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Mat pilates method improve postural alignment women undergoing hormone therapy adjunct to breast cancer treatment. Clinical trial.

Complement Ther Clin Pract 2021 Jun 1;44:101424. Epub 2021 Jun 1.

Department of Physical Education at the Center for Health Sciences and Sports and Professor Postgraduate Program in Human Movement Sciences, Santa Catarina State University, Brazil.

The purpose of the study is to analyze the effects of a mat Pilates intervention on the postural alignment and balance of breast cancer women receiving hormone therapy. A two-arm randomized clinical trial included 34 breast cancer survivors divided randomly between a mat Pilates group (n = 18), that performed 16 weeks of mat Pilates exercises, and a control group (n = 16), who were invited to maintain their daily routine activities and received three educational sessions. Data collection occurred at baseline and at post-intervention time. Read More

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Optic nerve mobilization as an alternative to anterior clinoidectomy in superior carotid-ophthalmic aneurysms: Operative technique.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurosurgery, Padilla Hospital, Tucumán, Argentina.

Background: Carotid-ophthalmic aneurysms arise from the internal carotid artery between the distal dural ring and the origin of the posterior communicating artery. The surgical treatment of these aneurysms usually requires an anterior clinoidectomy. However, this procedure is not without complications. Read More

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IN VITRO and IN VIVO TRYPANOCIDAL ACTIVITY OF A BENZOFUROXAN DERIVATIVE AGAINST Trypanosoma cruzi.

Exp Parasitol 2021 Jun 12:108125. Epub 2021 Jun 12.

Department of Microbiology and Parasitology, Federal University of Santa Maria, Santa Maria, RS, Brazil.

Chagas disease, caused by Trypanosoma cruzi, is a major public health problem and is described as one of the most neglected diseases worldwide. It affects about 6-7 million people. Currently, only two drugs are available for the treatment of this disease: nifurtimox and benznidazole. Read More

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Genetic diversity and geographic distribution of parasitic flies of the Philornis torquans complex in Argentina.

Med Vet Entomol 2021 Jun 15. Epub 2021 Jun 15.

Laboratorio de Ecología de Enfermedades, Instituto de Ciencias Veterinarias del Litoral (ICIVET-Litoral), Universidad Nacional del Litoral (UNL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Esperanza, Argentina.

Philornis Meinert 1890 (Diptera: Muscidae) is a genus of flies that parasitize birds in the Neotropical region. The characteristics of the host-parasite interactions and its consequences may depend on the Philornis species involved, and thus precise identification of these parasites is crucial for the interpretation of ecological and epidemiological studies. However, morphological identification of Argentine Philornis species is elusive while molecular evidence points towards the existence of a complex of cryptic species or lineages undergoing a speciation process, which were named the 'Philornis torquans complex'. Read More

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Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment.

Biochem J 2021 Jun 15. Epub 2021 Jun 15.

University of Guelph, Guelph, Canada.

Reductions in mitochondrial function have been proposed to cause insulin resistance, however the possibility that impairments in insulin signaling negatively affects mitochondrial bioenergetics has received little attention. Therefore, we tested the hypothesis that insulin could rapidly improve mitochondrial ADP sensitivity, a key process linked to oxidative phosphorylation and redox balance, and if this phenomenon would be lost following high-fat diet (HFD)-induced insulin resistance. Insulin acutely (60 minutes post I. Read More

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Forest Coverage and Socioeconomic Factors Associated with Dengue in El Salvador, 2011-2013.

Vector Borne Zoonotic Dis 2021 Jun 14. Epub 2021 Jun 14.

Department of Public Health, School of Social Sciences Humanities and Arts, University of California Merced, Merced, California, USA.

Dengue virus serotypes 1, 2, 3, and 4 are transmitted by and mosquitoes, which cause illness in an estimated 100 million annually. Although dengue viruses are endemic throughout El Salvador, very little is known about their ecology and epidemiology. The principal methods to prevent and reduce dengue cases are through vector control and by adoption of a vaccine. Read More

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Programmable, Multiplexed DNA Circuits Supporting Clinically Relevant, Electrochemical Antibody Detection.

ACS Sens 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemical Science and Technologies, University of Rome, Tor Vergata, 00133 Rome, Italy.

