20,530 results match your criteria valve tissue


Bail-out edge-to-edge mitral repair for an acute single leaflet device attachment: a case report.

Eur Heart J Case Rep 2021 Apr 30;5(4):ytab147. Epub 2021 Apr 30.

University Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany.

Background: An acute single leaflet device attachment (SLDA) may occur during transcatheter mitral valve edge-to-edge repair (TMVr), if an inadequate grasping of the target leaflet and/or a leaflet injury are concomitant. The bail-out TMVr often fails due to the complex pathophysiology.

Case Summary: We report a case of an acute SLDA after TMVr with the PASCAL Repair System for severe mitral regurgitation (MR) with mixed aetiology, i. Read More

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Fourier transform infrared spectroscopy coupled with machine learning classification for identification of oxidative damage in freeze-dried heart valves.

Sci Rep 2021 Jun 10;11(1):12299. Epub 2021 Jun 10.

Biostabilization Laboratory, Lower Saxony Centre for Biomedical Engineering, Implant Research and Development, University of Veterinary Medicine Hannover, Stadtfelddamm 34, 30625, Hannover, Germany.

Freeze-drying can be used to ensure off-the-shelf availability of decellularized heart valves for cardiovascular surgery. In this study, decellularized porcine aortic heart valves were analyzed by nitroblue tetrazolium (NBT) staining and Fourier transform infrared spectroscopy (FTIR) to identify oxidative damage during freeze-drying and subsequent storage as well as after treatment with HO and FeCl. NBT staining revealed that sucrose at a concentration of at least 40% (w/v) is needed to prevent oxidative damage during freeze-drying. Read More

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Repeated transcatheter aortic valve implantation for the treatment of a degenerated transcatheter aortic valve implantation valve (valve-in-valve technique): a case report.

Eur Heart J Case Rep 2020 Dec 23;4(6):1-6. Epub 2020 Oct 23.

Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou av, 176 74 Athens, Greece.

Background: Valve-in-valve transcatheter aortic valve implantation (TAVI) has emerged as a competent alternative for the treatment of degenerated bioprosthetic valves after surgical aortic valve replacement, or during TAVI procedure as a bailout option. Herein, we report a rare case of a self-expandable Medtronic Evolut R valve into a failing Medtronic CoreValve, with the use of modern pre-TAVI imaging screening, suggesting the proper procedural design steps for so complicated implantations.

Case Summary: A frail 78-year-old woman with a degenerated Medtronic Core Valve 26 mm bioprosthesis, implanted in 2011 due to severe aortic stenosis, was referred to our hospital due to worsening dyspnoea New York Heart Association III. Read More

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December 2020

Warfarin Anticoagulation and Fetal Central Nervous System Abnormalities: a Case Report.

Clin Lab 2021 Jun;67(6)

Background: Anticoagulation of pregnant woman with mechanical prosthetic heart valves is associated with significant maternal and fetal risks.

Methods: We describe a case of dorsal midline dysplasia in a fetus at 11 weeks' gestation. The mother was receiving warfarin therapy at a dose of 7. Read More

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Carvedilol improves left ventricular diastolic dysfunction in patients with transfusion-dependent thalassemia.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):152-158. Epub 2021 May 3.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Iron overload cardiomyopathy is the most common cause of death in patients with transfusion-dependent thalassemia.

Aim: The aim of this study was to determine the efficacy of carvedilol treatment in patients with transfusion-dependent thalassemia who had left ventricular diastolic dysfunction.

Methods: Eighteen patients with transfusion-dependent thalassemia who had left ventricular diastolic dysfunction were enrolled. Read More

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Efficacy of Anti-Staphylococcal Lysin, LSVT-1701, in Combination with Daptomycin in Experimental Left-Sided Infective Endocarditis Due to Methicillin-Resistant (MRSA).

Antimicrob Agents Chemother 2021 Jun 7:AAC0050821. Epub 2021 Jun 7.

