70,744 results match your criteria values functional

QABF - Polish adaptation and validation of the tool for assessing the functions of challenging behaviors.

Res Dev Disabil 2021 Jul 19;116:104032. Epub 2021 Jul 19.

Pedagogical University of Krakow, Institute of Special Needs Education, R. Ingardena 4 St., 30-060, Cracow, Poland. Electronic address:

Background: Autism spectrum disorders are a diagnostic unit predisposing the occurrence of challenging behaviors. Depending on their frequency and severity, behavioral problems may significantly limit the developmental possibilities of people with ASD, and also significantly affect family life and the therapeutic process. Aggressive, self-injury, destructive or stereotypic behaviors require intervention based on individualized support, the basis of which should be a functional assessment. Read More

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Multicomponent exercise to improve motor functions, cognition and well-being for nursing home residents who are unable to walk - A randomized controlled trial.

Exp Gerontol 2021 Jul 19:111484. Epub 2021 Jul 19.

Institute of Human Movement Science, University of Hamburg, Mollerstr, 10, 20148 Hamburg, Germany; Biological Psychology and Neuroergonomics, TU Berlin, Fasanenstr. 1, 10623 Berlin, Germany. Electronic address:

Background: Older nursing home residents are often characterized by multimorbidity and dependency in activities of daily living. Most exercise studies in this setting aim at residents who are still able to walk despite the huge group of residents that is unable to walk. Thus, little is known about the effectiveness to improve cognitive and motor functions as well as well-being within this target group, e. Read More

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Transforming C Molecules into Polyhedral Carbon Micro-Nano Shells for Electrochemically Producing HO in Neutral Electrolytes.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

The electrochemical production of hydrogen peroxide (HO) via the two-electron oxygen reduction reaction (ORR) can realize the customer-oriented onsite synthesis of HO in a green and sustainable method. The ongoing challenge that needs to be solved is the fabrication of robust electrocatalysts of excellent performance. In this work, C was selected as a precursor due to its uniform structure and abundant pentagon rings. Read More

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Оxidative stress and endogenous intoxication in cancer patients.

Klin Lab Diagn 2021 Jul;66(7):401-406

Federal State Budgetary Institution "National Medical Research Center of Oncology N.N. Blokhin", under the Ministry of Health of the Russian Federation.

In the blood serum of 93 patients with various localities of the malignant process, the content of nitric oxide (NO), indicators of lipid peroxidation (POL): superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione in red blood cells were determined. 9 patients with ovarian cancer were examined during chemotherapy (6 courses), 40 patients with colon cancer, previously operated, were with malignant liver damage. In 39 patients with anemia, NO indicators were compared with the level of interleukin 6 (IL-6) and hepcidin-25 (GP-25). Read More

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sp. nov., isolated from marine sediment.

Int J Syst Evol Microbiol 2021 Jul;71(7)

Department of Microbiology, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea.

A Gram-stain-negative, aerobic, non-motile, rod-shaped bacterial strain (CAU 1508) was isolated from marine sediment collected in the Republic of Korea. Growth was observed at 10-45 °C (optimum, 30 °C), pH 4.0-11. Read More

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Palladium-Catalyzed Direct C2-Biarylation of Indoles.

J Org Chem 2021 Jul 22. Epub 2021 Jul 22.

School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Vithura, Kerala 695551, India.

Biaryl and indole units are important structural motifs in several bioactive molecules and functional materials. We have accomplished straightforward access to C2-biarylated indole derivatives through palladium-catalyzed C-H activation strategy with a broad range of substrate scope in yields of 24 to 92%. Besides, the UV/visible absorption and fluorescence properties of the ensuing products were explored. Read More

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Glutamate Chemical Exchange Saturation Transfer Imaging and Functional Alterations of Hippocampus in Rat Depression Model: A Pilot Study.

J Magn Reson Imaging 2021 Jul 22. Epub 2021 Jul 22.

School of Medical Imaging, Binzhou Medical University, Yantai, China.

Background: Adjusting abnormal glutamate neurotransmission is a crucial mechanism in the treatment of depression. However, few non-invasive techniques could effectively detect changes in glutamate neurotransmitters, and no consensus exists on whether glutamate could affect resting-state function changes in depression.

