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Multi-level multi-modality (PET and CT) fusion radiomics: Prognostic modeling for non-small cell lung carcinoma.

Phys Med Biol 2021 Sep 20. Epub 2021 Sep 20.

Division of Nuclear Medicine, University Hospital of Geneva, 24 Rue Micheli-du-Crest, 1211 Geneva 4, Geneva, SWITZERLAND.

We developed multi-modality radiomic models by integrating information extracted from 18F-FDG PET and CT images using feature- and image-level fusions, toward improved prognosis for non-small cell lung carcinoma (NSCLC) patients. Two independent cohorts of NSCLC patients from two institutions (87 and 95 patients) were cycled as training and testing datasets. Fusion approaches were applied at two levels, namely feature- and image-levels. Read More

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September 2021

Modifiable Risk Factors Increase Length of Stay and 90-Day Cost of Care After Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 Sep 17. Epub 2021 Sep 17.

Background: Baseline health conditions can negatively impact cost of care and risk of complications after joint replacement, necessitating additional care and incurring higher costs. Bundled payments have been utilized for hip and knee replacement and CMS (Centers for Medicare and Medicaid Services) is testing bundled payments for upper extremity arthroplasty. The purpose of this study was to determine the impact of pre-defined modifiable risk factors (MRF) on total encounter charges, hospital length of stay (LOS), related emergency department (ED) visits and charges, and related hospital readmissions within 90 days after shoulder arthroplasty. Read More

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September 2021

Optimal Thyroid Hormone Replacement.

Endocr Rev 2021 Sep 20. Epub 2021 Sep 20.

Georgetown University, Division of Endocrinology, Washington, DC, USA.

Hypothyroidism is a common endocrinopathy and levothyroxine is frequently prescribed. Despite the basic tenets of initiating and adjusting levothyroxine being agreed upon, there are many nuances and complexities to consistently maintaining euthyroidism. Understanding the impact of patient weight and residual thyroid function on initial levothyroxine dosage and consideration of age, co-morbidities, TSH goal, life stage, and quality of life as levothyroxine is adjusted can be challenging and continually evolving. Read More

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September 2021

Improving the Performance of Individually Calibrated SSVEP-BCI by Task-Discriminant Component Analysis.

IEEE Trans Neural Syst Rehabil Eng 2021 Sep 20;PP. Epub 2021 Sep 20.

A brain-computer interface (BCI) provides a direct communication channel between a brain and an external device. Steady-state visual evoked potential based BCI (SSVEP-BCI) has received increasing attention due to its high information transfer rate, which is accomplished by individual calibration for frequency recognition. Task-related component analysis (TRCA) is a recent and state-of-the-art method for individually calibrated SSVEP-BCIs. Read More

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September 2021

A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration.

Bioact Mater 2022 Feb 30;8:559-572. Epub 2021 Jun 30.

Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610064, PR China.

We demonstrate a simple, effective and feasible method to address the shrinkage of Poly (lactic--glycolic acid) (PLGA) through a core-shell structure fiber strategy. The results revealed that introducing size-stable poly-caprolactone (PCL) as the core fiber significantly improved the PLGA-based fibrous scaffold's dimensional maintenance. We further utilized fish collagen to modify the PLGA shell layer (PFC) of coaxial fibers and loaded baicalin (BA) into the PCL core layer (PCL-BA) to endow fibrous scaffold with more functional biological cues. Read More

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February 2022

Dangers of residual confounding: a cautionary tale featuring cognitive ability, socioeconomic background, and education.

BMC Psychol 2021 Sep 18;9(1):145. Epub 2021 Sep 18.

Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden.

Background: Cognitive ability and socioeconomic background (SEB) have been previously identified as determinants of achieved level of education. According to a "discrimination hypothesis", higher cognitive ability is required from those with lower SEB in order to achieve the same level of education as those with higher SEB. Support for this hypothesis has been claimed from the observation of a positive association between SEB and achieved level of education when adjusting for cognitive ability. Read More

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September 2021

Impacts of dietary self-monitoring via MyFitnessPal to undergraduate women: A qualitative study.

