz. dabigatran, rivaroxaban, apixaban, edoxaban, and VKA. Read More

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Carcinoid heart disease of gonadal primary presenting with hypoxia: a case report.

Eur Heart J Case Rep 2021 May 14;5(5):ytaa536. Epub 2021 May 14.

Department of Cardiology, St George Hospital, Gray Street, Kogarah 2217, NSW, Australia.

Background: Carcinoid heart disease is a potential sequela of metastatic neuroendocrine tumour that has characteristic valve appearances. Patients can present with symptoms of carcinoid syndrome or be relatively asymptomatic until symptoms of progressive heart failure manifest.

Case Summary: We present a case of a 54-year-old male who was admitted to the hospital for investigation of hypoxia. Read More

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Molecular and Mechanical Mechanisms of Calcification Pathology Induced by Bicuspid Aortic Valve Abnormalities.

Front Cardiovasc Med 2021 26;8:677977. Epub 2021 May 26.

Section of Pediatric Cardiology, The Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, United States.

Bicuspid aortic valve (BAV) is a congenital defect affecting 1-2% of the general population that is distinguished from the normal tricuspid aortic valve (TAV) by the existence of two, rather than three, functional leaflets (or cusps). BAV presents in different morphologic phenotypes based on the configuration of cusp fusion. The most common phenotypes are Type 1 (containing one raphe), where fusion between right coronary and left coronary cusps (BAV R/L) is the most common configuration followed by fusion between right coronary and non-coronary cusps (BAV R/NC). Read More

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Cardiac hydatid cyst in the right ventricle - A rare case report of echinococcosis presentation.

Ann Med Surg (Lond) 2021 Jun 25;66:102427. Epub 2021 May 25.

Department of Cardiovascular Surgery, Ibn Rochd University Hospital, Casablanca, Morocco.

Introduction: The hydatid cyst (HC) of the right ventricle (RV) is an extremely uncommon and a serious location that can cause sudden death following pulmonary embolism, obstruction of the valvular orifice or anaphylactic shock.

Case Presentation: We report a case of a 14 years-old girl with a HC of the RV. Surgical excision of the HC under Cardiopulmonary bypass (CPB) was successful in managing this rare case. Read More

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SLE strikes the heart! A rare presentation of SLE myocarditis presenting as cardiogenic shock.

BMC Cardiovasc Disord 2021 Jun 13;21(1):294. Epub 2021 Jun 13.

Division of Rheumatology, Department of Internal Medicine, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134, USA.

Background: Although systemic lupus erythematosus (SLE) can affect the cardiovascular system in many ways with diverse presentations, a severe cardiogenic shock secondary to SLE myocarditis is infrequently described in the medical literature. Variable presenting features of SLE myocarditis can also make the diagnosis challenging. This case report will allow learners to consider SLE myocarditis in the differential and appreciate the diagnostic uncertainty. Read More

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Emergent valve replacement after circular mapping catheter entrapment in mitral valve apparatus.

Interact Cardiovasc Thorac Surg 2021 Jun 12. Epub 2021 Jun 12.

Department of Advanced Cardiovascular Therapies and Transplantation, Center for Advanced Heart Failure, University of Texas Health Science Center-Houston, Houston, TX, USA.

We present the case of a 47-year-old male patient with a history of symptomatic paroxysmal atrial fibrillation who failed guideline-directed medical treatment and cardioversion. Electrical mapping was attempted and complicated with catheter entrapping in the mitral valve (MV) apparatus, and multiple attempts for retrieval were unsuccessful and caused severe valvular dysfunction. Emergent valve replacement was required secondary to the extensive disruption of the valvular apparatus and posterior annulus. Read More

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Left atrial strain by speckle tracking predicts atrial fibrosis in patients undergoing heart transplantation.

Eur Heart J Cardiovasc Imaging 2021 Jun 12. Epub 2021 Jun 12.

Department of Public Health and Clinical Medicine, Umeå University and Heart Centre, Umeå, Sweden.

Aims: In patients with heart failure (HF), chronically raised left ventricular (LV) filling pressures lead to progressive left atrial (LA) dysfunction and fibrosis. We aimed to assess the correlation of LA reservoir strain (peak atrial longitudinal strain, PALS) by speckle tracking echocardiography (STE) and LA fibrosis assessed by myocardial biopsy in patients undergoing heart transplantation (HTx).

Methods And Results: Forty-eight patients with advanced HF [mean age 51. Read More

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Statin therapy for patients with aortic stenosis who underwent transcatheter aortic valve implantation: a report from a Japanese multicentre registry.