Purpose: To study the changes in glutamate chemical exchange saturation transfer (GluCEST) value in the hippocampus of rat model exposed to chronic unpredictable mild stress (CUMS), and to explore the effect of this change on the activity of hippocampal glutamatergic neurons. Read More

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The Effect of Nixtamalization Extrusion Process and Tortillas Making on the Stability of Anthocyanins from Blue Corn through the Kinetic and Thermodynamic Parameters.

Plant Foods Hum Nutr 2021 Jul 22. Epub 2021 Jul 22.

Departamento de Biotecnología y Ciencias Alimentarias, Instituto Tecnológico de Sonora (ITSON), Sonora, 85000, Cd. Obregón, México.

The blue corn-based products are considered functional foods due to their high concentration of anthocyanins. The aim of this study was to estimate the kinetic and thermodynamic parameters of the thermal degradation of anthocyanins from extruded nixtamalized corn products. A comparative study of anthocyanins thermal stability in these matrices in a buffer solution (pH 2. Read More

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Functional expression and characterization of a novel aminopeptidase B from in .

Peng Song Wei Feng

3 Biotech 2021 Aug 6;11(8):366. Epub 2021 Jul 6.

School of Life Sciences, Liaocheng University, Liaocheng, 252000 China.

A novel aminopeptidase B (APB-AN) was identified from CGMCC 3.1454 for the first time and was cloned and expressed in . The mature enzyme of approximately 100 kDa was purified for characterization. Read More

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Acta Ortop Bras 2021 May-Jun;29(3):127-131

Universidade de São Paulo, Faculty of Medicine, Hospital das Clínicas, Institute of Orthopedics and Traumatology, HC-FMUSP, São Paulo, SP, Brazil.

Objective: To compare the long-term effects of a brace designed to stabilize the patellofemoral (PF) joint in comparison to a standard neoprene sleeve for the knee with patellar hole in patients with patellofemoral osteoarthritis (PFOA).

Methods: 38 patients with PFOA and comorbidities received either a functional PF brace (Study Group, SG) or a neoprene sleeve for the knee (Control Group, CG). Both groups received clinical treatment to OA and comorbidities according to a program from the institution. Read More

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September 2020

Evaluation of psychometric properties of the segmental assessment of trunk control (SATCo) in children with spastic quadriplegic cerebral palsy.

J S Tedla R S Reddy

Niger J Clin Pract 2021 Jul;24(7):1077-1081

Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Guraiger, Abha, Kingdom of Saudi Arabia.

Background: Segmental Assessment of Trunk Control (SATCo) is a scientific evaluation measure used to assess trunk control in subjects with cerebral palsy (CP).

Aims: The present study aimed at assessing the psychometric properties of SATCo in children with spastic quadriplegic CP.

Methodology: This was an observational study in which we validated a test instrument in 31 children (aged 1-5 years) with spastic quadriplegic CP. Read More

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Validity and reliability of the Turkish version of the functional assessment of cancer therapy-bone marrow transplant (FACT-BMT) quality of life questionnaire in patients undergoing bone marrow transplantation.

Palliat Support Care 2021 Jul 22:1-8. Epub 2021 Jul 22.

Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.

Objective: The Functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 (FACT-BMT) is a widely used instrument to assess quality of life in individuals treated with bone marrow transplantation (BMT). Our aim was to determine the reliability and validity of the Turkish version of the FACT-BMT in patients undergoing BMT.

Method: Patients between the age of 20 and 65 years and who had undergone BMT at least 3 months before the study were included. Read More

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Development and Validation of Urologic and Appearance Domains of the Post-affirming Surgery Form and Function Individual Reporting Measure (AFFIRM) for Transwomen following Genital Surgery.

J Urol 2021 Jul 21:101097JU0000000000002141. Epub 2021 Jul 21.

Center for Female Pelvic Health, Department of Urology, Weill Cornell Medicine, New York, New York.

Purpose: As feminizing gender-affirming surgery becomes increasingly accessible, functional outcomes are increasingly relevant. We aim to develop and validate the first patient-reported outcome questionnaire focusing on postoperative symptomatology and quality of life.