Department of Medicine, Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.

We utilized the rabbit model of aortic valve infective endocarditis to examine the combined efficacy of the lysin, LSVT-1701, plus daptomycin. The combination of LSVT-1701 plus daptomycin was highly effective at reducing target tissue MRSA counts. When given for four daily doses, both lysin dose-regimens in combination with daptomycin sterilized all target tissues. Read More

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Investigation into early stage fatigue-damage accumulation in glutaraldehyde-fixed bovine pericardium using a novel equibiaxial bulge inflation system.

J Mech Behav Biomed Mater 2021 May 27;121:104588. Epub 2021 May 27.

Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Department of Mechanical, Manufacturing and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland. Electronic address:

A primary cause of bioprosthetic heart valve failure is premature degeneration of the pericardial leaflets, owing specifically to mechanical fatigue. There remains a paucity of experimental data and understanding of the fatigue-damage behaviour of this collagenous tissue under complex loading regimes. To meet this knowledge gap, a novel pressure inflation system was designed and built, to cyclically load circular samples of glutaraldehyde fixed bovine pericardium, under equibiaxial bulge conditions. Read More

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Replacement of mitochondrion-rich cells during regeneration of the gills and opercular epithelium in zebrafish (Danio rerio).

Acta Histochem 2021 Jun 3;123(5):151738. Epub 2021 Jun 3.

Department of Biology, University of Ottawa, 30 Marie Curie Pvt., Ottawa, ON, K1N 6N5, Canada. Electronic address:

Transport epithelia maintain the volume, ion concentration and acid-base balance of blood and extracellular fluids. In teleost fish, mitochondrion-rich cells (MRCs) are specialized ionocytes that perform this role. These cells are found in epithelia of the gills and buccal surface of the operculum (the bony structure covering the gills). Read More

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Importance of epicardial adipose tissue localization using cardiac magnetic resonance imaging in patients with heart failure with mid-range and preserved ejection fraction.

Clin Cardiol 2021 Jun 4. Epub 2021 Jun 4.

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Background: Epicardial adipose tissue (EAT) has been implicated in the pathophysiology of heart failure (HF) with left ventricular ejection fraction (LVEF) >40%, but whether this is due to a regional or global effect of EAT remains unclear.

Hypothesis: Regional EAT is associated with alterations in local cardiac structure and function.

Methods: Patients with HF and LVEF >40% were studied. Read More

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Strategies to Improve Survival from Surgery for Heart Valve Implantation in Sheep.

Comp Med 2021 Jun 3. Epub 2021 Jun 3.

Sheep are a commonly used and validated model for cardiovascular research and, more specifically, for heart valve research.Implanting a heart valve on the arrested heart in sheep is complex and is often complicated by difficulties in restarting the heart, causing significant on-table mortality. Therefore, optimal cardioprotective management during heart valve implantation in sheep is essential. Read More

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Models of immunogenicity in preclinical assessment of tissue engineered heart valves.

Acta Biomater 2021 May 31. Epub 2021 May 31.

Department of Medicine, University of Auckland, Grafton, Auckland 1024, New Zealand.

Tissue engineered heart valves may one day offer an exciting alternative to traditional valve prostheses. Methods of construction vary, from decellularised animal tissue to synthetic hydrogels, but the goal is the same: the creation of a 'living valve' populated with autologous cells that may persist indefinitely upon implantation. Previous failed attempts in humans have highlighted the difficulty in predicting how a novel heart valve will perform in vivo. Read More

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When form meets function: the cells and signals that shape the lymphatic vasculature during development.

Development 2021 Jun 3;148(11). Epub 2021 Jun 3.

Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5001, Australia.