BMJ Open 2021 06 11;11(6):e044319. Epub 2021 Jun 11.

Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Japan.

Objective: Data on statin for patients with aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI) are limited. The present study aimed to evaluate the impact of statin on midterm mortality of TAVI patients.

Design: Observational study. Read More

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Low Relative Valve Load is Associated With Paradoxical Low-Flow Aortic Stenosis Despite Preserved Left Ventricular Ejection Fraction and Adverse Clinical Outcomes.

Heart Lung Circ 2021 Jun 8. Epub 2021 Jun 8.

Department of Cardiology, National University Heart Centre Singapore, National University Health System, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Background: Paradoxical low-flow (LF) severe aortic stenosis (AS) despite preserved left ventricular (LV) ejection fraction (LVEF) has been shown to be distinct from normal-flow (NF) AS, with a poorer prognosis. Relative valve load (RVL) is a novel echocardiographic haemodynamic index based on the ratio of transaortic mean pressure gradient to the global valvulo-arterial impedance (Zva) in order to estimate the contribution of the valvular afterload to the global LV load. We aimed to determine the usefulness of RVL in LF AS versus NF AS. Read More

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MAUDE Database Analysis of Post-Approval Outcomes following Left Atrial Appendage Closure with the Watchman Device.

Am J Cardiol 2021 Jun 8. Epub 2021 Jun 8.

Cardiac Arrhythmia Service, MGH Heart Center, Massachusetts General Hospital Heart, Boston, Massachusetts. Electronic address:

Left atrial appendage closure (LAAC) is an important strategy to reduce stroke risk in patients with non-valvular atrial fibrillation (AF) who are at high risk of bleeding on long-term anticoagulation. Real-world assessments of the safety of the Watchman LAAC device remain limited. The objective of this study was to determine the frequency and timing of adverse events associated with Watchman LAAC device implants performed after FDA approval. Read More

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Left Ventricular Recruitment in Patients With Hypoplastic Left Heart Syndrome.

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:30-36

Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Hypoplastic left heart complex with "borderline left ventricle" and intact ventricular septum is a clinical conundrum for the congenital heart surgeon. The choice between neonatal biventricular repair and single ventricle palliation can be challenging, and the current tools to aid in the decision-making process fail to account for the morbidity associated with intermediate and late diastolic dysfunction. Staged ventricular recruitment, consisting of valvular repair techniques, resection of endocardial fibroelastosis, atrial septal restriction, and augmentation of pulmonary blood flow, has been shown to improve left ventricular size and function culminating in eventual biventricular circulation. Read More

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January 2021

Simultaneous transcatheter treatment of ascending aortic aneurysm with aortic and mitral regurgitation: an in vitro study.

Interact Cardiovasc Thorac Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China.

Objectives: We sought to explore the efficacy of the endovascular repair of an ascending aortic aneurysm with aortic and mitral regurgitation by 2 novel valved stents.

Methods: We established models of ascending aortic aneurysms combined with aortic and mitral regurgitation in 10 pig hearts, then implanted self-expanding aortic fenestrated and mitral valved stents via the transapical approach. We applied a fluoroscopy-guided in vitro setting to test the approach, then analysed continuous circulating flushing at 37°C. Read More

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Real-world safety and effectiveness of rivaroxaban using Japan-specific dosage during long-term follow-up in patients with atrial fibrillation: XAPASS.

PLoS One 2021 11;16(6):e0251325. Epub 2021 Jun 11.

Medical Affairs and Pharmacovigilance, Bayer Yakuhin, Ltd., Osaka, Japan.

Background: The Xarelto Post-Authorization Safety and Effectiveness Study in Japanese Patients with Atrial Fibrillation (XAPASS) was designed to investigate safety and effectiveness during long-term follow-up of rivaroxaban treatment, using reduced doses compared with other global regions, in Japanese patients with non-valvular atrial fibrillation in real-world clinical practice.

Methods: In this prospective, open-label, single-arm, observational study, 11,308 patients with non-valvular atrial fibrillation newly prescribed rivaroxaban (15/10 mg once daily) at 1416 sites across Japan were enrolled and followed for a mean of 2.5 years. Read More

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The relationship between plasma vitamin D level and heart valves calcification in acute coronary syndrome and non acute coronary syndrome patients.

Cardiovasc Endocrinol Metab 2021 Jun 21;10(2):113-119. Epub 2020 Sep 21.

Department of Cardiology, Barzilai University Medical Center, Ashkelon and The Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel.

