277 results match your criteria uveitis attack

Fluorescein angiographic findings and Behcet's disease ocular attack score 24 (BOS24) as prognostic factors for visual outcome in patients with ocular Behcet's disease.

Int J Retina Vitreous 2021 Aug 28;7(1):48. Epub 2021 Aug 28.

Oculoplastic and Reconstructive Surgery Division, Department of Ophthalmology, Phramongkutklao Hospital, 315 Rajawithi Rd, Thung Phayathai, Ratchathewi, Bangkok, 10400, Thailand.

Purpose: To determine the application of fluorescein angiographic (FA) findings and Behcet's disease ocular attack score 24 (BOS24) scoring system in predicting poor visual outcome in patients with ocular Behcet's disease.

Study Design: Retrospective cohort study.

Methods: We included 73 eyes of 38 patients with ocular Behcet's disease who underwent FA and reviewed FA images, anterior chamber cells, vitreous opacity, retinal and optic disc lesions, which are parameters in BOS24. Read More

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Ankylosing Spondylitis.

J Ophthalmic Vis Res 2021 Jul-Sep;16(3):462-469. Epub 2021 Jul 29.

Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

The seronegative spondyloarthropathies are a group of autoimmune inflammatory diseases lacking rheumatoid factor or antinuclear antibody in their serum. They include ankylosing spondylitis (AS), reactive arthritis, psoriatic arthritis, spondylitis associated with Crohn's disease and ulcerative colitis, and undifferentiated spondyloarthropathies. Inflammation mostly affects the axial joints, entheses, and extra-articular structures such as uveal tract, gastrointestinal tract, mucocutaneous tissue, and heart. Read More

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Uveitis following the BNT162b2 mRNA vaccination against SARS-CoV-2 infection: a possible association.

Retina 2021 Aug 2. Epub 2021 Aug 2.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel Department of Ophthalmology, Rambam Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine ,Technion, Israel Institute of Technology, Haifa, Israel Department of Ophthalmology, Galilee Medical Center, Bar Ilan University, Faculty of Medicine in the Galilee, Israel Department of Ophthalmology, Shaare Zedek Medical Center,Jerusalem Goldschleger Eye Institute, Department of Ophthalmology, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel Department of Ophthalmology, Barzilai Medical Center, Ashkelon, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel Department of Ophthalmology, Wolfson Medical Center, Holon, Sackler Faculty of Medicine, Tel Aviv University, Israel Department of Ophthalmology, Kaplan Medical Center, Rehovot, Faculty of Medicine, Hebrew University of Jerusalem, Israel.

Purpose: To describe uveitis cases following the BNT162b2 mRNA SARS-CoV-2 vaccination.

Methods: This is a multicenter, retrospective study. Vaccine related-uveitisdiagnosis was supported by the classification of the World Health Organization Adverse Drug Terminology and the Naranjo criteria. Read More

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Comparison of the Safety and Efficacy of Interferon Alpha-2a and Cyclosporine-A When Combined With Glucocorticoid in the Treatment of Refractory Behçet's Uveitis: A Randomized Controlled Prospective Study.

Front Pharmacol 2021 19;12:699903. Epub 2021 Jul 19.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To evaluate and compare the efficacy and safety of interferon alpha-2a (IFN-α2a) and cyclosporine-A (CsA) in patients with refractory Behçet's uveitis (BU). In this 12-month randomized, controlled, prospective trial, 26 participants (44 eyes) completed the study. Patients were randomly allocated to the IFN-α2a or CsA groups. Read More

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Neuromyelitis Optica Spectrum Disorder and Uveitis.

Ocul Immunol Inflamm 2021 Jul 2:1-4. Epub 2021 Jul 2.

Division of Retina, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MA, USA.

: Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare disease marked by CNS demyelination with a predilection for the optic nerve and spinal cord often resulting in severe vision loss. We aimed to characterize uveitis occurring in the setting of NMOSD.: Retrospective chart review: Of 572 NMOSD patients, 1% were found to have uveitis with a relative risk of 6. Read More

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Triggering factors associated with a new episode of recurrent acute anterior uveitis.

Sci Rep 2021 06 9;11(1):12156. Epub 2021 Jun 9.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok Noi, Bangkok, 10700, Thailand.

