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Ratiometric fluorescence and smartphone dual-mode detection of glutathione using carbon dots coupled with Ag+-triggered oxidation of o-phenylenediamine.

Nanotechnology 2021 Jul 30. Epub 2021 Jul 30.

College of Chemistry and Materials Science, Anhui Normal University, Huajin campus of Anhui Normal University, 189 Jiuhua South Road, Yijiang District, Wuhu City, Anhui Province, Wuhu, 241002, CHINA.

Developing ratiometric fluorescence and smartphone dual-mode bioanalysis methods is important but challenging. A ratiometric fluorescence method for determining glutathione (GSH) using carbon dots (CDs) and Ag+-triggered o‑phenylenediamine (OPD) oxidation is described here. Ag+ oxidizes OPD to give 2,3-diaminophenazine (oxOPD), which effectively quenches CD fluorescence at 436 nm through the inner filter effect and causes a new emission peak at 561 nm. Read More

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An Accessible, 16-Week Neck Strength Training Program Improves Head Kinematics Following Chest Perturbation in Young Soccer Athletes.

J Sport Rehabil 2021 Jul 30:1-8. Epub 2021 Jul 30.

Context: Neck size and strength may be associated with head kinematics and concussion risks. However, there is a paucity of research examining neck strengthening and head kinematics in youths. In addition, neck training is likely lacking in youth sport due to a perceived inadequacy of equipment or time. Read More

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Ivermectin resistance in the multi-host tick Hyalomma anatolicum (Acari: Ixodidae) in India.

Ticks Tick Borne Dis 2021 Jul 21;12(6):101791. Epub 2021 Jul 21.

Department of Veterinary Parasitology, College of Veterinary Science & AH, Kamdhenu University (Erstwhile SDAU), Sardarkrushinagar, 385506 Gujarat (India); Director Resident Instruction-cum-Dean, Post Graduate Studies, BASU, Patna, 800 014, Bihar (India). Electronic address:

The multi-host tick, Hyalomma anatolicum is a widely distributed vector of many pathogens of veterinary and public health importance. Ivermectin (IVM), as an alternative to control pyrethroid-resistant ticks, has been used extensively for the past 4-6 years in tropical and sub-tropical countries including India resulting in declining tick control efficacy. The present study used adult immersion test (AIT) to examine the resistance status of H. Read More

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Combustion operating conditions for municipal Waste-to-Energy facilities in the U.S.

Waste Manag 2021 Jul 27;132:124-132. Epub 2021 Jul 27.

Department of Civil & Environmental Engineering, University of Delaware, Newark, DE 19716, USA.

This paper reports the first known comprehensive survey of combustion operating conditions across the wide range of municipal waste-to-energy facilities in the U.S. The survey was conducted in a step-wise fashion. Read More

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Investigating the impact of the CT Hounsfield unit range on radiomic feature stability using dual energy CT data.

Phys Med 2021 Jul 26;88:272-277. Epub 2021 Jul 26.

McGill University, Medical Physics Unit, Montreal, Canada.

Purpose: Radiomic texture calculation requires discretizing image intensities within the region-of-interest. FBN (fixed-bin-number), FBS (fixed-bin-size) and FBN and FBS with intensity equalization (FBNequal, FBSequal) are four discretization approaches. A crucial choice is the voxel intensity (Hounsfield units, or HU) binning range. Read More

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Energy Decomposition Analysis of Lewis Acid/Base Adducts and Frustrated Lewis Pairs: The Use of / Ratios as a Reaction Parameter.

Inorg Chem 2021 Jul 30. Epub 2021 Jul 30.

Department of Chemistry, North Carolina State University (NCSU), 2620 Yarbrough Drive, Raleigh, North Carolina 27695-8204, United States.

The nature of bonding in classical adducts and frustrated Lewis pairs (FLPs) of oxorhenium and nitridorhenium complexes with B(CF) was investigated computationally (B3PW91-D3). These studies have revealed that the primary noncovalent interaction (NCI) in the FLPs involves lone pair/π interactions between the terminal M≡X bond and the aromatic CF ring in B(CF). Energy decomposition analyses on classical adducts and FLPs reveal that these species can be defined by the ratio (/) of covalent-to-noncovalent contributions to the total interaction energy, . Read More

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Amphiphilic tocopheryl polyethylene glycol succinate as gas chromatographic stationary phase for high-resolution separations of challenging isomers and analysis of lavender essential oil.

