11,398 results match your criteria vaccination general

Implementation of a program to improve influenza vaccination rates among medical students: a comparative study involving two university affiliated hospitals.

Hum Vaccin Immunother 2021 Jun 15:1-8. Epub 2021 Jun 15.

Unit of Infectious Diseases, University Hospital "12 de Octubre", Instituto de Investigación Hospital "12 de Octubre" (Imas12), School of Medicine, Universidad Complutense, Madrid, Spain.

: Influenza vaccination rates among medical students (MSs) are below the standards recommended in hospitals where influenza vaccination is not mandatory. We carried out a comparative study in two Spanish university hospitals to reassert this fact and evaluated the impact on vaccination rates of a specific program aimed at promoting influenza vaccination among MSs.: A descriptive cross-sectional study was performed describing influenza vaccination rates and motivations for vaccination during the 2017/18 campaign among MSs in two hospitals affiliated to the same university. Read More

View Article and Full-Text PDF

Feasibility and safety of rVSV-ZEBOV vaccination of humanitarian health workers against Ebola virus disease: an observational study.

J Travel Med 2021 Jun 15. Epub 2021 Jun 15.

Division of Tropical and Humanitarian Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 6, Geneva 1205, Switzerland.

Background And Rationale: Geneva University Hospitals were granted a temporary authorization to administer the recombinant live vesicular stomatitis virus rVSV-ZEBOV (Ervebo®) vaccine to expatriate humanitarian frontline workers (FLWs) prior to mission deployment.

Objectives: Our aims were to assess the feasibility of FLW vaccination before deployment and to report adverse events (AEs).

Methods: FLWs received a single injection of rVSV-ZEBOV (>7. Read More

View Article and Full-Text PDF

Prevention and management of herpes zoster in patients with rheumatoid arthritis and psoriatic arthritis: a clinical review.

Clin Exp Rheumatol 2021 May 28. Epub 2021 May 28.

Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.

The risk of herpes zoster (HZ) and HZ-related complications is increased in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) relative to the general population; therefore, HZ vaccination is recommended in these patient groups. In this literature-based review, we summarise the available evidence on the use of HZ vaccines in patients with RA and PsA, and discuss strategies for managing breakthrough infection. Currently available data show suboptimal rates of HZ vaccination among these patients and highlight a need for strategies to improve HZ vaccination programmes in clinical practice. Read More

View Article and Full-Text PDF

The epidemic burden on prisons in Lombardy (Italy) during the first wave of the COVID-19 pandemic: the transmission and measures of prevention in detention facilities.

Int J Prison Health 2021 06;ahead-of-print(ahead-of-print)

Welfare General Directorate, Lombardy Regional Health Authority, Milan, Italy.

Purpose: Early on in the COVID-19 pandemic, the scientific community highlighted a potential risk of epidemics occurring inside prisons. Consequently, specific operational guidelines were promptly released, and containment measures were quickly implemented in prisons. This paper aims to describe the spread of COVID-19 in detention facilities within the Lombardy region of Italy during March to July 2020, and the impact of the prevention and control measures implemented. Read More

View Article and Full-Text PDF

Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study.

Ann Rheum Dis 2021 Jun 14. Epub 2021 Jun 14.

Rheumatology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Introduction: Vaccination represents a cornerstone in mastering the COVID-19 pandemic. Data on immunogenicity and safety of messenger RNA (mRNA) vaccines in patients with autoimmune inflammatory rheumatic diseases (AIIRD) are limited.

Methods: A multicentre observational study evaluated the immunogenicity and safety of the two-dose regimen BNT162b2 mRNA vaccine in adult patients with AIIRD (n=686) compared with the general population (n=121). Read More

View Article and Full-Text PDF

Patient characteristics associated with the use of pharmacist-administered vaccination services and predictors of service utilization.

J Am Pharm Assoc (2003) 2021 May 29. Epub 2021 May 29.

Background: Data on the impact of pharmacists as vaccinators are available; however, research on understanding the characteristics of users of pharmacist-administered vaccinations is scarce.

Objectives: This study aimed to identify the characteristics of the users of pharmacist-administered vaccinations and recognize predictors of utilizing these services.

Methods: Data were obtained from a cross-sectional online survey, and the sample size was 26,173 respondents from all over the United States. Read More

View Article and Full-Text PDF

School-based HPV vaccination positively impacts parents' attitudes toward adolescent vaccination.

Vaccine 2021 Jun 11. Epub 2021 Jun 11.

Speciality of Child and Adolescent Health, Faculty of Medicine and Health, University of Sydney, NSW, Australia.

Introduction: This qualitative study aimed to explore parental attitudes, knowledge and decision-making about HPV vaccination for adolescents in the context of a gender-neutral school-based Australian National Immunisation Program (NIP).

