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Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis.

ESMO Open 2021 Jun 9;6(4):100187. Epub 2021 Jun 9.

Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan; Outpatient Treatment Center, National Cancer Center Hospital, Tokyo, Japan. Electronic address:

Background: Precision and matched cancer medicine has the potential to complement the existing biomarker approaches in cancer treatment. However, despite their promising potential, certain negative results have highlighted their limitations in molecular biology-driven treatment strategies. This study aimed to evaluate the clinical benefits of precision therapies. Read More

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Investigating the potential of Sentinel-2 configuration to predict the quality of Mediterranean permanent grasslands in open woodlands.

Sci Total Environ 2021 May 29;791:148101. Epub 2021 May 29.

Department of Forest Engineering, ETSIAM, University of Cordoba, Ctra. Madrid, Km 396, 14071 Córdoba, Spain. Electronic address:

The assessment of pasture quality in permanent grasslands is essential for their conservation and management, as it can contribute to making real-time decisions for livestock management. In this study, we assessed the potential of Sentinel-2 configuration to predict forage quality in high diverse Mediterranean permanent grasslands of open woodlands. We evaluated the performance of Partial Least Squares Regression (PLS) models to predict crude protein (CP), neutral detergent fibre (NDF), acid detergent fibre (ADF) and enzyme digestibility of organic matter (EDOM) by using three different reflectance datasets: (i) laboratory measurements of reflectance of dry and ground pasture samples re-sampled to Sentinel-2 configuration (Spec-lab) (ii) field in-situ measurements of grasslands canopy reflectance resampled to Sentinel-2 configuration (Spec-field); (iii) and Bottom Of Atmosphere Sentinel-2 imagery. Read More

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Estimation of municipal solid waste amount based on one-dimension convolutional neural network and long short-term memory with attention mechanism model: A case study of Shanghai.

Sci Total Environ 2021 Jun 9;791:148088. Epub 2021 Jun 9.

The State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, 1515 North Zhongshan Rd. (No. 2), Shanghai 200092, China. Electronic address:

Municipal solid waste (MSW) amount has direct influence on MSW management, policy-decision making, and MSW treatment methods. Machine learning has great potential for prediction, but few studies apply the approaches of deep learning to forecast the quantity of MSW. Therefore, the aim of this study is to evaluate the feasibility and practicability of employing the methods of supervised learning, including Attention, one-dimension Convolutional Neural Network (1D-CNN) and Long Short-Term Memory (LSTM) to predict the MSW Amount in Shanghai. Read More

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Trends in environmental chemical concentrations in the Canadian population: Biomonitoring data from the Canadian Health Measures Survey 2007-2017.

Environ Int 2021 Jun 9;155:106678. Epub 2021 Jun 9.

Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.

Ten years of nationally representative biomonitoring data collected between 2007 and 2017 are available from the Canadian Health Measures Survey (CHMS). These data establish baseline environmental chemical concentrations in the general population. Here we sought to evaluate temporal trends in environmental chemical exposures in the Canadian population by quantifying changes in biomarker concentrations measured in the first five two-year cycles of the CHMS. Read More

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Assessment of arsenic status and distribution in Usangu agro-ecosystem-Tanzania.

J Environ Manage 2021 Jun 9;294:113012. Epub 2021 Jun 9.

School of Geography, Earth and Environmental Science, University of Plymouth, Drake Circus, PL4 8AA, UK.

This study was conducted to assess arsenic (As) status and distribution in Usangu agroecosystem-Tanzania, including three land use. About 198 soil samples were collected in ten irrigation schemes in three land uses. Total and bioavailable As were determined by acid digestion (Aqua regia (AQ)) and Mehlich 3 method (M3) to estimate status, distribution and bioavailability. Read More

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Anti-seizure activity of African medicinal plants: the identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model.

J Ethnopharmacol 2021 Jun 9:114282. Epub 2021 Jun 9.

Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa, 0001. Electronic address:

Ethnopharmacological Relevance: Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available antiepileptic drugs (AEDs) which are also effective in only two-thirds of the patients. Accordingly, the identification of scaffolds with promising anti-seizure activity remains an important first step towards the development of new anti-epileptic therapies, with improved efficacy and reduced adverse effects. Read More

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Revealing the Mechanism of "Huai Hua San" in the Treatment of Ulcerative Colitis based on Network Pharmacology and Experimental Study.

