140 results match your criteria vacuolization damaged


Behavioral and ultrastructural effects of novaluron on Aedes aegypti larvae.

Infect Genet Evol 2021 09 21;93:104974. Epub 2021 Jun 21.

Department of General Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil. Electronic address:

Chitin synthesis inhibitors (CSI) are supposed to inhibit formation of chitin microfibrils in newly synthesized cuticle during molting process. Conversely, there has been comparatively few data on morphological effects of CSI on non-target insect organs. In this work, the effects of the CSI novaluron on behavior and midgut of A. Read More

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September 2021

Effects of MPK3 and MPK6 kinases on the chloroplast architecture and function induced by cold acclimation in Arabidopsis.

Photosynth Res 2021 Aug 16;149(1-2):201-212. Epub 2021 Jun 16.

Dpto. de Bioquímica, Conjunto E. Facultad de Química, Universidad Nacional Autónoma de México, UNAM, Ciudad Universitaria Universitaria, Coyoacán, 04510, México City, México.

Exposure to low, non-freezing temperatures develops freezing tolerance in many plant species. Such process is called cold acclimation. Molecular changes undergone during cold acclimation are orchestrated by signalling networks including MAP kinases. Read More

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Transcriptomic analysis of lead-induced hepatoxicology in female Japanese quails (Coturnix japonica): Implications of triglyceride synthesis, degradation and transport disruption.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jun 22;244:109024. Epub 2021 Feb 22.

College of Life Sciences, Shaanxi Normal University, Xi'an 710119 No. 620, West Chang'an Avenue, Chang'an District, Xi'an, Shaanxi 710119, China. Electronic address:

Lead (Pb) pollution poses great threats to mammals including human and it is also hazardous to bird life. In this study, RNA sequencing analysis was employed to examine the molecular responses to lead exposure in the liver of a toxicological model species Japanese quails (Coturnix japonica). Female birds were exposed to 0, 50, 500 and 1000 ppm waterborne Pb for 49 days. Read More

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Methanolic Extract of Winter Cherry Causes Morpho-Histological and Immunological Ailments in Mulberry Pyralid .

Front Physiol 2020 7;11:908. Epub 2020 Aug 7.

Department of Plant Protection, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran.

The effect of Withania somnifera a medicinal plant seed extract was tested against lesser mulberry pyralid, a potential pest of mulberry. The mulberry leaves were used for silk production in rural areas of northern Iran. The extract was administered orally by leaf dipping method in two lower (5%W/V) and higher (15%W/V) dosages to third instar larvae (<24 h) for biological assays and to fifth instar larvae (<24 h) for Physiological studies. Read More

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Protection of procyanidin B2 on mitochondrial dynamics in sepsis associated acute kidney injury via promoting Nrf2 nuclear translocation.

Aging (Albany NY) 2020 08 15;12(15):15638-15655. Epub 2020 Aug 15.

Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong, China.

In septic acute kidney injury (SAKI), the positive feedback between damaged mitochondria and accumulation of reactive oxygen species results in cell and tissue damage through multiple mechanisms. Removing the damaged mitochondria or neutralizing the reactive oxygen species has been considered beneficial to alleviating cell damage. The antioxidant Procyanidin B2 has been reported to inhibits reactive oxygen species and thereby reduces cell injury. Read More

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Histoprotective effect of rutin against cisplatin-induced toxicities in tumor-bearing mice: Rutin lessens cisplatin-induced toxicities.

Authors:
R Prasad S B Prasad

Hum Exp Toxicol 2021 Feb 13;40(2):245-258. Epub 2020 Aug 13.

Cell and Tumor Biology Laboratory, Department of Zoology, School of Life Sciences, 29666North-Eastern Hill University, Shillong, India.

Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. Read More

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February 2021

Physiological and Pathological Mitochondrial Clearance Is Related to Pectoralis Major Muscle Pathogenesis in Broilers With Wooden Breast Syndrome.

Front Physiol 2020 16;11:579. Epub 2020 Jun 16.

Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.