J Sep Sci 2021 Jul 30. Epub 2021 Jul 30.

Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China.

This work presents the investigation of using tocopheryl polyethylene glycol succinate as the stationary phase for GC separations of isomers with different varieties and GC-MS analysis of a wide range of components in lavender essential oil. Its capillary column exhibited moderate polarity and column efficiency of 4000 plates/m determined by n-dodecane at 120°C. As demonstrated, it showed outstanding separation performance towards challenging isomers such as xylenes, alkanes, phenols and anilines and a wide range of components in essential oils with distinct advantages over the commercial polyethylene glycol and polysiloxane columns. Read More

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Analytical Comparison of Pregnancy-Associated Plasma Protein-A (PAPP-A) Immunoassays for Biochemical Determination of Gestational Age.

J Appl Lab Med 2021 Jul 30. Epub 2021 Jul 30.

Gynuity Health Projects, New York, NY 10017.

Background: Accurate pregnancy dating is critical for maternal and child health and for counseling on safe and effective abortion methods. While last menstrual period and first trimester ultrasound are often used together to determine gestational age (GA), they have limited accuracy and availability, respectively. Prior studies have shown that pregnancy-associated plasma protein-A (PAPP-A) increases exponentially during pregnancy and has the potential to serve as a biochemical marker of GA. Read More

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Development of an artificial neural network as a tool for predicting the chemical attributes of fresh peach fruits.

PLoS One 2021 30;16(7):e0251185. Epub 2021 Jul 30.

Food Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria, Egypt.

This investigation aimed to develop a method to predict the total soluble solids (TSS), titratable acidity, TSS/titratable acidity, vitamin C, anthocyanin, and total carotenoids contents using surface color values (L*, Hue and chroma), single fruit weight, juice volume, and sphericity percent of fresh peach fruit. Multiple regression analysis (MLR) and an artificial neural network (ANN) were employed. An ANN model was developed with six inputs and 15 neurons in the first hidden layer for the prediction of six chemical composition parameters. Read More

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Quantification of Pb pollution sources in complex urban environments through a multi-source isotope mixing model based on Pb isotopes in lichens and road sediment.

Environ Pollut 2021 Jul 20;288:117815. Epub 2021 Jul 20.

Department of Geology and Environmental Earth Science, Miami University, Oxford, OH, United States.

Despite a growing focus on anthropogenic toxic metal pollution in urban environments, few studies have addressed the problem of quantification when more than two pollution sources are likely present, particularly within complex urban settings in the United States (U.S.). Read More

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Rational design-aided discovery of novel 1,2,4-oxadiazole derivatives as potential EGFR inhibitors.

Bioorg Chem 2021 Jul 1;114:105124. Epub 2021 Jul 1.

Division of Biological & Life Sciences (Formerly Institute of Life Sciences), School of Arts & Sciences, Ahmedabad University, Navaragnpura, Ahmedabad 380009, Gujarat, India; National Institute of Animal Biotechnology, Near Gowlidoddy, Extended Q City Road, Gachibowli, Hyderabad 500032, Telangana, India.

A molecular dynamics-based sampling of epidermal growth factor receptor tyrosine kinase (EGFR-TK) was carried out to search for energetically more stable protein, which was then used for molecular docking of a series of 1,2,4-oxadiazole derivatives previously reported from our laboratory. A total of 14 compounds were docked, where compounds 6a and 6b showed better binding to EGFR in silico. Further, physicochemical properties of all the compounds were calculated, which suggested that all the molecules obeyed Lipinski's rule of 5 and had favorable polar surface area and CaCO2 permeability along with the low potential for HERG inhibition. Read More

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Relationship between obesity index and cardiovascular risk in primary care patients on Crete, Greece: a data driven sub-analysis.

Ann Ig 2021 Aug 3. Epub 2021 Aug 3.

Clinic of Social and Family Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.

Background: The present sub-analysis aimed to examine the relationship between obesity index and cardiovascular risk among primary care attendees.

Study Design: Stratified random sampling was previously used to recruit general practitioners, practicing on Crete island, Greece, whose patients were then enrolled.