J Ethnopharmacol 2021 Jun 9:114321. Epub 2021 Jun 9.

Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, Wuhan, 430065, China; Collaborative Innovation Center of Traditional Chinese Medicine of New Products for Geriatrics Hubei Province, Wuhan, 430065, China. Electronic address:

Ethnopharmacological Relevance: "Huai Hua San" (HHS) is one of the first hundred ancient classic prescriptions drugs, which is commonly used to treat hemorrhoids, colitis, and other symptoms of wind heat in stool. However, the potential molecular mechanism of action of this substance remains unclear.

Aims Of The Study: In this study, we explored the active compounds of HHS for the treatment of ulcerative colitis (UC), predicted the potential targets of the drug, and studied its mechanism of action through network pharmacology via in vitro and in vivo experiments. Read More

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Ultrasound-guided erector spinae plane block for open inguinal hernia repair: a randomized controlled trial.

Braz J Anesthesiol 2021 Jun 9. Epub 2021 Jun 9.

SIANEST/Hospital Florianópolis, Unidade de Anestesiologia, Florianópolis, SC, Brazil; Universidade do Sul de Santa Catarina (UNISUL), Florianópolis, SC, Brazil; TSA, Sociedade Brasileira de Anestesiologia, Brazil.

Introduction And Objectives: Inguinal hernia repair is associated with significant postoperative pain. We assessed the analgesia efficacy of unilateral Erector Spinae Plane block (ESP) performed under ultrasound guidance in patients submitted to open unilateral inguinal hernia repair, comparing ESP to spinal anesthesia administered with or without opioid.

Method: Forty-five patients with ages ranging from 27 to 83 years were randomly allocated into three groups: control group receiving spinal anesthesia (n = 14), ESP group receiving ESP block combined with spinal anesthesia (n = 16), and spinal morphine group receiving spinal anesthesia with morphine 1 mcg. Read More

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A comparison of SARS-CoV-2 nucleocapsid and spike antibody detection using three commercially available automated immunoassays.

Clin Biochem 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Health System, Lebanon, NH, United States; he Geisel School of Medicine at Dartmouth, Hanover, NH, United States.

Introduction: Commercially available serological assays for SARS-CoV-2 detect antibodies to either the nucleocapsid or spike protein. Here we compare the performance of the Beckman-Coulter SARS-CoV-2 spike IgG assay to that of the Abbott SARS-CoV-2 nucleocapsid IgG and Roche Anti-SARS-CoV-2 nucleocapsid total antibody assays. In addition, we document the trend in nucleocapsid and spike antibodies in sequential samples collected from convalescent plasma donors. Read More

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Synthesis and Evaluation of F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging.

Methods Mol Biol 2021 ;2275:49-64

Innovation Center for Molecular Probe Development, Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, South Korea.

We have previously reported that radiolabeled phosphonium cations accumulate in the mitochondria down a transmembrane potential gradient. We present an optimized procedure for synthesis of three [F]-labeled fluoroalkyl triphenylphosphonium salts ([F]FATPs) via two-step simple nucleophilic substitution reactions to develop new myocardial imaging agents for positron emission tomography (PET) . The total reaction time of [F]FATPs was within 60 min, and the overall decay-corrected radiochemical yield was approximately 15-30% (decay corrected). Read More

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January 2021

Validation and psychometric properties of the Indonesian version of the Fear of Missing Out Scale in adolescents.

Psicol Reflex Crit 2021 Jun 12;34(1):15. Epub 2021 Jun 12.

Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan.

Background: This study's main purpose was to examine the psychometric properties of FoMOs' adaptation among the Indonesian adolescents' population. The second aim was to investigate the concurrent validity of the Indonesian version to provide evidence for the validity. Also, FoMOs' difference level between demographic variance analyses was performed. Read More

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Comprehensive aptamer-based screen of 1317 proteins uncovers improved stool protein markers of colorectal cancer.

J Gastroenterol 2021 Jun 12. Epub 2021 Jun 12.

Department of Biomedical Engineering, University of Houston, Houston, USA.

Background: To screen and validate novel stool protein biomarkers of colorectal cancer (CRC).

