251 results match your criteria vaccination claim


High Doses of Inactivated African Swine Fever Virus Are Safe, but Do Not Confer Protection against a Virulent Challenge.

Vaccines (Basel) 2021 Mar 10;9(3). Epub 2021 Mar 10.

VISAVET Health Surveillance Center, Complutense University of Madrid, 28040 Madrid, Spain.

African swine fever (ASF) is currently the major concern of the global swine industry, as a consequence of which a reconsideration of the containment and prevention measures taken to date is urgently required. A great interest in developing an effective and safe vaccine against ASF virus (ASFV) infection has, therefore, recently appeared. The objective of the present study is to test an inactivated ASFV preparation under a vaccination strategy that has not previously been tested in order to improve its protective effect. Read More

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Richard Pfeiffer's typhoid vaccine and Almroth Wright's claim to priority.

Vaccine 2021 Apr 13;39(15):2074-2079. Epub 2021 Mar 13.

Trust Archivist and Curator, Alexander Fleming Laboratory Museum, Imperial College Healthcare NHS Trust, St Mary's Hospital, Praed Street, London W2 1NY, United Kingdom. Electronic address:

Following the 1892 cholera pandemic, Richard Pfeiffer, Director of the science section of Robert Koch's Institute for Hygiene in Berlin, began laboratory-based studies on the pathogenesis of the disease using an animal model. These investigations resulted in his discovery of bacterial endotoxin; recognition of the bacteriolytic properties of both animal and human immune sera; and identification of the specific nature of protective immune responses. His research led naturally from cholera to typhoid fever and in November 1896 Pfeiffer published the results of experimental studies on a typhoid vaccine. Read More

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Ethics of vaccine refusal.

Authors:
Michael Kowalik

J Med Ethics 2021 Feb 26. Epub 2021 Feb 26.

Independent Researcher, Melbourne, VIC 3000, Australia

Proponents of vaccine mandates typically claim that everyone who can be vaccinated has a moral or ethical obligation to do so for the sake of those who cannot be vaccinated, or in the interest of public health. I evaluate several previously undertheorised premises implicit to the 'obligation to vaccinate' type of arguments and show that the general conclusion is false: there is neither a moral obligation to vaccinate nor a sound ethical basis to mandate vaccination under any circumstances, even for hypothetical vaccines that are medically risk-free. Agent autonomy with respect to self-constitution has absolute normative priority over reduction or elimination of the associated risks to life. Read More

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February 2021

Immuno-informatics approach for B-cell and T-cell epitope based peptide vaccine design against novel COVID-19 virus.

Vaccine 2021 02 9;39(7):1087-1095. Epub 2021 Jan 9.

Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160 012, India. Electronic address:

COVID-19 has brought the world to a standstill with a wave of destruction in country after country with tremendous loss of lives and livelihood in advanced to developing nations. Whole world is staring at the prospect of repeated lockdowns with another wave of COVID-19 predicted to hit the world in September of 2020. The second wave is assumed to be even more destructive with severe impact across much of the world. Read More

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February 2021

The European tiered approach for virucidal efficacy testing - rationale for rapidly selecting disinfectants against emerging and re-emerging viral diseases.

Euro Surveill 2021 01;26(3)

Schülke & Mayr GmbH, Norderstedt, Germany.

When facing an emerging virus outbreak such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a quick reaction time is key to control the spread. It takes time to develop antivirals and vaccines, and implement vaccination campaigns. Therefore, preventive measures such as rapid isolation of cases and identification and early quarantine of cases' close contacts-as well as masks, physical distancing, hand hygiene, surface disinfection and air control-are crucial to reduce the risk of transmission. Read More

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January 2021

Unfolding the Determinants of COVID-19 Vaccine Acceptance in China.

J Med Internet Res 2021 01 15;23(1):e26089. Epub 2021 Jan 15.

Zhejiang Gongshang University, Hangzhou, China.

