Environ Sci Pollut Res Int 2016 Jun 14;23(12):12206-15. Epub 2016 Mar 14.
Laboratory of Histology and Cytogenetic (Research Unit of Genetic, Genotoxicity and Child Disease UR 12 ES 10), Faculty of Medicine, University of Monastir, Street Avicenna, Monastir, 5019, Tunisia.
Lead (Pb) intoxication is a worldwide health problem which frequently affects the liver. This study was carried out to investigate the potential protective effect of thymoquinone (TQ), the major active ingredient of volatile oil of Nigella sativa seeds, against Pb-induced liver damage. Adult male rats were randomized into four groups: Control group received no treatment, Pb group was exposed to 2000 ppm Pb acetate in drinking water, Pb-TQ group was cotreated with Pb plus TQ (5 mg/kg/day, per orally), and TQ group receiving only TQ. Read More