Methods: Initial sample included 815 primary care attendees (55. Read More

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[Development of a reference substance for live bacterial count of Streptococcicosis live vaccines].

Sheng Wu Gong Cheng Xue Bao 2021 Jul;37(7):2554-2562

China Institute of Veterinary Drug Control, Beijing 100081, China.

This study attempts to develop a reference substance for the live bacteria count of Streptococcicosis live vaccines in order to evaluate the validity of live bacterial count in inspection and testing. We prepared a batch of live Streptococcus suis reference substance for live bacterial count, tested their physical property, purity, vacuum degree, remaining moisture, and determined their homogeneity, thermal stability and transportation stability. Moreover, we organized collaborative calibration to assign count values to the reference substance and determine the shelf life of the reference substance in 12 months. Read More

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Cardiac Magnetic Resonance Follow-Up of Children After Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 With Initial Cardiac Involvement.

J Magn Reson Imaging 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatric Radiology, Medical University of Warsaw, Warsaw, Poland.

Background: Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is an inflammatory disease occurring in a small minority of children a few weeks after acute infection. Cardiac manifestations are common, but little is known about the potentially persistent heart changes after PIMS-TS.

Purpose: To analyze the frequency and type of myocardial complications of PIMS-TS with initial cardiac involvement assessed with cardiac magnetic resonance imaging (MRI), including parametric imaging, performed 3 months after hospitalization. Read More

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Long-Term Outcomes and Health-Related Quality of Life in a Swiss Patient Group with Esophageal Atresia.

Eur J Pediatr Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatric Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

Introduction:  Surgical treatment of esophageal atresia (EA) has markedly improved, allowing the focus to shift from short-term complications and mortality to long-term complications and quality of life. Health-related quality of life (HRQoL) is variable and reported to range from reduced to unimpaired in patients with repaired EA. We assessed the HRQoL, determined the prevalence of long-term complications and their possible impact on the HRQoL in patients who had correction of EA in Switzerland. Read More

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Validity of skeletal muscle mass index measurements for assessing sarcopenia in patients with gynecological cancer.

Jpn J Clin Oncol 2021 Jul 30. Epub 2021 Jul 30.

Division of Orthopedic Surgery, National Hospital Organization, Hokkaido, Sapporo, Japan.

Background: The current study investigated an optimal method for using CT scan in detection of low skeletal muscle mass quantity (SMQ).

Methods: In total, 82 consecutive patients with gynecological cancers were examined using computed tomography (CT) and dual-energy X-ray absorptiometry (DEXA) before treatment. Low SMQ was defined as a DEXA-based skeletal muscle mass index (SMI) of <5. Read More

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Design and Synthesis of Core-Shell Carbon Polymer Dots with Highly Stable Fluorescence in Polymeric Materials.

ACS Appl Nano Mater 2019 Oct 20;2(10):6503-6512. Epub 2019 Sep 20.

College of Textile & Clothing, Jiangnan University, Wuxi 214122, China.

In recent years, fluorescent carbon dots have attracted great attention due to their good luminescence and low toxicity. Here, blue fluorescent core-shell structured carbon polymer dots (CPDs) with high stability under a wide range of pH values, long storage time and excellent fluorescence in various solvents and even in solid state were prepared by hydrothermal synthesis of dendritic tris(2-aminoethyl)amine (TAEA) and citric acid. The CPDs core structure provides strong fluorescent luminescence, a shell structure of the core possesses high amount of dendritic primary amino groups connected by ethylene groups to the core. Read More

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October 2019

Antibacterial and Mode of Action of Extracts from Endophytic Fungi Derived from , , and .

Biomed Res Int 2021 15;2021:6697973. Epub 2021 Jul 15.

Department of Biochemistry, Faculty of Science, University of Yaoundé I, PO Box 812, Messa-Yaoundé, Cameroon.

Emerging drug-resistant bacteria creates an urgent need to search for antibiotics drugs with novel mechanisms of action. Endophytes have established a reputation as a source of structurally novel secondary metabolites with a wide range of biological activities. In the present study, we explore the antibacterial potential of endophytic fungi isolated from different tissues of , , and . Read More

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Percutaneous Balloon Pulmonary Valvuloplasty of Critical Pulmonary Stenosis and severe pulmonary stenosis in Neonates and Early Infancy: A Challenge in the Cyanotic.