Wooden breast syndrome (WB) constitutes an emerging myopathy in the pectoralis major muscle (PM) of broiler chickens, characterized by myofiber hypertrophy and degeneration along with severe fibrosis. WB pathogenesis has been considered to involve hypoxia induced by rapid growth of the PM. In this study, we focused on mitochondrial morphology and dynamics in the myofibers, as these organelles are sensitive to damage by hypoxia, and examined the effects on WB pathogenesis. Read More

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Impact of pesticide monocrotophos on microbial populations and histology of intestine in the Indian earthworm Lampito mauritii (Kinberg).

Microb Pathog 2020 Feb 26;139:103893. Epub 2019 Nov 26.

Department of Zoology, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India; Department of Zoology, Government College for Women (Autonomous), Kumbakonam, Tamil Nadu, 612 001, India. Electronic address:

Soil contamination has enlarged over the decades due to intensive use of pesticides and chemical fertilizers in agronomy. Earthworms are significant organisms in the soil community. Earthworms are the major role in soil fertility in most ecological system and the production of biogenic structures. Read More

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February 2020

Harmful Effect of sp. EpRS3 () Against the Protist (Ciliophora, Spirotrichea): Insights Into the Ecological Role of Antimicrobial Compounds From Environmental Bacterial Strains.

Front Microbiol 2019 22;10:510. Epub 2019 Mar 22.

Department of Biology, University of Pisa, Pisa, Italy.

sp. strain EpRS3, isolated from the rhizosphere of , is already known for its ability to produce antibacterial compounds. By use of culture experiments, we verified and demonstrated its harmful effect against the ciliated protist (strain EASCc1), which by FISH experiments resulted to harbor in its cytoplasm the obligate bacterial endosymbiont () and the secondary endosymbiont " Nebulobacter yamunensis" (). Read More

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Ferrocenyl-Triphenyltin Complexes as Lysosome-Targeted Imaging and Anticancer Agents.

Inorg Chem 2019 Jan 28;58(2):1710-1718. Epub 2018 Dec 28.

Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering , Qufu Normal University , Qufu 273165 , China.

In this paper, two ferrocenyl-triphenyltin complexes were synthesized and characterized. Complex 2 is constructed as new multifunctional therapeutic platform for lysosome-targeted imaging and displayed much higher cytotoxicity than its analogue 1 by the introduction of a methyl group instead of a hydrogen atom in acylhydrazone. The cyclic voltammograms and reaction with GSH (glutathione) further confirmed that complex 1 has a reversible redox peak and can react with GSH, which indicate that complex 1 might lose its anticancer effect by undergoing reaction with GSH once it enters the cancer cell. Read More

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January 2019

The effect of 2.45 GHz non-ionizing radiation on the structure and ultrastructure of the testis in juvenile rats.

Histol Histopathol 2019 Apr 27;34(4):391-403. Epub 2018 Sep 27.

Department of Anatomy, Histology and Physiology, Institute of Histology and Embryology, University of Veterinary Medicine and Pharmacy in Košice, Slovakia.

Background: Nowadays, mobile devices that emit non-ionizing electromagnetic radiation (EMR) are predominantly used by juveniles and pubescents. The aim of the present study was to evaluate the effect of whole body pulsed EMR on the juvenile Wistar albino rat testis at a frequency of 2.45 GHz and mean power density of 2. Read More

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Dynamic influence of Rhein lysinate on HeLa cells.

Int J Oncol 2018 Nov 5;53(5):2047-2055. Epub 2018 Sep 5.

The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China.

In a previous study, it was demonstrated that Rhein lysinate (RHL) inhibited HeLa cell proliferation via a specific mechanism. The aim of the present study was to clarify the mechanism of RHL by investigating its effect on mitochondrial damage and cell apoptosis. The results indicated that RHL inhibited cell growth and proliferation in HeLa cells. Read More

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November 2018

Increased expression of CHOP and LC3B in newborn rats with bronchopulmonary dysplasia.

Int J Mol Med 2018 Sep 8;42(3):1653-1665. Epub 2018 Jun 8.

Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.