Current health emergencies have highlighted the need to have rapid, sensitive, and convenient platforms for the detection of specific antibodies. In response, we report here the design of an electrochemical DNA circuit that responds quantitatively to multiple specific antibodies. The approach employs synthetic antigen-conjugated nucleic acid strands that are rationally designed to induce a strand displacement reaction and release a redox reporter-modified strand upon the recognition of a specific target antibody. Read More

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A Review of Acute Pancreatitis.

JAMA 2021 Jun;325(23):2402-2403

Fundación Santa Fe de Bogotá, Bogotá, Colombia.

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Neurotrophic factors in systemic lupus erythematosus: markers of disease activity.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Locomotor System, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

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Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality.

Expert Rev Mol Diagn 2021 Jun 15. Epub 2021 Jun 15.

Research Unit. Hospital Universitario de Canarias. Ofra, s/n. La Laguna 38320. Santa Cruz de Tenerife. Spain.

Background: Cell death by apoptosis is increased in septic patients. However, there are not data about circulating concentrations of sFas (proapoptotic protein of extrinsic pathway) and Bcl2 (antiapoptotic protein of intrinsic pathway) in COVID-19 patients. Thus, our objective study was to determine whether exists an association between serum concentrations of sFas and Bcl2 and COVID-19 patient mortality. Read More

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Consensus on the treatment of allergic asthma with sublingual house dust mite immunotherapy in the field of Pneumology.

Expert Rev Respir Med 2021 Jun 15. Epub 2021 Jun 15.

Unidad de Asma. Hospital Universitario de Galdakao. Galdakao, Bizkaia, Spain.

Introduction: : Many patients sensitized to mites remain symptomatic and uncontrolled despite traditional treatment. Sublingual immunotherapy (SLIT) has demonstrated to reduce the symptoms of allergic rhinitis, the need for additional drug treatments, and to reduce the number of moderate and severe exacerbations in patients with allergic asthma caused by mites that had not been adequately controlled.

Areas Covered: : After reviewing the most recent literature, a scientific committee composed by 5 pneumologists experts in asthma proposed 41 items that addressed the diagnosis of allergic asthma caused by mites, the role of house dust mite (HDM) SLIT tablet in the therapeutic plan and in the control of the disease, and the profile of patients with asthma candidates for this therapy. Read More

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Robot-assisted arm therapy in neurological health conditions: rationale and methodology for the evidence synthesis in the CICERONE Italian Consensus Conference.

Eur J Phys Rehabil Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Electrical and Information Engineering, Politecnico di Bari, Bari, Italy.

Background: Robot-assisted Arm Therapy (RAT) has been increasingly applied in the last years for promoting functional recovery in patients with disabilities related to neurological health conditions. Evidence of a knowledge-to-action gap for applying robot-assisted technologies in the rehabilitation of patients with neurological health conditions and the difficulty to apply and tailor the knowledge to the local contexts solicited the need for a national consensus conference on these interventions.

Aim: This paper aims to explain the methodology used by the working group dedicated to synthesize evidence on the effectiveness of RAT in neurological health conditions in the context of the CICERONE Italian Consensus Conference. Read More

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ADRB2 Haplotypes and Asthma Exacerbations in Children and Young Adults: An Individual Participant Data Meta-Analysis.

Clin Exp Allergy 2021 Jun 15. Epub 2021 Jun 15.

Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands.

Background: The polymorphism Arg16 in β -adrenergic receptor (ADRB2) gene has been associated with an increased risk of exacerbations in asthmatic children treated with long-acting β -agonists (LABA). However, it remains unclear whether this increased risk is mainly attributed to this single variant or the combined effect of the haplotypes of polymorphisms at codons 16 and 27.

Objective: We assessed whether the haplotype analysis could explain the association between the polymorphisms at codons 16 (Arg16Gly) and 27 (Gln27Glu) in ADRB2 and risk of asthma exacerbations in patients treated with inhaled corticosteroids (ICS) plus LABA. Read More

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Occupational exposure to crystalline silica and peripheral biomarkers: An update.

J Appl Toxicol 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Toxicology (LATOX), Department of Analysis, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Peripheral biomarkers are important tools for detecting occupational exposures to prevent the onset and/or progression of diseases. Studies that reveal early peripheral biomarkers are highly important to preserve the health of workers and can potentially contribute to diagnosing and/or prognosing occupational pathologies. Exposure to crystalline silica is a problem in several workplaces because it increases the risk of chronic obstructive pulmonary disease (COPD), tuberculosis, cancer, and pulmonary fibrosis, clinically defined as silicosis. Read More

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Correction: Empirical study on the effects of acquisition parameters for FTIR hyperspectral imaging of brain tissue.