Material And Methods: Questions were developed from interviews with postoperative transwomen followed by face validation from a multi-specialty clinician group. Read More

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Assessment of older adults' decision-making capacity in relation to independent living: A scoping review.

Health Soc Care Community 2021 Jul 20. Epub 2021 Jul 20.

Discipline of Occupational Therapy, Trinity College Dublin, Dublin, Ireland.

With a growing global ageing population, approaches to assess and support decision-making are becoming more pertinent. This scoping review aimed to identify and map current knowledge on assessment of older adults' decision-making capacity in relation to independent living. A five-stage scoping review framework was followed. Read More

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Rate and fate of dissolved organic carbon release by seaweeds: a missing link in the coastal ocean carbon cycle.

J Phycol 2021 Jul 21. Epub 2021 Jul 21.

Institute for Marine and Antarctic Studies, University of Tasmania, Hobart Tasmania, 7001, Australia.

Dissolved organic carbon (DOC) release by seaweeds (marine macroalgae) is a critical component of the coastal oceans biogeochemical carbon cycle but is an aspect of seaweed carbon physiology that we know relatively little about. Seaweed-derived DOC is found throughout coastal ecosystems and supports multiple food web linkages. Here we discuss the mechanisms of DOC release by seaweeds and group them into passive (leakage, requires no energy) and active release (exudation, requires energy) with particular focus on the photosynthetic 'overflow' hypothesis. Read More

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Time course of exercise capacity in patients recovering from COVID-19-associated pneumonia.

J Bras Pneumol 2021 19;47(4):e20210076. Epub 2021 Jul 19.

. Divisione di Pneumologia Riabilitativa, Istituti Clinici Scientifici Maugeri - IRCCS - Tradate, Italia.

Objective: High prevalences of muscle weakness and impaired physical performance in hospitalized patients recovering from COVID-19-associated pneumonia have been reported. Our objective was to determine whether the level of exercise capacity after discharge would affect long-term functional outcomes in these patients.

Methods: From three to five weeks after discharge from acute care hospitals (T0), patients underwent a six-minute walk test (6MWT) and were divided into two groups according to the distance walked in percentage of predicted values: <75% group and ≥75% group. Read More

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Reliability, validity and important difference estimates for the NCCN-FACT Ovarian Symptom Index-18 (NFOSI-18).

Future Oncol 2021 Jul 21. Epub 2021 Jul 21.

Adelphi Values, Bollington, UK.

To evaluate psychometric performance of the NCCN-FACT Ovarian Cancer Symptom Index-18 (NFOSI-18) in advanced ovarian cancer. Cross-sectional, observational data from patients receiving treatment for ovarian cancer. Other measures included European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core (EORTC QLQ-C30) and associated ovarian cancer module (EORTC QLQ-OV28) and Work Productivity and Activity Impairment. Read More

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Construction of a hydroxide responsive -symmetric supramolecular gel for controlled release of small molecules.

Soft Matter 2021 Jul 21. Epub 2021 Jul 21.

Key Laboratory of Preparation and Application of Environmental Friendly Materials (Jilin Normal University), Ministry of Education, Changchun, 130103, China.

A C3-symmetric acylhydrazone-based low molecular weight gelator (BHTP) bearing three pyridine units was synthesized and it was found to form a stable supramolecular gel in the mixture solvent of DMSO-H2O. The morphology of the gel as observed by FE-SEM showed a dense sheet structure. Hydrogen bonding and π-π stacking between the gelators were determined as the non-covalent interactions for the gelation, which were investigated thoroughly using XRD, UV-Vis, 1H NMR and FT-IR instruments. Read More

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Time dependant functional and morphological recovery of the kidney after relief of obstruction in patients with impacted ureteral stones.

Arch Ital Urol Androl 2021 Jun 28;93(2):178-183. Epub 2021 Jun 28.

Biruni University, Faculty of Medicine, Department of Urology, Istanbul.

Objectives: To assess the course of functional and morphological recovery of the kidney following the relief of obstruction with ureteral JJ stent in cases with unilateral impacted stones.