Background: China is at the forefront of global efforts to develop COVID-19 vaccines and has five fast-tracked candidates at the final-stage, large-scale human clinical trials testing phase. Vaccine-promoting policymaking for public engagement is a prerequisite for social mobilization. However, making an informed and judicious choice is a dilemma for the Chinese government in the vaccine promotion context. Read More

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January 2021

Coronavirus Disease 2019 (COVID-19) Vaccines and Pregnancy: What Obstetricians Need to Know.

Obstet Gynecol 2021 03;137(3):408-414

Departments of Pediatrics, Obstetrics and Gynecology, and Epidemiology, University of Florida College of Medicine and College of Public Health and Health Professions, Gainesville, Florida; and the Division of Infectious Diseases and the Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, the Grady Healthcare System, Infectious Diseases Program, Atlanta, and the Hope Clinic of the Emory Vaccine Center, Decatur, Georgia.

Coronavirus disease 2019 (COVID-19) vaccines have begun to be distributed across the United States and to be offered initially to priority groups including health care personnel and persons living in long-term care facilities. Guidance regarding whether pregnant persons should receive a COVID-19 vaccine is needed. Because pregnant persons were excluded from the initial phase 3 clinical trials of COVID-19 vaccines, limited data are available on their efficacy and safety during pregnancy. Read More

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Analysis of 44 Vibrio anguillarum genomes reveals high genetic diversity.

PeerJ 2020 3;8:e10451. Epub 2020 Dec 3.

National Institute of Aquatic Resources Technical University of Denmark, Kongens Lyngby, Denmark.

Vibriosis, a hemorrhagic septicemic disease caused by the bacterium , is an important bacterial infection in Danish sea-reared rainbow trout. Despite of vaccination, outbreaks still occur, likely because the vaccine is based on strains from abroad/other hosts than rainbow trout. Information about the genetic diversity of specifically in Danish rainbow trout, is required to investigate this claim. Read More

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December 2020

Factors Associated with Survey Non-Response in a Cross-Sectional Survey of Persons with an Axial Spondyloarthritis or Osteoarthritis Claims Diagnosis.

Int J Environ Res Public Health 2020 12 9;17(24). Epub 2020 Dec 9.

Department of Health Services Research, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.

Non-response in surveys can lead to bias, which is often difficult to investigate. The aim of this analysis was to compare factors available from claims data associated with survey non-response and to compare them among two samples. A stratified sample of 4471 persons with a diagnosis of axial spondyloarthritis (axSpA) and a sample of 8995 persons with an osteoarthritis (OA) diagnosis from a German statutory health insurance were randomly selected and sent a postal survey. Read More

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December 2020

Does the BCG vaccine have different effects on strains of tuberculosis?

Clin Exp Immunol 2021 Feb 1;203(2):281-285. Epub 2020 Dec 1.

Family Health Research Institute, Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Several explanations have been suggested concerning the variety in bacille Calmette-Guerin (BCG) vaccine efficacy on strains of Mycobacterium tuberculosis (Mtb). This study aimed to compare the effect of BCG vaccination history in the prevention of the occurrence of Mtb-Beijing and non-Beijing strains. In this cross-sectional study, 64 patients with pulmonary tuberculosis (TB) were recruited from the Iranian border provinces (North West and West). Read More

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February 2021

Digging the rabbit hole, COVID-19 edition: anti-vaccine themes and the discourse around COVID-19.

Microbes Infect 2020 Nov - Dec;22(10):608-610. Epub 2020 Nov 7.

University of California Hastings College of the Law, San Francisco, CA, USA. Electronic address:

This article draws on a broadcast popular among the anti-vaccine community to map out six themes used by the broadcast to mislead viewers about COVID-19. The themes are the claim that "they" - government and pharma - are lying to you, claims that COVID-19 is an excuse to remove civil liberties, viewing everyone as an expert, claiming that science cannot save us, skewing the science, and a claim that "they" are out to harm the viewers. The article points out that similar themes are used to mislead followers with anti-vaccine information. Read More

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January 2021

Effects of immunization program on morbidity and mortality rates ofvaccine-preventable diseases in Turkey

Turk J Med Sci 2020 12 17;50(8):1909-1915. Epub 2020 Dec 17.

