939 results match your criteria vaccine autism

A proposed service model for early identification of autism spectrum disorder in ethnic communities in Southern Israel.

Health Soc Care Community 2021 Jun 3. Epub 2021 Jun 3.

Department of Health Systems Management, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Early autism spectrum disorder (ASD) detection is a precondition for effective intervention and facilitates significant improvements in functioning. In Israel, toddlers undergo general developmental screening by public health nurses (PHNs) at maternal and child health centres (MCHCs). Nevertheless, there are disparities among ethnic groups in the reported incidence of ASD. Read More

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Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.

Vaccine 2021 May 23. Epub 2021 May 23.

RAND Corporation, 1776 Main Street, Santa Monica, CA 90401, United States; Southern California Evidence Review Center, University of Southern California, Keck School of Medicine, 2001 N Soto Street, Los Angeles, CA 90033, United States.

Background: Understanding the safety of vaccines is critical to inform decisions about vaccination. Our objective was to conduct a systematic review of the safety of vaccines recommended for children, adults, and pregnant women in the United States.

Methods: We searched the literature in November 2020 to update a 2014 Agency for Healthcare Research and Quality review by integrating newly available data. Read More

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Understanding Vaccine Hesitancy Among Parents of Children With Autism Spectrum Disorder and Parents of Children With Non-Autism Developmental Delays.

J Child Neurol 2021 May 28:8830738211000505. Epub 2021 May 28.

Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Parents of children with autism spectrum disorder (ASD) may be at greater risk for developing antivaccine beliefs that lead to vaccine delays and/or refusals for their children. We investigated current parental vaccine hesitancy, parents' beliefs about causes of children's developmental delays, and children's vaccination histories among parents of children with ASD or non-ASD developmental delays. Data were analyzed from 89/511 parents (17. Read More

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Brief Report: Impact of COVID-19 in Individuals with Autism Spectrum Disorders: Analysis of a National Private Claims Insurance Database.

J Autism Dev Disord 2021 May 26. Epub 2021 May 26.

Autism Speaks, 1060 State Rd, Princeton, NJ, USA.

The COVID-19 pandemic continues to have a detrimental impact on individuals with disabilities. Data from FAIR Health's FH® NPIC (National Private Insurance Claims) database, one of the nation's largest databases of private insurance claim records, were analyzed to understand the experiences of individuals with ASD in the COVID-19 pandemic. Multivariate logistic regression models revealed that individuals with ASD + ID were nine times more likely to be hospitalized following COVID-19 infection (OR = 9. Read More

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Maternal nutrients and effects of gestational COVID-19 infection on fetal brain development.

Clin Nutr ESPEN 2021 06 29;43:1-8. Epub 2021 Apr 29.

Department of Psychiatry, University of Colorado Denver School of Medicine, Mail Stop F-546, Anschutz Medical Center, Aurora, CO, 80045, USA. Electronic address:

Background & Aims: Maternal gestational infection is a well-characterized risk factor for offsprings' development of mental disorders including schizophrenia, autism, and attention deficit disorder. The inflammatory response elicited by the infection is partly directed against the placenta and fetus and is the putative pathogenic mechanism for fetal brain developmental abnormalities. Fetal brain abnormalities are generally irreversible after birth and increase risk for later mental disorders. Read More

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Vaccine safety issues at the turn of the 21st century.

BMJ Glob Health 2021 May;6(Suppl 2)

Essential Medicines and Health Products, Organisation mondiale de la Sante, Geneve, Switzerland.

Global gains in vaccination coverage during the early 21st century have been threatened by the emergence of antivaccination groups that have questioned the effectiveness of vaccines to generate public distrust of vaccines and immunisation programmes. This manuscript summarises six key topics that have been at the centre of global discussions on vaccine safety during the early 21st century: thiomersal in multi-dose non-live vaccines, aluminium adjuvants used with several non-live vaccines, autism and auto-immune conditions as possible consequences of vaccination, a risk of immune overload with increasing numbers of vaccinations, and detrimental non-specific effects (NSEs) of vaccination. For each topic, we describe the hypothesis behind the public concern, the evidence reviewed by the WHO's Global Advisory Committee for Vaccine Safety (GACVS) during 1999-2019, and any significant new data that has emerged since GACVS conclusions were made. Read More

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Preventing the next pandemic and tackling antiscience: an interview with Peter Hotez.

Peter Hotez

Future Microbiol 2021 05 17;16:539-541. Epub 2021 May 17.

Departments of Pediatrics and Molecular Virology and Microbiology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

This interview was conducted by Atiya Henry, Commissioning Editor of . Peter J Hotez, MD, PhD is Dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine. He is an internationally recognized physician-scientist in neglected tropical diseases and vaccine development. Read More

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Attitudes and beliefs of parents about routine childhood vaccination in Greece.