Background: There is conflicting data regarding the association between low levels of plasma vitamin D and ischemic heart disease. We aimed to investigate the relationship between plasma vitamin D levels and heart valve calcification in hospitalized patients with ischemic heart disease versus non-ischemic heart disease controls.

Methods: A prospective case-control study comprising two age and gender-matched groups. Read More

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Concept of myocardial fatigue in reversible severe left ventricular systolic dysfunction from afterload mismatch: a case series.

Eur Heart J Case Rep 2021 Mar 7;5(3):ytab089. Epub 2021 Mar 7.

Department of Cardiology, University Hospitals of Coventry & Warwickshire NHS Trust, CV2 2DX, UK.

Background : There is already extensive literature on the natural history of hypertensive heart disease (HHD) and aortic stenosis (AS). Once these patients develop severe left ventricular systolic dysfunction (LVSD) despite guideline-directed therapy for heart failure (HF), it is often thought to be end-stage from irreversible adverse remodelling. Our case series challenges this traditional paradigm. Read More

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Cardiac disease in the Spix Macaw (Cyanopsitta spixii): two cases.

Aust Vet J 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87 - Butantã, São Paulo, SP, 05508-270, Brazil.

Cardiovascular disease in avian species, other than poultry, is being increasingly reported. In psittacine birds, atherosclerosis and congestive heart failure are the leading cardiovascular diseases, often resulting in multiorgan dysfunction and demise. The Spix's macaw (Cyanopsitta spixii) is arguably the most endangered psittacine species worldwide. Read More

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Cardiac Involvement in Facioscapulohumeral Muscular Dystrophy (FSHD).

Front Neurol 2021 24;12:668180. Epub 2021 May 24.

Department of Neurology, Mayo Clinic, Rochester, MN, United States.

Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common muscular dystrophies and predominantly affects facial and shoulder girdle muscles. Previous case reports and cohort studies identified minor cardiac abnormalities in FSHD patients, but their nature and frequency remain incompletely characterized. We reviewed cardiac, neurological and genetic findings of 104 patients with genetically confirmed FSHD. Read More

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Effect of continuity of care on anticoagulant therapy and quality of life after heart valve replacement: a systematic review and meta-analysis.

Ann Palliat Med 2021 May;10(5):5568-5579

Department of Nursing, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Valvular heart disease (VHD) is a leading cause of heart diseases and death, and heart valve replacement (HVR) plays a fundamental role in treating valve disease and improving the function of valves. The lack of continuity of care (CC, also known as transitional care) for postoperative patients after discharge often results in a variety of complications, bringing severe pain to the patients and diminishing their quality of life.

Methods: We systematically searched for relevant randomized controlled trials (RCTs) in Cochrane databases, PubMed, Embase, CINAHL, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Chongqing VIP, and Wanfang Data. Read More

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Indonesian registry on atrial fibrillation (OneAF).

Medicine (Baltimore) 2021 May;100(19):e25725

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

Background: Data on the optimal therapeutic international normalized ratio (INR) for non-valvular and valvular atrial fibrillation (AF) in Indonesia is currently unavailable. Therefore, we designed the Indonesian Registry on Atrial Fibrillation (OneAF) registry in order to seek a safe and beneficial range of INR in Indonesian patients with non-valvular and valvular AF.

Methods/design: The OneAF registry is a nationwide collaboration of the Indonesian Heart Rhythm Society (InaHRS) enrolling all hospitals with cardiac electrophysiologists in Indonesia. Read More

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British Society for Echocardiography and British Cardio-Oncology Society guideline for transthoracic echocardiographic assessment of adult cancer patients receiving anthracyclines and/or trastuzumab.

Echo Res Pract 2021 03 31;8(1):G1-G18. Epub 2021 Mar 31.

Department of Cardiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK

The subspecialty of cardio-oncology aims to reduce cardiovascular morbidity and mortality in patients with cancer or following cancer treatment. Cancer therapy can lead to a variety of cardiovascular complications, including left ventricular systolic dysfunction, pericardial disease, and valvular heart disease. Echocardiography is a key diagnostic imaging tool in the diagnosis and surveillance for many of these complications. Read More

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Unexpected acute pulmonary embolism in an old COVID-19 patient with warfarin overdose: a case report.

Eur Heart J Case Rep 2021 Jun 5;5(6):ytab206. Epub 2021 Jun 5.

Service d'hématologie biologique, Hôpital Lariboisière, 2rue Ambroise Pare ´,75010 Paris, Université de Paris, Paris, France.