Body Image 2021 Sep 14;39:221-226. Epub 2021 Sep 14.

Department of Nutritional Sciences, University of Michigan School of Public Health, United States.

The present study explored college women's perceptions of how dietary self-monitoring alters eating and body image-related cognitions and behaviors. The sample consisted of undergraduate women (N = 20), aged ≥ 18 (mean = 21.9 ± 6. Read More

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September 2021

Barriers to receiving testosterone replacement therapy in the community during COVID-19 pandemic.

Transl Androl Urol 2021 Aug;10(8):3312-3316

Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Background: While the etiology for the upsurge in testosterone testing and prescriptions is likely multifactorial, increased direct-to-consumer marketing and the expansion of clinical care centers devoted to testosterone treatment likely play a role. Many of these centers require patients to report, in-person, on a regular basis for their injectable therapy and/or lab studies. The purpose of our study was to investigate barriers of care that patients receiving treatment for testosterone deficiency may be experiencing in the setting of COVID-19. Read More

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Improving time to palliative care review with predictive modeling in an inpatient adult population: study protocol for a stepped-wedge, pragmatic randomized controlled trial.

Trials 2021 Sep 16;22(1):635. Epub 2021 Sep 16.

Department of Anesthesiology, Mayo Clinic, Rochester, MN, 55905, USA.

Background: Palliative care is a medical specialty centered on improving the quality of life (QOL) of patients with complex or life-threatening illnesses. The need for palliative care is increasing and with that the rigorous testing of triage tools that can be used quickly and reliably to identify patients that may benefit from palliative care.

Methods: To that aim, we will conduct a two-armed stepped-wedge cluster randomized trial rolled out to two inpatient hospitals to evaluate whether a machine learning algorithm accurately identifies patients who may benefit from a comprehensive review by a palliative care specialist and decreases time to receiving a palliative care consult in hospital. Read More

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September 2021

Caregiver rating of early childhood development: Reliability and validity of the ASQ-3 in rural Guatemala.

Early Hum Dev 2021 Aug 24;161:105453. Epub 2021 Aug 24.

Department of Rehabilitation, School of Medicine, University of Colorado, Children's Hospital Colorado, Aurora, CO, United States.

Background: Although performance-based assessment of early childhood development is preferred, there are a number of limitations to this methodology in low resource settings (LRSs). Hence, clinicians and researchers often rely on caregiver report screening tools. The Ages and Stages Questionnaire 3 (ASQ) is one of the most widely used caregiver report measures globally. Read More

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Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA.

Bioorg Chem 2021 Sep 13;116:105339. Epub 2021 Sep 13.

Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo 11884, Egypt. Electronic address:

Microbial resistance is a big concern worldwide, making the development of new antimicrobial drugs difficult. The thiazole and pyrazole rings are important heterocyclic compounds utilized to produce a variety of antimicrobial medications. As a result, a series of new bis-thiazolyl-pyrazole derivatives 3, 4a-c, 5a, b, and 6a-c was synthesized by reacting bis hydrazonoyl bromide with several active methylene reagents in a one-pot reaction. Read More

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September 2021

Progress in using zebrafish as a toxicological model for traditional Chinese medicine.

J Ethnopharmacol 2021 Sep 13;282:114638. Epub 2021 Sep 13.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Jinan, China. Electronic address:

Ethnopharmacological Relevance: Traditional Chinese medicine (TCM) has been applied for more than 2000 years. However, modern basic research on the safety of TCMs is limited. Establishing safety evaluation technology in line with the characteristics of TCM and conducting large-scale basic toxicity research are keys to comprehensively understand the toxicity of TCMs. Read More

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September 2021

Cost-minimization analysis of biweekly dosing of cetuximab and FOLFIRI compared with panitumumab and FOLFOX for first-line treatment of patients with KRAS wild type metastatic colorectal cancer in the United States.

J Med Econ 2021 Sep 16. Epub 2021 Sep 16.

Eli Lilly and Company, Indianapolis, IN, United States.