Ministry of Health, Ankara, Turkey

Background/aim: This study aims to serve as a unique consolidated source in Turkey’s vaccination history and as an example for other countries by objectively revealing the change in mortality and morbidity rates in Turkey following the beginning of vaccination without asserting any claim on the benefits or risks of vaccines. This unbiased research will also help health professionals identify the challenges more easily when they face with the people who hesitate to vaccinate their children.

Materials And Methods: Descriptive research design is adopted in this study. Read More

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December 2020

Correlation between human papillomavirus infection and histopathological diagnosis of women in Northeast Brazil.

J Med Virol 2020 May 30. Epub 2020 May 30.

Department of Histology, Center for Biosciences, Federal University of Pernambuco, Recife, Brazil.

Cervical carcinoma is the fourth leading cause of death among women worldwide. Epidemiological studies claim that human papillomavirus (HPV) infection is a necessary condition for cervical cancer development. Knowledge of the geographic distribution of HPV is important in guiding the introduction of prophylactic vaccines. Read More

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The Enigma of Low COVID-19 Fatality Rate in India.

Front Genet 2020 28;11:854. Epub 2020 Jul 28.

Department of Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, India.

Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has rapidly evolved into a pandemic. Though its origin has been linked to the Wuhan City of China's Hubei Province in December 2019, recent reports claim that the original animal-to-human transmission of the virus probably happened sometime between September and October 2019 in Guangdong Province, rather than Hubei. As of July 3, 2020, India has reported a case positivity rate of 6. Read More

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Accounting for indirect protection in the benefit-risk ratio estimation of rotavirus vaccination in children under the age of 5 years, France, 2018.

Euro Surveill 2020 08;25(33)

Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, High-Dimensional Biostatistics for Drug Safety and Genomics, CESP, Villejuif, France.

Background Rotavirus is a major cause of severe gastroenteritis in children worldwide. The disease burden has been substantially reduced in countries where rotavirus vaccines are used. Given the risk of vaccine-induced intussusception, the benefit–risk balance of rotavirus vaccination has been assessed in several countries, however mostly without considering indirect protection effects. Read More

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Incidence of Guillain-Barré Syndrome is not Associated with Influenza Vaccination in the Elderly.

Vaccines (Basel) 2020 Jul 31;8(3). Epub 2020 Jul 31.

Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.

We aimed to analyze the incidence of Guillain-Barré syndrome (GBS) and its association with influenza vaccination (IV) in the elderly population. This study included 2470 patients hospitalized with GBS (G61.0) between 2014 and 2016 based on the Korean National Health Insurance Service (NHIS) claims data. Read More

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Cost effectiveness of trivalent and quadrivalent influenza vaccines in 50- to 64-year-old adults in Korea.

Vaccine 2020 07 10;38(32):5002-5008. Epub 2020 Jun 10.

Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Republic of Korea; Department of Epidemiology and Health Informatics, Graduate School of Public Health, Korea University, Seoul, Republic of Korea. Electronic address:

Background: Influenza causes severe complications in at-risk populations, resulting in significant morbidity and mortality. Vaccination is the most effective measure to prevent infection and complications caused by seasonal influenza. However, no study has analyzed the cost-effectiveness of influenza vaccines in 50- to 64-year-olds in South Korea. Read More

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Modelling the spread of COVID-19 with new fractal-fractional operators: Can the lockdown save mankind before vaccination?

Authors:
Abdon Atangana

Chaos Solitons Fractals 2020 Jul 29;136:109860. Epub 2020 May 29.

Institute for Groundwater Studies, Faculty of Natural and Agricultural Sciences, University of the Free State, South Africa.