Background: Severe acute respiratory syndrome coronavirus 2 disease is strongly associated with a high incidence of thrombotic events. Anticoagulation could be a cornerstone in successfully managing severe forms of coronavirus disease 2019 (COVID-19). However, optimal anticoagulant dosing in elderly patients is challenging because of high risk of both thrombosis and bleeding. Read More

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Balloon valvuloplasty in 2 juvenile alpacas with severe valvular pulmonic stenosis.

J Vet Intern Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Veterinary Medicine and Surgery, Veterinary Health Center, University of Missouri, Columbia, Missouri, USA.

Two juvenile alpacas, 1 male and 1 female, were presented for evaluation of grade V/VI bilateral basilar systolic heart murmurs. Both animals were ultimately diagnosed with severe valvular pulmonic stenosis and a small ventricular septal defect. Transvenous balloon valvuloplasty was performed in each animal using methods described in the dog. Read More

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Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis.

Sci Rep 2021 Jun 7;11(1):11975. Epub 2021 Jun 7.

Department of Health Policy, London School of Economics, London, UK.

Transcatheter aortic valve replacement (TAVR) has shown to reduce mortality compared to surgical aortic valve replacement (sAVR). However, it is unknown which procedure is associated with better post-procedural valvular function. We conducted a meta-analysis of randomized clinical trials that compared TAVR to sAVR for at least 2 years. Read More

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Incidence of valvular regurgitation and leaflet perforation by using automated titanium fasteners (CORKNOT®) in heart valve repair or replacement: less usual than reported.

J Cardiothorac Surg 2021 Jun 7;16(1):163. Epub 2021 Jun 7.

Cardiac Surgery Experimental Laboratory, Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Background: CORKNOT® facilitates a reduction in cardiopulmonary bypass (CPB) time, aortic cross clamp (ACC) time and operative time, but reported to be associated with other complications. We aim to quantify the incidence of valvular complications related to CORKNOT® and determine the feasibility of its use between different valvular surgeries.

Methods: Patients who underwent heart valve repair or replacement surgery via the use of automated titanium suture fasteners (CORKNOT®) in a tertiary care hospital were included in the study. Read More

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Totally endoscopic surgical resection for a blood cyst originated from mitral valve: a case report.

J Cardiothorac Surg 2021 Jun 7;16(1):164. Epub 2021 Jun 7.

Department of Cardiovascular Surgery, Chinese PLA General Hospital, No.28. Fuxing Road, Haidian District, Beijing, 100853, China.

Background: Intracardiac blood cysts are very rare primary cardiac tumors. Blood cysts originated from the mitral valve represent a minority of cases, and previous cases have been mainly treated with conventional surgery through median sternotomy. When the tumor involves heart valves and histopathological diagnosis remains unknown preoperatively, minimally invasive surgical resection of an intracardiac tumor can be challenging, especially through an endoscopic approach. Read More

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Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation.

Wellcome Open Res 2021 18;6:73. Epub 2021 May 18.

Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.

: Four-dimensional (4D) flow cardiovascular magnetic resonance imaging (MRI) is an emerging technique used for intra-cardiac blood flow assessment. The role of 4D flow cardiovascular MRI in the assessment of trans-valvular flow in patients with atrial fibrillation (AF) has not previously been assessed. The purpose of this study was to assess the feasibility, image quality, and internal validity of 4D flow cardiovascular MRI in the quantification of trans-valvular flow in patients with AF. Read More

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Left atrial appendage occlusion in the UK: prospective registry and data linkage to Hospital Episode Statistics.

Eur Heart J Qual Care Clin Outcomes 2021 Jun 7. Epub 2021 Jun 7.

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.

Aims: Non-valvular atrial fibrillation (AF) greatly increases the risk of ischaemic stroke. For people with contraindications to oral anticoagulation, left atrial appendage occlusion (LAAO) provides a non-pharmacological management alternative. The aim of this study was to measure the procedural safety and longer-term effectiveness of LAAO for AF in a UK setting. Read More

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Artificial Intelligence Models Reveal Sex-Specific Gene Expression in Aortic Valve Calcification.

JACC Basic Transl Sci 2021 May 14;6(5):403-412. Epub 2021 Apr 14.

Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Male and female aortic stenosis patients have distinct valvular phenotypes, increasing the complexities in the evaluation of valvular pathophysiology. In this study, we present cutting-edge artificial intelligence analyses of transcriptome-wide array data from stenotic aortic valves to highlight differences in gene expression patterns between the sexes, using both sex-differentiated transcripts and unbiased gene selections. This approach enabled the development of efficient models with high predictive ability and determining the most significant sex-dependent contributors to calcification. Read More

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