Hum Vaccin Immunother 2021 May 10:1-7. Epub 2021 May 10.

Department of Paediatrics, Medical School, University of Patras, Patras, Greece.

Vaccine hesitancy remains one of the 10 major global threats as per the WHO report in 2019. The aim of the present study is to assess attitudes and perceptions of vaccine hesitant parents in Greece with a view to implementing strategies to increase vaccine uptake. A cross-sectional questionnaire-based prospective survey was conducted between September 2019 and June 2020 on parents of children attending primary education in the city of Patras in Western Greece. Read More

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Reviewing the association between aluminum adjuvants in the vaccines and autism spectrum disorder.

Alberto Boretti

J Trace Elem Med Biol 2021 Jul 27;66:126764. Epub 2021 Apr 27.

Prince Mohammad Bin Fahd University, P.O. Box 1664, Al Khobar, 31952, Saudi Arabia. Electronic address:

The manuscript reviews the association between aluminum adjuvants (AlAd) in vaccines and autism spectrum disorder (ASD). Aluminum (Al) is neurotoxic. Infants who have received AlAd in vaccines show a higher rate of ASD. Read More

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A megastudy of text-based nudges encouraging patients to get vaccinated at an upcoming doctor's appointment.

Proc Natl Acad Sci U S A 2021 05;118(20)

Harvard Kennedy School of Government, Harvard University, Cambridge, MA 02138.

Many Americans fail to get life-saving vaccines each year, and the availability of a vaccine for COVID-19 makes the challenge of encouraging vaccination more urgent than ever. We present a large field experiment ( = 47,306) testing 19 nudges delivered to patients via text message and designed to boost adoption of the influenza vaccine. Our findings suggest that text messages sent prior to a primary care visit can boost vaccination rates by an average of 5%. Read More

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The role of sex-differentiated variations in stress hormones, antioxidants, and neuroimmune responses in relation to social interaction impairment in a rodent model of autism.

Metab Brain Dis 2021 Apr 17. Epub 2021 Apr 17.

Central Laboratory, Female Center for Medical Studies and Scientific Section, King Saud University, P O Box 22452, Riyadh, 11495, Saudi Arabia.

Males are more likely to develop autism as a neurodevelopmental disorder than females, but the mechanisms underlying male susceptibility are not fully understood. In this paper, we used a well-characterized propionic acid (PPA) rodent model of autism to study sex differences in stress hormones, antioxidants' status, and the neuroimmune response that may contribute to the preponderance of autism in males. Sprague Dawley rats of both sexes were divided into a saline-treated group as controls and PPA-treated groups, receiving 250 mg/kg of PPA per day for three days. Read More

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["If there is a risk, I should have a choice:" Risk management and risk perception in Italian vaccine hesitancy movements].

Salud Colect 2021 Feb 10;17:e3231. Epub 2021 Feb 10.

Licenciada en Antropología Médica y Salud Global. Magíster en Antropología Médica y Salud Global, Universitat Rovira i Virgili, Tarragona, Cataluña, España.

In Italy, the passing of mandatory pediatric vaccinations in 2017 was a consequence of increasing vaccine hesitancy in the country, a phenomenon that has largely spread on social networks. This article examines risk management and risk perception regarding pediatric vaccinations through an analysis of online content shared by Italian vaccine hesitancy movements between December of 2019 and April of 2020. Results show that these movements carry out a reinterpretation of risk, scientific evidence, and parental responsibility, especially with regard to the alleged correlation between the measles vaccine and autism. Read More

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February 2021

Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study.

Am J Obstet Gynecol 2021 Mar 26. Epub 2021 Mar 26.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA. Electronic address:

Background: Pregnant and lactating women were excluded from initial coronavirus disease 2019 vaccine trials; thus, data to guide vaccine decision making are lacking.

Objective: This study aimed to evaluate the immunogenicity and reactogenicity of coronavirus disease 2019 messenger RNA vaccination in pregnant and lactating women compared with: (1) nonpregnant controls and (2) natural coronavirus disease 2019 infection in pregnancy.

Study Design: A total of 131 reproductive-age vaccine recipients (84 pregnant, 31 lactating, and 16 nonpregnant women) were enrolled in a prospective cohort study at 2 academic medical centers. Read More

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Vaccine hesitancy and reported non-vaccination in an Irish pediatric outpatient population.

Eur J Pediatr 2021 Mar 27. Epub 2021 Mar 27.

Department of General Pediatrics, CHI at Temple Street, Dublin, Ireland.

