Biotechnol Bioeng 2021 Apr 12. Epub 2021 Apr 12.
Grup d'Enginyeria Cel·lular i Bioprocessos, Escola d'Enginyeria, Universitat Autònoma de Barcelona, Campus de Bellaterra, Cerdanyola del Vallès, 08193, Barcelona, Spain.
The importance of developing new vaccine technologies towards versatile platforms that can cope with global virus outbreaks has been evidenced with the most recent SARS-CoV-2 pandemic. Virus-like particles (VLPs) are a highly immunogenic, safe and robust approach that can be used to base several vaccine candidates on. Particularly, HIV-1 Gag VLPs are a flexible system comprising a Gag core surrounded by a lipid bilayer that can be modified to present diverse types of membrane proteins or antigens against several diseases, like Influenza, dengue, west Nile virus or HPV, where it has been proven successful. Read More