Aim: To compare the cost of biweekly regimens of first-line (1L) treatments of cetuximab-FOLFIRI versus panitumumab-FOLFOX in patients with Kirsten's rat sarcoma wild type (KRAS WT) metastatic colorectal cancer (mCRC) in the US, across varying weights and body surface areas (BSAs).

Materials And Methods: Cost-minimization analysis (CMA) was performed to estimate per-patient cost differences of cetuximab-FOLFIRI versus panitumumab-FOLFOX. The CMA estimated the costs of rat sarcoma (RAS) testing, premedication, drug acquisition, treating infusion reactions (IRs), supportive therapy, and biweekly administration of chemotherapy, cetuximab (500 mg/m), and panitumumab (6 mg/kg) over 43 weeks (median progression-free survival). Read More

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September 2021

Enhanced clearing of biofilms on a 3D urothelial cell model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles.

Biomater Sci 2021 Sep 16. Epub 2021 Sep 16.

Department of Chemistry, Nazarbayev University, 53 Kabanbay Batyr Avenue, Nursultan city, 010000, Kazakhstan.

urinary tract biofilms are increasingly witnessed in nosocomial infections due to reduced immunity of patients and the hospital ecosystem. The indwelling devices utilized to support patients with urethral diseases that connect the unsterilized external environment with the internal environment of the patient are another significant source of urinary tract biofilm infections. Recently, nanoparticle (NP)-associated therapeutics have gained traction in a number of areas, including fighting antibiotic-resistant bacterial biofilm infection. Read More

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September 2021

Husband Support Mediates the Association between Self-Efficacy and Cervical Cancer Screening among Women in the Rural Area of Indonesia.

Asia Pac J Oncol Nurs 2021 Sep-Oct;8(5):560-564. Epub 2021 Jun 21.

Department of Maternity Nursing, Faculty of Health Science, University of Muhammadiyah Malang, Malang, Jawa Timur, Indonesia.

Objective: Standard cervical cancer screening is seen as the most efficient way of preventing cases of cervical cancer. This study aimed to test indirect husband support pathways and the use of self-efficacy and Visual Inspection with Acetic Acid (VIA) testing among women in Indonesian rural areas.

Methods: The research implemented a cross-sectional design carried out in East Java, Indonesia, a remote county. Read More

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Standard hospital blanket warming cabinets can be utilized for complete moist heat SARS-CoV2 inactivation of contaminated N95 masks for re-use.

Sci Rep 2021 09 15;11(1):18316. Epub 2021 Sep 15.

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.

Shortages of personal protective equipment for use during the SARS-CoV-2 pandemic continue to be an issue among health-care workers globally. Extended and repeated use of N95 filtering facepiece respirators without adequate decontamination is of particular concern. Although several methods to decontaminate and re-use these masks have been proposed, logistic or practical issues limit adoption of these techniques. Read More

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September 2021

Opportunity to elevate the quality of data reporting in Cytopathology.

Authors:
Colleen M Vrbin

Cytopathology 2021 Sep 15. Epub 2021 Sep 15.

Analytical Insights, LLC.

Accurate and thorough data analysis and reporting are essential to ensure the interpretation of the findings is appropriate. A detailed methods section in a manuscript contains enough information to permit a researcher with access to the study components, including the data, to replicate the findings. This descriptive study of 2. Read More

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September 2021

Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results.

Microbiol Spectr 2021 Sep 15:e0031321. Epub 2021 Sep 15.

Department of Genetics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.

The coronavirus disease 2019 (COVID-19) pandemic has brought about the unprecedented expansion of highly sensitive molecular diagnostics as a primary infection control strategy. At the same time, many laboratories have shifted focus to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research and diagnostic development, leading to large-scale production of SARS-CoV-2 nucleic acids that can interfere with these tests. We have identified multiple instances, in independent laboratories, in which nucleic acids generated in research settings are suspected to have caused researchers to test positive for SARS-CoV-2 in surveillance testing. Read More

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September 2021

Reporting at Least One Adverse Effect Post-COVID-19 Vaccination From Primary Health Care in Muscat.

Cureus 2021 Aug 10;13(8):e17055. Epub 2021 Aug 10.