Countries around the world are implementing lock-down measures in a bid to flatten the curve of the new deadly COVID-19 disease. Our paper does not claim to have found the cure for COVID-19, neither does it claim that the suggested model have taken into account all the complexities around the spread of the disease. Nonetheless, the fundamental question asked in this paper is to know if within the conditions taken into account in this suggested model, the integral lock-down is effective in saving human lives. Read More

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Relative vaccine efficacy of high-dose versus standard-dose influenza vaccines in preventing probable influenza in a Medicare Fee-for-Service population.

Vaccine 2020 06 20;38(29):4548-4556. Epub 2020 May 20.

Sanofi Pasteur, 1 Discovery Drive, Swiftwater, PA 18370, USA; Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada. Electronic address:

Background: High-dose (HD) influenza vaccine, currently the most commonly used vaccine among US seniors (aged ≥ 65 years), has been shown to be more efficacious than standard-dose (SD) vaccine in multiple randomized trials. This study evaluated the real-world relative vaccine effectiveness (rVE) of HD vs SD over four influenza seasons.

Methods: This study included Medicare Fee-for-Service enrollees who received HD or SD at an outpatient clinic or pharmacy during influenza seasons 2011-2012 through 2014-2015. Read More

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Global landscape analysis of no-fault compensation programmes for vaccine injuries: A review and survey of implementing countries.

PLoS One 2020 21;15(5):e0233334. Epub 2020 May 21.

Access to Medicines and Health Products Division, World Health Organization, Geneva, Switzerland.

To update the landscape analysis of vaccine injuries no-fault compensation programmes, we conducted a scoping review and a survey of World Health Organization Member States. We describe the characteristics of existing no-fault compensation systems during 2018 based on six common programme elements. No-fault compensation systems for vaccine injuries have been developed in a few high-income countries for more than 50 years. Read More

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Prediction, mapping and validation of tick glutathione S-transferase B-cell epitopes.

Ticks Tick Borne Dis 2020 07 23;11(4):101445. Epub 2020 Apr 23.

Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Farmacociências, Universidade Federal das Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

In search of ways to address the increasing incidence of global acaricide resistance, tick control through vaccination is regarded as a sustainable alternative approach. Recently, a novel cocktail antigen tick-vaccine was developed based on the recombinant glutathione S-transferase (rGST) anti-sera cross-reaction to glutathione S-transferases of Rhipicephalus appendiculatus (GST-Ra), Amblyomma variegatum (GST-Av), Haemaphysalis longicornis (GST-Hl), Rhipicephalus decoloratus (GST-Rd) and Rhipicephalus microplus (GST-Rm). Therefore, the current study aimed to predict the shared B-cell epitopes within the GST sequences of these tick species. Read More

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A Map of Racial and Ethnic Disparities in Influenza Vaccine Uptake in the Medicare Fee-for-Service Program.

Adv Ther 2020 05 9;37(5):2224-2235. Epub 2020 Apr 9.

Sanofi Pasteur, Swiftwater, PA, USA.

Introduction: Despite improved understanding of the risks of influenza and better vaccines for older patients, influenza vaccination rates remain subpar, including in high-risk groups such as older adults, and demonstrate significant racial and ethnic disparities.

Methods: This study considers demographic, clinical, and geographic correlates of influenza vaccination among Medicare Fee-for-Service (FFS) beneficiaries in 2015-2016 and maps the data on a geographic information system (GIS) at the zip code level.

Results: Analyses confirm that only half of the senior beneficiaries evidenced a claim for receiving an inactivated influenza vaccine (IIV), with significant disparities observed among black, Hispanic, rural, and poorer beneficiaries. Read More

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Confirmatory bias in health decisions: Evidence from the MMR-autism controversy.

J Health Econ 2020 03 10;70:102284. Epub 2020 Feb 10.