Bronchopulmonary dysplasia (BPD) seriously affects the health and prognosis of children, but the efficacy of treatments is poor. The present study aimed to examine the effects of C/EBP homologous protein (CHOP), activating transcription factor 4 (ATF4) and microtubule‑associated protein light chain 3β (LC3B), and the interaction between CHOP and LC3B, in newborn rats with BPD. At 1, 7, 14 and 21 days, the rats in the model [fraction of inspired oxygen (FiO2)=80‑85%] and control groups (FiO2=21%) were randomly sacrificed, and lung samples were collected. Read More

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September 2018

Positive PCNA and Ki-67 Expression in the Testis Correlates with Spermatogenesis Dysfunction in Fluoride-Treated Rats.

Biol Trace Elem Res 2018 Dec 10;186(2):489-497. Epub 2018 May 10.

College of Animal Science and Technology, Henan University of Science and Technology, Kaiyuan Avenue 263, Luoyang, 471000, Henan, People's Republic of China.

The present study aimed to evaluate the effect of fluoride (F) on spermatogenesis in male rats. F at 50 and 100 mg/L was administered for 70 days, after which the testicular and epididymis tissues were collected to observe the histopathological structure under a light microscope. The ultrastructure of the testis and sperm was also examined via transmission electron microscopy. Read More

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December 2018

[Effects of ShenFu Injection on Peripheral Neurotoxicity of Paclitaxel].

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Jan;49(1):44-47

Department of Gynecology and Obstetrics,West China Second University Hospital, Sichuan University,Chengdu 610041,China.

Objective: To investigate the effects and the underlying mechanisms of ShenFu Injection on paclitaxel-induced peripheral neuropathy.

Methods: Twenty-eight adult male Wister rats were randomized into 4 groups (=7) : control group, paclitaxel group, paclitaxel combined with low or high dose of ShenFu Injection groups. Rats were intraperitoneally injected with paclitaxel 8 mg/kg every 4 d for a total of 4 doses except control group. Read More

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January 2018

Mitochondria-Mediated Pathway Regulates C2C12 Cell Apoptosis Induced by Fluoride.

Biol Trace Elem Res 2018 Oct 29;185(2):440-447. Epub 2018 Mar 29.

Henan Provincial Open Laboratory of Key Disciplines, Environment and Animal Products Safety, College of Animal Science and Technology, Henan University of Science and Technology, Kaiyuan Avenue 263, Luoyang, 471000, Henan, People's Republic of China.

This study was designed to investigate the mechanisms of excessive fluoride-induced apoptosis via mitochondria-mediated pathway in skeletal muscle cells (C2C12 cells). C2C12 cells were cultured with the fluoride concentrations (0, 1, and 2.5 mmol/L) for 48 h. Read More

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October 2018

Therapeutic potential of (Linn.) on ageing induced damage in dorsal nerve of the penis and its implication on erectile function: an experimental study using albino rats.

Aging Male 2020 Dec 15;23(5):313-326. Epub 2018 Feb 15.

Department of Electrical and Electronics Engineering, Loyola-ICAM College of Engineering and Technology, Chennai, India.

Objective: To study the effect of ethanolic seed extract of on damaged dorsal nerve of the penis (DNP) in aged rat in relation to penile erection.

Methods: The rats were divided into four groups Young (3 months), Aged (24 - 28 months), Aged +  and Young +  (200 mg/kg b.w/60 days) and were subjected to the hypophysial - gonadal axis, nerve conduction velocity (NCV), and penile reflex. Read More

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December 2020

TP53-induced glycolysis and apoptosis regulator is indispensable for mitochondria quality control and degradation following damage.

Oncol Lett 2018 Jan 31;15(1):155-160. Epub 2017 Oct 31.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Mitochondria have been described as 'the powerhouse of the cell' as the organelle generates the majority of adenosine triphosphate (ATP) in cells to support life. Mitochondria can be damaged due to stress, for example by reactive oxygen species (ROS). TP53-induced glycolysis and apoptosis regulator (TIGAR) serves a role in suppressing ROS damage and may protect mitochondria integrity. Read More

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January 2018

Assessment of copper nanoparticles (Cu-NPs) and copper (II) oxide (CuO) induced hemato- and hepatotoxicity in Cyprinus carpio.

Nanotechnology 2018 Apr;29(14):144003

Department of Zoology, Government College University Faisalabad, Pakistan.