Methods: A novel aptamer-based screen of 1317 proteins was used to uncover elevated proteins in the stool of patients with CRC, as compared to healthy controls (HCs) in a discovery cohort. Selected biomarker candidates from the discovery cohort were ELISA validated in three independent cross-sectional cohorts comprises 76 CRC patients, 15 adenoma patients, and 63 healthy controls, from two different ethnicities. Read More

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Quantitative ultrasound to monitor the vascular response to tocilizumab in giant cell arteritis.

Rheumatology (Oxford) 2021 Jun 12. Epub 2021 Jun 12.

Department of Rheumatology and Immunology, University of Bern, Inselspital, Switzerland.

Objectives: To characterize the effect of ultra-short glucocorticoids followed by Tocilizumab monotherapy on the intima-media thickness (IMT) in GCA.

Methods: 18 GCA patients received 500mg methylprednisolone intravenously on days 0-2, followed by Tocilizumab (8mg/kg) intravenously on day 3 and thereafter weekly subcutaneous Tocilizumab injections (162 mg) over 52 weeks. Ultrasound of temporal (TA), axillary (AA) and subclavian (SA) arteries was performed at baseline, on days 2-3, at week 4, 8, 12, 24 and 52. Read More

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Bioethics in Africa: A contextually enlightened analysis of three cases.

Dev World Bioeth 2021 Jun 11. Epub 2021 Jun 11.

Across sub-Saharan Africa, bioethics is an emerging field of scholarly inquiry, informed by contextual features distinct to the region. A cultural mix comprised of Euro-American influences, indigenous traditions, Christian faiths and Muslim communities, a bioethics for the sub-Saharan region must be responsive to this milieu. This paper asks, what values and methods can best promote the practice of bioethics in Africa? We set forth a strategy that leans one way or another in response to contextual features of a particular setting. Read More

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Impact of delay in cystoscopic surveillance on recurrence and progression rates in non-muscle invasive bladder cancer patients during COVID-19 pandemic.

Int J Clin Pract 2021 Jun 12:e14490. Epub 2021 Jun 12.

Department of Urology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Purpose: To evaluate the impact of delay in cystoscopic surveillance on recurrence and progression rates in non-muscle-invasive bladder cancer (NMIBC).

Materials And Methods: A total of 407 patients from four high-volume centers with NMIBC that applied for follow-up cystoscopy were included in our study prospectively. Patients' demographics and previous tumor characteristics, presence of tumor in follow-up cystoscopy, the pathology results of the latest transurethral resection of bladder tumor (if tumor was detected), and delay in cystoscopy time were recorded. Read More

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Maximum slope using ultrafast breast DCE-MRI at 1.5 Tesla: a potential tool for predicting breast lesion aggressiveness.

Eur Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Institut de Cancérologie de Lorraine, 6 avenue de Bourgogne, 54 519, Vandoeuvre-les-Nancy, France.

Objectives: We evaluated the relationship between the maximum slope (MS) based on ultrafast breast DCE-MRI sequences, and the clinical parameters and routine prognostic factors of breast cancer.

Methods: 210 lesions were retrospectively evaluated: 150 malignant (30 each of luminal A invasive carcinoma, luminal B invasive carcinoma, HER2 overexpression (HER2), triple negative (TN), invasive lobular carcinoma (ILC)), and 60 benign. For each lesion, the MS was obtained with an ultrafast sequence and semi-quantitative curves were classified into three types with a conventional DCE sequence. Read More

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Fairness analysis and compensation strategy in the Triangle of Central China driven by water-carbon-ecological footprints.

Environ Sci Pollut Res Int 2021 Jun 11. Epub 2021 Jun 11.

Key Laboratory of Water Cycle and Related Land Surface Processes, Institute of Geographic Science and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China.

This study proposes water-carbon-ecological footprints to form footprint family indicators for identifying the ecological compensation and regional development equilibrium in the Triangle of Central China (TOCC). The occupation of natural capital stock and flow consumption can be illustrated using a three-dimensional ecological footprint model, and Gini coefficient is integrated into the evaluation framework for fairness measurement from various aspects. Quantificational ecological compensation standards can be given with considering indicators associated with ecological resource conversion efficiency and willingness to pay. Read More

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Patterns and Effects of Admission Hyperglycemia and Inflammatory Response in Trauma Patients: A Prospective Clinical Study.