Methods: Semi-structured interviews with parents of adolescents eligible for HPV vaccination were undertaken as part of an evaluation of a cluster-randomised controlled trial of a complex intervention in 40 schools (2013-2015). In this qualitative study, we purposively recruited a nested sample of parents from 11 schools across two Australian jurisdictions. Read More

View Article and Full-Text PDF

Post-vaccination HPV seroprevalence among female sexual health clinic attenders in England.

Vaccine 2021 Jun 11. Epub 2021 Jun 11.

Blood Safety, Hepatitis, Sexually Transmitted Infections (STI) and HIV Service, Public Health England, London, UK.

Background: The National HPV Immunisation Programme was introduced in England in September 2008 using the HPV16/18 bivalent vaccine. We conducted serological surveillance to explore vaccination coverage levels. We also conducted a case-control study to investigate a hypothesised cross-protective effect of the HPV16/18 vaccine against genital warts. Read More

View Article and Full-Text PDF

Allergic symptoms after mRNA COVID-19 vaccination and risk of incomplete vaccination.

J Allergy Clin Immunol Pract 2021 Jun 11. Epub 2021 Jun 11.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Clinical Epidemiology Program, The Mongan Institute, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

View Article and Full-Text PDF

History of influenza immunization in COVID-19 patients: impact on mortality.

Gac Med Mex 2021 ;157(1):102-106

Technical Committee for the Prevention, Care and Control of COVID-19.

Introduction: In the context of the COVID-19 pandemic, there is concern regarding the impact of the influenza season.

Objective: To analyze the impact of influenza immunization history on patients with SARS-CoV-2 infection.

Methods: Patients older than 18 years with COVID-19, registered between March and August 2020, were included. Read More

View Article and Full-Text PDF
January 2021

Severe Exacerbations of Systemic Capillary Leak Syndrome After COVID-19 Vaccination: A Case Series.

Ann Intern Med 2021 Jun 15. Epub 2021 Jun 15.

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (M.M., A.R.E., K.M.D.).

View Article and Full-Text PDF

Operational tolerance after pediatric composite liver-pancreas-intestine transplantation following severe graft-versus-host disease.

Pediatr Transplant 2021 Jun 14:e14069. Epub 2021 Jun 14.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: While operational tolerance has been previously described in isolated intestinal transplant, reports of this phenomenon in combined liver-intestine transplant are lacking.

Case Description: We detail a unique case of a patient who received a composite allograft including liver, pancreas, and small bowel due to short gut syndrome secondary to gastroschisis complicated by volvulus. The indication for transplantation was permanent dependence on total parenteral nutrition, end-stage liver disease, recurrent sepsis, and persistent stomal variceal hemorrhage. Read More

View Article and Full-Text PDF

Vaccination in Older Adults: An Underutilized Opportunity to Promote Healthy Aging in India.

Drugs Aging 2021 Jun 14;38(6):469-479. Epub 2021 Jun 14.

Medical Affairs Department, GlaxoSmithKline Pharmaceuticals Ltd., 205, 2nd Floor, 62 Navketan Building, Secunderabad, Hyderabad, 500003, India.

Over the last 50 years, the Indian population aged 50 years and above (older adults) has quadrupled and is expected to comprise 404 million people in 2036, representing 27% of the country's projected population. Consequently, the contribution of chronic disease to older adults' total burden of diseases in India is likely to escalate. Disease burden is notably amplified by immunosenescence, a deterioration of the immune system that develops with age, leading to increasing susceptibility to infectious diseases and other comorbidities. Read More

View Article and Full-Text PDF

Virologic features of SARS-CoV-2 infection in children.

medRxiv 2021 Jun 3. Epub 2021 Jun 3.

Harvard Medical School, Boston, MA, USA.

Background: Data on viral factors causing pediatric disease and guidance for pediatric-specific considerations have lagged behind adults throughout the COVID-19 pandemic. As COVID-19 infections and deaths increase in the pediatric population, characterization of SARS-CoV-2 viral dynamics in children would enable data-driven public health guidance.

Methods: Nasal swabs collected from children with COVID-19 were analyzed. Read More

View Article and Full-Text PDF

Mandatory Infant Vaccinations in France During the COVID-19 Pandemic in 2020.

Front Pediatr 2021 28;9:666848. Epub 2021 May 28.

EPI-PHARE (French National Agency for Medicines and Health Products Safety, ANSM; and French National Health Insurance, CNAM), Saint-Denis, France.

To describe changes in the dispensation of 11 mandatory vaccines to infants in France during the COVID-19 pandemic in 2020, considering the priming doses and boosters separately. With data from the French national health database, all dispensations of priming doses and boosters of 11 mandatory vaccines [penta/hexavalent, measles mumps rubella (MMR), meningococcal conjugate type-C (Men-C-C), 13-valent pneumococcal conjugate (PCV13)] for infants ≤24 months old were aggregated by 4-week periods in 2020. Expected counts in 2020 were estimated according to counts in 2019 weighted by a ratio considering the level of vaccine dispensation before the pandemic onset in 2020. Read More

View Article and Full-Text PDF

Infection control awareness level among dental laboratory technicians, Riyadh, Saudi Arabia.