Medicine, Al Nahdha Hospital, Muscat, OMN.

Introduction Vaccinations against COVID-19 were licensed with limited testing assurances to the public triggering a widespread hesitancy around expected adverse reactions. Limited data was reported from Arabian Gulf countries on vaccine adverse effects. Objectives This study looked at the rate of reporting at least one side effect post-COVID-19 vaccination and its associated factors (sociodemographic characteristics, clinical condition, and type of vaccines). Read More

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THE SEVERITY OF PREOPERATIVE HBA1C AND PREDICTING POSTOPERATIVE COMPLICATIONS IN SPINE SURGERY.

World Neurosurg 2021 Sep 11. Epub 2021 Sep 11.

Division of Neurosurgery, University of Missouri School of Medicine, One Hospital Dr. MC 320, Columbia, MO 65212, USA.

Background: Diabetes mellitus (DM) is associated with higher perioperative complications. Hemoglobin A1c (HbA1c) has not been routinely utilized in preoperative assessment for spine surgeries.

Methods: In this single institution prospective study, HbA1c testing was included in preoperative laboratory examination of spinal surgeries from 2016 through 2018. Read More

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September 2021

The Development and Testing of a Perinatal Tobacco, Attitudes, and Behaviors Survey (PTABS).

J Nurs Meas 2021 Sep 13. Epub 2021 Sep 13.

Binghamton University, State University of New York, Binghamton, New York.

Background And Purpose: Accurate assessment of tobacco use in pregnant smokers is key to effective nursing intervention. There is a lack of valid and reliable tools easily integrated into prenatal care. Therefore, the purpose of this study was to develop and test a perinatal survey, guided by the Health Promotion Model (HPM). Read More

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September 2021

Factor Analysis of the Short-Form Cohen-Mansfield Agitation Inventory (CMAI) and the Measurement Invariance by Gender.

J Nurs Meas 2021 Sep 13. Epub 2021 Sep 13.

University of Maryland School of Nursing, Baltimore, Maryland.

Background And Purpose: The Cohen-Mansfield Agitation Inventory (CMAI) is a widely used measure of agitation. The purpose of this study was to test the internal consistency, reliability, and validity of short-form CMAI in a sample of nursing home residents with cognitive impairment and examine if it is invariant across gender.

Methods: This study utilized baseline data from a randomized trial including 553 residents from 55 nursing homes. Read More

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September 2021

SERS-based copper-mediated signal amplification strategy for simple and sensitive detection of telomerase activity.

Talanta 2021 Dec 19;235:122814. Epub 2021 Aug 19.

Department of Chemistry, Liaocheng University, Liaocheng, 252059, Shandong, China.

Simple and sensitive detection of telomerase activity is of vital importance for both early diagnosis and therapy of malignant tumors. Inspired by DNA-biobarcode amplification reported by Chad A. Mirkin, we developed a facile DNA-biobarcode-like SERS-based copper-mediated signal amplification strategy for sensitive detection of telomerase activity. Read More

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December 2021

No-wash point-of-care biosensing assay for rapid and sensitive detection of aflatoxin B1.

Talanta 2021 Dec 2;235:122772. Epub 2021 Aug 2.

Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.

In many cases of in-situ or point-of-care testing (POCT), the single pursuit of good detection performance cannot meet the testing requirements, and thus no-wash testing has become one of the most effective methods to develop sustainable biosensing assay, providing more convenient operation procedures and shorting the detection time. Herein, a disposable POC biosensing assay was prepared based on the RGB color detector software on the smartphone and the peroxide-like activity of gold nanoparticles (Au NPs) for aflatoxin B1 (AFB1) sensitive detection. Using syringe filters for a simple physical separation procedure can easily realize washing free detection, which is superior to most biosensing assays with cumbersome detection procedures. Read More

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December 2021

Development of metastasis-associated seven gene signature for predicting lung adenocarcinoma prognosis using single-cell RNA sequencing data.

Math Biosci Eng 2021 Jul;18(5):5959-5977

Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China.