Anal Methods 2021 Jun 15. Epub 2021 Jun 15.

Centre for Biospectroscopy and School of Chemistry, Monash University, Victoria, 3800, Australia. and Department of Microbiology and the Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria 3800, Australia.

Correction for 'Empirical study on the effects of acquisition parameters for FTIR hyperspectral imaging of brain tissue' by J. Sacharz et al., Anal. Read More

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Safety of COVID-19 vaccines, their components or their platforms for pregnant women: A rapid review.

medRxiv 2021 Jun 6. Epub 2021 Jun 6.

Background: Pregnant women with COVID-19 are at an increased risk of severe COVID-19 illness as well as adverse pregnancy and birth outcomes. Many countries are vaccinating or considering vaccinating pregnant women with limited available data about the safety of this strategy. Early identification of safety concerns of COVID-19 vaccines, including their components, or their technological platforms is therefore urgently needed. Read More

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Disease-dependent interaction policies to support health and economic outcomes during the COVID-19 epidemic.

iScience 2021 Jun 10:102710. Epub 2021 Jun 10.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.

Lockdowns and stay-at-home orders have partially mitigated the spread of Covid-19. However, en mitigation has come with substantial socioeconomic costs. In this paper we demonstrate how individualized policies based on disease status can reduce transmission risk while minimizing impacts on economic outcomes. Read More

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Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?

Bone Marrow Transplant 2021 Jun 14. Epub 2021 Jun 14.

Banc de Sang i Teixits, Barcelona, Spain.

Cryopreservation was recommended to ensure continuity of unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) during COVID-19 pandemic. However, its impact on clinical outcomes and feasibility was not well known. We compared 32 patients who underwent UD HSCT using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period. Read More

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Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24.

Prostate Cancer Prostatic Dis 2021 Jun 14. Epub 2021 Jun 14.

School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Background: We previously developed an African-ancestry-specific polygenic hazard score (PHS46+African) that substantially improved prostate cancer risk stratification in men with African ancestry. The model consists of 46 SNPs identified in Europeans and 3 SNPs from 8q24 shown to improve model performance in Africans. Herein, we used principal component (PC) analysis to uncover subpopulations of men with African ancestry for whom the utility of PHS46+African may differ. Read More

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Factors influencing self-selected walking speed in fibrotic interstitial lung disease.

Sci Rep 2021 Jun 14;11(1):12459. Epub 2021 Jun 14.

Programa de Pós-Graduação Em Ciências Pneumológicas, Hospital de Clínicas de Porto Alegre/Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.

This study aimed to investigate the walking economy and possible factors influencing self-selected walking speed (SSWS) in patients with fibrotic interstitial lung disease (ILD) compared to controls. In this study, 10 patients with ILD (mean age: 63.8 ± 9. Read More

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P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas.

Nat Commun 2021 06 14;12(1):3615. Epub 2021 Jun 14.

School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

Glioblastoma is considered one of the most aggressive malignancies in adult and pediatric patients. Despite decades of research no curative treatment is available and it thus remains associated with a very dismal prognosis. Although recent pre-clinical and clinical studies have demonstrated the feasibility of chimeric antigen receptors (CAR) T cell immunotherapeutic approach in glioblastoma, tumor heterogeneity and antigen loss remain among one of the most important challenges to be addressed. Read More

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Light-emitting metalenses and meta-axicons for focusing and beaming of spontaneous emission.

Nat Commun 2021 Jun 14;12(1):3591. Epub 2021 Jun 14.

Department of Electrical and Computer Engineering, University of California Santa Barbara, CA, USA.

Phased-array metasurfaces have been extensively used for wavefront shaping of coherent incident light. Due to the incoherent nature of spontaneous emission, the ability to similarly tailor photoluminescence remains largely unexplored. Recently, unidirectional photoluminescence from InGaN/GaN quantum-well metasurfaces incorporating one-dimensional phase profiles has been shown. Read More

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Impact of Preceding Workload on Team Performance in Collegiate Men's Ice Hockey.

J Strength Cond Res 2021 Jun 11. Epub 2021 Jun 11.

Health Sciences, Rocky Mountain University of Health Professions, Provo, Utah; San Francisco 49ers, Santa Clara, California; Athletics, University of Minnesota, Minneapolis, Minnesota; and Kinesiology, Point Loma Nazarene University, San Diego, California.