Materials And Methods: A total of 42 adult patients who were admitted to our clinic with unilateral obstructing impacted ureteral stones requiring JJ stent placement were included in the study. The course of functional recovery was assessed by evaluating the serum creatinine levels, renal resistive index (RRI) values and urinary levels of kidney injury molecule-1, neutrophil gelatinaseassociated lipocalin as well as microalbumin before at 1 day, 1 week and 4 weeks after JJ stent placement. Read More

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Engineering skeletal muscle tissues with advanced maturity improves synapse formation with human induced pluripotent stem cell-derived motor neurons.

APL Bioeng 2021 Sep 13;5(3):036101. Epub 2021 Jul 13.

Department of Biological Sciences, Dornsife College of Arts and Letters, University of Southern California, Los Angeles, California 90089, USA.

To develop effective cures for neuromuscular diseases, human-relevant models of neuromuscular tissues are critically needed to probe disease mechanisms on a cellular and molecular level. However, previous attempts to co-culture motor neurons and skeletal muscle have resulted in relatively immature neuromuscular junctions (NMJs). In this study, NMJs formed by human induced pluripotent stem cell (hiPSC)-derived motor neurons were improved by optimizing the maturity of the co-cultured muscle tissue. Read More

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September 2021

Synthesis, antibacterial, anti-oxidant and molecular docking studies of imidazoquinolines.

Heliyon 2021 Jul 5;7(7):e07484. Epub 2021 Jul 5.

Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed-to-be University), Karunya Nagar, Coimbatore, 641 114, India.

Quinoline and imidazole derivatives have been playing a significant role in functional bioactivities and were potentially used as antibacterial, antifungal, anticancer, and anti-inflammatory drugs. Owing to the limitation of drug resistance, herein we synthesized thio-, chloro-, and hydroxyl-functionalized various imidazoquinolines by molecular hybridization approach. All the imidazoquinoline derivatives were examined for their antibacterial activity against selected bacterial pathogens by the agar well diffusion method. Read More

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High-yield synthesis of silver nanowires for transparent conducting PET films.

Beilstein J Nanotechnol 2021 1;12:624-632. Epub 2021 Jul 1.

Institute of Physics, Faculty of Science, The Islamia University of Bahawalpur, Baghdad-ul-Jadid Campus, Bahawalpur 63100, Pakistan.

Silver nanowires (AgNWs) with ultrahigh purity and high yield were successfully synthesized by employing a modified facile polyol method using PVP as a capping and stabilizing agent. The reaction was carried out at a moderate temperature of 160 °C under mild stirring for about 3 h. The prepared AgNWs exhibited parallel alignment on a large scale and were characterized by UV-vis spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), and PL spectroscopy. Read More

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Clinicopathological Study of Intradural Extramedullary Spinal Tumors and Its Correlation With Functional Outcome.

Cureus 2021 Jun 18;13(6):e15733. Epub 2021 Jun 18.

Neurosurgery, Mahatma Gandhi Memorial Medical College, Indore, IND.

Introduction Intradural extramedullary (IDEM) spinal cord tumors account for approximately two-thirds of largely benign intraspinal neoplasms. These are amenable to gross total excision and usually carry a good functional outcome. Methods In this study, we reviewed the surgical outcomes of 35 patients who underwent excision of intradural extramedullary tumors. Read More

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Short-Term Impact of Iron Deficiency in Different Subsets of Patients with Precapillary Pulmonary Hypertension from an Eastern European Pulmonary Hypertension Referral Center.

Int J Gen Med 2021 12;14:3355-3366. Epub 2021 Jul 12.

Department of Cardiology II, County Emergency Clinical Hospital, Targu Mures, 540042, Romania.

Background: Over the last few decades, interest in the role of iron status in pulmonary hypertension (PH) has grown considerably due to its potential impact on symptoms, exercise capacity (as assessed by the 6-minute walk distance [6MWD]), prognosis, and mortality. The aim of the present study was to identify iron deficiency (ID) prevalence in specific precapillary PH subgroups of Romanian patients and its short-term impact on 6MWD.