Metastasis is the primary cause of lung adenocarcinoma (LUAD)-related death. This study evaluated the metastasis-associated genes (MAGs) in single-cell RNA sequencing (scRNA-seq) data from LUAD tissues and developed a MAG signature to predict overall survival (OS) of LUAD patients. The LUAD scRNA-seq data was downloaded from the Gene Expression Omnibus (GEO) Database and MAGs were identified from LUAD scRNA-seq data. Read More

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Ehrlichiosis and anaplasmosis subcommittee report to the Tick-borne Disease Working Group.

Ticks Tick Borne Dis 2021 Sep 4;12(6):101823. Epub 2021 Sep 4.

The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555-0609, United States. Electronic address:

Ehrlichioses and anaplasmosis have undergone dramatic increases in incidence, and the geographic ranges of their occurrence and vectors have also expanded. There is marked underreporting of these diseases owing to deficient physician awareness and knowledge of the illnesses as well as limited access to appropriate diagnostic tests. Human monocytic ehrlichiosis and anaplasmosis are life threatening diseases with estimated case fatality rates of 2. Read More

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September 2021

Fecal Microbiota Transplantation and Medical Therapy for Clostridium difficile Infection: Meta-analysis of Randomized Controlled Trials.

J Clin Gastroenterol 2021 Sep 9. Epub 2021 Sep 9.

Departments of Medicine Gastroenterology and Hepatology Library Services, Cleveland Clinic Foundation Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH Department of Medicine, UPMC, Pittsburgh, PA Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL Department of Medicine, Asante Rogue Regional Medical Center, Medford, OR Baba Farid University of Health Sciences, Faridkot, Punjab, India.

Goals: The aim was to assess the effectiveness of fecal microbiota transplantation (FMT) against medical therapy (MT).

Background: FMT has shown good outcomes in the treatment of Clostridium difficile infection (CDI). We aimed to conduct a systematic review and meta-analysis to compare the effectiveness of FMT versus MT for CDI. Read More

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September 2021

Successful Implementation of an Increased Viral Risk Donor Waiting List for Preconsented Kidney Transplant Candidates in Victoria, Australia.

Transplant Direct 2021 Oct 7;7(10):e758. Epub 2021 Sep 7.

Department of Nephrology, Austin Health, Heidelberg, Australia.

Increased viral risk donors (IVRDs) with increased risk behaviors for blood-borne virus infection and negative nucleic acid testing have a low absolute risk of "window period" infection. Utilization and allocation of IVRD organs differ between jurisdictions.

Methods: We examined the characteristics and utilization of deceased donor IVRD kidneys and recipient outcomes within a 2-y period (July 31, 2018-July 31, 2020) postimplementation of a new opt-in allocation pathway for preconsented recipients in Victoria, Australia. Read More

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October 2021

Pulmonary Function Testing Pre-heart Transplant Predicts Posttransplant Survival.

Transplant Direct 2021 Oct 7;7(10):e752. Epub 2021 Sep 7.

Department of Internal Medicine, Division of Cardiology, University of Nebraska Medical Center, Omaha, NE.

Although pulmonary function testing (PFT) is typically performed for heart transplant evaluation, the prognostic utility of PFTs after transplantation is unknown. We evaluated whether PFT parameters were correlated with outcomes following heart transplantation.

Methods: International Society for Heart and Lung Transplantation Thoracic Organ Transplant Registry data were utilized. Read More

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October 2021

Portable and automated analyzer for rapid and high precision dissolution of drugs.

J Pharm Anal 2021 Aug 11;11(4):490-498. Epub 2020 Jun 11.

Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun, 130024, China.

We developed a novel portable and automated dissolution test analyzer for rapid and high precision in vitro dissolution testing of drugs. The analyzer consists of a flow-through-cell drug dissolution system, an automated sequential sampling system, a high-speed capillary electrophoresis (HSCE) system, and a data acquisition system. Combining the high-temporal resolution flow-gating sampling approach with HSCE, which has outstanding advantages of efficient separation and resolution, the analyzer can achieve rapid analysis and exhibits the ability in miniaturization for on-site assessment of different active pharmaceutical ingredients. Read More

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