Recently, Cu-based nanoparticles have drawn considerable attention for their various fascinating roles in multiple biological systems. It is recognized that their frequent use can create compatibility challenges for the recipient systems. Nevertheless, it is unclear how various biological interactions affect the compatibility of Cu oxide II (CuO) and Cu oxide nanoparticles (Cu-NPs) for different organisms. Read More

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[Effect of nerve growth factor on chronic peripheral neuropathy in rats induced by 1-bromopropane].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2017 Jul;35(7):497-500

Dept of Toxicology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China.

To observe the effect of nerve growth factor (NGF) and Mecobalamin on chronic peripheral neuropathy in rats induced by 1-bromopropane. 36 male SD rats were exposed to 1-bromopropane vapor at concentrations of 4 000 mg/m(3), 6 hours per day, 5 days per week for 12 weeks. The rats were randomed divided into 4 groups, and treated by Mecobalamin for 300 μg/kg qd, NGF for 40 μg/kg qd, Mecobalamin+NGF with the dose as mentioned above, respecively. Read More

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Mitochondria-rich cells changes induced by nitrite exposure in tambaqui (Colossoma macropomum Cuvier, 1818).

An Acad Bras Cienc 2017 Apr-Jun;89(2):965-972. Epub 2017 May 15.

Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos, Rodovia Washington Luis, Km 235, 13565-905 São Carlos, SP, Brazil.

The gill mitochondria-rich cells of the juvenile Amazonian fish Colossoma macropomum were analyzed using light and scanning and transmission electron microscopy after 96 h exposure to 0.04 and 0.2 mM nitrite. Read More

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Effects of concomitant diabetes mellitus and hyperthyroidism on testicular and epididymal histoarchitecture and steroidogenesis in male animals.

J Zhejiang Univ Sci B 2016 Nov.;17(11):850-863

Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

This study evaluated the effects of comorbid disorders of diabetes and hyperthyroidism in the adult male mice. In total, 32 ICR strain mice were equally distributed into four groups: control (C), diabetic (D), diabetic-plus-hyperthyroid (DH), and hyperthyroid (H). Mice allocated for diabetes received a single intraperitoneal injection of streptozotocin (STZ) at 200 mg/kg body weight. Read More

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Genotoxicity of ferric oxide nanoparticles in Raphanus sativus: Deciphering the role of signaling factors, oxidative stress and cell death.

J Environ Sci (China) 2016 Sep 18;47:49-62. Epub 2016 Apr 18.

Zoology Department, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; A.R. Al-Jeraisy Chair for DNA Research, Zoology Department, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

We have studied the genotoxic and apoptotic potential of ferric oxide nanoparticles (Fe2O3-NPs) in Raphanus sativus (radish). Fe2O3-NPs retarded the root length and seed germination in radish. Ultrathin sections of treated roots showed subcellular localization of Fe2O3-NPs, along with the appearance of damaged mitochondria and excessive vacuolization. Read More

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September 2016

Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine.

Toxicol Res (Camb) 2016 Jul 7;5(4):1202-1215. Epub 2016 Jun 7.

Discovery Sciences , Janssen Research & Development , L.L.C. , San Diego , CA , USA . Email:

This 10-day (D) study was conducted to evaluate changes in traditional and newer kidney safety biomarker expression levels in dogs. Animals received cisplatin (CDDP, 0.75 mg per kg per day) or 0. Read More

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Effects of L-cysteine on lead acetate induced neurotoxicity in albino mice.

Biotech Histochem 2016 Jul 4;91(5):327-32. Epub 2016 Apr 4.

a Zoology Department, Faculty of Science , Ain Shams University , Cairo , Egypt.

Lead is a toxic heavy metal that adversely affects nervous tissues; it often occurs as an environmental pollutant. We investigated histological changes in the cerebral cortex, hippocampus and cerebellum of adult albino mice following exposure to lead acetate. We also studied the possible ameliorative effect of the chelating agent, L-cysteine, on lead-induced neurotoxicity. Read More

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Protective effect of thymoquinone against lead-induced hepatic toxicity in rats.

Environ Sci Pollut Res Int 2016 Jun 14;23(12):12206-15. Epub 2016 Mar 14.