To identify triggering factors for the next inflammatory episode of recurrent acute anterior uveitis (RAAU), a 1:1 case-control study was conducted. We interviewed RAAU patients with recent acute anterior uveitis attack and quiescent controls for their information during a previous month using Srithanya Stress Test (ST-5) and questionnaires about potential triggering factors. Asymptomatic controls were matched for age (± 5 years), sex, and HLA-B27. Read More

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Tregs in Autoimmune Uveitis.

Adv Exp Med Biol 2021 ;1278:205-227

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Uveitis is a chronic disease with relapsing and remitting ocular attack, which requires corticosteroids and systemic immunosuppression to prevent severe vision loss. Classically, uveitis is referred to an autoimmune disease, mediated by pro-inflammatory Th17 cells and immunosuppressive CD4+CD25+FoxP3+ T-regulatory cells (Tregs). More and more evidence indicates that Tregs are involved in development, resolution, and remission of uveitis. Read More

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February 2021

Use of ultra-wide field retinal imaging and optical coherence tomography angiography in the diagnosis of incomplete Susac syndrome.

Eur J Ophthalmol 2020 Oct 26:1120672120965482. Epub 2020 Oct 26.

Clinic Institute of Ophthalmology (ICOF), Clinic Hospital of Barcelona, Barcelona, Spain.

Purpose: To describe clinical findings through ultra-wide field (UWF) images and optical coherence tomography angiography (OCT-A), in Susac's syndrome (SS).

Methods: SS patients were retrospectively analyzed in a single center. Clinical features, ultra-wide-field retinographies (UWF-PR), UWF fluorescein angiographies (UWF-FA), and optical coherence tomography angiography & (OCT-A/EF) were reviewed. Read More

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October 2020

Prevalence, risk factors and management of ocular hypertension or glaucoma in patients with Vogt-Koyanagi-Harada disease.

Br J Ophthalmol 2020 Oct 3. Epub 2020 Oct 3.

University Eye Clinic Maastricht, Maastricht, The Netherlands.

Background/aims: This study was performed to examine the prevalence, risk factors and treatment outcome of OHT/glaucoma in Chinese patients with Vogt-Koyanagi-Harada (VKH).

Methods: Retrospective non-interventional case series were conducted on a total of 2281 patients with VKH referred from April 2008 to April 2019. Of these cases, 1457 had a minimum follow-up period of 3 months and were included for this study. Read More

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October 2020

Paraneoplastic acute exudative polymorphous vitelliform maculopathy improved with intravitreal methotrexate.

Am J Ophthalmol Case Rep 2020 Dec 16;20:100930. Epub 2020 Sep 16.

Massachusetts Eye Research and Surgery Institution, United States.

Purpose: To describe a case of acute exudative polymorphous vitelliform maculopathy (AEPVM) treated with intravitreal methotrexate.

Observations: A 58-year-old man with a history of metastatic melanoma developed paraneoplastic acute exudative polymorphous vitelliform maculopathy, refractory to oral prednisone, intravitreal bevacizumab and intravitreal preservative-free triamcinolone. Improvement in vision and resolution of subfoveal fluid was later seen after intravitreal methotrexate therapy. Read More

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December 2020

Diurnal Spikes of Intraocular Pressure in Uveitic Glaucoma: A 24-hour Intraocular Pressure Monitoring Study.

Semin Ophthalmol 2020 May 3;35(4):246-251. Epub 2020 Sep 3.

Department of Ophthalmology, Marmara University School of Medicine , Istanbul, Turkey.

Purpose: The aim of this study was to document diurnal changes in intraocular pressure (IOP) in uveitic glaucoma (UG) and compare it with primary open angle glaucoma (POAG) patients.

Methods: Eight patients with UG and seven patients with POAG were included in this study. The patients were matched for age, gender, and glaucoma medications. Read More

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A Rare Case of Unilateral Progressive Cataract in a Young Patient Receiving Topiramate.

Case Rep Ophthalmol 2020 May-Aug;11(2):276-281. Epub 2020 Jul 3.

Rajas Eye and Retina Research Centre, Indore, India.