The lymphatic vasculature is an integral component of the cardiovascular system. It is essential to maintain tissue fluid homeostasis, direct immune cell trafficking and absorb dietary lipids from the digestive tract. Major advances in our understanding of the genetic and cellular events important for constructing the lymphatic vasculature during development have recently been made. Read More

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Echocardiographic Classification of Perimembranous Ventricular Septal Defect Guides Selection of the Occluder Design for Their Transcatheter Device Closure.

J Cardiovasc Imaging 2021 Mar 30. Epub 2021 Mar 30.

Department of Pediatric Cardiology, Institute of Cardio Vascular Diseases, Madras Medical Mission, Chennai, India.

Background: Perimembranous ventricular septal defects (VSDs) has proximate relation to the aortic and tricuspid valves as well as the conduction tissues. Transcatheter closure utilizes various off-label device designs.

Methods: Perimembranous VSD without aortic margin were classified as group A, with thick aortic margin as group B, with membranous septal aneurysm as group C and defects restricted by tricuspid valve attachments as group D. Read More

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[Treatment of Infective Endocarditis with Mitral Valve Plasty Using only Autologous Leaflets by "Washing and Rubbing Method":Report of a Case].

Kyobu Geka 2021 Jun;74(6):439-442

Department of Cardiovascular Surgery, Fuji City Central Hospital, Fuji, Japan.

We performed mitral valve plasty( MVP) with vegetation debridement by rubbing with a small gauze ball and by rinsing with saline( named "washing and rubbing method") for mitral regurgitation( MR) due to active infective endocarditis (IE). A 28-year-old male was referred to our hospital with a two-week history of fever. He had renal impairment and anemia, and echocardiography showed severe MR and two vegetations measuring more than 1 cm on the anterior and posterior mitral leaflets( A2-A3 and P2-P3). Read More

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Impact of Morbid Obesity and Obesity Phenotype on Outcomes After Transcatheter Aortic Valve Replacement.

J Am Heart Assoc 2021 Jun 31;10(12):e019051. Epub 2021 May 31.

Quebec Heart and Lung InstituteLaval University Quebec City Quebec Canada.

Background There is a paucity of outcome data on patients who are morbidly obese (MO) undergoing transcatheter aortic valve replacement. We aimed to determine their periprocedural and midterm outcomes and investigate the impact of obesity phenotype. Methods and Results Consecutive patients who are MO (body mass index, ≥40 kg/m, or ≥35 kg/m with obesity-related comorbidities; n=910) with severe aortic stenosis who underwent transcatheter aortic valve replacement in 18 tertiary hospitals were compared with a nonobese cohort (body mass index, 18. Read More

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Editorial: Heart Valve Tissue Engineering: Are We Ready for Clinical Translation?

Front Cardiovasc Med 2021 13;8:658719. Epub 2021 May 13.

Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.

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Case report of gastrointestinal localization of SARS-CoV-2 and open abdomen technique in an Italian emergency surgery department for gastrointestinal bleeding.

Ann Med Surg (Lond) 2021 Jun 25;66:102405. Epub 2021 May 25.

Department of Translational Medicine and for Romagna, University of Ferrara, Via Aldo Moro, 8 44124, Cona, Ferrara, Italy.

This article aims to present the case of a man affected by SARS CoV-2 and to discuss the association between this manifestation, viral infection and Open Abodmen. A 52 years old Caucasian man, affected by SARS CoV-2 infection, was admitted to the Emergency department of Arcispedale Sant'Anna of Ferrara for epigastralgia followed by syncopal episode, vomiting and diarrhea with bloody stools. The next day the patient underwent colonoscopy, which detected an ulceration proximally to the ileocecal valve without active bleeding. Read More

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Percutaneous edge-to-edge mitral valve repair: beyond the left heart.

J Am Soc Echocardiogr 2021 May 27. Epub 2021 May 27.

Cardiology Unit and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialities, Radiological Sciences and Publich Health, University of Brescia, Brescia, Italy.