Laboratory of Histology and Cytogenetic (Research Unit of Genetic, Genotoxicity and Child Disease UR 12 ES 10), Faculty of Medicine, University of Monastir, Street Avicenna, Monastir, 5019, Tunisia.

Lead (Pb) intoxication is a worldwide health problem which frequently affects the liver. This study was carried out to investigate the potential protective effect of thymoquinone (TQ), the major active ingredient of volatile oil of Nigella sativa seeds, against Pb-induced liver damage. Adult male rats were randomized into four groups: Control group received no treatment, Pb group was exposed to 2000 ppm Pb acetate in drinking water, Pb-TQ group was cotreated with Pb plus TQ (5 mg/kg/day, per orally), and TQ group receiving only TQ. Read More

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Selenite induces DNA damage and specific mitochondrial degeneration in human bladder cancer cells.

Toxicol In Vitro 2016 Apr 21;32:105-14. Epub 2015 Dec 21.

Department of Medical Biology and Genetics, Charles University in Prague, Faculty of Medicine in Hradec Králové, Šimkova 870, 500 38 Hradec Králové, Czech Republic. Electronic address:

We have investigated the cytotoxicity and specific effects of selenite in human bladder cancer cell line RT-112 and its clonogenic variant RT-112 HB. Selenite inhibited cell growth and proliferation in both cell lines. Treated cells developed extensive vacuolization which was dose independent but occurring in differing time frames. Read More

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Overexpression of AtPCS1 in tobacco increases arsenic and arsenic plus cadmium accumulation and detoxification.

Planta 2016 Mar 13;243(3):605-22. Epub 2015 Nov 13.

Department of Environmental Biology, "Sapienza" University of Rome, Rome, Italy.

Main Conclusion: The heterologous expression of AtPCS1 in tobacco plants exposed to arsenic plus cadmium enhances phytochelatin levels, root As/Cd accumulation and pollutants detoxification, but does not prevent root cyto-histological damages. High phytochelatin (PC) levels may be involved in accumulation and detoxification of both cadmium (Cd) and arsenic (As) in numerous plants. Although polluted environments are frequently characterized by As and Cd coexistence, how increased PC levels affect the adaptation of the entire plant and the response of its cells/tissues to a combined contamination by As and Cd needs investigation. Read More

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Morpho-functional characterization and esterase patterns of the midgut of Tribolium castaneum Herbst, 1797 (Coleoptera: Tenebrionidae) parasitized by Gregarina cuneata (Apicomplexa: Eugregarinidae).

Micron 2015 Sep 30;76:68-78. Epub 2015 May 30.

Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá (UEM), Paraná, Brazil. Electronic address:

Tribolium castaneum (Coleoptera: Tenebrionidae) is a common pest of stored grains and byproducts and is normally infected by Gregarina cuneata (Apicomplexa: Eugregarinidae). The life cycle of this parasite includes the sporozoite, trophozoite, gamont, gametocyte, and oocyst stages, which occur between the epithelium and lumen of the host's midgut. This study aims to describe the morphofunctional alterations in the midgut and determine the esterase patterns in T. Read More

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September 2015

4-Nitrobenzaldehyde thiosemicarbazone: a new compound derived from S-(-)-limonene that induces mitochondrial alterations in epimastigotes and trypomastigotes of Trypanosoma cruzi.

Parasitology 2015 Jun 25;142(7):978-88. Epub 2015 Feb 25.

Programa de Pós-graduação em Ciências Farmacêuticas,Universidade Estadual de Maringá,PR,Avenida Colombo,5790,Jd. Universitário,Maringá,Paraná 87020-900,Brazil.

Trypanosoma cruzi is the causative agent of Chagas' disease, a parasitic disease that remains a serious health concern with unsatisfactory treatment. Drugs that are currently used to treat Chagas' disease are partially effective in the acute phase but ineffective in the chronic phase of the disease. The aim of the present study was to evaluate the antitrypanosomal activity and morphological, ultrastructural and biochemical alterations induced by a new molecule, 4-nitrobenzaldehyde thiosemicarbazone (BZTS), derived from S-(-)-limonene against epimastigote, trypomastigote and intracellular amastigote forms of T. Read More

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