J Cardiovasc Thorac Res 2021 20;13(2):156-161. Epub 2021 May 20.

Rajaie Cardiovascular Medical and Research Center, Iran University of medical sciences, Tehran, Iran.

Pulmonary stenosis with an intact ventricular septum (PS-IVS) is one of the common causes of cyanotic heart disease in neonates with diverse morphologies as well as management and treatment protocols. The aim of this study was to evaluate short and midterm results of balloon pulmonary valvuloplasty (BPV) for this disorder. Between 2012 and 2016, Totally 45 neonates and infants under 6 months old were evaluated. Read More

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Gray Matter Volume in the Developing Frontal Lobe and Its Relationship With Executive Function in Late Childhood and Adolescence: A Community-Based Study.

Front Psychiatry 2021 13;12:686174. Epub 2021 Jul 13.

Department of Psychiatry, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.

During late childhood and adolescence, the frontal lobe undergoes critical developmental changes, affecting a wide range of executive functions significantly. Conversely, abnormality in the maturation of the frontal lobe during this period may result in a limited ability to effectively use various executive functions. However, at present, it is still unclear how the structural development of the frontal lobe is associated with different aspects of executive functions during this developmental period. Read More

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Damping Control and Experiment on Active Hydro-Pneumatic Suspension of Sprayer Based on Genetic Algorithm Optimization.

Front Neurorobot 2021 13;15:707390. Epub 2021 Jul 13.

School of Mechanical and Electrical Engineering, Shihezi University, Shihezi, China.

High ground clearance self-propelled sprayers usually work in complex road conditions. Due to the large body mass, wide spray boom breath and high center of gravity, the body and spray boom swing sharply during work, which affects operation quality and even endangers safety. This paper proposes a control plan for timely-started active hydro-pneumatic suspension, and designs a fuzzy PID control system based on genetic algorithm optimization. Read More

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Cardiopulmonary function in adolescent patients with pectus excavatum or carinatum.

BMJ Open Respir Res 2021 Jul;8(1)

Paediatric Pulmonology Unit, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland

Background: Pectus excavatum (PE) and pectus carinatum (PC) have generally been considered an aesthetic issue, although there is growing evidence of associated cardiopulmonary function (CPF) impairment, especially in PE patients. The study goal was to determine any correlation between pectus malformations and cardiopulmonary symptoms and function based on systematic assessment of CPF and thoracic measurements, such as Haller Index (HI) and sternal torsion angle (STA).

Methods: Data from 76 adolescent patients with PE (n=30) or PC (n=46) were retrospectively collected referred between January 2015 and April 2018. Read More

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Atlas-Based Quantification of DTI Measures in a Typically Developing Pediatric Spinal Cord.

AJNR Am J Neuroradiol 2021 Jul 29. Epub 2021 Jul 29.

From the Departments of Radiology (S.S., M.A., D.M., F.B.M.)

Background And Purpose: Multi-parametric MRI, provides a variety of biomarkers sensitive to white matter integrity, However, spinal cord MRI data in pediatrics is rare compared to adults. The purpose of this work was 3-fold: 1) to develop a processing pipeline for atlas-based generation of the typically developing pediatric spinal cord WM tracts, 2) to derive atlas-based normative values of the DTI indices for various WM pathways, and 3) to investigate age-related changes in the obtained normative DTI indices along the extracted tracts.

Materials And Methods: DTI scans of 30 typically developing subjects (age range, 6-16 years) were acquired on a 3T MR imaging scanner. Read More

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A Health Information Quality Assessment Tool for Korean Online Newspaper Articles: Development Study.

J Med Internet Res 2021 Jul 29;23(7):e24436. Epub 2021 Jul 29.

Liver Korea, Seoul, Republic of Korea.

Background: Concern regarding the reliability and accuracy of the health-related information provided by online newspaper articles has increased. Numerous criteria and items have been proposed and published regarding the quality assessment of online information, but there is no standard quality assessment tool available for online newspapers.