This case report presents an instance of unilateral cataract formation and its rapid progression following topiramate-induced bilateral acute angle closure. An 18-year-old female diagnosed with acute angle closure in both eyes had started treatment on the previous day at another healthcare facility. The patient presented with complaints of pain, sudden diminution of vision, excessive watering, and photophobia (both eyes) and reported the use of topiramate for headache for 10 days. Read More

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Proteomics Profiling of Plasma Exosomes in VKH Patients

Curr Mol Med 2020 07 18. Epub 2020 Jul 18.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Research Center of Ophthalmology and Vision Science, Tianjin Medical University Eye Institute, College of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, Tianjin 300382, China

Objectives: Vogt-Koyanagi-Harada syndrome is a common autoimmune uveitis that can cause blindness. Recent studies have shown that plasma exosomes carry disease-related proteins that may serve as biomarkers. Here, we aimed to find candidate biomarkers of Vogt-Koyanagi-Harada disease using proteomic analysis of plasma exosomes. Read More

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Complete blood count parameters and neutrophil-to-lymphocyte ratio values as markers for differentiation between systemic infectious and non-infectious uveitis.

Int Ophthalmol 2020 Nov 2;40(11):3033-3041. Epub 2020 Jul 2.

Department of Medical Microbiology, Haydarpasa Numune Training and Research Hospital, Tıbbiye Cad. No: 40, 34668, Üsküdar, Istanbul, Turkey.

Purpose: To compare complete blood count (CBC) parameters and neutrophil/lymphocyte ratio (NLR) between patients with infectious uveitis (IU) and those with non-infectious uveitis (NIU) during the first acute uveitis attack (AUA).

Methods: The records of 119 patients admitted with the first AUA between 2016 and 2019 and whose diagnosis was unknown at the time of admission were retrospectively reviewed. The patients were divided into two groups, IU and NIU according to diagnoses after ocular and systemic workup. Read More

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November 2020

Thiol/disulfide homeostasis in patients with ocular-active and ocular-inactive Behçet disease.

Int Ophthalmol 2020 Oct 1;40(10):2643-2650. Epub 2020 Jun 1.

Department of Biochemistry, Faculty of Medicine, Fırat University, Elazig, Turkey.

Purpose: To evaluate thiol/disulfide homeostasis in ocular-active (OA) and ocular-inactive (OI) Behçet disease (BD) patients and compare the data with healthy subjects.

Methods: Twenty OABD patients, 20 OIBD patients and 20 healthy control subjects were included into the study. The BD ocular attack score 24 (BOS24) scoring system was used to assess the activity of disease in ocular BD patients. Read More

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October 2020

Ultra-widefield fundus fluorescein angiography findings in patients with ankylosing spondylitis experiencing uveitis.

Int Ophthalmol 2020 Oct 2;40(10):2627-2634. Epub 2020 Jun 2.

Department of Ophthalmology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.

Aim: To evaluate ultra-widefield fundus fluorescein angiography (FFA) findings in cases of ankylosing spondylitis (AS)-associated uveitis.

Materials And Methods: Forty-five eyes of 23 AS patients followed up with a diagnosis of uveitis were included.

Results: Sixteen (69. Read More

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October 2020

Evaluation of changes in choroidal vascularity during acute anterior uveitis attack in patients with ankylosing spondylitis by using binarization of EDI-optical coherence tomography images.

Photodiagnosis Photodyn Ther 2020 Sep 17;31:101778. Epub 2020 May 17.

Department of Ophthalmology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

Background: To evaluate the effect of the first acute anterior uveitis (AAU) attack on the choroid by using an image binarization tool on images from enhanced depth imaging (EDI)-optical coherence tomography (OCT) scans in patients with ankylosing spondylitis (AS).

Methods: In this study, three groups were formed: uveitic eyes (UE; n = 20) of patients with AS, the non-uveitic eyes (NUE; n = 20) of these patients, and the eyes of healthy controls (n = 20). EDI-OCT images were obtained during the first AAU attack and at three months after treatment in patients with AS. Read More

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September 2020

An objective evaluation of crystalline lens density using Scheimpflug lens densitometry in different uveitis entities.

Int Ophthalmol 2020 Aug 23;40(8):2031-2040. Epub 2020 Apr 23.

Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

Aim: To measure lens densities with a Pentacam HR device in patients with active uveitis. Measurements were taken at the onset of the attack and after the treatment of inflammation.