J Family Med Prim Care 2021 Apr 29;10(4):1540-1546. Epub 2021 Apr 29.

General Dentist, College of Dentistry, PNU, Riyadh, Saudi Arabia.

Aims And Objectives: Infection control is an essential part in dental practices. Potential disease transmission in the dental lab is well documented. Dental technicians should strictly adhere to the standard precautions in order to prevent potential risks of cross-contamination, thereby producing a safe environment for patients and staff. Read More

View Article and Full-Text PDF

Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections.

Front Cell Infect Microbiol 2021 28;11:642583. Epub 2021 May 28.

Department of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, Spain.

Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen [HLA] A, B, and C) may affect susceptibility to many diseases such as cancer, auto-immune or infectious diseases. Individual genetic variation may help to explain different immune responses to microorganisms across a population. HLA typing can be fast and inexpensive; however, deciphering peptides loaded on MHC-I and II which are presented to T cells, require the design and development of high-sensitivity methodological approaches and subsequently databases. Read More

View Article and Full-Text PDF

Socio-demographic and health factors drive the epidemic progression and should guide vaccination strategies for best COVID-19 containment.

Results Phys 2021 Jul 8;26:104433. Epub 2021 Jun 8.

Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia.

We propose and study an epidemiological model on a social network that takes into account heterogeneity of the population and different vaccination strategies. In particular, we study how the COVID-19 epidemics evolves and how it is contained by different vaccination scenarios by taking into account data showing that older people, as well as individuals with comorbidities and poor metabolic health, and people coming from economically depressed areas with lower quality of life in general, are more likely to develop severe COVID-19 symptoms, and quicker loss of immunity and are therefore more prone to reinfection. Our results reveal that the structure and the spatial arrangement of subpopulations are important epidemiological determinants. Read More

View Article and Full-Text PDF

SARS-CoV-2 infection and COVID‒19 in Gaucher disease: indications for vaccination

László Maródi

Orv Hetil 2021 06 13;162(24):938-942. Epub 2021 Jun 13.

1 Semmelweis Egyetem, Általános Orvostudományi Kar, Bőr-, Nemikórtani és Dermatoonkológiai Klinika, Primer Immundeficiencia Klinikai Egység és Laboratórium, Budapest, Mária u. 41., 1085.

Összefoglaló. Az új típusú koronavírus (SARS-CoV-2) okozta pandémia kezdetén a szakmai közvélemény általános vélekedése a Gaucher-kóros betegek fokozott érzékenységét vetítette elő, magas morbiditási és mortalitási mutatókkal. Meglepő módon azonban az eddigi, nagyszámú betegen, az Egyesült Államokban, Európában és Izraelben végzett klinikai tanulmányok azt mutatják, hogy ezen súlyos anyagcsere-betegségben sem a fertőzésnek kitett betegek morbiditási adatait, sem a ritkán kialakult fertőzések súlyosságát tekintve nem áll fenn csökkent immunvédekezés a SARS-CoV-2-vel szemben. Read More

View Article and Full-Text PDF

Diabetes and COVID-19: The Past, The Present, and The Future.

Metabolism 2021 Jun 10:154814. Epub 2021 Jun 10.

Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia.

Diabetes, one of the most prevalent chronic diseases in the world, is strongly associated with a poor prognosis in COVID-19. Scrupulous blood sugar management is crucial, since the worse outcomes are closely associated with higher blood sugar levels in COVID-19 infection. Although recent observational studies showed that insulin was associated with mortality, it should not deter insulin use in hospitalized patients requiring tight glucose control. Read More

View Article and Full-Text PDF

Charting mandatory childhood vaccination policies worldwide.

Vaccine 2021 Jun 10. Epub 2021 Jun 10.

Oxford Vaccine Group and Oxford Martin School, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Old Road, Oxford OX3 7LE, United Kingdom.

Mandatory childhood vaccination is becoming an increasingly important policy intervention for governments trying to address low vaccination rates. Mandates require vaccination for a certain purpose, most commonly related to school entry for children. However, the discussion surrounding the extent and impact of mandatory vaccination programmes for babies and children have largely been limited to high-income countries. Read More

View Article and Full-Text PDF

Evaluation of post-introduction COVID-19 vaccine effectiveness: Summary of interim guidance of the World Health Organization.

Vaccine 2021 Jun 1. Epub 2021 Jun 1.

World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland.

