J Mol Biol 2019 09 6;431(20):4093-4102. Epub 2019 Jun 6.
Institut Jacques Monod, CNRS and Université Paris 7, Paris Université, Paris, France; Institut de Biologie de l'Ecole normale supérieure, PSL Université, INSERM, CNRS, Paris, France; Horizons 2020 Innovative Training Network, DNAREPAIRMAN, Paris, France.
Transcription-coupled repair is mediated by the Mfd protein. TCR is defined as the preferential repair of DNA lesions in the transcribed strand of actively transcribed genes, and is opposed to the strand-aspecific global genome repair. The Mfd protein mediates TCR by binding to and displacing RNA polymerase, which is stalled at a DNA lesion on the transcribed strand of DNA, then recruiting UvrA and UvrB. Read More