Patients And Methods: Complete datasets from 25 precapillary PH adults were examined and included in the analysis. Read More

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Identification of Underlying Hub Genes Associated with Hypertrophic Cardiomyopathy by Integrated Bioinformatics Analysis.

Pharmgenomics Pers Med 2021 12;14:823-837. Epub 2021 Jul 12.

Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310016, People's Republic of China.

Background: Considered as one of the major reasons of sudden cardiac death, hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease. However, effective treatment for HCM is still lacking. Identification of hub gene may be a powerful tool for discovering potential therapeutic targets and candidate biomarkers. Read More

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Acta Clin Croat 2020 Dec;59(4):597-604

1Clinical Center of Montenegro, Department of Physical Medicine and Rehabilitation, Podgorica, Montenegro; 2Faculty of Medicine, University of Montenegro, Podgorica, Montenegro; 3Faculty of Medicine, University of Prishtina, Kosovska Mitrovica, Serbia.

The aim of the study was to evaluate the effects of preoperative respiratory rehabilitation on functional capacity, length of stay in intensive care unit (ICU), duration of mechanical ventilation (MV) and total hospitalization, as well as to estimate arterial blood gas (ABG) values in patients undergoing cardiac surgery. Nineteen patients were included in the randomized observational study, divided into two groups: group A (intervention) and B (control). Preoperative and postoperative rehabilitation was performed in group A, and only postoperative rehabilitation in group B. Read More

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December 2020

Photopic negative response (PhNR) in the diagnosis and monitoring of raised intracranial pressure in children: a prospective cross-sectional and longitudinal protocol.

BMJ Open 2021 Jul 20;11(7):e047299. Epub 2021 Jul 20.

Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital For Children NHS Foundation Trust, London, UK.

Introduction: Raised intracranial pressure (rICP) can be a consequence of a variety of neurological disorders. A significant complication of rICP is visual impairment, due to retinal ganglion cell (RGC) dysfunction. In children, subjective measurements to monitor this, such as visual field examination, are challenging. Read More

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Measures of physical performance in COVID-19 patients: a mapping review.

Pulmonology 2021 Jun 24. Epub 2021 Jun 24.

Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Division of the Institute of Montescano, Pavia, Italy. Electronic address:

Background And Objective: There is evidence of short- and long-term impairment of physical performance in patients with COVID-19 infection, but a verification of measures of physical impairment in this condition is lacking. We reviewed the measures used to assess physical performance in these patients. Secondary targets were measures of exercise or daily life activities induced symptoms. Read More

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Involvement of Carbonic Anhydrase CAH3 in the Structural and Functional Stabilization of the Water-Oxidizing Complex of Photosystem II from Chlamydomonas reinhardtii.

Biochemistry (Mosc) 2021 Jul;86(7):867-877

Institute of Basic Biological Problems, Pushchino Scientific Center for Biological Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.

The involvement of carbonic anhydrases (CA) and CA activity in the functioning of photosystem II (PSII) has been studied for a long time and has been shown in many works. However, so far only for CAH3 from Chlamydomonas reinhardtii there is evidence for its association with the donor side of PSII, where the CA activity of CAH3 can influence the functioning of the water-oxidizing complex (WOC). Our results suggest that CAH3 is also involved in the organization of the native structure of WOC independently of its CA activity. Read More

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Exercise capacity, muscle strength, dyspnea, physical activity, and quality of life in preoperative patients with lung cancer.

Turk J Med Sci 2021 Jul 21. Epub 2021 Jul 21.

Background: To detect the extent to which physical impairments are observed in patients with lung cancer awaiting lung surgery, exercise capacity, muscle strength, physical activity, dyspnea, and quality of life (QOL) were objectively compared between the patients and healthy individuals in current study.

Methods: Patients with lung cancer (n= 26) and healthy individuals (n= 21) were included. Exercise capacity, respiratory (maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP)) and quadriceps femoris muscle strength, physical activity, dyspnea and QOL were evaluated using 6-minute walk test (6-MWT), a mouth pressure device, a hand-held dynamometer, a metabolic holter device, Modified Medical Research Council dyspnea scale and European Organization for Research and Treatment of Cancer QOL Questionnaire C30 version3. Read More

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