Lehigh University, United States. Electronic address:

Since Wakefield et al. (1998), the public was exposed to mixed information surrounding the claim that measles-mumps-rubella vaccine causes autism. A persistent trend to delay the vaccination during 1998-2011 in the US was driven by children of college-educated mothers, suggesting that these mothers held biases against the vaccine influenced by the early unfounded claim. Read More

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Human Papillomavirus Vaccination Schedule: Adherence Among Commercially Insured Adolescents and Young Adults in the United States, 2011-2017.

Am J Public Health 2020 03 16;110(3):385-390. Epub 2020 Jan 16.

All authors are affiliated with the Department of Epidemiology, University of Alabama at Birmingham.

To determine rates of human papillomavirus (HPV) vaccine adherence to the 2011 and 2016 Advisory Committee for Immunization Practices (ACIP) recommendations in the United States. We conducted a retrospective cohort study by using the 2011 to 2017 Marketscan data for beneficiaries aged 9 to 26 years who had at least 1 claim for HPV vaccination between January 1, 2011, and January 1, 2017. According to the 2011 ACIP recommendation, adherence is defined as 30 to 90 days between the first and second vaccination and 168 to 212 days between the first and third vaccination. Read More

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Global immunization systems strengthening through pediatric societies: the promise of private-public partnerships in Indonesia.

Hum Vaccin Immunother 2020 05 18;16(5):1194-1201. Epub 2019 Dec 18.

Indonesian Pediatric Society; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.

Vaccines are one of the most successful health interventions in history. Yet, vaccine-preventable diseases still claim the lives of 2.5 million individuals globally every year. Read More

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Association between quality-of-care indicators for HIV infection and healthcare resource utilization and costs.

AIDS 2020 02;34(2):291-300

Health Outcomes Division, The University of Texas at Austin College of Pharmacy, Austin.

Objectives: Multiple care quality indicators for HIV infection exist but few studies examine their impact on health outcomes. This study assessed which HIV care quality indicators were associated with healthcare resource utilization and costs.

Design: Retrospective analysis of Texas Medicaid claims data (01 January 2012 to 31 September 2016). Read More

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February 2020

Characteristics of vaccinating providers reported through Medicare claims in office-based settings: Volume of influenza and pneumococcal vaccinations.

Vaccine 2020 01 1;38(1):15-19. Epub 2019 Nov 1.

Center for Medicare, Centers for Medicare & Medicaid Services, Baltimore, MD, United States.

Vaccination coverage among older adults is low in the United States. A recommendation from a provider is a strong predictor of vaccine receipt. Using Medicare Fee-For-Service data (2015-2017) this study characterized providers by the number of influenza and pneumococcal vaccines administered in physician offices, age, gender, and professional specialty to determine the volume of vaccines provided by individual providers and characteristics of these providers. Read More

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January 2020

Childhood MMR vaccination and the incidence rate of measles infection: a ten year longitudinal cohort study of American children born in the 1990s.

BMC Pediatr 2019 09 10;19(1):325. Epub 2019 Sep 10.

Institute of Chronic Illnesses, Inc, 14 Redgate Ct, Silver Spring, MD, 20905, USA.

Background: Measles (rubeola) is a highly contagious disease with significant morbidity/mortality. Measles-Mumps-Rubella (MMR) is a live-attenuated vaccine used in the United States (US) since the early 1970s to prevent measles infection. This retrospective longitudinal cohort study examined childhood MMR vaccination effectiveness (VE) on preventing diagnosed measles cases. Read More

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September 2019

Influenza vaccination effectiveness for people aged under 65 years in Japan, 2013/2014 season: application of a doubly robust method to a large-scale, real-world dataset.

BMC Infect Dis 2019 Jul 5;19(1):586. Epub 2019 Jul 5.

Department of Drug Development and Regulatory Science, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.

Background: Influenza vaccination is recognized as a primary public health intervention which prevents the illness of patients and relieves the societal burdens of influenza for medical community as well as the economy. To date, no effectiveness study of influenza vaccination has been conducted including a large population with a wide age span, in Japan. Here, we evaluated the clinical effectiveness of influenza vaccination in a large Japanese population. Read More

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