Vaccine hesitancy is defined as a delay in acceptance, or refusal, of vaccines, despite availability. It is a complex and context specific phenomenon and identified as a global health priority. The "Parent Attitudes about Childhood Vaccines" (PACV) questionnaire is a validated tool for identifying vaccine hesitancy. Read More

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Vaccine hesitancy and anti-vaccination in the time of COVID-19: A Google Trends analysis.

Vaccine 2021 04 6;39(14):1877-1881. Epub 2021 Mar 6.

Institute of Life Course and Medical Sciences, University of Liverpool, Brownlow Hill, Liverpool L69 3BX, UK; Department of Rheumatology, Aintree Hospital, Liverpool University Hospitals NHS Foundation Trust, Lower Lane L9 7AL, UK. Electronic address:

The COVID-19 pandemic has produced many calls for a vaccine. There is growing concern that vaccine hesitancy and anti-vaccination presence will dampen the uptake of a coronavirus vaccine. There are many cited reasons for vaccine hesitancy. Read More

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Enhancement of Vaccination Attitude and Flu Vaccination Coverage among Pregnant Women Attending Birthing Preparation Course.

Vaccines (Basel) 2021 Feb 21;9(2). Epub 2021 Feb 21.

Women, Children and Public Health Sciences Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Most vaccinations are recommended within the 15th month of life, in order to reduce risks and to protect children from the initial stages of their lives. A vaccination training session was carried out during the birthing preparation course, aimed at increasing the attitude toward vaccination in maternal-child age. A questionnaire on vaccination awareness was administered before and after the training session and on-site flu vaccination was offered to women and their companions. Read More

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February 2021

Defending 'snake oil': The preservation of contentious knowledge and practices.

Catherine D Tan

Soc Stud Sci 2021 Feb 23:306312721992543. Epub 2021 Feb 23.

Vassar College, Poughkeepsie, NY, USA.

How does belief in controversial ideas persist? I study a community of parents and practitioners who contend that autism spectrum disorder is caused by harmful environmental exposures - notably, early childhood vaccinations - and that there are worthwhile alternative or experimental treatments. Despite objections from dominant experts, these actors maintain their disputed ideas. This study identifies a set of strategies that help maintain internal legitimacy. Read More

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February 2021

Medical Students and SARS-CoV-2 Vaccination: Attitude and Behaviors.

Vaccines (Basel) 2021 Feb 5;9(2). Epub 2021 Feb 5.

Department of Neurosurgery, Spine and Peripheral Nerves Surgery of Medical University of Lodz, 90-549 Łódź, Poland.

Since physicians play a key role in vaccination, the initial training of medical students (MS) should aim to help shape their attitude in this regard. The beginning of vaccination programs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an excellent time to assess the attitudes held by both medical and non-medical students regarding vaccination. A 51- to 53-item questionnaire including the Depression, Anxiety and Stress Scale was administered to 1971 students (49. Read More

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February 2021

Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder.

PLoS Genet 2021 02 4;17(2):e1009309. Epub 2021 Feb 4.

Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Recent advances in consortium-scale genome-wide association studies (GWAS) have highlighted the involvement of common genetic variants in autism spectrum disorder (ASD), but our understanding of their etiologic roles, especially the interplay with rare variants, is incomplete. In this work, we introduce an analytical framework to quantify the transmission disequilibrium of genetically regulated gene expression from parents to offspring. We applied this framework to conduct a transcriptome-wide association study (TWAS) on 7,805 ASD proband-parent trios, and replicated our findings using 35,740 independent samples. Read More

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February 2021

Effects of the Prenatal Administration of Tetanus Toxoid on the Sociability and Explorative Behaviors of Rat Offspring: A Preliminary Study.

Clin Psychopharmacol Neurosci 2021 Feb;19(1):84-92

Department of Radiation Oncolgy, Kartal Education and Research Hospital, Turkey.

Objective: Autism spectrum disorder (ASD) is a severely disabling psychiatric disease characterized by impairments in communication and social skills. Although efforts have been made to explore the etiology of ASD, its pathophysiology remains unclear. This issue is rendered more challenging by confounding data about the effects of vaccination on disease etiology. Read More

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February 2021

The impact of glutathione metabolism in autism spectrum disorder.

Pharmacol Res 2021 Apr 22;166:105437. Epub 2021 Jan 22.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy; CONEM Scientific Secretary, Verona, Italy.

This paper reviews the potential role of glutathione (GSH) in autism spectrum disorder (ASD). GSH plays a key role in the detoxification of xenobiotics and maintenance of balance in intracellular redox pathways. Recent data showed that imbalances in the GSH redox system are an important factor in the pathophysiology of ASD. Read More

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Compromised SARS-CoV-2-specific placental antibody transfer.

Cell 2021 02 23;184(3):628-642.e10. Epub 2020 Dec 23.