Methods: The study included 51 eyes with different anterior uveitis aetiologies and a control group of 48 eyes of age- and gender-matched healthy subjects. Read More

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Retinopathy and Uveitis in Congenital Generalized Lipodystrophy with Hypertriglyceridemia and Uncontrolled Diabetes (Berardinelli-Seip Syndrome).

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):250-252. Epub 2020 Jan 29.

Vitreoretinal and Uveitis Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Congenital lipodystrophy syndromes are characterized by a paucity of adipose tissue and are associated with metabolic abnormalities including insulin resistance, diabetes mellitus, and severe hypertriglyceridemia. Herein, we present a case of proliferative diabetic retinopathy with an attack of anterior uveitis in a young female with congenital generalized lipodystrophy - Berardinelli-Seip syndrome. To the best of our knowledge, this is the first description of ocular involvement in Berardinelli-Seip syndrome. Read More

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Can the CRP/albumin Ratio be Used as a New Indicator of Activation in Patients with Uveitis?

Ocul Immunol Inflamm 2020 Mar 3:1-6. Epub 2020 Mar 3.

Department of Ophthalmology, Sakarya Training and Research Hospital, Sakarya, Türkiye.

: To evaluate whether the C-reactive protein (CRP)/albumin ratio (CAR) in patients with uveitis during an attack is a marker that can give information about the activity, severity and prognosis of the disease.: This study included 35 patients with an uveitis attack and 35 healthy volunteers. The localization and severity of uveitis were recorded. Read More

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Epidemiology, morbidity and mortality in Behçet's disease: a cohort study using The Health Improvement Network (THIN).

Rheumatology (Oxford) 2020 10;59(10):2785-2795

Institute of Applied Health Research, University of Birmingham, BirminghamUK.

Objectives: The epidemiology of Behçet's disease (BD) has not been well characterized in the UK. Evidence on the risk of cardiovascular disease, thromboembolic disease and mortality in patients with BD compared with the general population is scarce.

Methods: We used a large UK primary care database to investigate the epidemiology of BD. Read More

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October 2020

Induction of ocular Behçet's disease remission after short-term treatment with infliximab: a case series of 11 patients with a follow-up from 4 to 16 years.

Clin Exp Rheumatol 2019 Nov-Dec;37 Suppl 121(6):137-141. Epub 2019 Dec 9.

Rheumatology Unit, First Department of Propedeutic Internal Medicine and Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, Greece.

Objectives: Initial recommendations on anti-TNF treatment for Behçet's disease (BD) included an intravenous infliximab infusion for acute posterior uveitis to achieve a fast-onset response. We aimed to examine the long-term outcome of our patients with acute sight-threatening BD who received successful short-term treatment with infliximab.

Methods: We performed a retrospective longitudinal outcome study including consecutive patients who responded to one infliximab infusion (5mg/kg) for BD-associated acute posterior uveitis or panuveitis, followed, or not, by one or two additional infusions. Read More

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January 2020

The characteristics of Posner-Schlossman syndrome: A comparison in the surgical outcome between cytomegalovirus-positive and cytomegalovirus-negative patients.

Medicine (Baltimore) 2019 Nov;98(48):e18123

Department of Ophthalmology, Gifu University Graduate School of Medicine.

This retrospective observational study aims to report the clinical characteristics and surgical results in eyes with Posner-Schlossman syndrome (PSS), and compare these outcomes between cytomegalovirus (CMV)-positive and -negative eyes.We reviewed the medical records of 21 consecutive immunocompetent patients clinically diagnosed with PSS between the years 2010 and 2018. Aqueous humor was collected from all the affected eyes to detect if CMV was present, and polymerase chain reaction (PCR) was performed using the herpesvirus family primers. Read More

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November 2019

Analysis of Parafoveal Microvascular Abnormalities in Behcet's Uveitis Using Projection-Resolved Optical Coherence Tomographic Angiography.

Ocul Immunol Inflamm 2021 Apr 19;29(3):524-529. Epub 2019 Nov 19.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

: To assess the characteristics of parafoveal microvascular abnormalities in Behcet's uveitis (BDU) using projection-resolved optical coherence tomographic angiography (PR-OCTA).: A retrospective study of BDU patients who underwent PR-OCTA examination between April 1, 2017 and October 31, 2018.: Sixty consecutive BDU patients (102 eyes) were included. Read More

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Clinical features and disease course of neurological involvement in Behcet's disease: HUVAC experience.