Objective: This study aimed to develop the Health Information Quality Assessment Tool (HIQUAL) for online newspaper articles. Read More

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Discriminating between IgG4-related orbital disease and other causes of orbital inflammation with intra voxel incoherent motion (IVIM) MR imaging at 3T.

Diagn Interv Imaging 2021 Jul 26. Epub 2021 Jul 26.

Department of Neuroradiology, Fondation Adolphe de Rothschild Hospital, 75019 Paris, France.

Purpose: The purpose of this prospective study was to determine the capabilities of intravoxel incoherent motion (IVIM) MRI at 3 Tesla in discriminating between IgG4-related orbital disease (IgG4-ROD) and other causes of orbital inflammation.

Materials And Methods: Main selection criteria for the patients enrolled in this prospective study were age over 18 years and histopathologicaly proven orbital inflammatory lesion. MRI examinations were performed prior to surgery and treatment in all patients with suspected orbital inflammation. Read More

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Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors.

MAbs 2021 Jan-Dec;13(1):1950264

Research & Development, Affimed GmbH, Heidelberg, Germany.

Epidermal growth factor receptor (EGFR)-targeted cancer therapy such as anti-EGFR monoclonal antibodies and tyrosine kinase inhibitors have demonstrated clinical efficacy. However, there remains a medical need addressing limitations of these therapies, which include a narrow therapeutic window mainly due to skin and organ toxicity, and primary and secondary resistance mechanisms of the EGFR-signaling cascade (e.g. Read More

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Investigation of the relationship between gene polymorphisms and glioma susceptibility in Chinese children.

Cancer Invest 2021 Jul 29:1-17. Epub 2021 Jul 29.

Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.

Glioma is a common central nervous system tumors in children. has a range of functions that are disrupted in various tumor cells, and may contribute to the occurrence and development of glioma. Two single nucleotide polymorphisms (rs4645943C > T and rs2070583 A > G) were genotyped in 190 cases and 248 controls from Wenzhou and Guangzhou hospitals. Read More

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Survey of the operational status of twenty-six urban stormwater biofilter facilities in Sweden.

J Environ Manage 2021 Jul 26;297:113375. Epub 2021 Jul 26.

Dept. of Civil, Environmental, and Natural Resources Engineering, Luleå Univ. of Technology, 97187, Luleå, Sweden. Electronic address:

This study evaluates the operational status of twenty-six biofilter facilities across nine cities in Sweden, with respect to their functional design criteria, engineered design features (filter media composition, hydraulic conductivity, and drawdown time), and includes a visual inspection of the biofilter components (pre-treatment, in/outlet structures, filter media, and vegetation). These indicators were used to examine the performance level of each biofilter in achieving their design objectives set by the operators. Furthermore, it was investigated whether the biofilter facilities had been properly maintained to meet the objectives. Read More

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SERS-based serodiagnosis of acute febrile diseases using plasmonic nanopopcorn microarray platforms.

Biosens Bioelectron 2021 Jul 21;192:113525. Epub 2021 Jul 21.

Department of Chemistry, Chung-Ang University, Seoul, 06974, South Korea. Electronic address:

We report a surface-enhanced Raman scattering (SERS)-based immunoassay platform for the rapid diagnosis of scrub typhus and murine typhus, which are the most common acute febrile diseases in South Korea. A microarray device, composed of multiple gold nanopopcorn substrates capable of detecting ultra-sensitive biomarkers, was used as a multiplex SERS-based assay platform. Sequentially diluted titers of Orientia tsutsugamushi and Rickettsia typhi specific human IgG/IgM antibodies, which are biomarkers of two typhus diseases, were analyzed by Raman spectroscopy, and the peak intensity was plotted against the different titer concentration range (0-2048 and 0-1024 for O. Read More

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AK bullet (7,62 × 39 mm) ricochet off flat, wooden targets; A forensic-based study.

Forensic Sci Int 2021 Jul 13;326:110903. Epub 2021 Jul 13.

School of Physical Sciences, University of Kent, UK. Electronic address:

The ricochet behaviour of AK bullets (7,62 × 39 mm), one of the prominently reported bullet type in recent shooting incidents worldwide, has been examined on a range of different wooden surfaces in this study. The critical angles of AK bullets for teak, Jack wood, mahogany and pine were reported with close values ranging from 9.9 to 13. Read More

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