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address:

SARS-CoV-2 infection causes more severe disease in pregnant women compared to age-matched non-pregnant women. Whether maternal infection causes changes in the transfer of immunity to infants remains unclear. Maternal infections have previously been associated with compromised placental antibody transfer, but the mechanism underlying this compromised transfer is not established. Read More

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February 2021

Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020.

Microbiome 2021 01 4;9(1). Epub 2021 Jan 4.

Department of Medicine, The University of Texas at Houston Health Sciences Center, 6431 Fannin St, Houston, TX, 77030, USA.

The inaugural "Microbiome for Mars" virtual workshop took place on July 13, 2020. This event assembled leaders in microbiome research and development to discuss their work and how it may relate to long-duration human space travel. The conference focused on surveying current microbiome research, future endeavors, and how this growing field could broadly impact human health and space exploration. Read More

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January 2021

Deceptology in cancer and vaccine sciences: Seeds of immune destruction-mini electric shocks in mitochondria: Neuroplasticity-electrobiology of response profiles and increased induced diseases in four generations - A hypothesis.

Mahin Khatami

Clin Transl Med 2020 Dec;10(8):e215

Inflammation, Aging and Cancer, National Cancer Institute (NCI), the National Institutes of Health (NIH) (Retired), Bethesda, Maryland, USA.

From Rockefeller's support of patent medicine to Gates' patent vaccines, medical establishment invested a great deal in intellectual ignorance. Through the control over medical education and research it has created a public illusion to prop up corporate profit and encouraged the lust for money and power. An overview of data on cancer and vaccine sciences, the status of Americans' health, a survey of repeated failed projects, economic toxicity, and heavy drug consumption or addiction among young and old provide compelling evidence that in the twentieth century nearly all classic disease categories (congenital, inheritance, neonatal, or induced) shifted to increase induced diseases. Read More

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December 2020

Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic.

JAMA Netw Open 2020 12 1;3(12):e2030455. Epub 2020 Dec 1.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Biological data are lacking with respect to risk of vertical transmission and mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Objective: To quantify SARS-CoV-2 viral load in maternal and neonatal biofluids, transplacental passage of anti-SARS-CoV-2 antibody, and incidence of fetoplacental infection.

Design, Setting, And Participants: This cohort study was conducted among pregnant women presenting for care at 3 tertiary care centers in Boston, Massachusetts. Read More

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December 2020

Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility.

Science 2020 12;370(6523)

Department of Biology, University of Bari 'Aldo Moro', 70125 Bari, Italy.

The rhesus macaque () is the most widely studied nonhuman primate (NHP) in biomedical research. We present an updated reference genome assembly (Mmul_10, contig N50 = 46 Mbp) that increases the sequence contiguity 120-fold and annotate it using 6.5 million full-length transcripts, thus improving our understanding of gene content, isoform diversity, and repeat organization. Read More

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December 2020

Global Measles Epidemic Risk: Current Perspectives on the Growing Need for Implementing Digital Communication Strategies.

Risk Manag Healthc Policy 2020 3;13:2819-2826. Epub 2020 Dec 3.

Pediatric Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

A safe vaccine against measles has been available and globally recommended since 1974. The World Health Organization established measles elimination as a goal for 2020 but, unfortunately, this objective has not been achieved yet and outbreaks still occur. Herd immunity, ie, a population immunity higher than 95%, is required to stop the measles virus transmission. Read More

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December 2020

The Politicization of Health and Science: Role of Political Cues in Shaping the Beliefs of the Vaccine-Autism Link.

Health Commun 2020 Dec 14:1-9. Epub 2020 Dec 14.

School of Journalism and Mass Communication, University of South Carolina.

One critical lesson learned from public opinion research about climate change is that the cost of politicization is disastrous. Although the literature has shown the dire consequences of politicized science issues, few have examined how such politicization is possibly triggered by political leaders in a seemingly nonpartisan science topic. Using two experiments (total n = 1,249), this article demonstrates how political cues over scientific expertise shape individuals' beliefs in the vaccine and autism debate. Read More

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December 2020

Trends in Web Searches About the Causes and Treatments of Autism Over the Past 15 Years: Exploratory Infodemiology Study.

JMIR Pediatr Parent 2020 Dec 7;3(2):e20913. Epub 2020 Dec 7.

Paediatric Medicine, The Hospital for Sick Children, Toronto, ON, Canada.

Background: Ninety percent of adults in the United States use the internet, and the majority of internet users report looking on the web for health information using search engines. The rising prevalence of autism spectrum disorder (ASD), uncertainty surrounding its etiology, and variety of intervention approaches contribute to questions about its causes and treatments. It is not known which terms people search most frequently about ASD and whether web search queries have changed over time. Read More

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December 2020