Mult Scler Relat Disord 2020 Feb 9;38:101512. Epub 2019 Nov 9.

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Hacettepe University Vasculitis Center, Ankara, Turkey. Electronic address:

Background/aim: Neurological involvement (Neuro-Behcet's Disease: NBD) is a rare manifestation of Behcet's Disease (BD) and it is related with significant mortality and morbidity. We aimed to evaluate disease course and outcome of NBD patients registered in Hacettepe University Vasculitis Center (HUVAC) prospective database starting from October 2014.

Methods: Totally, 419 patients (329 of the patients had fulfilled the International Study Group (ISG) criteria and 90 patients were considered as incomplete BD) were recorded as BD to March 2018. Read More

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February 2020

Enhanced NLRP3 and DEFA1B Expression During the Active Stage of Parenchymal Neuro-Behçet's Disease.

In Vivo 2019 Sep-Oct;33(5):1493-1497

Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

Background/aim: Neurological symptoms (neuro-Behçet's disease; NBD) occur in a fraction of Behçet's disease (BD) patients and often present with parenchymal brain lesions and clinical exacerbations. Our aim was to identify genes associated with attack and remission periods of NBD.

Materials And Methods: Microarray analysis was performed using peripheral blood mononuclear cell (PBMC) samples obtained during attack and remission periods of five NBD patients. Read More

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January 2020

Recovery of the Ellipsoid and Interdigitation Zones in Acute Behcet's Uveitis after Therapy.

Ocul Immunol Inflamm 2020 Oct 16;28(7):1129-1132. Epub 2019 Aug 16.

Vitreoretinal Division and Uveitis Division, King Khaled Eye Specialist Hospital , Riyadh, Saudi Arabia.

: To report acute photoreceptor layers loss in Behcet's disease and its anatomical recovery after treatment with systemic steroids, mycophenolate mofetil, and adalimumab. : Case report. : A 16-year-old male who presented with an acute attack of Behcet's panuveitis along with loss of the ellipsoid zone (EZ) and interdigitation zone (IZ) on optical coherence tomography (OCT). Read More

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October 2020

The Relationship between Fluorescein Angiography Leakage after Infliximab Therapy and Relapse of Ocular Inflammatory Attacks in Ocular Behçet's Disease Patients.

Ocul Immunol Inflamm 2020 Nov 14;28(8):1166-1170. Epub 2019 Aug 14.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine , Tokyo, Japan.

: To clarify the relationship between fluorescein angiography (FA) leakage after infliximab therapy and ocular attack relapse in patients with ocular Behçet's disease (BD). : Patients with ocular BD were divided into two groups based on the presence (Group 1) or absence (Group 2) of ocular attacks after IFX therapy. FA leakage was evaluated by FA score in each of the optic discs, macula, large retinal vessels, and capillary vessels. Read More

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November 2020

Serum Cortistatin Levels in Patients with Ocular Active and Ocular Inactive Behçet Disease.

Ocul Immunol Inflamm 2020 May 17;28(4):601-605. Epub 2019 Jul 17.

Faculty of Medicine, Department of Biochemistry, Fırat University , Elazığ, Turkey.

Purpose: To evaluate serum cortistatin (CST) levels in patients with ocular active and ocular inactive Behçet disease (BD) and its relationship with disease activity.

Methods: 24 BD patients with ocular active, 24 BD patients with ocular inactive patients and 24 healthy control subjects were included in the study.

Results: In ocular active and ocular inactive BD patients and healthy control subjects, the mean serum CST levels were 4. Read More

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Pattern recognition is a sequential process-accurate diagnosis and treatment 20 years after presentation.

Oxf Med Case Reports 2019 Jul 5;2019(7):omz058. Epub 2019 Jul 5.

Rheumatology Department, Norfolk and Norwich University Hospital, Norfolk, UK.

A 25-year-old woman presented with ophthalmic and neurological manifestations. Her ocular manifestations included bilateral uveitis, multifocal retinal phlebitis, vitreitis and multiple retinal haemorrhages. Her neurological manifestations included migrainous headaches with visual aura, transient sensory symptoms and posterior circulation Transient Ischemic Attack (TIA). Read More

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