World J Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, Trauma Surgery, Hamad General Hospital, Doha, Qatar.

Background: The constellation of the initial hyperglycemia, proinflammatory cytokines and severity of injury among trauma patients is understudied. We aimed to evaluate the patterns and effects of on-admission hyperglycemia and inflammatory response in a level 1 trauma center. We hypothesized that higher initial readings of blood glucose and cytokines are associated with severe injuries and worse in-hospital outcomes in trauma patients. Read More

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Head-to-head comparison of (R)-[C]verapamil and [F]MC225 in non-human primates, tracers for measuring P-glycoprotein function.

Eur J Nucl Med Mol Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.

Purpose: P-glycoprotein (P-gp) function is altered in several brain disorders; thus, it is of interest to monitor the P-gp function in vivo using PET. (R)-[C]verapamil is considered the gold standard tracer to measure the P-gp function; however, it presents some drawbacks that limit its use. New P-gp tracers have been developed with improved properties, such as [F]MC225. Read More

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Distinguishing swept-source optical coherence tomography findings in active toxoplasmic retinochoroiditis.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

Objective: To define the swept-source optical coherence tomography (SS-OCT) features which distinguish ocular toxoplasmosis (OT) from other forms of retinochoroiditis.

Methods: This is a prospective diagnostic study enrolling 43 eyes of 43 patients with active toxoplasmic (TOXO) retinochoroiditis matched to 54 eyes (54 lesions) with non-TOXO retinochoroiditis evaluated by structural SS-OCT.

Results: The finding of retinal hyper-reflective round deposits, sub-lesional choroidal thickening, and sub-lesional retinal pigment epithelium elevation were more likely to be found in TOXO lesions with a positive likelihood ratio of 45. Read More

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Oncostatin-M Does Not Predict Treatment Response in Inflammatory Bowel Disease in a Pediatric Cohort.

J Pediatr Gastroenterol Nutr 2021 Jun 10. Epub 2021 Jun 10.

Divisions of Pediatric Gastroenterology Pathology Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA Division of Pediatric Gastroenterology, Inova Children's Hospital, Fairfax, VA, USA Division of Pediatric Gastroenterology, Pediatric Specialists of Virginia, Fairfax, VA, USA.

Objectives: This study aimed to determine whether mRNA expression of oncostatin-M (OSM) and its receptor (OSMR) in initial, pre-treatment intestinal biopsies is predictive of response to tumor necrosis factor antagonists (antiTNF) in a pediatric inflammatory bowel disease (IBD) cohort. Secondary outcomes correlated OSM and OSMR expression with demographic variables; IBD type, extent, phenotype, and severity; laboratory values; and endoscopic findings.

Methods: A retrospective chart review was conducted on 98 pediatric patients. Read More

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A comparison of heat acclimation by post-exercise hot water immersion and exercise in the heat.

J Sci Med Sport 2021 May 18. Epub 2021 May 18.

School of Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom.

Objectives: To compare heat acclimation adaptations after three and six days of either post-exercise hot water immersion (HWI) or exercise-heat-acclimation (EHA) in recreationally active individuals.

Design: Randomised, mixed model, repeated measures.

Methods: Post-exercise HWI involved a daily 40-min treadmill-run at 65% V̇O in temperate conditions (19 °C, 45% RH) followed by HWI (≤40 min, 40 °C water; n = 9). Read More

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Enzymatic production of 3'-sialyllactose in milk.

Enzyme Microb Technol 2021 Aug 14;148:109829. Epub 2021 May 14.

Section for Protein Chemistry and Enzyme Technology, Department of Biotechnology and Biomedicine, Building 221, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark. Electronic address:

Human milk oligosaccharides (HMOs) are lactose-based glycan molecules present in human breast milk. HMOs are essentially not present in cow's milk and hence not naturally available in infant formulas. HMOs possess several health and developmentally beneficial properties, and the sialylated HMOs are thought to play a particularly important role for infant brain development. Read More

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Relationships between motor scores and cognitive functioning in FMR1 female premutation X carriers indicate early involvement of cerebello-cerebral pathways.

Cerebellum Ataxias 2021 Jun 11;8(1):15. Epub 2021 Jun 11.

School of Psychology and Public Health, La Trobe University, Melbourne, Bundoora, Victoria, Australia.