Right ventricular dysfunction and tricuspid regurgitation (TR) are known to be associated with adverse outcome in patients undergoing percutaneous mitral valve repair (PMVR). While the effect of PMVR on left ventricular function is well known, data about the response of the right ventricle (RV) to PMVR, and its impact on prognosis, are limited. In this review we summarize available data regarding the prognostic role of RV function and TR in PMVR recipients and the possible effects of PMVR on the right heart. Read More

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Comprehensive Assessment of Heart Failure with Preserved Ejection Fraction Using Cardiac MRI.

Heart Fail Clin 2021 Jul;17(3):447-462

Marcus Heart Valve Center, Piedmont Heart Institute, Atlanta, GA, USA. Electronic address: https://twitter.com/ManiVannanheart.

Heart failure with preserved ejection fraction (HFpEF) burden is increasing. Its diagnostic process is challenging and imprecise due to absence of a single diagnostic marker, and the multiparametric echocardiography evaluation needed. Left ventricular (LV) ejection fraction (LVEF) is a limited marker of LV function; thus, allocating HF phenotypes based on LVEF can be misleading. Read More

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Late results of aortic valve repair for isolated severe aortic regurgitation.

J Thorac Cardiovasc Surg 2021 Apr 16. Epub 2021 Apr 16.

Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain and Division of Cardiothoracic and Vascular Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address:

Objectives: The objectives were to analyze the long-term outcomes of tricuspid aortic valve repair for isolated severe aortic regurgitation and the impact of different annuloplasty techniques.

Methods: The study cohort consists of 127 consecutive patients who received aortic valve repair for isolated severe aortic regurgitation in the tricuspid aortic valve between 1996 and 2019 in our institution. Exclusion criteria were aorta dilatation (≥45 mm), connective tissue disease, active endocarditis, type A dissection, and rheumatic disease. Read More

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Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension.

Matrix Biol 2021 May 25. Epub 2021 May 25.

The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, 1300 Morris Park Avenue Forchheimer G46B, Bronx, NY 10461, United States. Electronic address:

Tissue injury results in profound alterations in the collagen network, associated with unfolding of the collagen triple helix, proteolytic degradation and generation of fragments. In the infarcted myocardium, changes in the collagen network are critically involved in the pathogenesis of left ventricular rupture, adverse remodeling and chronic dysfunction. We hypothesized that myocardial infarction is associated with temporally and spatially restricted patterns of collagen denaturation that may reflect distinct molecular mechanisms of collagen unfolding. Read More

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Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure.

J Mol Cell Cardiol 2021 May 31;158:72-81. Epub 2021 May 31.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America. Electronic address:

Background: Both gap junctional remodeling and interstitial fibrosis have been linked to impaired electrical conduction velocity (CV) and fatal ventricular arrhythmias in nonischemic heart failure (HF). However, the arrhythmogenic role of the ventricular gap junctional Cx43 in nonischemic HF remains in debate. Here, we assessed this in a newly developed arrhythmogenic canine model of nonischemic HF. Read More

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Cecal Ligation and Puncture.

Methods Mol Biol 2021 ;2321:1-8

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria.

Cecal ligation and puncture (CLP) is referred to as the "gold standard" rodent model for abdominal sepsis. CLP creates a continuously leaking, polymicrobial infectious focus in the abdomen. The abdominal cavity is opened under general anesthesia and analgesia and the cecum is exposed, ligated underneath the ileocecal valve, and punctured with a needle. Read More

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January 2021

Considerations in the Surgical Management of Unicuspid Aortic Stenosis.

Pediatr Cardiol 2021 Jun 28;42(5):993-1001. Epub 2021 May 28.

Divisions of Cardiothoracic Surgery, University of Illinois College of Medicine at Chicago, 840 S Wood St Suite 417(MC 958), Chicago, IL, 60612, USA.