Phase 3 randomized-controlled trials have provided promising results of COVID-19 vaccine efficacy, ranging from 50 to 95% against symptomatic disease as the primary endpoints, resulting in emergency use authorization/listing for several vaccines. However, given the short duration of follow-up during the clinical trials, strict eligibility criteria, emerging variants of concern, and the changing epidemiology of the pandemic, many questions still remain unanswered regarding vaccine performance. Post-introduction vaccine effectiveness evaluations can help us to understand the vaccine's effect on reducing infection and disease when used in real-world conditions. Read More

View Article and Full-Text PDF

Willingness to get vaccinated against Covid-19 and attitudes toward vaccination in general.

Vaccine 2021 May 26. Epub 2021 May 26.

UCLouvain, IRSS (Institute for Health and Society) & IRES (Institute of Economic and Social Research), Université catholique de Louvain - Clos Chapelle-aux-Champs, 30, Box B1.30.01, B-1200 Brussels, Belgium. Electronic address:

Background: High uptake of Covid-19 vaccination is required to reach herd immunity.

Methods: A representative sample of 2,060 Belgians were surveyed in October 2020. Regression analyses identified the predictors associated with willingness to get vaccinated against Covid-19, and attitudes toward vaccination in general. Read More

View Article and Full-Text PDF

SARS-CoV-2 vaccination for patients with inflammatory bowel disease - Authors' reply.

Lancet Gastroenterol Hepatol 2021 07;6(7):523-524

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK. Electronic address:

View Article and Full-Text PDF

Perspectives of research ethics committee members on human challenge studies in the development of vaccines against COVID-19: a mixed methods study.

Ann Palliat Med 2021 Jun 7. Epub 2021 Jun 7.

Ethics Committee for Medical Scientific Research, Peking University Third Hospital, Beijing, China; Department of Orthopedics, Peking University Third Hospital, Beijing, China.

Background: Vaccines are considered the most effective protection against the coronavirus disease 2019 (COVID-19). Human Challenge Studies can help to shorten the development process of vaccines. The reviewers' opinions from research ethics committees (REC) play an essential gate-keeping role in determining whether a clinical trial can be conducted or not. Read More

View Article and Full-Text PDF

Emerging Infection, Vaccination, and Guillain-Barré Syndrome: A Review.

Neurol Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.

Guillain-Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system that typically develops within 4 weeks after infection. In addition to conventional infectious diseases with which we are familiar, emerging infectious diseases, such as Zika virus infection and coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have also been suggested to be associated with GBS. GBS is mainly categorized into a demyelinating subtype known as acute inflammatory demyelinating polyneuropathy (AIDP) and an axonal subtype known as acute motor axonal neuropathy (AMAN). Read More

View Article and Full-Text PDF

Implications of mRNA-based SARS-CoV-2 vaccination for cancer patients.

J Immunother Cancer 2021 06;9(6)

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.

SARS-CoV-2 infection and the resulting COVID-19 have afflicted millions of people in an ongoing worldwide pandemic. Safe and effective vaccination is needed urgently to protect not only the general population but also vulnerable subjects such as patients with cancer. Currently approved mRNA-based SARS-CoV-2 vaccines seem suitable for patients with cancer based on their mode of action, efficacy, and favorable safety profile reported in the general population. Read More

View Article and Full-Text PDF

Vaccinations in patients with inflammatory bowel disease.

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Department of Biomedical and Clinical Sciences, L Sacco" University of Milan, Via Giovan Battista Grassi 74, Milan 20157, Italy.

Treatment of inflammatory bowel disease (IBD) frequently requires administration of immunosuppressive therapies, which increases susceptibility to a number of infectious pathogens. However, many infections can be prevented by correct and appropriate utilization of vaccinations. While several guidelines have been published on vaccination schedules in patients with IBD, vaccination rates remain suboptimal and even lower than those in the general population. Read More

View Article and Full-Text PDF

Topics and Sentiments in COVID-19 Vaccine-related Discussion on Twitter.

J Med Internet Res 2021 Jun 10. Epub 2021 Jun 10.

Department of Mathematics, University of California, Davis, Davis, US.

Background: Though vaccination is a cornerstone for the prevention of communicable infectious diseases, vaccination has traditionally faced public fears, hesitancy. COVID-19 vaccines are no exception. Social media use plays a role in low acceptance of vaccines. Read More

View Article and Full-Text PDF

Temporary vaccination clinic for COVID-19 in Zhuhai, China.

Hum Vaccin Immunother 2021 Jun 11:1-3. Epub 2021 Jun 11.

Deputy Secretary of Party Committee & Vice President, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, China.

Vaccines are urgently needed to control the COVID-19 pandemic. To gradually increase the vaccination rate among residents, temporary vaccination clinic for COVID-19 plays an important role. It should be located in an area with convenient transportation and concentrated population. Read More

View Article and Full-Text PDF