Background: Smaller expansions of CGG trinucleotide repeats in the FMR1 X-linked gene termed 'premutation' lead to a neurodegenerative disorder: Fragile X Associated Tremor/Ataxia Syndrome (FXTAS) in nearly half of aged carrier males, and 8-16% females. Core features include intention tremor, ataxia, and cognitive decline, and white matter lesions especially in cerebellar and periventricular locations. A 'toxic' role of elevated and expanded FMR1 mRNA has been linked to the pathogenesis of this disorder. Read More

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Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia.

BMC Pediatr 2021 Jun 11;21(1):275. Epub 2021 Jun 11.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Several factors like altitude, age, sex, pregnancy, socioeconomic status, life style and race influence hematological reference interval (RIs), which are critical to support clinical decisions and to interpret laboratory data in research. Currently there are no well-established RIs for cord blood hematological parameters of newborns in Ethiopia. This study aims to generate RIs for umbilical cord blood hematological parameters of newborns from Addis Ababa, Ethiopia. Read More

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Initial in-hospital heart rate is associated with three-month functional outcomes after acute ischemic stroke.

BMC Neurol 2021 Jun 11;21(1):222. Epub 2021 Jun 11.

Department of Neurology, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Background: Increased heart rate (HR) has been associated with stroke risk and outcomes.

Material And Methods: We analyzed 1,420 patients from a hospital-based stroke registry with acute ischemic stroke (AIS). Mean initial in-hospital HR and the coefficient of variation of HR (HR-CV) were derived from the values recorded during the first 3 days of hospitalization. Read More

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Five metastasis-related mRNAs signature predicting the survival of patients with liver hepatocellular carcinoma.

BMC Cancer 2021 Jun 11;21(1):693. Epub 2021 Jun 11.

Department of Interventional Radiology, The Second Clinical College of North Sichuan Medical College, Nan Chong Central Hospital, Nan Chong, 637000, Sichuan, China.

Backgrounds: Liver hepatocellular carcinoma (HCC) is one of the most malignant tumors, of which prognosis is unsatisfactory in most cases and metastatic of HCC often results in poor prognosis. In this study, we aimed to construct a metastasis- related mRNAs prognostic model to increase the accuracy of prediction of HCC prognosis.

Methods: Three hundred seventy-four HCC samples and 50 normal samples were downloaded from The Cancer Genome Atlas (TCGA) database, involving transcriptomic and clinical data. Read More

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The Effects of Additional Local-Mixing Compartments in the DISST Model-Based Assessment of Insulin Sensitivity.

J Diabetes Sci Technol 2021 Jun 11:19322968211021602. Epub 2021 Jun 11.

Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand.

Background: The identification of insulin sensitivity in glycemic modelling can be heavily obstructed by the presence of outlying data or unmodelled effects. The effect of data indicative of local mixing is especially problematic with models assuming rapid mixing of compartments. Methods such as manual removal of data and outlier detection methods have been used to improve parameter ID in these cases, but modelling data with more compartments is another potential approach. Read More

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Improving selective targeting to cancer-associated fibroblasts by modifying liposomes with arginine based materials.

J Drug Target 2021 Jun 11:1-50. Epub 2021 Jun 11.

Department of Materials Science & Engineering, Iowa State University, Ames, Iowa 50011.

A library of arginine-like surface modifiers was tested to improve the targetability of DOPE:DOPC liposomes towards myofibroblasts in a tumor microenvironment. Liposomes were characterized using zeta potential and dynamic light scattering. Cell viability remained unchanged for all liposomes. Read More

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Copeptin combined with National Early Warning Score for predicting survival in elderly critical ill patients at emergency department.

Am J Emerg Med 2021 Jun 8;49:153-157. Epub 2021 Jun 8.

Emergency Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China. Electronic address:

Objective: Copeptin, reflecting vasopressin release, as well as the National Early Warning Score (NEWS), reflecting the severity of critical illness, might qualify for survival prediction in elderly patients with critical illness. This prospective observational study aims at assessing the predictive value of copeptin combined with NEWS on the prognosis of elderly critical ill patients at emergency department (ED).

Methods: We analyzed serum copeptin levels and the NEWS at admission to the ED in a prospective, single-center, and observational study comprising 205 elderly patients with critical illness. Read More

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