Unicuspid aortic valve (UAV) stenosis is a rare condition accounting for 5% of non-rheumatic aortic stenosis. The diagnosis can be difficult to make prior to surgical intervention and transesophageal echocardiography has been demonstrated to be more accurate in making the diagnosis compared to transthoracic echocardiography. The presence of a posteriorly located aortic orifice on the short-axis views, with one or two visible raphe anteriorly; the absence of commissures (acommissural); or the presence of a lone commissure (unicommissural) between the left and noncoronary, or the left and right cusps suggests the diagnosis. Read More

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Dissecting Calcific Aortic Valve Disease-The Role, Etiology, and Drivers of Valvular Fibrosis.

Front Cardiovasc Med 2021 10;8:660797. Epub 2021 May 10.

Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.

Calcific aortic valve disease (CAVD) is a highly prevalent and progressive disorder that ultimately causes gradual narrowing of the left ventricular outflow orifice with ensuing devastating hemodynamic effects on the heart. Calcific mineral accumulation is the hallmark pathology defining this process; however, fibrotic extracellular matrix (ECM) remodeling that leads to extensive deposition of fibrous connective tissue and distortion of the valvular microarchitecture similarly has major biomechanical and functional consequences for heart valve function. Significant advances have been made to unravel the complex mechanisms that govern these active, cell-mediated processes, yet the interplay between fibrosis and calcification and the individual contribution to progressive extracellular matrix stiffening require further clarification. Read More

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Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive heart failure secondary to myxomatous mitral valve disease.

Am J Vet Res 2021 Jun;82(6):487-493

Objective: To evaluate whether mesenchymal stem cells (MSCs) can be safely administered IV to dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD) to improve cardiac function and prolong survival time.

Animals: 10 client-owned dogs with CHF secondary to MMVD.

Procedures: Dogs with an initial episode of CHF secondary to MMVD were enrolled in a double-blind, placebo-controlled clinical trial. Read More

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"Powered Cheese Wire Technique" for Septal Fenestration in Complex Endovascular Repair for Chronic Thoracoabdominal Aortic Dissection.

J Endovasc Ther 2021 May 25:15266028211007474. Epub 2021 May 25.

Department of Vascular Medicine, German Aortic Center Hamburg, University Heart Center, Hamburg, Germany.

Purpose: Endovascular repair of chronic thoracoabdominal aortic dissection with aneurysmal degeneration presents a therapeutic challenge when one or more visceral branches arise from the false lumen without an adjacent reentry. The chronic dissection flap can be thick and resistant to flap fenestration with standard techniques.

Technique: facilitates cutting of a dissection flap using electrical current on a noninsulated through-and-through wire segment. Read More

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Clinically isolated aortitis presenting as inferior ST-elevation myocardial infarction due to an unruptured sinus of Valsalva aneurysm: a rare and forgotten cause of acute coronary syndrome in a young patient with no evidence of systemic vasculitis.

BMJ Case Rep 2021 May 24;14(5). Epub 2021 May 24.

Section of Cardiothoracic Surgery, Aga Khan University Hospital, Karachi, Pakistan.

A 21-year-old man presented with chest pain, diaphoresis and dyspnoea. Electrocardiogram (ECG) showed inferior ST-elevation myocardial infarction. Troponin I was positive. Read More

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Double valve replacement in a patient with Maroteaux - Lamy syndrome as an ultimate team challenge.

J Cardiothorac Surg 2021 May 24;16(1):141. Epub 2021 May 24.

Cardiovascular Surgery Department, Athens Medical Center, Athens, Greece.

Background: The Maroteaux-Lamy syndrome (Mucopolysaccharidosis type VI) is a rare, inherited metabolic disease that results in progressive tissue accumulation of dermatan-sulfated glycosaminoglycans and inflammatory consequences that almost always affects the heart valves. From the anesthesia point of view, managing the airway and ventilation might be a serious challenge due to specific features of the syndrome. Additionally, it is more than probable that the surgical team will perform a non-straightforward procedure. Read More

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