Abstract: Neeld, KL, Peterson, BJ, Dietz, CC, Cappaert, TA, and Alvar, BA. Impact of preceding workload on team performance in collegiate men's ice hockey. J Strength Cond Res XX(X): 000-000, 2021-Although the workload-injury relationship has received ample research attention, the relationship between prior workload and performance in team sport remains poorly understood. Read More

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Musings From a Musician Anesthesiologist.

Authors:
Lynn Ngai Gerber

Anesth Analg 2021 Jul;133(1):290

From the Department of Anesthesiology, Santa Clara Valley Medical Center, Stanford University School of Medicine, Stanford, California.

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Updating recommendations of the Brazilian Group of Flow Cytometry (GBCFLUX) for diagnosis of acute leukemias using four-color flow cytometry panels.

Hematol Transfus Cell Ther 2021 May 21. Epub 2021 May 21.

Hospital Amaral Carvalho, Jaú, SP, Brazil.

Introduction: Flow cytometry has become an increasingly important tool in the clinical laboratory for the diagnosis and monitoring of many hematopoietic neoplasms. This method is ideal for immunophenotypic identification of cellular subpopulations in complex samples, such as bone marrow and peripheral blood. In general, 4-color panels appear to be adequate, depending on the assay. Read More

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CT ​EvaLuation ​by ​ARtificial ​Intelligence ​For ​Atherosclerosis, Stenosis and Vascular ​MorphologY ​(CLARIFY): ​A ​Multi-center, international study.

J Cardiovasc Comput Tomogr 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, The George Washington University School of Medicine, Washington, DC, USA.

Background: Atherosclerosis evaluation by coronary computed tomography angiography (CCTA) is promising for coronary artery disease (CAD) risk stratification, but time consuming and requires high expertise. Artificial Intelligence (AI) applied to CCTA for comprehensive CAD assessment may overcome these limitations. We hypothesized AI aided analysis allows for rapid, accurate evaluation of vessel morphology and stenosis. Read More

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Relationship between polymorphisms in the FAS/FASL death receptor system and progression of low-grade precursor lesions infected with high-risk human papilloma virus.

Hum Immunol 2021 Jun 11. Epub 2021 Jun 11.

Facultad de Ciencias de la Salud, Catholic University of Murcia (UCAM), Murcia, Spain; Clinical Analysis Department, HGUSL, Cartagena, Spain; Molecular Pathology and Pharmacogenetic Group. Institute for Biohealth Research from Murcia (IMIB), HGUSL, Cartagena, Spain. Electronic address:

Squamous intraepithelial lesions (SIL) and cervical cancer are primary due to suboptimal immune response against human papillomavirus (HPV). The FASL/FAS system is a trigger of extrinsic pathway apoptosis. The distribution of polymorphisms rs1800682 (-670 A > G) FAS and rs763110 (-844C > T) FASL was studied in cervical smears from 372 females (182 with stable or regressed low-grade SIL (LSIL) (groupI) and a group of 190 high-grade SIL (HSIL) (groupII). Read More

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In vitro effects of 2 bioactive compounds, gallic acid and methyl gallate, on urolithiasis.

Actas Urol Esp 2021 Jun 11. Epub 2021 Jun 11.

Programa de Pós-graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brasil. Electronic address:

Introduction And Objectives: This study aimed to evaluate the role of 2 widely distributed natural phenolic compounds, gallic acid (GA) and methyl gallate (MG), in an in vitro model of urolithiasis, by using the methodology of calcium oxalate crystals formation, which is the most common type of urinary or kidney stones.

Material And Methods: The compounds GA and MG were subjected to anti-crystallization activities in different concentrations (0.003-0. Read More

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Mental health impact of the first wave of COVID-19 pandemic on Spanish healthcare workers: A large cross-sectional survey.

Rev Psiquiatr Salud Ment (Engl Ed) 2021 Apr-Jun;14(2):90-105

Center for Public Health Psychiatry, Universitair Psychiatrisch Centrum, KU Leuven, Leuven, Belgium.

Introduction: Healthcare workers are vulnerable to adverse mental health impacts of the COVID-19 pandemic. We assessed prevalence of mental disorders and associated factors during the first wave of the pandemic among healthcare professionals in Spain.

Methods: All workers in 18 healthcare institutions (6 AACC) in Spain were invited to web-based surveys assessing individual characteristics, COVID-19 infection status and exposure, and mental health status (May 5 - September 7, 2020). Read More

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October 2020